Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 G 0 -2 0 -1 -2 -2 -2 5 -2 -4 -4 -1 -3 -3 -2 0 -2 -2 -3 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 2 S 1 -1 1 0 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 3 L -2 -3 -4 -4 -2 -3 -3 -4 -3 3 4 -3 1 0 -3 -3 -1 -2 -2 1 0 0 0 0 0 0 0 0 0 24 70 0 0 0 0 0 0 0 0 6 0.54 0.14 4 T -1 -2 0 3 -2 -1 0 -2 -2 -2 -2 -1 -2 -3 -2 1 5 -3 -2 -1 0 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 76 0 0 0 0.57 0.14 5 N 0 1 4 0 -2 0 -1 -1 -1 -3 -3 0 -2 -3 -2 3 0 -4 -2 -3 0 9 39 0 0 0 0 0 0 0 0 0 0 0 0 52 0 0 0 0 0.53 0.14 6 K -1 2 -1 -1 -4 1 0 -2 -1 -3 -3 6 -2 -4 -1 -1 -1 -4 -2 -3 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0.75 0.14 7 V -1 -3 -3 -3 -1 -3 -3 -4 -3 3 0 -3 0 -1 -3 -1 2 -3 -2 4 0 0 0 0 0 0 0 0 0 33 0 0 0 0 0 0 18 0 0 49 0.42 0.14 8 V -1 -3 -3 -3 -1 -2 -3 -3 -3 2 0 -3 0 -2 -3 -1 2 -3 -2 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 80 0.51 0.19 9 K -1 4 -1 -1 -4 1 0 -2 -1 -3 -3 5 -2 -4 -2 -1 -1 -4 -2 -3 0 20 0 0 0 0 0 0 0 0 0 80 0 0 0 0 0 0 0 0 0.77 0.19 10 D 1 -2 2 5 -3 -1 2 -2 -1 -3 -4 -1 -3 -4 -2 0 -1 -4 -3 -3 18 0 9 60 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0.72 0.19 11 F -3 -3 -3 -4 -3 -3 -3 -4 2 -1 0 -3 3 6 -4 -3 -2 0 2 -1 0 0 0 0 0 0 0 0 8 0 0 0 18 74 0 0 0 0 0 0 0.81 0.19 12 M -2 -3 -3 -4 -2 -2 -3 -4 -3 4 2 -2 6 -1 -3 -2 -1 -2 -2 1 0 0 0 0 0 0 0 0 0 39 5 0 56 0 0 0 0 0 0 0 0.59 0.19 13 L -2 3 -2 -3 -2 1 -2 -3 -2 0 3 -1 0 -1 -3 -1 2 -3 -2 -1 0 22 0 0 0 8 0 0 0 0 51 0 0 0 0 0 20 0 0 0 0.32 0.19 14 Q -1 0 0 -1 -3 5 1 -2 2 -3 -3 3 -1 -4 -2 2 -1 -3 -2 -3 0 0 0 0 0 56 0 0 6 0 0 20 0 0 0 18 0 0 0 0 0.60 0.19 15 T -1 3 -1 -2 -3 0 0 -2 -1 -3 -3 5 -2 -3 -2 0 2 -3 -2 -2 0 18 0 0 0 0 0 0 0 0 0 60 0 0 0 0 21 0 0 0 0.58 0.19 16 L -2 -3 -4 -4 -2 -3 -4 -4 -3 1 5 -3 2 0 -4 -3 -2 -2 -2 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.74 0.19 17 N -2 -1 5 3 -3 -1 -1 -2 3 -2 1 -1 -1 -2 -3 -1 -1 -4 -2 -2 0 0 52 18 0 0 0 0 9 0 20 0 0 0 0 0 0 0 0 0 0.52 0.19 18 D 0 -1 0 3 -3 0 3 -2 -1 -3 -3 -1 -3 -3 -2 4 0 -4 -3 -3 0 0 0 21 0 0 28 0 0 0 0 0 0 0 0 51 0 0 0 0 0.55 0.19 19 I -2 -3 -4 -4 -2 -3 -4 -4 -3 2 4 -3 2 0 -4 -3 -2 -2 -2 1 0 0 0 0 0 0 0 0 0 17 79 0 5 0 0 0 0 0 0 0 0.63 0.19 20 D -2 2 1 6 -4 -1 1 -2 -2 -4 -4 0 -3 -4 -2 -1 -2 -5 -3 -4 0 18 0 82 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.99 0.19 21 I -1 -2 -3 -3 -1 -2 -3 -3 -3 5 2 -2 1 0 -2 -2 -1 -2 -1 2 1 1 1 1 0 1 1 1 0 62 22 1 0 1 1 1 1 0 1 1 0.40 0.16 22 R -2 3 -1 2 -4 1 0 -2 -1 -4 -3 3 -2 -4 4 -1 -1 -4 -3 -3 0 21 0 18 0 6 0 0 0 0 0 35 0 0 20 0 0 0 0 0 0.60 0.19 23 G 0 -3 -1 -2 -3 -2 -3 6 -3 -4 -4 -2 -3 -4 -3 0 -2 -3 -4 -4 0 0 0 0 0 0 0 92 0 0 0 0 0 0 0 8 0 0 0 0 1.19 0.19 24 S -1 0 4 -1 -3 0 -1 -2 2 -2 -2 2 3 -3 -2 1 -1 -3 -2 -2 0 0 37 0 0 0 0 0 8 0 0 20 18 0 0 17 0 0 0 0 0.38 0.19 25 A 5 -2 -2 -2 -1 -1 -1 0 -2 -2 -2 -1 -2 -3 -1 1 -1 -3 -2 -1 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.68 0.19 26 S 0 0 0 -1 -2 0 0 -1 -1 -2 -2 2 -2 -2 -1 4 0 -2 -2 -2 1 1 1 1 0 1 1 1 0 1 2 21 0 1 1 63 1 0 1 1 0.40 0.16 27 K -1 1 -1 -1 -3 3 2 -2 -1 -3 -3 4 -2 -3 -1 -1 -1 -3 -2 -2 1 1 1 1 0 21 18 1 0 1 1 49 0 1 1 1 1 0 0 1 0.52 0.18 28 D -2 -2 1 7 -4 -1 1 -2 -2 -4 -4 -1 -4 -4 -2 -1 -2 -5 -4 -4 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.30 0.21 29 P 2 -3 -2 -2 -3 -2 -2 -2 -3 -3 -3 -2 -3 -4 7 -1 0 -4 -3 -2 21 0 0 0 0 0 0 0 0 0 0 0 0 0 74 0 5 0 0 0 1.55 0.21 30 A 3 -2 -2 0 -2 -1 1 -2 -2 0 -1 0 -1 -3 -2 0 -1 -4 -2 2 40 0 0 4 0 0 13 0 0 0 0 7 0 0 0 3 0 0 0 31 0.26 0.21 31 Y -2 -2 -2 -4 -3 -2 -3 -4 4 -2 -1 -2 -1 4 -4 -2 -2 1 7 -2 0 0 0 0 0 0 0 0 11 0 0 0 0 18 0 0 0 0 70 0 1.01 0.19 32 A 4 1 -2 -2 -2 -1 -2 2 -2 -2 -2 -1 -2 -3 -2 0 -1 -3 -3 -1 68 14 0 0 0 0 0 18 0 0 0 0 0 0 0 0 0 0 0 0 0.49 0.19 33 S -1 6 -1 -2 -3 0 0 -2 -1 -4 -3 3 -2 -3 -2 1 -1 -3 -2 -3 0 66 0 0 0 0 0 0 0 0 0 19 0 0 0 15 0 0 0 0 0.74 0.19 34 Q -1 1 -1 -1 -4 7 1 -2 0 -3 -3 1 -1 -4 -2 -1 -1 -3 -2 -3 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.99 0.19 35 T 3 -2 -1 -2 -1 -2 -2 -2 -3 -1 -1 -2 -1 -3 -2 0 4 -3 -2 1 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 50 0 0 16 0.43 0.20 36 R -1 1 -3 -4 8 -2 -3 -3 -2 -1 1 -2 -1 -1 -3 -2 -2 -2 3 -1 0 13 0 0 55 0 0 0 0 0 16 0 0 0 0 0 0 0 16 0 0.82 0.20 37 E -2 -1 0 3 -4 1 6 -3 -1 -4 -4 0 -3 -4 -2 -1 -2 -4 -3 -3 0 0 0 18 0 0 82 0 0 0 0 0 0 0 0 0 0 0 0 0 0.93 0.20 38 A 5 -2 -2 -2 -1 -1 -1 0 -2 -2 -2 -1 -2 -3 -1 2 0 -3 -2 -1 78 0 0 0 0 0 0 0 0 0 0 0 0 0 0 22 0 0 0 0 0.59 0.20 39 I -1 -3 -2 -3 -2 -2 -3 -3 -3 3 0 -2 5 -1 -3 -1 3 -3 -2 2 0 0 0 0 0 0 0 0 0 28 0 0 29 0 0 0 28 0 0 15 0.42 0.22 40 L -2 -3 -4 -4 -2 -3 -3 -4 -1 0 4 -3 1 1 -4 -3 -2 0 5 0 0 0 0 0 0 0 0 0 0 0 69 0 0 0 0 0 0 0 31 0 0.64 0.22 41 S 3 -2 -1 -2 5 3 -1 -2 -2 -3 -3 -1 -2 -3 -2 3 0 -3 -3 -2 27 0 0 0 15 20 0 0 0 0 0 0 0 0 0 38 0 0 0 0 0.52 0.31 42 A 3 -2 -2 -2 -2 -2 -2 0 -3 -3 -3 -2 -2 -3 4 2 2 -4 -3 -2 42 0 0 0 0 0 0 6 0 0 0 0 0 0 20 19 13 0 0 0 0.57 0.31 43 V -1 -3 -4 -4 5 0 -3 -4 -4 3 0 -3 0 -2 -3 -2 -1 -4 -2 4 0 0 0 0 20 6 0 0 0 27 0 0 0 0 0 0 0 0 0 46 0.62 0.31 44 Y -2 -3 -2 -3 -3 -2 -3 -3 0 -2 -2 -2 -1 4 -3 -1 3 1 7 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 0 26 0 58 0 0.85 0.27 45 S 0 -2 -1 -2 -2 -1 -1 -2 -2 -1 -2 -1 -2 -3 -2 5 0 -4 -2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 74 0 0 0 26 0.53 0.27 46 K -2 -1 5 0 -4 0 3 -2 -1 2 -2 1 -2 -3 -3 -1 -1 -4 -3 -2 0 0 38 0 0 0 32 0 0 19 0 12 0 0 0 0 0 0 0 0 0.53 0.34 47 N 3 -2 4 -2 -2 -1 -2 -2 1 2 -2 1 -2 -2 -3 0 -1 -3 1 -1 32 0 27 0 0 0 0 0 3 19 0 10 0 0 0 4 0 0 5 0 0.31 0.34 48 K -2 1 -1 -2 -4 0 0 -3 -2 -4 -3 6 -2 -4 -2 -1 -2 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 1.05 0.34 49 D -3 -2 0 6 -4 2 0 -3 -2 2 -3 -2 -2 -4 -3 -1 -2 -5 -3 -2 0 0 0 68 0 14 0 0 0 19 0 0 0 0 0 0 0 0 0 0 0.85 0.34 50 Q 1 3 -1 -2 -3 3 -1 -3 3 -2 -2 1 -2 -3 -2 -1 2 -3 -2 0 14 18 0 0 0 23 0 0 8 0 0 8 0 0 0 0 19 0 0 10 0.36 0.34 51 C -2 -4 -4 -4 6 -4 -4 -1 -2 -1 -1 -4 -1 5 -4 -3 -2 -1 3 2 0 0 0 0 22 0 0 4 0 0 0 0 0 42 0 0 0 0 13 19 0.74 0.34 52 C -1 -4 -4 -4 9 -4 -4 -4 -3 -1 -2 -4 -2 -2 -4 -2 -2 -2 3 2 0 0 0 0 68 0 0 0 0 0 0 0 0 0 0 0 0 0 14 19 1.30 0.34 53 N -2 4 3 -2 -4 0 -1 -3 -1 -2 -2 3 4 -3 -3 -1 -2 -4 -3 -2 0 25 24 0 0 0 0 0 0 0 0 28 23 0 0 0 0 0 0 0 0.57 0.36 54 L -2 -2 -1 3 -3 -1 1 -3 -1 -1 2 -2 -1 1 -2 -2 -2 -2 3 -1 1 1 1 24 0 1 12 1 0 1 34 1 0 5 1 1 1 0 14 1 0.32 0.30 55 L -1 -2 -2 -2 -2 -2 -2 -3 -2 -1 3 -2 3 -1 4 1 -1 -2 -2 -1 1 1 1 1 0 1 1 1 0 1 38 1 12 1 24 14 1 0 0 1 0.47 0.30 56 I 3 -3 -3 -3 -2 -2 -3 -2 -3 4 -1 -2 -1 -2 -3 1 -1 -4 -3 2 38 0 0 0 0 0 0 0 0 39 0 0 0 0 0 13 0 0 0 9 0.44 0.36 57 S -1 -2 4 -1 -2 -1 -2 -2 -2 -2 -3 -1 -2 -3 -2 4 3 -4 -3 1 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 40 23 0 0 13 0.51 0.36 58 K -2 4 -1 -2 -4 1 -1 2 -2 -4 -4 5 -2 -4 -2 -1 -2 -4 -3 -4 0 23 0 0 0 6 0 15 0 0 0 56 0 0 0 0 0 0 0 0 0.73 0.36 59 G 1 -3 -1 -2 -3 -2 1 6 -3 -4 -4 -2 -3 -4 -3 -1 -2 -4 -4 -3 13 0 0 0 0 0 11 76 0 0 0 0 0 0 0 0 0 0 0 0 1.04 0.33 60 I -1 -2 -2 -2 -2 -2 -2 3 -3 3 0 2 -1 -2 -2 -2 -1 -3 -2 1 1 1 1 1 0 0 1 27 0 31 5 17 0 0 1 1 1 0 0 13 0.30 0.30 61 N -1 -2 4 3 -3 -1 -1 -2 -1 -3 -2 -1 3 -3 -2 3 -1 -4 -3 -3 0 0 33 19 0 0 0 0 0 0 0 0 16 0 0 33 0 0 0 0 0.56 0.33 62 I 0 -4 -4 -4 -2 -3 -3 -4 -4 5 0 -3 0 -2 3 -2 -1 -4 -3 3 8 0 0 0 0 0 0 0 0 48 0 0 0 0 16 0 0 0 0 27 0.60 0.33 63 A 1 3 -1 -2 -3 -1 2 -2 -1 -3 -3 0 -2 -2 -2 1 2 -2 2 -2 13 24 0 0 0 0 16 0 0 0 0 0 0 0 0 13 21 0 11 0 0.36 0.33 64 P -1 -3 -2 -2 -4 -2 -2 3 -3 -4 -4 -2 -4 -5 7 -2 -2 -4 -4 -4 0 0 0 0 0 0 0 30 0 0 0 0 0 0 70 0 0 0 0 0 1.66 0.33 65 F -3 -3 -4 -4 -3 -3 -4 -4 -1 -1 1 -4 -1 6 -4 -3 -3 0 5 -2 0 0 0 0 0 0 0 0 0 0 11 0 0 59 0 0 0 0 30 0 1.06 0.33 66 L -2 -3 -4 -4 -2 -3 -4 -4 -4 2 4 -3 2 0 -3 -3 -2 -3 -2 2 0 0 0 0 0 0 0 0 0 11 65 0 6 0 0 0 0 0 0 19 0.57 0.22 67 Q 1 2 -1 -1 -3 2 2 -2 -1 -3 -3 5 -2 -4 -2 -1 -1 -4 -3 -3 14 5 0 0 0 9 11 0 0 0 0 61 0 0 0 0 0 0 0 0 0.57 0.22 68 E 2 -1 -1 3 -3 0 5 -2 -1 -3 -3 0 -2 -4 -2 0 -1 -4 -3 -2 30 0 0 16 0 0 54 0 0 0 0 0 0 0 0 0 0 0 0 0 0.61 0.22 69 I -2 -3 -4 -4 -2 -3 -4 -4 -4 4 3 -3 2 -1 -3 -3 -1 -3 -2 2 0 0 0 0 0 0 0 0 0 40 38 0 6 0 0 0 0 0 0 16 0.55 0.22 70 G 0 -3 -1 -2 -3 -3 -3 6 -3 -5 -4 -2 -3 -4 -3 -1 -2 -3 -4 -4 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.37 0.22 71 E 1 -1 0 4 -4 0 5 -2 -1 -4 -4 0 -3 -4 -2 -1 -1 -4 -3 -3 16 0 0 30 0 0 54 0 0 0 0 0 0 0 0 0 0 0 0 0 0.71 0.22 72 A 5 -2 -2 -2 -1 -1 -2 0 -2 -2 -2 -1 -2 -3 -1 1 -1 -3 -2 -1 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.73 0.22 73 A 5 -2 -2 -3 -1 -2 -2 -1 -2 -2 -2 -1 -2 -3 -2 0 -1 -3 -3 -1 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.77 0.25 74 K -2 3 -1 -2 1 4 0 -3 -1 -3 0 3 -1 -3 -2 -1 -2 -3 -2 -2 0 20 0 0 5 34 0 0 0 0 11 30 0 0 0 0 0 0 0 0 0.51 0.25 75 N 2 -1 4 -1 -2 2 -1 -2 -1 2 -2 0 -1 -3 -2 0 -1 -4 -3 -1 25 0 35 0 0 11 0 0 0 22 0 6 0 0 0 0 0 0 0 0 0.32 0.25 76 A 4 -2 -2 -2 -2 -2 -2 3 -3 -2 -3 -2 -2 -3 -2 0 2 -3 -3 -1 61 0 0 0 0 0 0 22 0 0 0 0 0 0 0 0 16 0 0 0 0.55 0.25 77 G -1 -3 -2 -2 -3 -2 -1 5 -3 -3 -3 -2 -3 3 -3 -1 -2 -2 -1 -3 0 0 0 0 0 0 5 72 0 0 0 0 0 23 0 0 0 0 0 0 0.91 0.26 78 L -2 -3 -4 -4 -2 -3 -4 -5 -3 1 5 -3 1 0 -4 -3 -2 -2 1 0 0 0 0 0 0 0 0 0 0 0 95 0 0 0 0 0 0 0 5 0 0.77 0.26 79 P -2 -3 -3 -2 -4 -2 1 -3 -3 -3 -2 -2 -3 -4 8 -2 -2 -4 -4 -3 0 0 0 0 0 0 10 0 0 0 5 0 0 0 85 0 0 0 0 0 1.85 0.26 80 G -1 -3 -1 -2 -3 -3 -3 6 -3 -5 -5 -2 -4 -4 -3 -1 -2 -3 -4 -4 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.42 0.26 81 T 2 0 -1 0 -3 3 4 -2 -1 -3 -3 1 -2 -4 -2 0 0 -3 -3 -2 23 0 0 0 0 23 38 0 0 0 0 10 0 0 0 0 6 0 0 0 0.51 0.26 82 T -2 -3 1 2 -3 -2 -2 -3 -1 3 -1 -2 -1 0 -3 -1 2 -2 4 0 0 0 9 14 0 0 0 0 0 37 0 0 0 0 0 0 17 0 23 0 0.33 0.26 83 K -2 1 -1 1 -3 0 0 -3 -2 2 -2 5 -1 -3 -2 -1 -1 -4 -3 -1 0 0 0 10 0 0 0 0 0 23 0 67 0 0 0 0 0 0 0 0 0.51 0.26 84 N -2 -1 6 0 -4 2 -1 -1 3 -4 -4 -1 -3 -4 -3 0 -1 -4 -2 -4 0 0 76 0 0 14 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0.93 0.26 85 D -1 -3 -1 3 -3 -2 -1 4 -3 -2 1 -2 -2 -3 -3 -1 -2 -3 -3 -2 0 0 0 27 0 0 0 50 0 0 23 0 0 0 0 0 0 0 0 0 0.60 0.26 86 V -1 -3 -2 -3 -2 -2 -2 -4 5 2 -1 -2 0 -2 -3 -2 1 -4 -1 4 0 0 0 0 0 0 0 0 23 8 0 0 0 0 0 0 10 0 0 59 0.49 0.26 87 F -3 -3 -4 -4 -3 -4 -4 -4 -1 -1 -1 -4 -1 7 -4 -3 -3 1 5 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 0 23 0 1.15 0.26 88 T -1 -2 -1 -2 -2 -2 -2 -3 -3 2 -1 -2 -1 -2 -2 1 5 -3 -2 0 0 0 0 0 0 0 0 0 0 19 0 0 0 0 0 3 77 0 0 0 0.65 0.26 89 P -2 3 -2 -2 -4 -1 -2 -3 -2 -4 -4 -1 -3 -4 7 -2 -2 -4 -3 -3 0 23 0 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 0 0 1.71 0.26 90 S 0 -2 0 0 -2 -1 -1 3 -2 -3 -3 -1 -2 -3 -2 4 2 -4 -3 -2 3 0 0 3 0 0 0 23 0 0 0 0 0 0 0 61 10 0 0 0 0.57 0.26 91 G -1 -3 -2 -3 -3 -3 -3 6 -2 -4 -4 -3 -3 -1 -3 -1 -3 -2 4 -4 0 0 0 0 0 0 0 78 0 0 0 0 0 0 0 0 0 0 22 0 1.12 0.32 92 A 4 -2 -1 1 -2 2 -1 -1 -2 -3 -3 -1 -2 -3 -2 2 -1 -4 -3 -2 55 0 0 10 0 13 0 0 0 0 0 0 0 0 0 22 0 0 0 0 0.51 0.32 93 G -1 -3 -2 -3 -3 -3 -3 6 -3 2 -2 -3 -2 -3 -3 -2 -2 -4 -4 -2 0 0 0 0 0 0 0 78 0 22 0 0 0 0 0 0 0 0 0 0 1.00 0.32 94 A 4 2 -2 -3 -2 -1 -2 -1 -2 -2 -2 -1 -2 -3 -2 0 2 -4 -3 -1 67 13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 0 0.57 0.32 95 N -2 -2 7 0 -3 -1 -1 -2 -1 1 -3 -1 -2 -3 -3 1 -1 -4 -3 -2 0 0 77 0 0 0 0 0 0 13 0 0 0 0 0 10 0 0 0 0 0.88 0.32 96 P -1 -3 -2 -2 -3 -2 -2 -3 -3 -3 0 -2 -2 -3 7 2 -1 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 13 0 0 0 65 22 0 0 0 0 1.33 0.32 97 F -3 -3 -2 3 -3 -3 -2 -4 -3 -1 2 -3 0 6 -4 -3 -3 -1 1 -1 0 0 0 22 0 0 0 0 0 0 29 0 0 49 0 0 0 0 0 0 0.66 0.32 98 I -1 -2 -2 -2 -3 -1 2 -3 -2 2 -1 -2 -1 -1 -3 1 -1 -2 3 3 0 0 0 0 0 0 22 0 0 14 0 0 0 0 0 13 0 0 16 35 0.33 0.32 99 T 1 -2 2 -2 -2 -1 -2 -2 -2 0 -2 -2 -2 -3 -2 3 3 -4 -3 1 8 0 10 0 0 0 0 0 0 4 0 0 0 0 0 35 31 0 0 12 0.42 0.32 100 P 1 -2 2 -1 -4 -1 3 -3 -2 -4 -4 -2 -3 -3 5 -1 -2 -3 2 -3 12 0 14 0 0 0 23 0 0 0 0 0 0 0 39 0 0 0 12 0 0.86 0.47 101 L -2 -4 -4 -4 -3 -3 -4 1 -4 3 4 -3 0 -1 -4 -1 -2 -3 -3 2 0 0 0 0 0 0 0 14 0 23 45 0 0 0 0 6 0 0 0 12 0.50 0.47 102 I -3 3 -4 -4 -3 -3 -3 -5 -3 5 2 -2 0 -2 -4 -3 -2 -4 -3 2 0 23 0 0 0 0 0 0 0 52 16 0 0 0 0 0 0 0 0 8 0.65 0.47 103 S 2 -2 -2 -2 -3 1 2 -2 -2 1 1 -2 -1 -3 -3 2 0 -4 -3 -1 20 0 0 0 0 8 14 0 0 12 16 0 0 0 0 25 5 0 0 0 0.28 0.47 104 S 0 3 -1 -2 -3 -1 -1 -2 -2 -3 -3 -1 -3 -4 2 4 0 -4 -3 -3 5 25 0 0 0 0 0 0 0 0 0 0 0 0 12 50 0 0 0 0 0.52 0.37 105 A 5 -3 -3 -3 -1 -2 -2 -1 -3 -1 -2 -2 -2 -3 -2 0 -1 -3 -3 1 80 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0.63 0.37 106 N -1 -1 2 3 -3 3 0 -2 -1 -4 -3 -1 -3 -3 -2 3 -1 -3 1 -3 0 0 9 25 0 23 0 0 0 0 0 0 0 0 0 29 0 0 7 0 0.45 0.37 107 S -1 -2 -2 -3 1 -2 -2 -3 -3 2 1 1 1 -2 -3 2 3 -4 -3 0 0 0 0 0 3 0 0 0 0 18 11 12 3 0 0 21 27 0 0 5 0.29 0.37 108 K -2 0 -2 -2 -4 0 2 -3 -2 -2 2 5 -1 -3 -2 -2 -1 -4 -3 -2 0 0 0 0 0 0 15 0 0 0 25 57 0 0 0 0 3 0 0 0 0.54 0.37 109 Y -3 -3 -3 -4 -3 -2 -3 -4 0 -1 -1 -3 5 4 -4 -3 -2 0 7 -2 0 0 0 0 0 0 0 0 0 0 0 0 25 23 0 0 0 0 52 0 1.03 0.37 110 P -1 -3 -2 -2 -4 -3 -2 4 -3 -4 -4 -2 -4 -5 7 -2 -2 -4 -4 -4 0 0 0 0 0 0 0 37 0 0 0 0 0 0 63 0 0 0 0 0 1.58 0.37 111 R 2 0 -1 -3 -3 -1 -2 -3 8 -3 0 -2 -2 -2 -3 -1 -2 -3 1 -2 25 6 0 0 0 0 0 0 53 0 11 0 0 0 0 0 0 0 5 0 0.78 0.37 112 M -2 2 -2 -2 -3 -1 3 -4 -2 -1 0 -1 6 -2 -3 -2 0 -3 -2 1 0 12 0 0 0 0 25 0 0 0 0 0 48 0 0 0 5 0 0 11 0.55 0.37 113 F -3 -4 -4 -5 -3 -4 -4 -4 -3 0 3 -4 0 6 -4 -3 -3 -1 1 -1 0 0 0 0 0 0 0 0 0 0 41 0 0 59 0 0 0 0 0 0 0.90 0.32 114 I 2 1 -3 -3 -2 -2 -3 -3 -3 3 1 -2 -1 0 -3 -1 2 -3 -2 0 28 9 0 0 0 0 0 0 0 32 11 0 0 4 0 0 16 0 0 0 0.28 0.32 115 N 2 -2 6 0 -3 -1 -1 -1 -1 -3 -4 -1 -3 -4 -2 2 -1 -4 -3 -3 28 0 59 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 0 0 0.73 0.32 116 Q -2 4 -1 -2 -4 3 1 -3 5 -4 -3 2 -2 -3 -3 -1 -2 -3 1 -3 0 28 0 0 0 22 9 0 23 0 0 12 0 0 0 0 0 0 6 0 0.66 0.33 117 H -2 -2 4 -1 -3 -1 -1 -2 5 -4 -4 -1 -3 -4 4 2 -1 -4 -2 -4 0 0 33 0 0 0 0 0 22 0 0 0 0 0 28 17 0 0 0 0 0.83 0.33 118 Q -2 0 -1 -1 -4 6 4 -3 -1 -4 -3 0 -2 -4 -2 -1 -2 -3 -3 -3 0 0 0 0 0 72 28 0 0 0 0 0 0 0 0 0 0 0 0 0 1.03 0.33 119 Q -2 0 -1 -2 -4 6 0 -3 0 -3 -3 2 -2 -1 -3 -1 -2 -1 5 -3 0 0 0 0 0 60 0 0 0 0 0 12 0 0 0 0 0 0 28 0 0.82 0.33 120 A 2 4 -2 -3 -3 -1 -2 1 -2 -1 -2 0 -2 -3 -3 -1 0 -4 -3 2 22 37 0 0 0 0 0 12 0 0 0 0 0 0 0 0 5 0 0 24 0.38 0.33 121 S -1 -2 -1 -1 -3 -1 3 -2 -2 -2 0 -1 -2 2 -2 4 0 -3 -1 -2 0 0 0 0 0 0 28 0 0 0 9 0 0 12 0 51 0 0 0 0 0.44 0.33 122 F -3 -3 -4 -4 -3 -4 -4 -4 -2 0 2 -4 0 7 -4 -3 -3 0 2 -1 0 0 0 0 0 0 0 0 0 0 26 0 0 74 0 0 0 0 0 0 0.95 0.26 123 K -2 3 2 -1 -4 4 0 -2 -1 -4 -3 5 -2 -4 -2 -1 -1 -4 -3 -3 0 12 10 0 0 26 0 0 0 0 0 52 0 0 0 0 0 0 0 0 0.67 0.26 124 I 2 -2 -2 1 -2 2 -1 -2 -2 2 -2 -1 -1 -3 3 1 -1 -4 -3 -1 30 0 0 12 0 12 0 0 0 20 0 0 0 0 13 13 0 0 0 0 0.29 0.26 125 Y -3 -3 -3 -4 -3 -2 -3 -4 1 -2 -2 -3 -2 4 -4 -3 -2 1 8 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 88 0 1.31 0.26 126 A 5 -2 -2 -3 -1 -2 -2 -1 -2 -2 -2 -1 -2 -3 -2 0 -1 -3 -3 -1 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.78 0.26 127 E -2 4 -1 0 -4 1 5 -3 -1 -4 -3 1 -3 -4 -2 -1 -2 -4 -3 -3 0 38 0 0 0 0 62 0 0 0 0 0 0 0 0 0 0 0 0 0 0.85 0.26 128 K -2 2 -1 -1 -4 5 1 -2 -1 -4 -3 5 -2 -4 -2 -1 -1 -3 -2 -3 0 4 0 0 0 38 0 0 0 0 0 58 0 0 0 0 0 0 0 0 0.77 0.26 129 I -2 -1 -2 -3 -3 3 -1 -4 -2 4 2 1 0 -2 -3 -2 -2 -3 -2 0 0 0 0 0 0 26 0 0 0 43 19 12 0 0 0 0 0 0 0 0 0.37 0.26 130 I 2 -3 -3 -3 -2 -2 -3 -2 -3 4 0 -2 0 -2 -3 1 -1 -3 -2 2 26 0 0 0 0 0 0 0 0 46 0 0 0 0 0 12 0 0 0 16 0.39 0.26 131 M -1 -2 -3 -3 -2 -2 -3 -3 -3 3 1 -2 7 -1 -3 0 -1 -3 -2 1 0 0 0 0 0 0 0 0 0 26 0 0 62 0 0 12 0 0 0 0 0.61 0.26 132 T -2 -1 -1 3 4 0 2 -2 -2 -3 -3 3 -2 -4 -2 -1 2 -4 -3 -2 0 0 0 26 12 0 15 0 0 0 0 27 0 0 0 0 20 0 0 0 0.47 0.26 133 E -2 -1 -2 0 -3 0 5 -3 -2 -1 2 -1 -1 -2 -2 -2 -2 -3 -2 -2 0 0 0 0 0 0 62 0 0 0 38 0 0 0 0 0 0 0 0 0 0.58 0.26 134 V -1 -3 -4 -4 -2 -3 -3 -4 -4 2 0 -3 0 -2 -3 -2 -1 -4 -2 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0.77 0.26 135 A 4 -2 -2 -2 -2 -2 -2 1 -3 -1 -2 -2 -2 -3 -2 0 3 -3 -3 1 50 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 28 0 0 10 0.44 0.26 136 P -2 -2 2 -1 -4 -1 -1 -2 -2 -4 -4 1 -3 -4 7 0 -1 -4 -3 -3 0 0 17 0 0 0 0 0 0 0 0 13 0 0 65 5 0 0 0 0 1.37 0.28 137 L 2 -3 -3 -3 -2 -2 -3 -3 3 2 3 -3 0 -1 -3 -2 -2 -3 -2 0 27 0 0 0 0 0 0 0 13 13 47 0 0 0 0 0 0 0 0 0 0.38 0.28 138 F 0 -3 -3 -3 4 -3 0 -3 -2 -1 1 -3 -1 5 -3 -2 -2 -1 1 -1 13 0 0 0 13 0 9 0 0 0 17 0 0 47 0 0 0 0 0 0 0.53 0.28 139 N 1 1 5 -1 -3 -1 -1 -2 -1 -4 -4 2 -3 -4 3 -1 -1 -4 -3 -3 13 9 42 0 0 0 0 0 0 0 0 19 0 0 17 0 0 0 0 0 0.60 0.28 140 E 1 -1 -1 3 -3 0 4 -2 -2 -4 -4 2 -3 -4 -2 1 -1 -4 -3 -3 17 0 0 15 0 0 45 0 0 0 0 13 0 0 0 11 0 0 0 0 0.57 0.32 141 C -1 2 4 -1 5 0 -2 4 -2 -4 -4 -1 -3 -4 -3 -1 -2 -4 -3 -3 0 18 26 0 16 4 0 37 0 0 0 0 0 0 0 0 0 0 0 0 0.64 0.32 142 A 2 -2 0 -2 -2 -2 -2 3 4 -3 -3 -2 -2 -3 -2 1 3 -4 -2 -1 19 0 4 0 0 0 0 27 17 0 0 0 0 0 0 5 26 0 0 2 0.45 0.32 143 M -2 -3 -3 -4 -2 -2 -3 -3 -3 0 2 -3 6 3 -3 1 -1 6 0 -1 0 0 0 0 0 0 0 0 0 0 15 0 41 15 0 17 0 12 0 0 0.59 0.32 144 P -2 -3 -2 -2 -3 -1 1 2 -3 1 -2 -2 -2 -3 6 -2 -2 -4 -3 1 0 0 0 0 0 3 12 17 0 15 0 0 0 0 42 0 0 0 0 11 0.74 0.32 145 T -1 -2 -1 -1 -2 -1 1 -2 -2 -2 -3 -1 -2 -3 2 2 5 -4 -3 -2 0 0 0 0 0 0 11 0 0 0 0 0 0 0 12 18 59 0 0 0 0.64 0.32 146 P -2 -3 -3 -3 -3 -3 -2 -3 -3 -2 1 -2 -2 2 7 -2 -2 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 17 0 0 11 72 0 0 0 0 0 1.50 0.32 147 Q 2 2 -2 -2 -3 5 0 -2 -1 -2 -2 0 -1 -3 -2 -1 -1 -3 -2 1 29 11 0 0 0 45 0 0 0 0 0 0 0 0 0 0 0 0 0 15 0.50 0.32 148 Q 1 3 -1 -1 -4 6 3 -3 -1 -4 -3 0 -2 -4 -2 -1 -2 -3 -3 -3 12 17 0 0 0 54 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0.73 0.32 149 F -3 -4 -3 -4 -3 -4 -4 -4 -2 -1 -1 -4 -1 7 -4 -3 1 0 2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 89 0 0 11 0 0 0 1.16 0.32 150 Q 1 2 -1 -2 -3 5 0 1 2 -2 -3 0 -2 -3 -3 -1 -2 -3 -2 0 12 17 0 0 0 39 0 15 6 0 0 0 0 0 0 0 0 0 0 11 0.42 0.32 151 L 1 -1 -2 -3 -2 4 -1 -3 -2 0 3 -1 0 -2 -3 -2 -2 -3 -2 1 12 0 0 0 0 36 0 0 0 0 37 0 0 0 0 0 0 0 0 15 0.39 0.32 152 I -1 1 -2 -3 -2 -1 -2 -3 -3 2 -1 -1 3 -2 -3 0 5 -3 -2 0 0 12 0 0 0 0 0 0 0 16 0 0 15 0 0 0 57 0 0 0 0.51 0.32 153 L -2 -3 -4 -4 -2 -3 -4 -5 -4 2 4 -3 2 -1 -4 -3 -2 -3 -2 3 0 0 0 0 0 0 0 0 0 13 58 0 3 0 0 0 0 0 0 27 0.64 0.32 154 E -2 -1 -1 3 -5 3 5 -3 -1 -4 -4 0 -3 -4 -2 -1 -2 -4 -3 -3 0 0 0 15 0 17 69 0 0 0 0 0 0 0 0 0 0 0 0 0 0.95 0.32 155 N 2 -1 5 -1 -3 -1 -1 -1 -1 -3 -3 2 -2 -4 -2 0 2 -4 -3 -2 26 0 40 0 0 0 0 0 0 0 0 14 0 0 0 3 17 0 0 0 0.51 0.32 156 I -2 -3 -4 -4 -2 -3 -4 -4 -4 5 2 -3 0 -1 -3 -2 1 -3 -2 2 0 0 0 0 0 0 0 0 0 57 17 0 0 0 0 0 12 0 0 14 0.60 0.32 157 A 4 -3 -2 2 -2 -2 -1 2 -2 -3 -3 -2 -2 -2 -2 0 -1 -2 2 -2 57 0 0 17 0 0 0 14 0 0 0 0 0 0 0 0 0 0 12 0 0.49 0.32 158 N 1 3 5 -1 -3 -1 -1 -2 -1 -4 -3 0 -3 -4 -2 2 -1 -4 -3 -3 17 26 37 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0.56 0.32 159 K -2 4 -1 -2 -4 0 -1 -3 -2 -3 -3 4 -2 -4 3 -1 2 -4 -3 -3 0 26 0 0 0 0 0 0 0 0 0 43 0 0 14 0 17 0 0 0 0.66 0.32 160 Y 0 -3 -3 -4 -3 -2 -3 -3 2 -2 -2 -3 -2 2 -4 -2 -2 6 7 -2 12 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 14 70 0 1.17 0.32 161 I 1 -3 -4 -4 -2 -3 -3 -3 -3 3 4 -3 1 -1 -3 -2 -2 -3 -2 0 20 0 0 0 0 0 0 0 0 21 59 0 0 0 0 0 0 0 0 0 0.50 0.28 162 Q -1 1 0 -1 -4 7 1 -2 0 -3 -3 1 -1 -4 -2 -1 -1 -3 -2 -3 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.97 0.18 163 N -2 -1 5 4 -4 -1 0 -1 0 -4 -4 -1 -3 -3 -2 0 -1 -3 1 -3 0 0 59 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0.78 0.18 164 T 0 -1 0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -2 -1 1 5 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0.54 0.05 165 P -1 -2 -2 -2 -3 -1 -1 -2 -2 -3 -3 -1 -3 -4 8 -1 -1 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 2.06 0.02 K Lambda Standard Ungapped 0.1310 0.3159 Standard Gapped 0.0410 0.2670 PSI Ungapped 0.1606 0.3177 PSI Gapped 0.0492 0.2670