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Acknowledgements

We would like to thank the developers of the algorithms we have considered for their helpful discussions and cooperation in this study. In particular Drs B. Rost, D. Frishman V. Solovyev, R. King and M. Zvelebil, for providing their software. We also thank Matt Finlay for coding many of the routines to parse prediction output, as well as Dr. A.S. Siddiqui for his automatic alignment building algorithm. We thank Prof. L. N. Johnson. for her encouragement and support. This work was supported in part by grants from the Medical Research Council and the Royal Society. JC is an Oxford Centre for Molecular Sciences/MRC student.



james@ebi.ac.uk