Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 C -4 -7 -6 -7 12 -7 -7 -6 -7 -5 -5 -7 -5 -6 -6 -4 -4 -6 -6 -4 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.66 1.71 2 P -3 3 -2 -3 -6 -1 -1 -2 -3 -4 -4 4 -4 -5 6 -1 -2 -4 -4 -5 1 13 2 1 0 3 4 4 1 1 1 24 0 1 37 4 2 0 1 1 0.99 1.87 3 Q -1 1 2 1 -2 2 1 -1 1 -3 -4 2 -4 -5 -1 2 1 -4 -4 -2 4 6 8 8 1 10 7 4 3 2 1 12 0 0 4 16 9 0 0 4 0.29 1.92 4 E 1 1 -2 -3 3 3 1 1 -2 -3 -3 2 1 -3 -2 0 -1 -6 -2 -1 13 8 1 1 5 15 9 10 1 2 2 10 4 1 2 6 3 0 1 4 0.27 1.91 5 D 0 -1 -1 -1 -5 0 1 -1 0 -4 -4 2 -3 -4 6 0 -3 -6 -3 -2 9 3 3 3 0 4 9 4 3 1 1 13 0 1 33 6 1 0 1 4 0.66 1.90 6 S 2 -2 -3 -6 -3 -2 -5 -4 -4 3 3 -1 3 -1 -5 -2 0 -6 -2 2 18 3 1 0 0 2 0 1 0 13 22 4 7 2 0 3 5 0 2 15 0.45 1.97 7 D -5 -4 2 8 -7 -3 1 -5 -2 -7 -6 -4 -5 -6 -5 -3 -4 -8 -7 -6 1 1 8 77 0 0 8 0 1 0 0 0 0 0 0 1 1 0 0 0 1.94 2.02 8 I -3 -6 -7 -7 -5 -6 -7 -7 -7 6 4 -6 1 -1 -7 -5 -3 -6 -3 4 2 0 0 0 0 0 0 0 0 37 30 0 3 2 0 0 1 0 1 24 1.19 2.04 9 A 1 -5 -6 -7 -1 -5 -5 -3 -4 2 1 -6 3 -1 -6 -3 -2 -4 2 6 10 0 0 0 1 0 0 2 0 8 12 0 6 2 0 1 2 0 7 47 0.88 2.08 10 F -5 -7 -7 -8 -4 -7 -7 -7 -6 2 2 -7 1 8 -6 -6 -4 -2 -1 -1 1 0 0 0 0 0 0 0 0 11 18 0 3 61 0 0 1 0 1 3 1.70 2.10 11 L 0 -6 -6 -6 -3 -4 -6 -6 -7 2 4 -6 1 -3 -6 -4 -3 -6 -4 5 9 0 0 0 1 1 0 1 0 10 39 0 2 0 0 1 1 0 0 35 1.02 2.13 12 I -4 -6 -6 -7 -1 -5 -5 -7 -7 5 4 -6 2 0 -7 -5 -4 -6 -3 4 1 0 0 0 1 0 1 0 0 26 40 0 5 3 0 0 1 0 1 21 1.10 2.16 13 D -5 -4 -2 9 -8 -3 0 -4 -2 -7 -7 -3 -7 -8 -4 -3 -5 -8 -5 -6 1 0 1 89 0 0 3 1 1 0 0 1 0 0 1 1 0 0 0 0 2.32 2.19 14 G 0 0 -1 -2 -1 -3 -1 3 -3 -1 -3 -1 -2 -4 -5 3 2 -3 -4 1 9 5 2 2 2 1 3 23 1 3 3 4 1 1 0 19 10 0 1 11 0.36 2.18 15 S -2 -4 -2 -4 -2 -4 -4 -3 -3 -6 -6 -4 -4 -6 -4 8 0 -7 -6 -5 1 0 1 0 1 0 0 1 0 0 0 0 0 0 1 90 4 0 0 1 1.89 2.20 16 G -1 -2 1 0 -1 -1 0 6 -2 -5 -5 -2 -4 -4 -4 1 -2 3 -2 -5 4 3 6 5 1 3 6 46 1 1 1 2 1 1 1 9 3 3 2 1 0.75 2.18 17 S -2 -3 1 -2 -5 -3 -3 -2 -3 -5 -6 -2 -4 -5 -5 7 -1 -7 -4 -5 2 1 6 1 0 1 1 2 0 0 0 2 0 0 0 79 2 0 0 1 1.53 2.24 18 I -4 -6 -5 -6 -3 -3 -5 -6 -4 4 -1 -5 8 -3 -5 -4 -3 -6 -4 4 1 0 1 0 0 1 0 0 0 24 4 0 36 1 0 1 1 0 0 28 1.42 2.24 19 I -1 0 1 0 -4 0 -1 4 -2 -4 -3 0 -3 -3 -4 2 0 0 0 -3 5 5 5 6 0 4 4 26 1 1 2 6 1 1 1 14 6 1 4 2 0.30 2.20 20 P 0 1 -1 0 -4 1 1 2 0 -2 -3 0 -2 -4 3 0 -1 -1 -2 -4 7 6 2 6 0 6 10 13 2 2 3 6 1 1 15 7 4 1 2 1 0.20 2.23 21 H 0 0 2 1 -4 0 2 -1 1 -3 -3 -1 -2 -3 -1 1 1 -1 1 -2 8 4 9 9 0 5 14 4 3 2 3 4 1 1 3 10 8 1 4 3 0.13 2.21 22 D -3 1 5 4 -4 -2 1 -2 0 -3 -4 0 -3 -4 -1 -1 -2 -3 -3 -4 2 7 26 22 0 2 7 4 2 2 2 7 1 1 3 4 2 0 1 1 0.57 2.17 23 F -4 -3 -5 -5 -6 -3 -5 -6 -2 0 2 -2 1 7 -2 -4 -4 6 2 -3 1 1 1 1 0 1 1 1 1 6 15 4 3 41 3 1 1 9 5 1 1.03 2.20 24 R -1 1 2 1 -4 3 3 -2 0 -3 -2 1 -2 -4 -1 -1 -1 -3 -2 -3 5 7 10 7 0 11 19 3 2 2 4 8 1 1 4 5 5 0 1 2 0.26 2.21 25 R 0 2 0 -1 -4 1 0 -3 0 0 0 3 -1 -3 -2 -1 0 -2 -2 -2 8 11 4 4 0 7 6 2 2 5 11 17 1 1 3 5 6 1 2 2 0.14 2.24 26 M 2 -4 -4 -5 -2 -1 -2 -4 -4 3 1 -4 5 -2 -4 -1 -1 -2 -3 3 14 1 1 1 1 4 3 1 1 14 13 1 12 1 1 5 3 1 1 20 0.43 2.23 27 K -2 3 -3 -4 -2 1 -2 -4 -3 0 0 6 -2 -4 -4 -3 -2 -2 -1 -2 2 12 1 1 1 5 2 1 1 5 9 45 1 1 1 2 2 1 2 3 0.72 2.22 28 E -1 1 2 2 -4 3 3 -3 0 -3 -4 1 -2 -4 -3 0 0 -2 -1 -4 5 6 9 12 0 11 17 2 2 1 2 8 1 1 1 7 5 1 2 1 0.30 2.21 29 F 2 -4 -3 -4 -2 -4 -3 -4 -3 -2 -1 -3 -1 7 -5 0 -2 1 0 -1 15 1 1 1 1 1 1 2 1 2 6 2 1 43 1 7 3 2 2 4 0.83 2.19 30 V 1 -6 -6 -4 -1 -5 -4 -4 -6 3 2 -4 4 -1 -6 -2 -1 -6 -3 4 12 0 0 1 1 0 1 2 0 12 20 1 8 2 0 3 3 0 1 28 0.59 2.17 31 S 1 1 0 -2 -2 1 1 -2 -1 0 -1 3 -1 -1 -4 1 0 -1 -1 -1 10 8 4 2 1 5 8 3 2 6 6 14 2 3 1 11 5 1 2 4 0.09 2.25 32 T 0 1 3 2 -2 1 1 -1 0 -3 -2 1 -1 -2 -3 1 1 -1 -2 -4 7 7 12 9 1 6 7 4 2 1 5 7 2 2 1 11 9 1 1 1 0.15 2.23 33 V -2 -3 -4 -6 -1 -3 -4 -4 -1 2 3 -4 3 3 -6 -2 -1 0 -1 2 3 2 1 0 1 1 1 2 1 11 27 1 6 13 0 3 4 1 2 15 0.46 2.21 34 M -1 -3 -6 -3 1 -2 -4 -4 -2 4 2 -3 3 -1 -3 -2 0 0 -2 3 6 1 0 2 2 2 1 2 1 19 15 1 7 3 2 3 5 1 1 20 0.39 2.25 35 E -2 0 1 3 -1 2 0 -2 0 -2 -2 1 0 1 -2 0 0 0 -1 -3 4 5 6 15 2 8 7 4 2 2 5 7 2 6 2 7 6 2 2 2 0.11 2.26 36 Q -1 2 1 1 1 2 0 -1 1 -1 -2 0 1 -1 -1 0 -1 2 0 -1 5 9 6 7 3 8 6 4 3 4 5 5 4 3 3 6 4 3 3 4 0.04 2.23 37 L -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 38 K -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 39 K -1 2 0 -1 2 -1 -1 -1 0 0 -1 0 0 -1 3 0 -1 2 -1 -1 4 12 5 3 4 3 4 4 2 5 6 5 2 3 14 7 3 2 3 5 0.13 2.20 40 S -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 41 K -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 42 T -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 43 L -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 44 F -1 -4 1 0 3 1 0 -1 -4 0 -1 0 2 1 -5 0 0 -5 2 0 6 0 6 6 6 6 6 6 0 6 6 6 6 6 0 6 6 0 6 6 0.07 1.78 45 S -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 46 L -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 47 M -1 -2 -1 -2 1 -1 -2 -2 0 3 0 -2 1 0 -2 -2 -1 2 0 4 5 3 3 2 2 2 3 3 2 16 7 2 4 4 3 3 3 2 3 23 0.25 2.25 48 Q -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 49 Y -2 -5 -1 -1 1 -1 -2 -3 2 -1 -2 -2 0 5 -1 -2 -1 2 5 -1 3 0 3 4 3 3 3 3 5 3 4 3 2 21 3 3 5 2 18 4 0.46 2.07 50 S -1 0 0 0 3 1 0 -1 2 0 -1 0 -4 -4 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 0 0 5 5 5 5 5 5 0.07 2.01 51 E -2 -1 1 3 -1 -2 -1 1 2 -4 -4 -2 -2 -2 -2 2 1 0 2 -4 3 4 7 17 1 2 4 10 5 1 1 2 1 2 2 17 9 1 6 1 0.29 2.22 52 E -2 1 1 2 -1 1 1 -2 2 -1 -3 0 -1 -2 -2 1 1 1 0 -1 4 8 6 9 2 5 10 4 4 4 3 6 2 2 3 9 8 2 3 4 0.07 2.26 53 F 2 -2 0 -2 1 -1 -2 -2 0 0 -2 -2 0 0 3 0 -1 2 0 2 14 3 4 3 3 3 3 4 3 5 3 3 3 4 12 6 4 2 3 13 0.12 2.25 54 R -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 55 I -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 56 H -2 -1 -1 -1 -1 1 3 -2 2 0 0 -1 0 -2 -2 -2 -1 3 0 1 4 3 3 4 2 7 18 3 4 6 8 3 2 2 2 3 4 4 3 11 0.15 2.24 57 F -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 58 T -1 -1 1 1 0 -1 -1 -1 1 -3 -3 -1 -1 -2 4 1 1 1 -1 -2 4 4 6 8 2 3 5 5 3 2 3 4 2 2 18 10 7 2 3 3 0.19 2.25 59 F -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 60 K -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 61 E -1 0 0 2 -6 1 1 -2 1 -2 -2 0 1 -1 0 0 0 2 0 -1 5 6 4 11 0 7 8 4 3 3 4 5 3 3 5 8 6 3 3 4 0.05 2.18 62 F -1 -1 -1 0 1 -1 -2 -2 2 0 -1 -2 0 3 0 0 0 3 4 -1 5 3 3 5 2 3 3 4 5 5 6 3 3 10 4 6 6 3 11 4 0.11 2.14 63 Q -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 64 N -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 65 N -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 66 P -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 67 N -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 68 P -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 69 R -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 70 S -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 71 L -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 72 V -1 -2 -1 -2 1 -1 -2 -3 0 4 1 -1 1 0 -2 -2 -1 2 0 2 4 3 3 3 2 3 3 3 3 18 12 4 4 3 3 3 3 2 3 14 0.17 2.23 73 K -1 1 1 2 1 1 0 -2 1 -1 -2 1 1 -1 -1 0 0 2 -1 -2 5 7 8 9 3 5 6 4 3 3 5 7 3 3 4 7 5 2 3 3 0.03 2.24 74 P -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 75 I -2 -2 -2 -1 -1 -2 -2 -3 -1 4 2 -2 3 -1 -3 -2 0 0 -1 2 3 2 3 4 2 2 2 3 2 20 17 2 7 2 2 3 5 2 2 12 0.26 2.27 76 T -1 2 0 -1 -1 1 0 -2 0 0 -2 0 2 -1 1 0 0 1 -1 -1 5 10 4 4 2 6 6 4 2 5 5 6 5 2 8 8 6 2 2 4 0.04 2.25 77 Q -1 0 -1 -2 0 3 -2 -3 3 -1 -1 -1 0 1 0 -2 -2 2 5 -1 5 4 3 3 2 13 3 2 7 4 6 4 3 5 5 4 2 2 17 4 0.29 2.25 78 L -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 79 L -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 80 G -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 81 R -1 -1 1 -1 0 0 0 3 0 -1 -1 -1 0 -1 -1 -1 0 2 0 -1 4 4 6 3 2 4 6 23 3 4 6 4 3 3 3 5 5 2 3 4 0.14 2.22 82 T -1 0 0 0 3 1 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.07 2.01 83 H -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 84 T -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 85 A -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 86 T -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 87 G 2 -1 0 0 1 -1 -1 2 0 -2 -2 -2 1 -1 0 -1 -1 -5 1 -1 19 3 5 5 3 3 4 15 3 3 4 3 3 3 4 5 3 0 5 5 0.12 2.06 88 I -1 0 0 0 3 1 0 -1 -4 0 -1 -4 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 0 5 5 0 5 5 5 5 5 5 5 5 0.07 2.01 89 R 0 0 0 0 0 2 0 -1 1 -1 1 0 0 -1 -1 -1 -2 2 0 -1 8 5 5 5 2 8 7 6 3 3 12 6 3 3 3 5 3 2 3 4 0.01 2.13 90 K -2 1 -1 -1 0 0 -1 -3 3 0 1 0 0 1 -2 -1 -1 2 3 -1 4 6 3 3 2 4 4 3 6 4 13 6 3 6 3 4 5 3 10 4 0.10 2.23 91 V -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 92 V -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 93 R -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 94 E -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 95 L -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 96 F -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 97 N -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 98 I 0 0 -1 -1 0 0 1 -1 0 -1 -2 0 1 -2 2 1 -1 1 -1 -1 9 5 3 4 2 4 10 5 2 3 4 6 3 2 9 11 4 2 3 5 0.05 2.14 99 T -1 0 0 0 -5 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.12 100 N -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 101 G -1 0 1 0 0 0 -1 2 1 -1 -2 0 0 1 0 -1 -1 2 0 -2 4 5 7 5 2 4 4 17 4 4 4 5 3 5 5 4 4 3 4 4 0.08 2.17 102 A -1 0 0 0 -5 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.12 103 R -2 5 0 -1 1 0 -1 -2 1 -1 -3 1 0 -1 -1 -2 -2 2 0 -2 3 32 5 4 3 3 4 4 3 3 3 6 3 3 4 4 3 3 3 3 0.39 2.16 104 K -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 105 N -2 0 2 1 1 0 -1 2 1 -2 -2 1 0 -1 -1 0 -1 2 0 -2 4 5 10 9 2 4 5 16 3 3 4 7 3 3 3 6 4 2 3 3 0.11 2.18 106 A 2 -1 -1 0 1 -1 -2 -1 1 0 -2 -1 1 -1 -1 0 0 2 0 2 18 4 3 6 3 3 3 4 3 4 3 4 3 3 3 6 5 2 3 14 0.11 2.18 107 F -1 2 1 -2 0 0 -1 -2 1 -1 -2 1 0 -1 3 0 -1 2 0 0 4 10 7 3 2 4 4 3 3 4 4 9 3 3 13 6 5 2 3 6 0.14 2.19 108 K -2 3 1 -1 1 1 -2 -2 2 -2 -3 5 -1 -2 0 0 -1 1 -1 -3 3 12 5 3 3 6 2 3 4 2 3 29 2 2 5 7 3 2 2 2 0.42 2.14 109 I -1 -1 -3 -3 -1 -2 -3 -4 1 4 0 -3 2 0 -3 -2 -1 -1 1 4 4 3 2 1 1 2 2 1 3 18 7 2 4 4 1 4 4 1 4 31 0.47 2.12 110 L -1 0 0 -4 3 1 0 -1 -4 0 -1 0 2 1 0 0 0 -5 1 0 6 6 5 0 5 5 6 6 0 6 6 6 5 5 6 6 6 0 5 6 0.05 1.89 111 V -2 -1 -1 -2 1 -1 -5 -2 -5 5 0 -2 1 1 -1 -2 -1 -5 1 2 4 3 3 3 3 3 0 3 0 27 8 3 3 5 3 3 3 0 5 12 0.31 1.93 112 V -3 -3 -2 -2 0 -5 -3 -3 -1 2 3 -5 2 0 -1 -3 -2 1 1 3 2 2 2 3 2 0 2 2 2 11 24 0 5 4 3 2 2 2 4 21 0.35 1.96 113 I -2 -2 -3 -3 -1 -3 -2 -1 -1 3 3 -5 2 1 -2 -1 -1 -5 -1 2 3 3 1 2 2 1 3 5 1 17 22 0 5 6 2 4 4 0 2 12 0.27 1.99 114 T -1 -2 -2 0 1 -3 -3 -1 0 -3 -3 -3 0 -3 -3 1 6 0 -3 -3 3 2 1 5 2 1 1 5 3 1 3 1 2 1 1 10 49 1 1 1 0.72 2.03 115 D -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 116 G -1 -1 1 1 -5 0 -1 4 0 0 -2 -1 0 -1 -1 0 -1 -5 0 -1 5 4 5 7 0 3 4 25 3 5 3 3 3 3 3 7 4 0 3 4 0.18 2.12 117 E -2 2 -1 -1 -1 0 0 -2 2 -2 -1 1 -1 -1 2 -1 1 1 1 -1 3 10 3 3 2 3 7 4 4 3 5 9 2 3 10 4 9 2 4 4 0.08 2.16 118 K 1 0 1 -1 0 -1 -2 -1 -1 -2 -2 -2 -1 -2 1 4 0 0 -2 -2 10 6 6 4 2 3 3 4 2 3 5 3 2 2 7 25 6 1 2 3 0.18 2.18 119 F -2 -2 3 -1 -2 2 -1 -1 3 -3 -3 -2 -1 1 -1 1 2 0 0 -1 3 2 15 4 1 8 4 4 6 2 3 2 2 6 3 11 12 1 3 6 0.22 2.18 120 G -2 0 0 4 -2 0 0 2 -1 -3 -3 -1 -1 0 -2 0 -1 1 -1 -1 4 6 5 25 1 4 5 14 2 2 3 3 1 4 3 8 3 2 2 4 0.31 2.12 121 D -2 -1 1 5 -2 -1 1 1 0 -3 -3 0 -1 -2 -1 1 -1 -1 -1 -3 3 3 5 33 1 2 9 9 2 1 3 6 1 2 3 8 4 1 2 2 0.49 2.08 122 P 0 -1 0 0 -2 1 0 -1 -2 0 -2 -1 -2 -1 4 0 -1 1 -1 2 7 4 4 4 1 5 6 5 1 5 3 4 1 3 19 7 4 2 2 14 0.22 2.08 123 L 0 1 0 0 -2 1 0 -2 0 0 1 0 0 -1 -1 0 0 -2 -1 1 9 8 4 6 1 6 7 3 2 6 11 6 2 3 3 6 5 1 3 8 0.05 2.04 124 G 0 1 2 2 -2 0 1 0 -2 -2 -2 1 -2 -3 0 1 1 -2 -1 -1 7 7 9 11 1 4 7 6 1 3 4 7 1 1 5 9 8 1 2 4 0.13 2.15 125 Y -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 126 E 1 0 -1 1 0 1 1 -2 1 0 -2 0 1 -1 1 0 0 2 -1 -1 12 4 3 8 2 5 9 3 3 5 4 6 3 3 7 6 5 2 3 4 0.05 2.23 127 D 0 0 0 3 -1 1 2 -2 0 -2 -2 0 0 -2 -1 0 1 1 -1 -2 6 5 5 13 2 7 12 3 2 3 4 6 3 2 3 6 7 2 2 3 0.10 2.21 128 V 3 -1 -1 -1 -1 0 0 -3 -1 1 -1 -2 1 -2 -1 -1 -1 1 -1 2 20 3 4 4 1 4 6 2 2 8 7 2 3 2 4 4 4 2 3 14 0.14 2.22 129 I 4 -2 -2 -3 -1 -2 -3 -3 -2 3 1 -3 0 -2 -3 -1 -2 0 -2 1 29 2 2 1 1 2 2 2 1 16 15 2 2 1 1 5 2 1 1 8 0.37 2.25 130 P 1 3 1 0 -2 3 1 -3 -1 -3 -2 3 -2 -3 -1 -1 -2 0 -2 -3 10 12 6 4 1 10 8 2 2 2 4 16 1 1 4 5 3 1 1 2 0.24 2.24 131 E 1 1 0 1 -2 1 3 -2 -1 -1 -1 1 0 -3 -1 -1 -1 -1 -1 -2 10 7 4 7 1 7 16 4 1 4 7 8 2 1 3 5 3 1 2 2 0.11 2.21 132 A -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 133 D -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 134 R 0 1 1 1 1 2 0 -1 1 -1 -2 1 0 -1 -1 -1 -1 2 0 -2 9 8 5 6 3 9 7 5 3 4 4 8 3 3 3 5 4 3 3 3 0.05 2.22 135 E 0 0 1 1 0 1 1 -1 1 -1 -2 1 0 -1 0 0 -2 1 0 -2 9 6 5 8 2 6 7 5 3 3 5 10 2 3 5 6 3 2 4 3 0.02 2.25 136 G -1 0 0 0 -5 1 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 0 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.01 137 V -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 138 I -1 2 0 0 0 0 0 -2 1 1 -2 2 0 -1 -1 0 1 2 0 -1 4 9 4 6 2 4 6 4 3 7 3 10 3 3 3 7 9 2 3 4 0.05 2.24 139 R -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 140 Y -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 141 V 2 -2 -2 -5 2 -2 -5 0 0 1 -1 -4 0 -1 0 0 2 2 -1 3 16 2 2 0 4 2 0 8 2 6 5 0 2 2 4 5 13 2 2 19 0.29 2.02 142 I -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 143 G 0 -1 -1 -1 1 -1 -2 3 0 1 -1 -2 1 -1 -1 -1 -1 -5 1 1 7 3 3 3 3 3 3 19 3 9 5 3 3 3 3 5 4 0 5 8 0.08 2.18 144 V -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 145 G -1 0 0 -1 1 1 -1 3 2 -1 -2 -1 0 -1 -1 -1 0 2 0 -2 6 5 4 4 2 6 4 20 5 3 3 4 3 3 3 4 6 2 4 3 0.10 2.21 146 D -2 0 3 2 0 0 -1 0 1 -1 -2 -1 0 -1 0 -1 -2 2 -1 -1 4 5 14 11 2 4 3 9 3 4 5 3 3 3 6 4 3 2 2 4 0.11 2.10 147 A 3 -2 -1 0 0 -1 -1 2 0 -2 -2 -2 0 -2 -1 0 -1 0 2 -1 23 2 3 5 2 3 4 13 3 3 4 3 3 2 3 5 4 1 7 4 0.15 2.04 148 F -2 -1 1 1 -1 -1 -1 -1 -1 1 -1 -1 -1 3 -1 0 -1 1 2 2 4 3 6 7 1 3 4 5 2 7 6 3 2 10 4 6 4 2 6 12 0.06 1.93 149 R -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 150 S -1 -1 2 0 1 0 0 -1 1 -2 -2 1 0 -1 0 1 0 2 0 -1 6 4 9 5 2 4 6 6 3 3 4 7 3 3 5 9 7 2 3 4 0.02 2.21 151 E -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 152 K 0 -1 0 -1 3 0 0 -1 2 0 -1 0 1 0 0 -1 -1 2 0 0 9 4 5 4 5 5 5 5 4 5 6 6 3 4 5 5 4 2 4 7 0.01 2.18 153 S 0 -1 3 3 0 -1 -1 -2 0 -2 -1 -2 0 2 -1 1 -1 1 -1 -2 7 4 14 15 2 3 4 3 2 3 6 3 3 7 3 9 4 2 2 2 0.18 2.17 154 R -2 2 -1 0 -1 1 1 -3 0 0 0 0 2 -1 -2 -1 -2 4 0 0 4 11 3 5 1 6 10 2 3 6 10 5 6 2 3 4 3 5 3 6 0.11 2.18 155 Q -1 0 0 0 -5 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.12 156 E -1 -1 -1 0 -6 2 4 -2 1 -1 -1 -1 1 0 -1 -1 0 2 0 -2 5 3 3 4 0 10 27 3 3 3 6 3 3 3 3 5 5 3 3 4 0.29 2.07 157 L -2 -3 -2 -3 0 -2 -3 -3 -6 2 5 -5 3 -1 -2 -3 -2 1 -1 -1 3 2 2 2 2 2 2 2 0 8 53 0 7 2 2 2 2 2 2 3 0.73 2.05 158 N -2 3 2 -1 -1 2 1 -1 2 -2 -2 2 -1 -2 -2 0 -1 -6 1 -2 4 13 9 4 1 9 9 4 5 2 3 13 2 1 2 6 4 0 4 3 0.22 2.06 159 T 1 1 0 0 1 2 1 -1 0 -2 0 0 -1 -1 -2 -1 0 1 -1 -1 11 7 5 5 3 7 11 5 2 3 9 5 2 2 2 5 7 2 2 4 0.06 2.10 160 I -1 0 -4 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.07 2.12 161 A 3 -2 0 -1 1 -1 -2 0 -5 -1 0 -1 0 -1 -1 -1 0 2 0 0 23 3 5 3 3 3 3 7 0 3 9 4 2 3 4 5 5 2 3 6 0.09 2.14 162 S 0 -1 0 1 0 -1 -2 0 0 -2 -2 -1 0 -2 -2 3 1 2 -1 -2 7 3 3 8 2 3 2 8 2 3 4 4 3 2 2 24 8 2 2 3 0.16 2.19 163 K 0 -1 1 2 -1 2 1 -2 0 -1 -2 0 0 -3 0 0 0 0 -1 -2 7 3 7 12 2 8 9 4 2 4 4 6 2 1 5 7 6 1 2 3 0.08 2.19 164 P 0 -1 0 0 1 -1 -2 1 0 -2 -3 0 -2 -2 5 0 1 -1 -1 -2 7 4 4 4 2 2 3 10 3 3 2 5 1 2 23 8 7 1 2 3 0.28 2.13 165 P 0 -1 1 1 -2 -2 -2 2 0 -2 -3 -1 -2 -2 2 2 1 -1 -2 -2 7 3 7 9 1 2 3 13 3 2 3 4 1 2 9 13 9 1 2 3 0.13 2.14 166 R -2 1 0 2 1 1 3 2 -1 -3 -3 0 -2 -3 -1 0 -2 -1 -1 -3 3 7 4 10 2 5 17 15 2 2 3 6 1 1 3 6 3 1 2 2 0.20 2.15 167 D -2 1 2 2 -2 2 2 1 -1 -3 -4 1 -1 -4 -2 -1 0 -2 -3 -3 4 7 9 12 1 7 11 12 2 2 2 8 1 1 2 5 6 1 1 2 0.20 2.12 168 H -2 1 3 -2 -3 -1 -2 -3 7 -3 -3 0 -1 2 -2 -2 -1 -4 4 -3 3 6 11 2 1 2 2 2 26 2 3 6 2 7 2 2 4 0 12 2 0.66 2.09 169 V 1 -3 -3 -4 -1 -3 -4 -4 -2 1 0 -4 1 2 -4 -2 -1 -2 3 4 10 1 1 1 1 1 1 1 1 7 9 1 3 8 1 3 4 1 8 30 0.42 2.14 170 F -3 -3 -4 -5 -3 -4 -5 -4 2 1 -1 -3 -2 7 -5 -3 -3 -1 5 -1 2 1 1 1 1 1 1 2 4 7 6 2 1 45 1 2 1 1 15 4 1.13 2.25 171 Q -2 1 2 -2 -3 1 -1 -3 2 0 -1 0 1 2 -2 -1 0 -2 3 -1 4 8 8 2 0 6 3 2 5 6 7 6 3 9 2 6 6 1 9 4 0.13 2.24 172 V 1 -3 -4 -2 -3 -2 -3 -4 -4 2 1 -4 1 -3 -3 -2 -1 -6 -3 5 13 1 1 2 0 2 2 1 0 10 15 1 3 1 2 3 4 0 1 35 0.53 2.24 173 N -1 -1 2 3 -3 1 2 -2 0 -4 -3 0 -3 -5 1 2 1 -6 -3 -4 6 4 8 17 1 5 14 3 2 1 3 5 1 1 6 15 9 0 1 1 0.35 2.20 174 N -3 -2 4 5 -6 -1 -1 1 -2 -5 -4 -2 -3 -4 -4 2 1 -1 -4 -5 2 2 18 31 0 2 4 10 1 1 2 2 1 1 1 13 7 1 1 1 0.71 2.20 175 F -1 -3 -3 -3 -3 -2 0 -4 -3 -2 -2 -3 -1 7 -2 -1 -2 2 4 1 6 2 1 1 1 2 6 2 1 2 3 1 2 37 2 5 3 3 10 10 0.75 2.19 176 E 0 -2 1 5 -4 0 3 -1 -1 -4 -5 0 -4 -4 -2 1 0 -4 -4 -4 8 2 7 27 0 5 16 4 1 1 1 5 0 1 2 11 5 0 1 1 0.52 2.23 177 A 3 -2 -1 3 -3 2 2 -1 -2 -2 -2 -1 -1 -4 -4 1 0 -6 -3 -2 22 2 3 17 0 7 13 4 1 2 4 3 1 1 0 8 6 0 1 4 0.35 2.22 178 L -3 -3 -5 -5 -5 -3 -5 -6 -3 1 6 -4 1 1 -5 -4 -3 -5 -3 -1 2 2 1 1 0 1 1 1 1 7 69 1 2 5 1 1 1 0 1 3 1.15 2.20 179 K -2 1 1 2 -4 2 2 -1 1 -3 -4 3 -3 -4 2 0 -2 -4 -3 -3 4 6 7 11 0 7 15 5 3 2 2 16 1 1 8 7 3 0 1 2 0.34 2.20 180 T 0 0 1 2 -4 2 1 0 2 -3 -4 1 -3 -4 -2 1 1 -3 -2 -1 8 5 5 11 0 9 7 8 4 2 2 9 1 1 2 9 9 0 1 4 0.19 2.20 181 I -2 -1 -5 -5 -4 -2 -3 -6 -2 6 3 -2 1 2 -6 -4 -3 -3 -2 2 3 4 1 0 0 2 2 0 1 35 23 3 2 8 0 1 1 0 1 11 0.75 2.22 182 Q 1 2 -4 -4 -6 1 0 -4 -3 1 0 -1 -2 2 -4 -1 0 -3 2 2 10 10 1 1 0 7 7 2 0 7 9 4 1 9 1 4 5 0 7 15 0.25 2.22 183 N -2 1 2 4 -5 2 2 -1 -2 -5 -5 1 -4 -5 0 1 -1 -3 -4 -5 4 6 10 23 0 8 11 5 1 0 1 9 0 1 5 11 3 0 1 1 0.46 2.22 184 Q -1 1 0 1 -6 3 4 -4 -2 -3 -3 2 -2 -5 -3 0 1 -2 -4 -2 5 8 5 8 0 12 21 1 1 1 3 12 1 0 1 8 8 1 0 4 0.39 2.21 185 L -4 -5 -7 -6 -4 -5 -5 -7 -7 5 5 -5 2 2 -7 -6 -3 -6 -3 1 1 0 0 0 0 0 1 0 0 29 46 0 5 7 0 0 1 0 0 8 1.13 2.21 186 R 0 0 -3 -2 -3 2 -3 -1 -2 4 1 0 -1 -2 -4 0 0 -6 -2 2 7 6 1 2 1 9 1 5 1 18 11 5 1 2 1 8 7 0 1 13 0.24 2.18 187 E -2 1 1 2 -2 4 3 -2 0 -4 -4 1 -3 -2 -3 2 -1 -3 -3 -4 3 8 7 12 1 15 16 4 2 1 2 8 1 2 1 13 4 0 1 1 0.40 2.18 188 K -1 3 1 -1 -4 2 0 -2 0 -5 -4 4 -2 -3 -4 0 2 1 2 -4 5 14 6 4 0 7 6 4 2 0 1 20 1 1 1 8 11 2 6 1 0.38 2.17 189 I -2 -3 -5 -4 -3 -4 -5 -6 -5 6 3 -5 1 -2 -5 -2 -1 -6 -3 3 3 1 0 1 0 1 1 1 0 39 23 1 2 1 0 3 4 0 1 16 0.90 2.13 190 F -2 -4 -4 -4 10 -4 -4 -5 -4 1 0 -4 -2 4 -4 -2 -3 -4 0 -1 4 1 1 1 46 1 1 1 0 7 8 1 1 15 1 3 2 0 3 4 1.43 2.13 191 C 1 -6 -3 -1 9 -3 -3 -1 -4 -4 -5 -3 -3 -4 -2 2 3 -7 -6 -2 11 0 1 3 35 1 2 4 0 1 0 1 1 1 2 16 18 0 0 2 1.12 2.10 192 I -2 -4 -4 -4 -5 -5 -3 -6 -5 5 1 -3 -2 -3 -1 0 0 -6 -3 4 3 1 1 1 0 0 2 0 0 34 12 2 0 1 3 8 5 0 1 26 0.76 2.04 193 G 4 -4 -2 -2 -2 -4 -4 6 3 -6 -6 -4 -6 -6 -4 -2 -2 -6 -5 -4 30 1 1 2 1 1 1 52 7 0 0 0 0 0 1 1 2 0 0 1 1.21 1.89 194 S 1 -4 2 -4 -5 -4 -4 2 -4 -6 -6 -4 -5 -6 -5 6 2 -6 -5 -5 10 0 11 0 0 0 0 17 0 0 0 0 0 0 0 51 12 0 0 0 1.06 1.74 K Lambda Standard Ungapped 0.1383 0.3210 Standard Gapped 0.0410 0.2670 PSI Ungapped 0.1070 0.3180 PSI Gapped 0.0327 0.2670