Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 E -2 -2 -1 5 -5 0 6 -3 -2 -5 -4 -1 -4 -5 -2 -1 -2 -5 -4 -4 0 0 0 33 0 0 67 0 0 0 0 0 0 0 0 0 0 0 0 0 1.16 0.46 2 T -3 -3 -3 -4 -4 -3 -3 -4 0 -3 -3 -3 -2 1 -4 -3 0 5 8 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 7 84 0 1.60 0.55 3 S -2 -1 -2 -2 -3 1 0 -3 1 -2 -3 4 -2 -4 -3 2 4 -4 -3 1 0 0 0 0 0 4 3 0 4 0 0 31 0 0 0 14 33 0 0 11 0.51 0.55 4 Y -3 -3 -4 -5 -4 -3 -4 -5 0 -3 -2 -3 -2 3 -4 -3 -3 1 8 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 91 0 1.78 0.55 5 G 1 -4 -4 -4 5 -4 -4 0 -4 0 0 -4 -1 -3 -4 -2 -2 -4 -3 5 11 0 0 0 18 0 0 9 0 0 9 0 0 0 0 0 0 0 0 54 0.67 0.55 6 Y -1 1 -3 -4 -4 -3 -3 -4 0 -3 -3 -3 -2 2 -4 -3 -3 1 8 -3 6 9 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 83 0 1.48 0.55 7 A 5 -2 -3 -3 -2 -2 -2 -2 -3 -2 -3 1 -2 -4 -2 -1 -1 -4 -3 1 79 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 13 0.81 0.55 8 T 1 -3 -2 -1 -3 -2 -1 5 -3 -4 -4 -2 -3 -4 -3 1 2 -4 -4 -3 10 0 0 3 0 0 2 57 0 0 0 0 0 0 0 10 17 0 0 0 0.86 0.55 9 L -3 -4 -5 -5 -3 -3 -4 -5 -4 1 5 -4 3 -1 -4 -4 -3 -3 -2 0 0 0 0 0 0 0 0 0 0 3 87 0 7 0 0 0 0 0 0 3 1.03 0.55 10 S -1 -2 0 0 -2 -2 -2 -2 -3 -3 -3 -2 -2 -4 0 3 5 -4 -3 -2 0 0 3 4 0 0 0 0 0 0 0 0 0 0 3 32 58 0 0 0 0.83 0.55 11 Y -4 -4 -5 -5 -4 -3 -4 -4 -2 -4 -3 -4 -3 0 -5 -4 -4 11 5 -4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 77 23 0 2.74 0.55 12 A 4 -3 0 2 -3 -1 0 2 -3 -3 -4 -2 -3 -4 -3 1 -1 -4 -4 -2 55 0 3 15 0 3 4 13 0 0 0 0 0 0 0 6 2 0 0 0 0.59 0.55 13 D -2 -1 -1 2 -5 3 6 -3 -1 -5 -4 -1 -3 -5 -3 -2 -2 -4 -3 -4 0 0 0 9 0 16 75 0 0 0 0 0 0 0 0 0 0 0 0 0 1.18 0.55 14 Y -3 -3 -4 -5 -4 -3 -4 -5 0 -3 -2 -3 -2 2 -4 -3 -3 1 9 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 97 0 1.86 0.55 15 W -4 -4 -5 -6 -4 -3 -4 -4 -3 -4 -3 -4 -3 0 -5 -4 -4 12 2 -4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95 5 0 3.24 0.55 16 A 5 -2 -1 -1 -2 1 1 -2 -2 -3 -3 -1 -2 -3 -2 -1 -2 -3 2 -2 69 0 2 2 0 6 9 0 0 0 0 3 0 0 0 0 0 0 9 0 0.67 0.55 17 G 3 -2 3 -2 -3 0 -2 2 1 -4 -4 -2 -3 -4 -3 3 -1 -4 -3 -3 38 0 20 0 0 3 0 13 4 0 0 0 0 0 0 22 0 0 0 0 0.57 0.55 18 E -2 -2 -2 1 -5 1 7 -2 -2 -5 -4 -1 -4 -5 -3 -2 -2 -4 -4 -4 0 0 0 4 0 0 93 3 0 0 0 0 0 0 0 0 0 0 0 0 1.35 0.55 19 L 3 -3 4 2 -3 -2 -2 -1 -3 -2 0 -2 -2 -3 -1 -1 0 2 -3 1 28 0 23 11 0 0 0 2 0 0 11 0 0 0 2 0 7 3 0 12 0.34 0.55 20 G 1 -3 -2 -1 -3 -2 -1 3 -3 -2 -3 -2 -2 -2 -3 1 3 -3 2 2 11 0 0 3 0 0 3 22 0 0 0 0 0 0 0 8 26 0 11 16 0.38 0.55 21 Q 2 -2 1 2 -3 4 -1 -2 -2 -4 -3 -1 -2 -4 -2 3 -1 -4 -3 -3 21 0 4 11 0 29 0 0 0 0 2 0 0 0 0 33 0 0 0 0 0.57 0.55 22 S 2 -2 0 -2 -2 -1 -2 -1 -2 -4 -4 -2 -3 -4 -2 5 1 -4 -3 -3 19 0 2 0 0 2 0 3 0 0 0 0 0 0 0 68 6 0 0 0 0.78 0.55 23 R 1 1 1 1 -3 -1 1 2 -2 -4 -4 -1 -3 -4 -3 4 -1 -4 -3 -3 11 9 7 6 0 0 9 15 0 0 0 0 0 0 0 43 0 0 0 0 0.51 0.55 24 D 0 -3 2 6 -4 -2 0 -1 -2 -4 -5 -1 -4 -5 -3 2 -2 -5 -4 -4 10 0 9 55 0 0 3 2 0 0 0 2 0 0 0 19 0 0 0 0 0.87 0.55 25 V 1 -2 -2 1 -3 -2 0 -3 -3 -1 -2 0 -2 -3 -3 1 3 -4 -3 3 11 0 0 10 0 0 5 0 0 0 0 7 0 0 0 12 20 0 0 35 0.37 0.55 26 L 1 -2 -2 -1 -3 -2 -1 -3 -3 -2 2 0 1 -3 -3 2 4 -4 -3 -2 13 0 0 3 0 0 3 0 0 0 25 7 3 0 0 15 31 0 0 0 0.36 0.55 27 L -2 3 -1 3 -4 -1 0 1 3 -3 0 0 -2 -3 -3 1 -2 -4 -2 -3 0 27 0 25 0 0 4 10 9 0 11 3 0 0 0 11 0 0 0 0 0.37 0.34 28 A 2 -3 0 -1 -2 -2 -2 5 -2 -4 -4 -2 -3 -4 -2 2 -1 -4 -3 -3 22 0 4 2 0 0 0 47 0 0 0 0 0 0 0 25 0 0 0 0 0.69 0.34 29 D -2 -1 -1 4 -5 1 6 -3 1 -4 -4 0 -3 -4 -2 -1 -2 -4 -3 -4 0 0 0 22 0 0 75 0 3 0 0 0 0 0 0 0 0 0 0 0 1.03 0.34 30 L 0 -2 -2 -3 -2 -1 -2 -3 -1 -1 2 -2 0 1 -3 1 2 -1 4 -1 6 0 0 0 0 3 0 0 0 0 31 0 2 2 0 18 15 0 23 0 0.34 0.34 31 D -3 -3 0 7 -5 -1 1 -2 -2 -4 -5 -2 -4 -5 -2 -1 -2 -5 -4 -4 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.49 0.34 32 A 2 0 0 -2 -3 0 -1 -2 -2 -2 0 4 2 -3 -2 -1 0 -4 -3 -2 22 0 3 0 0 0 0 0 0 0 12 51 8 0 0 0 4 0 0 0 0.41 0.34 33 G -1 -3 -1 -2 -4 -3 -3 7 -3 -5 -5 -3 -4 -4 -3 -1 -3 -4 -4 -4 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.52 0.34 34 M 4 -3 -2 -3 -2 -2 -2 2 -3 -2 -1 -2 4 -3 -2 0 -1 -3 -3 -1 61 0 0 0 0 0 0 18 0 0 0 0 22 0 0 0 0 0 0 0 0.58 0.34 35 F -3 -3 -4 -4 -3 -4 -4 -4 -1 -1 -1 -4 -1 7 -5 -3 -3 0 5 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 72 0 0 0 0 28 0 1.26 0.34 36 D -3 -3 0 7 -5 -1 1 -2 -2 -4 -5 -2 -4 -5 -2 -1 -2 -5 -4 -4 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.49 0.34 37 A 4 -2 -2 -3 -2 -2 -2 -2 -3 -1 -2 -2 -1 -3 -2 0 3 -4 -3 2 50 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 31 0 0 19 0.51 0.34 38 V -1 -4 -4 -4 -2 -3 -4 -4 -4 2 0 -3 0 -2 -3 -3 -1 -4 -2 6 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 96 0.87 0.34 39 S 0 -2 -1 -2 -2 -1 -1 -2 -2 -2 -3 -1 -2 -3 -2 4 5 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 45 55 0 0 0 0.75 0.34 40 R -2 7 -1 -3 -5 0 -1 -3 -1 -4 -3 1 -2 -4 -3 -2 -2 -4 -3 -4 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.33 0.34 41 A 5 -2 -3 -3 -1 -2 -2 -1 -3 -2 -3 -2 -2 -3 0 0 -1 -4 -3 -1 96 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0.85 0.34 42 T -1 -2 -1 -2 -2 -2 -2 -3 -3 -2 -2 -2 -2 -3 -2 1 6 -3 -3 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 1.02 0.34 43 H 1 -2 -1 -2 -2 -2 -2 -2 3 -1 -2 -1 -2 -3 -2 1 4 -3 -1 1 16 0 0 0 0 0 0 0 11 0 0 3 0 0 0 8 48 0 2 13 0.45 0.34 44 G -2 -2 6 0 -4 -1 -1 3 -1 -4 -5 0 -3 -4 -3 0 -1 -4 -3 -4 0 0 75 0 0 0 0 22 0 0 0 4 0 0 0 0 0 0 0 0 1.01 0.34 45 H -3 -1 0 -2 -4 -1 -1 -3 9 -4 -4 -2 -2 -1 -3 -2 -3 -2 3 -4 0 0 0 0 0 0 0 0 90 0 0 0 0 0 0 0 0 0 10 0 1.54 0.34 46 G -1 -3 -1 -2 -4 -3 -3 7 -3 -5 -5 -3 -4 -4 -3 -1 -3 -4 -4 -4 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.52 0.34 47 A 0 -3 -4 -4 -2 -3 -4 -4 -4 1 5 -3 1 -1 -4 -3 -2 -3 -2 0 11 0 0 0 0 0 0 0 0 3 86 0 0 0 0 0 0 0 0 0 0.74 0.34 48 F -2 -2 -1 -2 -4 -1 -1 1 9 -4 -3 -2 -2 2 -3 -2 -3 -3 1 -4 0 0 0 0 0 0 0 10 78 0 0 0 0 11 0 0 0 0 0 0 1.25 0.34 49 R -2 7 -1 -3 -5 0 -1 -3 -1 -4 -3 1 -2 -4 -3 -2 -2 -4 -3 -4 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.33 0.34 50 Q -1 -3 -2 -2 -3 1 -2 6 -3 -3 -1 -2 -2 -4 -3 -1 -2 -3 -4 -3 0 0 0 0 0 11 0 78 0 0 10 0 0 0 0 0 0 0 0 0 1.02 0.34 51 Q 0 -1 0 -1 -2 2 -1 -1 -2 -3 -3 -1 -2 -4 -2 5 0 -4 -3 -3 0 0 0 0 0 11 0 0 0 0 0 0 0 0 0 89 0 0 0 0 0.81 0.34 52 F -3 -3 -4 -4 -3 -3 -4 -4 -1 -1 -1 -4 -1 7 -4 -3 -3 1 6 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 64 0 0 0 0 36 0 1.25 0.34 53 Q -2 0 -1 -1 -4 7 1 -3 -1 -4 -3 0 -1 -4 -2 -1 1 -3 -2 -3 0 0 0 0 0 90 0 0 0 0 0 0 0 0 0 0 10 0 0 0 1.08 0.34 54 Y -1 -3 -3 -3 9 1 -3 -2 -2 -2 -2 -3 -2 -2 -3 0 1 -2 2 -2 0 0 0 0 61 12 0 3 0 0 0 0 0 0 0 4 9 0 11 0 1.08 0.34 55 A 2 -2 1 1 -2 -1 1 -2 -2 -1 -2 -1 2 -3 -2 0 3 -4 -3 -1 28 0 8 11 0 0 11 0 0 3 0 0 9 0 0 4 24 0 0 2 0.30 0.34 56 V 4 -3 -2 -1 -2 -2 -2 -2 -3 0 -2 -2 -1 -3 -2 1 1 -4 -3 3 47 0 0 2 0 0 0 0 0 0 0 0 0 0 0 6 12 0 0 33 0.43 0.34 57 E -1 -2 1 -1 -3 -1 2 -3 -2 0 -2 0 -1 -3 -3 -1 3 -4 -3 3 0 0 10 2 0 0 18 0 0 4 0 8 0 0 0 0 25 0 0 34 0.31 0.34 58 V 0 -4 -4 -4 -2 -3 -4 -4 -4 5 0 -3 1 -1 -3 -3 -1 -4 -2 3 10 0 0 0 0 0 0 0 0 65 0 0 4 0 0 0 0 0 0 21 0.67 0.34 59 L -1 0 -2 -2 -2 -1 0 -2 -1 0 2 1 0 2 -2 -1 1 -1 3 0 2 4 1 1 0 1 7 2 1 4 24 9 1 10 1 2 10 0 15 6 0.16 0.26 60 G 2 -1 2 1 -2 -1 -1 3 -1 -2 -2 0 -2 -2 -1 0 0 -2 -2 -2 24 2 12 10 1 1 2 22 1 2 3 6 1 1 2 2 7 0 1 2 0.23 0.24 61 E -1 -1 0 1 -2 0 3 -1 -1 -2 -2 1 -1 -2 -1 1 2 -2 -2 -1 3 2 2 5 1 2 33 3 1 2 3 9 1 1 2 13 14 1 1 2 0.27 0.21 62 K -1 0 3 3 -2 0 1 -1 -1 -2 -2 2 1 -2 -1 0 -1 -2 -1 -2 3 2 21 18 1 2 6 3 1 2 4 16 5 2 2 3 3 1 1 3 0.24 0.19 63 V 0 -1 -1 -1 -1 -1 -1 4 -1 -1 -1 -1 -1 -2 -1 -1 -1 -2 -2 1 3 2 2 2 1 2 3 44 1 2 4 3 1 2 2 3 3 1 1 18 0.34 0.19 64 L -1 0 1 0 -1 1 2 -1 -1 0 1 1 -1 -1 -1 0 -1 -1 -1 -1 4 2 8 3 1 9 13 4 1 6 16 12 1 2 3 8 3 1 2 3 0.09 0.18 65 S 1 0 0 -1 -1 0 0 -1 -1 -1 -1 0 3 -1 -1 2 0 -1 -1 -1 13 5 5 3 1 2 6 4 1 3 5 3 11 2 3 26 3 1 2 3 0.13 0.17 66 K 1 0 -1 -1 -1 0 -1 -1 0 -1 -1 1 -1 0 -1 0 -1 0 4 -1 14 3 2 3 1 2 3 4 1 3 5 14 1 2 3 8 3 1 25 3 0.19 0.17 67 Q 0 0 0 1 -1 3 1 -1 -1 -1 -1 1 -1 -2 3 0 -1 -1 -1 -1 7 3 2 9 1 17 10 4 1 3 5 7 1 2 16 4 3 1 2 3 0.22 0.16 68 E -1 -1 -1 0 -1 -1 2 -1 -1 1 -1 -1 -1 2 -1 -1 -1 -1 2 1 4 3 2 5 1 2 18 4 1 10 5 3 1 11 3 4 3 1 7 11 0.11 0.27 69 T 1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 3 3 -1 -1 -1 10 3 2 3 1 2 3 4 1 3 5 3 1 2 3 25 24 1 2 3 0.23 0.28 70 E -1 -1 0 0 -1 0 3 0 -1 -1 -1 -1 -1 -1 -1 1 1 -1 1 -1 4 3 5 3 1 2 24 7 1 3 5 3 1 2 3 12 10 1 6 3 0.16 0.27 71 D -1 -1 1 4 -1 -1 0 -1 -1 -1 -1 0 -1 -1 -1 1 -1 3 -1 -1 4 3 8 25 1 2 4 4 1 3 5 6 1 2 3 13 3 5 2 4 0.23 0.25 72 S 1 -1 -1 -1 -1 -1 -1 2 -1 1 -1 -1 -1 -1 -1 2 1 -1 -1 -1 11 3 2 3 1 2 3 15 1 11 5 3 1 2 3 15 11 1 2 4 0.11 0.27 73 R -1 2 1 1 -1 0 0 -1 -1 -1 -1 3 -1 -1 -1 0 -1 -1 0 -1 4 12 9 10 1 2 3 4 1 3 5 20 1 2 3 8 3 1 4 4 0.16 0.27 74 G 0 -1 -1 -1 -1 -1 1 3 -1 -1 -1 0 -1 -1 -1 -1 0 -1 2 -1 7 3 2 3 1 2 11 26 1 3 5 6 1 2 3 4 6 1 10 4 0.18 0.27 75 R -1 2 1 0 -2 0 2 -1 -1 -1 -1 1 -1 -1 -1 -1 -1 -1 2 -1 4 12 9 3 1 2 19 4 1 3 5 7 1 2 3 4 3 1 10 6 0.15 0.27 76 K -1 0 2 -1 -1 0 1 -1 -1 -1 -1 3 -1 -2 -1 1 0 -1 -1 0 4 3 11 3 1 2 12 4 1 3 5 21 1 2 3 9 7 1 2 8 0.15 0.28 77 K -1 -1 -1 -1 -1 -1 -1 2 -1 0 -1 2 -1 -1 -1 0 0 -1 2 0 4 2 2 3 1 2 3 16 1 5 7 15 1 2 3 8 6 1 10 9 0.10 0.30 78 W 2 -1 -1 -1 -1 -1 -1 -1 -1 0 0 -1 -1 0 1 0 -1 7 0 -1 19 2 2 3 1 2 3 4 1 6 8 3 1 5 6 9 3 17 2 3 0.32 0.30 79 E 0 -1 -1 1 -2 0 3 0 1 -2 -1 1 -1 -1 -1 -1 -1 -1 3 -1 7 3 2 6 1 2 26 6 4 3 4 7 1 2 3 4 3 1 13 3 0.21 0.29 80 Y -2 -2 -2 0 -2 0 -1 -2 0 -2 -2 -2 -1 0 -2 -1 1 5 6 -1 3 2 2 6 1 4 2 2 1 2 3 2 1 1 2 2 11 9 40 5 0.58 0.39 81 E -1 -1 -1 3 -2 -1 2 -2 -2 -2 -2 1 0 -2 -2 1 0 5 -2 0 2 1 1 20 1 1 15 2 1 1 3 11 2 1 2 11 4 9 1 10 0.29 0.41 82 T 0 -1 2 -1 -2 -1 -1 -2 -2 -1 -2 2 -1 -2 -1 1 4 -2 -2 1 5 2 9 2 1 1 2 2 1 2 3 15 1 1 2 7 31 0 1 13 0.28 0.40 83 D -1 1 1 5 -3 -1 2 0 -2 -3 -3 -1 -2 -3 -2 -1 -2 2 -2 -3 6 10 7 39 0 1 12 6 1 1 2 1 1 1 1 2 1 3 1 2 0.50 0.43 84 P -1 -2 -1 0 -3 0 -2 4 -2 -3 -3 0 -2 -3 4 -1 -2 -3 -3 -3 2 1 1 5 0 5 1 42 1 1 2 7 1 1 21 4 1 0 1 2 0.63 0.45 85 S -1 -1 2 2 -3 -1 -1 1 -2 -1 -3 3 -2 -3 -2 2 1 -3 -2 -2 2 1 12 14 0 1 1 9 0 3 2 22 0 1 1 17 12 0 1 1 0.31 0.47 86 V 1 0 2 -1 -2 0 1 -2 -2 -2 -2 1 -2 -3 -2 1 2 -3 -2 1 15 3 10 1 0 4 10 2 0 1 2 10 1 1 1 8 18 0 1 12 0.20 0.45 87 T 2 -2 -2 -2 -2 -2 -2 -2 -1 -1 -1 -2 -1 1 -2 1 3 -1 4 -1 19 1 1 1 0 1 2 2 1 4 5 1 1 6 1 11 20 0 21 2 0.32 0.44 88 K -2 -1 0 2 -3 0 2 -2 -2 -2 -2 3 -2 -2 0 -1 0 1 -2 0 2 1 5 14 1 4 13 2 1 1 2 29 1 1 3 2 5 3 1 10 0.30 0.43 89 M 1 -2 -2 0 -2 -2 -2 -2 -2 1 2 -2 4 -1 0 -1 -1 -2 0 2 14 2 1 5 1 1 2 2 1 5 20 2 13 1 4 2 2 0 3 18 0.20 0.40 90 V 1 -2 -1 2 -2 -1 -1 -1 -2 0 -1 -1 -1 -2 -1 2 2 -2 -2 2 11 2 2 13 1 2 2 3 1 4 3 2 1 1 2 20 13 0 1 17 0.19 0.37 91 R -1 2 0 0 -2 -1 -1 -1 1 -2 -1 -1 -1 2 -1 0 0 -1 4 -1 3 13 5 6 1 2 3 5 4 2 4 3 1 10 2 5 6 1 20 3 0.22 0.33 92 A 1 -1 0 -2 -2 -1 -1 2 -1 -2 -2 0 -1 0 -1 -1 -1 8 2 -2 12 2 4 2 1 2 3 18 1 2 4 6 1 5 2 3 2 23 6 3 0.50 0.35 93 S -1 -1 1 -1 -2 -1 0 -1 -1 -2 -2 2 -1 -1 -1 2 3 -1 2 -1 3 2 7 2 1 2 6 3 1 2 3 13 1 1 2 18 20 1 10 2 0.22 0.36 94 A 2 -1 -1 3 -1 -1 -1 0 -1 0 -1 -1 -1 0 -1 1 -1 -2 0 1 17 2 2 17 1 2 3 6 1 5 4 2 1 5 2 11 3 1 4 11 0.13 0.33 95 S 1 -1 -1 -1 -1 -1 -1 2 -1 -1 -1 0 -1 -1 -1 2 0 -1 1 0 12 2 2 2 1 2 3 14 1 2 4 7 1 2 2 23 5 1 5 7 0.15 0.31 96 F 0 -1 1 0 -2 -1 -1 -1 -1 -1 -1 -1 -1 2 -1 1 2 -1 3 1 6 2 8 4 1 2 3 3 1 2 4 2 1 10 2 13 13 1 11 12 0.14 0.35 97 Q 0 0 -1 0 -2 2 1 -1 -1 -2 -2 -1 -1 -2 -1 2 2 2 -1 -2 7 6 2 6 1 13 9 3 1 2 3 2 1 1 2 21 13 4 1 2 0.22 0.36 98 D 1 -1 2 2 -2 -1 -1 0 3 -1 -2 -1 0 -1 0 0 0 -2 -1 0 15 2 10 11 1 2 2 6 11 2 3 2 3 3 4 6 5 1 1 10 0.14 0.36 99 L -1 1 -2 -2 -2 -1 -2 -2 -2 1 2 0 -1 -1 -2 -1 0 5 -1 2 4 10 2 2 1 1 2 3 1 6 20 8 1 1 2 2 6 10 1 17 0.22 0.38 100 G -1 -2 0 -1 -2 -1 -1 3 -2 -1 1 -1 -1 -2 -1 1 1 -2 -2 -1 3 2 5 2 1 2 2 25 1 2 21 2 1 1 2 14 12 0 1 2 0.22 0.37 101 E 0 -1 -1 3 -2 -1 3 -2 -1 -2 -2 0 -2 -2 -1 2 2 1 -2 -2 5 2 1 16 1 1 21 2 1 2 3 5 1 1 2 16 16 2 1 2 0.31 0.40 102 D -2 -2 3 6 -3 -1 0 1 -1 -3 -3 -1 -3 -3 -2 -1 -1 -3 -3 -3 2 1 17 51 1 1 2 10 1 1 2 2 1 1 1 2 2 0 1 2 0.72 0.42 103 G -1 -2 0 -2 -3 -2 -2 5 -2 -3 -3 1 -3 -3 -2 1 -2 -3 -3 -3 2 1 4 1 0 1 1 63 0 1 2 9 0 1 1 9 1 0 1 1 0.83 0.46 104 E -1 1 -1 -1 -3 1 2 -1 -2 -3 -3 5 -2 -3 -2 0 1 -3 -2 -2 4 4 1 1 0 5 15 4 0 1 2 43 1 1 1 4 11 0 1 1 0.46 0.45 105 I 0 -2 0 -2 -2 -2 -2 0 -2 3 -1 0 -1 -2 -2 0 3 -3 -2 2 8 1 5 1 0 1 2 6 1 23 2 5 1 1 1 6 20 0 1 14 0.22 0.44 106 K -1 -1 -2 -2 -2 2 -1 -1 -2 1 0 1 -1 0 -2 -1 3 -2 -2 1 4 1 1 1 0 13 2 5 1 8 8 12 1 4 1 2 23 0 1 12 0.19 0.44 107 F 0 -2 -1 -1 -2 -2 -2 -3 -2 1 1 -2 1 5 -3 -2 -2 -1 3 1 10 1 4 3 0 1 1 2 0 9 12 1 3 26 1 1 1 0 14 8 0.35 0.46 108 E -1 -1 0 -1 -2 1 2 -2 -1 0 -1 1 -1 -1 -1 0 1 2 1 1 3 2 5 2 1 5 16 3 1 6 7 9 1 1 2 8 12 3 6 9 0.12 0.38 109 A 1 -2 -2 -1 1 -2 -2 1 -2 -1 2 -2 -1 1 -2 1 1 -2 0 -1 13 1 1 4 3 1 2 11 1 1 24 2 1 5 2 10 11 0 4 2 0.13 0.41 110 V -1 -2 0 2 -2 -2 -1 -2 -2 1 -2 -1 -1 -2 0 1 3 -3 -2 2 4 1 3 12 0 1 1 1 0 10 2 4 0 1 4 10 27 0 1 18 0.27 0.47 111 E -1 -1 -1 5 -3 -1 2 -1 -2 -3 -3 3 -3 -3 -2 -1 0 -3 -3 -3 4 1 1 39 0 1 13 5 0 1 2 24 0 1 1 1 4 0 1 1 0.60 0.48 112 G -1 -1 0 2 -3 -2 -2 5 -2 -3 -3 -2 -3 -3 -2 0 -2 -3 -3 -2 1 3 4 16 0 1 1 56 0 1 2 1 0 1 1 5 1 0 1 4 0.74 0.47 113 A 1 0 -2 -1 -2 0 0 -2 -2 -2 -2 1 -2 -3 -2 2 3 -4 -3 1 15 6 0 3 0 3 5 1 0 0 1 11 0 0 0 16 22 0 0 14 0.29 0.53 114 V -2 -2 -3 -2 -3 -1 -1 -3 -3 2 0 2 -1 -3 -3 -1 2 -4 -3 4 0 0 0 2 0 3 3 0 0 15 4 17 0 0 0 5 15 0 0 34 0.36 0.55 115 A 1 -3 1 -3 0 -2 -3 0 -3 2 -1 -1 -1 -3 -3 0 2 -4 -3 3 14 0 9 0 2 0 1 6 0 16 3 2 0 0 0 5 15 0 0 23 0.26 0.53 116 L -1 0 0 -2 -3 0 -2 2 -2 -1 0 1 -2 0 -3 0 2 2 2 -1 3 4 3 1 0 5 1 17 0 4 11 9 0 3 1 5 16 4 10 4 0.16 0.47 117 A 2 -2 -1 1 -2 -2 -2 0 -2 -2 -2 -2 -2 4 0 0 0 4 3 -2 19 1 3 8 0 1 1 7 0 1 1 1 0 19 5 5 8 5 14 1 0.31 0.45 118 D 0 -2 4 3 -3 -1 2 -2 -1 -3 -3 0 -3 -2 0 0 -1 -3 2 -3 10 1 23 21 0 1 14 1 0 1 1 4 0 1 4 8 1 0 8 1 0.41 0.45 119 R 0 4 3 -1 -3 -1 -1 1 -1 -3 -3 3 -2 -3 -2 -1 -1 -3 -2 -1 8 33 16 1 0 1 1 9 0 1 2 18 0 1 1 1 1 0 1 4 0.45 0.41 120 A 1 -2 -1 -2 -3 -2 -2 5 -2 -3 -3 1 -3 -3 -2 -1 0 -3 -3 -3 14 1 1 1 0 1 1 58 0 1 1 13 0 1 1 1 5 0 0 1 0.75 0.42 121 S 1 -2 -1 -2 -2 1 1 0 -2 -2 -3 -1 -2 -3 -2 2 4 -3 -3 -1 9 1 0 1 0 7 10 8 0 1 1 1 0 0 1 16 40 0 0 4 0.42 0.44 122 S -2 -2 -2 0 -2 -2 0 -3 -3 4 0 0 2 -2 -2 0 2 -3 -2 0 1 1 1 4 0 1 6 1 0 39 7 8 7 1 1 10 13 0 0 1 0.29 0.43 123 F -1 -2 -2 -2 -2 0 -2 -3 -2 1 -1 0 -1 3 -2 -1 4 -2 -1 0 1 1 1 1 0 4 1 1 0 10 5 6 0 16 1 1 44 0 1 5 0.39 0.42 124 M -1 -1 -1 0 -3 -1 0 -3 -2 -2 -1 2 3 0 -2 0 4 -3 -2 0 4 1 3 6 0 0 7 1 0 1 4 15 13 6 1 3 32 0 0 4 0.28 0.44 125 V 3 -2 0 -1 -2 -2 1 -2 -2 0 -2 -2 -2 -2 0 -1 0 -3 1 3 28 1 4 3 0 0 13 1 0 4 1 1 0 0 3 1 6 0 7 27 0.25 0.44 126 D -2 -2 2 6 -3 -1 0 0 -2 -3 -4 -2 -3 -4 -2 0 0 -4 -3 -3 1 1 11 63 0 1 1 8 0 1 1 1 0 0 1 3 6 0 0 1 0.90 0.43 127 S 0 -2 1 -2 -3 -2 -1 5 -2 -3 -3 -1 0 -3 -2 1 -2 -3 -1 -3 4 1 7 1 0 1 4 57 0 1 1 3 3 0 1 12 1 0 3 1 0.71 0.43 128 E 0 -1 1 0 -3 -1 2 -2 -2 -2 -3 2 -2 -3 -2 2 3 -3 -3 -1 7 0 5 3 0 0 19 1 0 0 1 17 0 0 0 18 21 0 0 5 0.34 0.45 129 E 1 -2 -1 0 -2 1 2 -2 -2 -1 -2 1 -2 -3 -2 0 4 -3 -3 0 13 0 0 3 0 7 15 1 0 3 1 7 0 0 0 4 38 0 0 5 0.38 0.45 130 Y 0 -2 -2 -1 -2 -2 0 -1 -1 -1 -2 0 -2 1 -2 1 2 -1 4 1 7 1 1 2 0 1 5 5 0 1 1 6 0 4 1 9 19 0 22 14 0.26 0.42 131 K 0 -1 0 0 -3 1 1 -2 -2 -1 -3 4 -2 -3 -2 0 3 -3 -3 -2 5 0 3 4 0 6 7 1 0 4 1 32 0 0 0 4 31 0 0 1 0.42 0.45 132 I -2 -3 -3 -4 -3 -1 -3 -4 -2 2 2 -3 6 1 -4 -3 -2 -2 3 1 0 0 0 0 0 3 0 0 0 16 20 0 34 4 0 0 0 0 15 5 0.55 0.39 133 T 1 -1 -1 4 -3 -1 0 -2 -2 -3 -3 2 -3 -4 -2 0 2 -4 -3 -2 13 0 0 37 0 0 4 0 0 0 2 16 0 0 0 4 20 0 0 3 0.48 0.40 134 N -2 -1 3 2 -4 -1 1 -1 7 -4 -4 0 -3 -3 -3 1 -2 -4 -1 -4 0 0 15 14 0 0 9 3 44 0 0 5 0 0 0 9 0 0 0 0 0.77 0.40 135 V -2 -3 -3 -4 -3 -2 -3 -4 2 -2 -2 -3 -2 1 -4 0 -2 1 8 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 11 0 0 76 10 1.14 0.41 136 K -1 -1 0 0 -3 0 3 -3 1 -2 -2 3 0 -3 -3 0 0 -3 0 1 3 0 3 4 0 0 31 0 3 0 0 22 4 0 0 4 7 0 4 15 0.33 0.41 137 V -1 -4 -1 -4 -2 -3 -4 -4 -4 3 0 -3 0 -2 -4 -3 -1 -4 -2 5 0 0 4 0 0 0 0 0 0 16 0 0 0 0 0 0 0 0 0 80 0.82 0.41 138 H -2 -1 -2 -3 -3 -1 -2 -3 3 -1 0 2 -1 -2 -3 0 4 -3 2 1 0 0 0 0 0 0 0 0 10 0 9 19 0 0 0 6 36 0 9 12 0.36 0.41 139 G -1 -3 -1 -2 -4 -3 -3 7 -3 -5 -5 -3 -4 -4 -3 -1 -3 -4 -4 -4 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.59 0.41 140 M -2 -3 -4 -4 -3 -3 -4 -4 -4 3 3 -3 4 0 2 -3 0 -3 -2 0 0 0 0 0 0 0 0 0 0 26 40 0 14 3 11 0 6 0 0 0 0.55 0.41 141 K -2 1 -1 -2 -4 0 0 -3 -2 -4 -4 7 -2 -4 -2 -1 -2 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 1.15 0.41 142 F -3 -3 -3 -4 -4 -3 -3 -4 1 -2 -2 -3 -2 3 -4 -3 -3 1 8 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 90 0 1.57 0.41 143 V -1 -4 -4 -4 -2 -3 -4 -4 -4 3 0 -3 0 -2 -4 -3 -1 -4 -2 6 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 90 0.92 0.41 144 P -2 -3 -3 -3 -4 -2 -2 -3 -3 -4 -4 -2 -4 -5 8 -2 -2 -5 -4 -4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 2.48 0.41 145 V -1 -4 -4 -4 -2 -3 -4 -4 -4 2 0 -3 0 -2 -4 -3 -1 -4 -2 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0.98 0.41 146 A 4 0 -2 -2 -2 0 -1 -2 -2 -3 -3 4 -2 -4 -2 0 -1 -4 -3 -2 55 3 0 0 0 3 0 0 0 0 0 39 0 0 0 0 0 0 0 0 0.64 0.41 147 V -1 -4 -4 -4 -2 -3 -4 -4 -4 2 0 -3 0 -2 -4 -3 -1 -4 -2 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0.98 0.41 148 P 0 1 -2 -2 -4 0 -1 -3 -2 -4 -4 5 -3 -4 4 -1 -2 -4 -3 -3 9 4 0 0 0 0 0 0 0 0 0 64 0 0 21 2 0 0 0 0 0.84 0.41 149 H 2 -2 0 -2 -2 -1 -1 -2 3 -2 -3 0 -2 -3 -2 1 5 -4 -2 -2 23 0 4 0 0 0 2 0 10 0 0 5 0 0 0 8 48 0 0 0 0.52 0.41 150 E 2 -2 -1 2 -3 -1 3 -1 -2 -4 -4 0 -3 -4 -2 3 0 -4 -3 -3 21 0 0 13 0 0 23 3 0 0 0 4 0 0 0 33 3 0 0 0 0.48 0.41 151 L -3 -3 1 6 -4 0 2 -3 -2 -3 0 -2 -3 -4 -3 -1 -2 -5 -4 -3 0 0 4 73 0 2 8 0 0 0 13 0 0 0 0 0 0 0 0 0 1.00 0.41 152 K -3 -2 -3 -4 -3 -2 -3 -4 0 -1 2 0 -1 2 -4 -3 -3 0 7 -2 0 0 0 0 0 0 0 0 0 0 31 10 0 5 0 0 0 0 55 0 0.85 0.41 153 G 2 -2 1 3 -4 0 4 1 -2 -4 -4 -1 -3 -4 -2 0 -2 -4 -3 -3 21 0 7 16 0 2 41 10 0 0 0 0 0 0 0 2 0 0 0 0 0.56 0.41 154 I 3 -3 -1 5 -3 -2 0 -2 -3 0 -3 -2 -2 -4 -2 -1 -2 -4 -3 -2 44 0 0 42 0 0 5 0 0 10 0 0 0 0 0 0 0 0 0 0 0.62 0.41 155 A 0 -4 -4 -5 -3 -4 -4 -4 -3 -1 1 -4 -1 7 -4 -3 -3 0 2 -2 10 0 0 0 0 0 0 0 0 0 11 0 0 80 0 0 0 0 0 0 1.12 0.41 156 K 0 0 -2 -2 5 1 1 -3 -2 -3 -3 5 -2 -4 -2 -1 -2 -4 -3 -3 6 0 0 0 20 3 7 0 0 0 0 65 0 0 0 0 0 0 0 0 0.80 0.41 157 E 3 -1 0 -1 -3 2 2 -2 -2 -3 -3 3 -2 -4 -2 2 -1 -4 -3 -3 28 0 3 0 0 11 19 0 0 0 0 24 0 0 0 15 0 0 0 0 0.46 0.41 158 K 2 0 0 -2 -3 2 0 -2 0 -2 -3 5 -2 -4 -2 0 -1 -4 -3 -3 21 0 3 0 0 10 3 0 2 2 0 54 0 0 0 2 2 0 0 0 0.56 0.41 159 F -3 -3 -3 -4 -4 -3 -3 -4 2 -2 -2 -3 -2 4 -4 -3 -3 1 8 -2 0 0 0 0 0 0 0 0 3 0 0 0 0 16 0 0 0 0 81 0 1.44 0.41 160 H -1 0 2 0 -3 0 -1 -2 3 -3 -3 2 -2 -4 1 2 3 -4 -2 -2 3 4 10 3 0 4 0 0 10 0 0 18 0 0 6 14 25 0 0 2 0.36 0.41 161 F -1 -4 -4 -4 -2 -3 -4 -4 -4 2 0 -4 0 2 -4 -3 -1 -3 -1 6 0 0 0 0 0 0 0 0 0 3 0 0 0 10 0 0 0 0 0 88 0.85 0.41 162 V -1 -4 -4 -4 -2 -3 -4 -4 -3 2 0 -3 0 -1 -4 -3 0 -3 1 5 0 0 0 0 0 0 0 0 0 2 4 0 0 0 0 0 6 0 7 81 0.75 0.41 163 E -2 -1 -1 0 -5 1 6 -3 -1 -4 -4 2 -3 -4 -2 0 -1 -4 -3 -3 0 0 0 0 0 3 81 0 0 0 0 10 0 0 0 3 4 0 0 0 1.03 0.41 164 D -2 -2 7 3 -4 -1 -1 -2 -1 -4 -5 -1 -3 -4 -3 0 -1 -5 -3 -4 0 0 74 19 0 0 0 0 0 0 0 3 0 0 0 4 0 0 0 0 1.11 0.41 165 S 5 -3 -2 -1 -2 -2 -2 1 -3 -3 -3 -2 -2 -4 -2 1 -1 -4 -3 -2 76 0 0 4 0 0 0 11 0 0 0 0 0 0 0 10 0 0 0 0 0.72 0.41 166 R -1 1 3 4 -4 1 2 -1 -1 -4 -4 0 -3 -4 -3 0 -2 -5 -3 -4 5 10 21 32 0 4 17 4 0 0 0 2 0 0 0 5 0 0 0 0 0.59 0.41 167 V -1 -4 -4 -4 -2 -3 -4 -4 -4 2 0 -3 0 -2 -4 -3 -1 -4 -2 6 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 96 0.93 0.41 168 T -1 -2 2 3 -2 -2 -1 -3 -2 -2 -2 -2 -2 -3 -2 1 5 -4 -3 -2 0 0 11 17 0 0 0 0 0 0 4 0 0 0 0 4 65 0 0 0 0.71 0.41 169 E 4 -2 -2 -1 -3 0 4 -2 -2 -3 -3 1 -2 -4 0 -1 -1 -4 -3 -1 50 0 0 0 0 0 35 0 0 0 0 9 0 0 3 0 0 0 0 3 0.57 0.41 170 N -1 -2 6 3 -4 0 0 -2 -1 -4 -4 -1 -3 -4 -3 0 -1 -5 -3 -4 5 0 67 17 0 3 4 0 0 0 0 2 0 0 0 2 0 0 0 0 0.96 0.41 171 T -1 -2 -1 -2 -2 -2 -2 -3 -3 -2 -2 -2 -2 -3 -2 0 7 -4 -3 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 1.11 0.41 172 N -2 -2 7 1 -4 -1 -1 -2 -1 -4 -4 -1 -3 -4 0 0 -1 -4 -1 -4 0 0 86 4 0 0 0 0 0 0 0 0 0 0 4 4 0 0 3 0 1.16 0.41 173 G -1 -3 -1 -2 -4 -3 -3 7 -3 -5 -5 -3 -4 -4 -3 -1 -3 -4 -4 -4 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.59 0.41 174 L -3 -3 -5 -5 -2 -3 -4 -5 -4 1 5 -4 1 -1 -4 -4 -2 -3 -2 0 0 0 0 0 0 0 0 0 0 4 96 0 0 0 0 0 0 0 0 0 0.97 0.41 175 K -2 1 -1 -2 -4 0 0 -3 -2 -4 -4 7 -2 -4 -2 -1 -2 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 1.15 0.41 176 T -1 -2 -2 -2 -2 -1 1 -3 -2 0 -2 -1 -2 -2 -3 0 5 -2 3 1 0 0 0 0 0 0 13 0 0 5 0 4 0 0 0 3 53 0 14 9 0.51 0.41 177 M 5 -3 -3 -3 -2 -2 -2 -1 -3 -1 -2 -2 2 -3 -2 0 -1 -4 -3 2 75 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 16 0.67 0.41 178 L 0 -2 -2 -2 -2 -1 3 -3 -3 -1 0 -2 -1 -3 -3 1 4 -4 -3 2 5 0 0 0 0 0 23 0 0 0 10 0 0 0 0 7 37 0 0 19 0.39 0.41 179 T -2 1 -1 -2 -4 2 2 -3 -2 -3 -2 6 -2 -4 -2 -1 1 -4 -3 -3 0 0 0 0 0 7 10 0 0 0 4 70 0 0 0 0 10 0 0 0 0.75 0.41 180 E -2 -1 6 1 -4 3 2 0 -1 -4 -4 -1 -3 -4 -3 -1 -1 -4 -3 -4 0 0 53 5 0 20 13 6 0 0 0 0 0 0 0 0 2 0 0 0 0.79 0.41 181 D 2 -2 -1 2 -3 -1 3 1 -2 -3 -4 0 -3 -4 -2 2 0 -4 -3 -3 27 0 0 13 0 0 25 9 0 0 0 4 0 0 0 16 4 0 0 0 0.43 0.41 182 S -1 -2 -1 2 -2 -1 -1 -2 -2 -3 -3 1 -2 -4 -2 4 3 -4 -3 -2 0 0 0 11 0 0 0 0 0 0 0 7 0 0 0 55 27 0 0 0 0.64 0.41 183 F -3 -4 -4 -5 -4 -4 -4 -4 -2 -1 -1 -4 -1 8 -5 -4 -3 0 2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 1.54 0.41 184 S 1 -2 -1 -1 -2 -1 0 1 -2 -4 -4 0 -3 -4 -2 5 1 -4 -3 -3 6 0 0 0 0 0 4 12 0 0 0 6 0 0 0 68 5 0 0 0 0.64 0.41 185 A 5 -1 -2 -2 -2 1 1 -1 -2 -3 -3 2 -2 -4 -2 0 -1 -4 -3 -2 68 0 0 0 0 7 9 0 0 0 0 16 0 0 0 0 0 0 0 0 0.62 0.41 186 R -1 7 -2 -3 -4 0 -1 -3 -1 -4 -3 2 -2 -4 -3 -2 -2 -4 -3 -3 6 89 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 0 1.22 0.41 187 K 2 0 0 -2 -3 2 0 -2 1 -2 -3 4 -2 -4 -2 1 1 -4 -3 -2 22 0 5 0 0 12 3 0 3 2 0 33 0 0 0 11 10 0 0 0 0.39 0.40 188 V 0 -2 3 -2 -2 -2 -2 -2 -2 -1 -2 -2 -2 -3 -2 0 5 -4 -3 1 6 0 20 0 0 0 0 0 0 0 0 0 0 0 0 3 56 0 0 15 0.60 0.39 189 S -1 -3 -1 -2 -3 -2 -3 6 -3 -5 -5 -2 -4 -4 -3 2 -2 -4 -4 -4 0 0 0 0 0 0 0 80 0 0 0 0 0 0 0 20 0 0 0 0 1.19 0.38 190 S 0 -2 0 -2 -2 -1 -1 -2 -2 -2 -3 -1 -2 -3 -2 4 5 -4 -3 -2 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 39 58 0 0 0 0.73 0.35 191 M -1 -1 -2 -3 -2 0 -2 -3 -2 1 2 -1 6 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0.33 0.00 K Lambda Standard Ungapped 0.1284 0.3134 Standard Gapped 0.0410 0.2670 PSI Ungapped 0.1436 0.3179 PSI Gapped 0.0439 0.2670