Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 M -1 -3 -3 -4 -2 -2 -3 -4 -3 2 3 -3 5 0 -3 -2 -1 -2 -2 3 0 0 0 0 0 0 0 0 0 0 33 0 32 0 0 0 0 0 0 35 0.43 0.13 2 C -1 0 -2 -3 6 -1 -1 -3 -2 -1 0 3 4 -2 -3 -1 -1 -3 -2 -1 0 0 0 0 32 0 0 0 0 0 0 33 35 0 0 0 0 0 0 0 0.46 0.13 3 I -2 -4 -4 -4 -2 -3 -4 -4 -4 5 1 -3 1 -1 -3 -3 -1 -3 -2 2 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0.62 0.13 4 G 0 -2 0 -1 -2 -2 -2 5 -2 -4 -4 -1 -3 -3 -2 3 -1 -3 -3 -3 0 0 0 0 0 0 0 65 0 0 0 0 0 0 0 35 0 0 0 0 0.78 0.13 5 N -2 0 4 0 -3 0 0 -2 6 -4 -3 3 -2 -3 -2 0 -1 -4 -1 -3 0 0 32 0 0 0 0 0 33 0 0 35 0 0 0 0 0 0 0 0 0.57 0.13 6 S 0 -3 -2 -2 7 -2 -2 -2 -3 0 -1 -2 -1 -2 -2 2 0 -3 -2 2 0 0 0 0 35 0 0 0 0 0 0 0 0 0 0 32 0 0 0 33 0.47 0.13 7 T 0 -2 0 4 -2 -1 0 -1 -2 -2 -3 -1 -2 -3 -2 3 3 -4 -3 -2 0 0 0 35 0 0 0 0 0 0 0 0 0 0 0 33 32 0 0 0 0.49 0.13 8 P 2 -2 -2 -2 -2 -2 -1 -2 -2 -3 -3 -1 -2 -4 7 0 -1 -4 -3 -2 33 0 0 0 0 0 0 0 0 0 0 0 0 0 67 0 0 0 0 0 1.33 0.13 9 N -1 0 4 1 -4 4 4 -2 0 -4 -3 0 -2 -4 -2 0 -1 -3 -2 -3 0 0 32 0 0 33 35 0 0 0 0 0 0 0 0 0 0 0 0 0 0.61 0.13 10 E -1 -1 -1 0 -3 1 5 -3 -1 2 -1 0 -1 -2 -2 -1 -1 -3 -2 0 0 0 0 0 0 0 65 0 0 35 0 0 0 0 0 0 0 0 0 0 0.46 0.13 11 Q -2 0 0 4 -4 5 1 -2 0 -3 -3 0 -2 -4 -2 -1 -1 -3 -2 -3 0 0 0 33 0 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.72 0.13 12 E -1 -1 -1 -1 -3 4 3 -3 -1 -1 2 0 0 -2 -2 -1 -1 -3 -2 -1 0 0 0 0 0 35 32 0 0 0 33 0 0 0 0 0 0 0 0 0 0.38 0.13 13 T -1 0 4 0 -3 4 0 -2 0 -3 -3 0 -1 -3 -2 0 3 -3 -2 -2 0 0 33 0 0 35 0 0 0 0 0 0 0 0 0 0 32 0 0 0 0.48 0.13 14 F -3 -3 -4 -4 -3 -4 -4 -4 -2 -1 0 -4 0 7 -4 -3 -3 1 3 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 1.02 0.13 15 R -2 5 -1 -2 -4 4 0 -3 0 -4 -3 2 -1 -3 -2 -1 -1 -3 -2 -3 0 67 0 0 0 33 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.77 0.13 16 A 2 4 -1 -1 -3 1 3 -2 -1 -3 -3 1 -2 -3 -2 0 -1 -3 -2 -2 32 35 0 0 0 0 33 0 0 0 0 0 0 0 0 0 0 0 0 0 0.43 0.13 17 K -2 -1 -2 -3 -3 -1 -2 -3 -2 3 0 2 0 4 -3 -2 -2 -1 1 0 0 0 0 0 0 0 0 0 0 33 0 32 0 35 0 0 0 0 0 0 0.30 0.13 18 V -1 -2 -2 -3 -1 -2 -2 -3 -3 2 0 -2 0 -2 -2 -1 3 -3 -2 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 35 0 0 65 0.40 0.13 19 D -1 0 -1 4 -3 0 0 -2 -2 0 -2 3 -1 -3 -2 -1 -1 -4 -2 2 0 0 0 32 0 0 0 0 0 0 0 33 0 0 0 0 0 0 0 35 0.30 0.13 20 E 0 -1 0 0 -2 0 3 -1 -1 -3 -3 0 -2 -3 -1 4 1 -3 -2 -2 0 0 0 0 0 0 32 0 0 0 0 0 0 0 0 68 0 0 0 0 0.52 0.13 21 I -2 -3 -1 3 -2 -2 -1 -3 -3 4 0 -2 0 -1 -3 -2 -1 -4 -2 1 0 0 0 33 0 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 0.40 0.13 22 W -3 -3 -4 -5 -3 -3 -4 -3 -2 -2 -1 -4 -1 4 -4 -3 -3 10 2 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 33 0 0 0 67 0 0 1.79 0.13 23 F -2 -3 -1 4 -3 -2 -1 -3 -2 0 2 -2 0 4 -3 -2 -2 -1 0 -1 0 0 0 35 0 0 0 0 0 0 33 0 0 32 0 0 0 0 0 0 0.38 0.13 24 R -1 4 -1 1 -4 1 5 -3 -1 -4 -3 1 -2 -4 -2 -1 -1 -3 -2 -3 0 32 0 0 0 0 68 0 0 0 0 0 0 0 0 0 0 0 0 0 0.72 0.13 25 L -2 -3 -4 -4 -2 -3 -4 -4 -4 3 4 -3 1 0 -3 -3 -1 -2 -2 1 0 0 0 0 0 0 0 0 0 33 67 0 0 0 0 0 0 0 0 0 0.54 0.13 26 T -1 -2 -1 -2 -1 -2 -2 -3 -3 3 0 -2 0 -2 -2 0 5 -3 -2 1 0 0 0 0 0 0 0 0 0 35 0 0 0 0 0 0 65 0 0 0 0.43 0.13 27 Q -1 0 0 0 -4 6 4 -2 0 -4 -3 1 -1 -4 -2 -1 -1 -3 -2 -3 0 0 0 0 0 65 35 0 0 0 0 0 0 0 0 0 0 0 0 0 0.76 0.13 28 K 3 0 -1 -1 -1 0 0 -1 -1 -2 -1 3 -1 -2 -1 0 0 -2 -1 -1 37 2 1 2 1 1 2 2 1 2 3 34 1 1 2 2 2 0 1 2 0.21 0.09 29 T 0 -1 4 0 -2 -1 -1 -1 -1 -2 -3 -1 -2 -3 -2 3 3 -4 -2 -2 0 0 33 0 0 0 0 0 0 0 0 0 0 0 0 35 32 0 0 0 0.48 0.13 30 D -1 -2 0 4 -4 0 3 3 -1 -4 -4 -1 -3 -4 -2 -1 -2 -4 -3 -3 0 0 0 32 0 0 33 35 0 0 0 0 0 0 0 0 0 0 0 0 0.63 0.13 31 G -1 -3 -2 -2 -3 -3 -3 5 -3 2 -1 -2 -1 -2 -3 -1 -2 -3 -3 0 0 0 0 0 0 0 0 67 0 33 0 0 0 0 0 0 0 0 0 0 0.64 0.13 32 T 0 -2 0 3 -2 -1 0 -2 -2 -2 -3 -1 -2 -3 -2 3 4 -4 -3 -2 0 0 0 24 0 0 0 0 0 0 0 0 0 0 0 26 50 0 0 0 0.51 0.18 33 V -1 -3 -3 -4 -2 -2 -3 -4 -3 1 1 -3 4 4 -3 -2 -1 -2 0 4 0 0 0 0 0 0 0 0 0 0 0 0 24 26 0 0 0 0 0 50 0.45 0.18 34 M -1 3 -2 -2 -3 -1 -1 -3 -2 -1 -1 0 4 -2 4 -1 2 -3 -2 -1 0 26 0 0 0 0 0 0 0 0 0 0 23 0 24 0 26 0 0 0 0.49 0.18 35 R 2 3 -1 -2 -2 -1 -1 -2 -2 -1 1 0 -1 -2 -2 2 -1 -3 -2 -1 24 23 0 0 0 0 0 0 0 0 26 0 0 0 0 26 0 0 0 0 0.24 0.18 36 D -2 -1 0 5 -4 1 4 -2 -1 -4 -4 0 -3 -4 -2 -1 -2 -4 -3 -3 0 0 0 50 0 0 50 0 0 0 0 0 0 0 0 0 0 0 0 0 0.89 0.18 37 F -2 -3 -2 3 -3 -2 -2 -3 -2 -1 0 -2 4 5 -3 -2 -2 -1 1 -1 0 0 0 26 0 0 0 0 0 0 0 0 24 50 0 0 0 0 0 0 0.53 0.18 38 L -3 -3 -4 -4 -3 -4 -4 -4 -2 0 2 -4 0 7 -4 -3 -3 0 2 -1 0 0 0 0 0 0 0 0 0 0 23 0 0 77 0 0 0 0 0 0 0.85 0.18 39 I -2 -4 -4 -4 -2 -3 -4 -5 -4 6 1 -3 1 -1 -3 -3 -1 -3 -2 2 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0.71 0.18 40 E -2 -1 -2 -1 -3 0 2 -3 -2 -1 2 2 0 4 -3 -2 -2 -2 0 -1 0 0 0 0 0 0 23 0 0 0 26 24 0 26 0 0 0 0 0 0 0.29 0.18 41 K -2 0 3 -1 -3 0 -1 -2 -1 -2 1 4 -1 -2 -2 -1 -1 -3 -2 -2 0 0 24 0 0 0 0 0 0 0 26 50 0 0 0 0 0 0 0 0 0.36 0.18 42 A 4 -2 -3 -3 -1 -2 -2 -1 -3 -1 2 -2 0 -2 -2 0 -1 -3 -2 0 74 0 0 0 0 0 0 0 0 0 26 0 0 0 0 0 0 0 0 0 0.43 0.18 43 A 5 -2 -2 -2 -1 -1 -1 0 -2 -2 -2 -1 -2 -3 -1 1 -1 -3 -2 -1 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.67 0.18 44 E -2 3 3 0 -4 1 3 -2 -1 -4 -3 3 -2 -4 -2 -1 -1 -4 -3 -3 0 26 24 0 0 0 23 0 0 0 0 26 0 0 0 0 0 0 0 0 0.54 0.18 45 Y -2 5 -2 -3 -4 0 -1 -3 0 -3 -2 0 -2 1 -3 -2 -2 0 6 -2 0 53 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 47 0 0.76 0.18 46 F -3 -3 -3 -4 -3 -3 -4 -4 -1 -1 0 -3 -1 7 -4 -3 -3 1 5 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 74 0 0 0 0 26 0 1.01 0.18 47 K -2 4 3 -1 -4 0 0 -2 -1 -4 -3 4 -2 -4 -2 -1 -1 -4 -2 -3 0 26 26 0 0 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 0.61 0.18 48 Q -2 -1 -2 -2 -3 5 0 -3 -1 2 2 -1 0 -2 -3 -2 -1 -3 -2 0 0 0 0 0 0 47 0 0 0 26 26 0 0 0 0 0 0 0 0 0 0.38 0.18 49 P -1 -2 -1 -2 -3 -1 -1 -2 5 -3 -3 -1 -3 -3 6 2 -1 -4 -1 -3 0 0 0 0 0 0 0 0 26 0 0 0 0 0 47 26 0 0 0 0 1.01 0.18 50 E -1 0 -1 0 -4 1 4 3 -1 -4 -4 3 -3 -4 -2 -1 -2 -3 -3 -3 0 0 0 0 0 0 47 26 0 0 0 26 0 0 0 0 0 0 0 0 0.57 0.18 51 Q -1 1 -1 -1 -4 7 1 -2 0 -3 -3 1 -1 -4 -2 -1 -1 -3 -2 -3 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.98 0.18 52 P 0 -2 -1 -1 -2 -1 -1 -2 -2 -3 -3 -1 -2 -3 4 4 3 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 23 53 24 0 0 0 0.64 0.18 53 K -2 -1 -3 -3 -3 -2 -2 -4 -2 0 3 2 1 4 -3 -2 -2 -1 0 -1 0 0 0 0 0 0 0 0 0 0 50 23 0 26 0 0 0 0 0 0 0.38 0.18 54 Q -1 0 -1 0 -4 4 4 -3 -1 -4 -3 3 -2 -4 -2 -1 -1 -3 -2 -3 0 0 0 0 0 23 50 0 0 0 0 26 0 0 0 0 0 0 0 0 0.69 0.18 55 N -2 -1 7 1 -3 -1 -1 -1 0 -4 -4 -1 -3 -4 -3 0 -1 -4 -3 -4 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.06 0.18 56 A 5 -2 -2 -2 -1 -1 -1 -1 -2 -2 -2 -1 -2 -3 -2 2 0 -3 -3 -1 80 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0.64 0.24 57 I -2 3 -2 -3 -2 -2 -2 -4 -3 3 2 -1 0 -2 -3 -2 2 -3 -2 0 0 24 0 0 0 0 0 0 0 36 20 0 0 0 0 0 20 0 0 0 0.34 0.24 58 E -1 0 0 3 -3 3 3 -2 -1 -4 -3 3 -2 -4 -2 2 -1 -4 -3 -3 0 0 0 18 0 20 18 0 0 0 0 24 0 0 0 20 0 0 0 0 0.50 0.24 59 V -1 -3 -4 -4 -2 -2 -3 -4 -3 2 2 -3 4 -1 -3 -3 -1 -3 -2 4 0 0 0 0 0 0 0 0 0 0 20 0 24 0 0 0 0 0 0 56 0.55 0.24 60 I -2 -4 -4 -4 -2 -4 -4 -5 -4 6 2 -4 1 -1 -4 -3 -2 -3 -2 2 0 0 0 0 0 0 0 0 0 81 19 0 0 0 0 0 0 0 0 0 0.77 0.29 61 S -1 3 -1 -2 -3 3 0 -2 -2 -3 -3 2 -2 -4 -2 2 3 -3 -3 -2 0 17 0 0 0 17 0 0 0 0 0 17 0 0 0 15 34 0 0 0 0.47 0.29 62 A 1 -2 -2 -2 -2 2 -1 -2 -1 -1 -2 -1 -2 -1 3 1 -1 -2 3 1 15 0 0 0 0 17 0 0 0 0 0 0 0 0 15 17 0 0 19 17 0.34 0.29 63 I -2 -4 -4 -4 -2 -4 -4 -5 -4 5 1 -3 0 -1 -4 -3 -1 -4 -2 4 0 0 0 0 0 0 0 0 0 64 0 0 0 0 0 0 0 0 0 36 0.74 0.29 64 M -2 -3 -4 -5 -2 -3 -4 -4 -3 1 4 -3 4 3 -4 -3 -2 -2 -1 0 0 0 0 0 0 0 0 0 0 0 68 0 15 17 0 0 0 0 0 0 0.68 0.29 65 A 3 2 -2 -3 -2 -2 -2 -2 -3 0 1 -1 -1 -2 -2 -1 2 -3 -2 2 32 15 0 0 0 0 0 0 0 0 17 0 0 0 0 0 19 0 0 17 0.27 0.29 66 P -2 -3 -2 -3 5 -2 -2 2 4 -4 -4 -2 -3 -4 6 -2 -2 -4 -2 -3 0 0 0 0 17 0 0 17 19 0 0 0 0 0 47 0 0 0 0 0 1.09 0.29 67 Q 1 0 -1 -2 -3 4 0 -2 -1 -3 -3 4 -2 -4 -2 0 2 -3 -3 -2 17 0 0 0 0 31 0 0 0 0 0 36 0 0 0 0 17 0 0 0 0.50 0.29 68 E -2 -1 5 3 -4 0 3 -2 -1 -4 -4 -1 -3 -4 -2 0 2 -4 -3 -3 0 0 36 17 0 0 31 0 0 0 0 0 0 0 0 0 17 0 0 0 0.64 0.29 69 E 1 -2 -1 -1 -2 -1 2 -2 -2 -2 -2 -1 -2 -3 3 0 4 -3 -2 -1 18 1 1 1 0 1 16 1 0 1 1 1 0 1 18 1 36 0 0 1 0.43 0.24 70 Q -2 -2 4 -1 -3 2 -1 -2 -1 -3 -3 -1 -2 -1 3 -1 2 -2 3 -3 0 0 33 0 0 15 0 0 0 0 0 0 0 0 17 0 17 0 19 0 0.54 0.29 71 T -1 -2 -3 -3 5 2 -2 -4 -3 2 1 -2 0 -2 -3 -2 2 -3 -2 2 0 0 0 0 19 17 0 0 0 15 17 0 0 0 0 0 15 0 0 17 0.37 0.29 72 K -1 -2 -3 -4 -2 -2 -3 -4 -4 4 0 1 0 -2 -3 -2 -1 -4 -2 4 0 0 0 0 0 0 0 0 0 36 0 15 0 0 0 0 0 0 0 49 0.52 0.29 73 S -1 -2 -1 -2 -2 -1 -2 -2 -2 -2 -2 -1 -2 -3 -2 2 6 -3 -3 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15 85 0 0 0 0.82 0.29 74 K -2 -2 -3 -4 -3 -2 -3 -4 -2 4 2 1 0 3 -4 -3 -2 -1 3 0 0 0 0 0 0 0 0 0 0 36 17 15 0 17 0 0 0 0 15 0 0.40 0.29 75 A 1 -3 -2 2 -3 -2 -2 -2 -2 -2 1 -2 -1 3 3 1 -1 -3 -1 -2 15 0 0 15 0 0 0 0 0 0 17 0 0 17 19 17 0 0 0 0 0.33 0.29 76 D -3 -2 0 7 -5 -1 3 -2 -2 -4 -5 -1 -4 -5 -2 -1 -2 -5 -4 -4 0 0 0 83 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 1.25 0.32 77 L -3 -4 -4 -5 -3 -4 -4 -4 -3 0 2 -4 0 7 -5 -3 -3 0 2 -1 0 0 0 0 0 0 0 0 0 0 26 0 0 74 0 0 0 0 0 0 1.04 0.32 78 Y 2 -3 -3 -3 5 -2 -3 -2 -1 -2 -2 -3 -2 3 -3 -1 1 -1 5 -2 29 0 0 0 17 0 0 0 0 0 0 0 0 14 0 0 14 0 27 0 0.53 0.32 79 K -2 2 -2 -2 -3 -1 -1 -3 -2 2 -2 4 -1 -3 -3 -1 2 -4 -3 1 0 14 0 0 0 0 0 0 0 16 0 41 0 0 0 0 17 0 0 13 0.39 0.32 80 F -3 -4 -4 -5 -3 -4 -4 -4 -2 -1 0 -4 -1 8 -5 -3 -3 0 2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 1.40 0.32 81 L -2 -3 -4 -4 -3 -3 -4 -4 -2 0 3 -3 5 3 -4 -3 -2 -1 3 -1 0 0 0 0 0 0 0 0 0 0 39 0 30 17 0 0 0 0 15 0 0.64 0.32 82 A 5 -2 -3 -3 -1 -2 -2 -1 -3 -2 1 -2 -1 -3 -2 0 -1 -3 -3 -1 85 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 0 0.67 0.32 83 M 1 5 -2 -3 -3 0 -1 -3 -2 -2 -1 2 5 -3 -3 -1 -2 -3 -2 -2 15 46 0 0 0 0 0 0 0 0 0 14 26 0 0 0 0 0 0 0 0.59 0.32 84 F -3 -4 -4 -5 -3 -4 -4 -4 -2 -1 0 -4 -1 8 -5 -3 -3 0 2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 1.40 0.32 85 G -1 -3 -1 2 -4 -2 -2 6 -3 -5 -5 -2 -4 -4 -3 -1 -2 -4 -4 -4 0 0 0 16 0 0 0 84 0 0 0 0 0 0 0 0 0 0 0 0 1.22 0.32 86 P -2 -3 -3 -2 -4 -2 -2 -3 -3 -4 -4 -2 -4 -5 8 -2 -2 -5 -4 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 2.40 0.32 87 Y -2 -1 -2 2 -4 -1 3 -3 -1 -3 -2 1 -2 4 -3 -2 -2 -1 3 -3 0 0 0 17 0 0 29 0 0 0 0 14 0 29 0 0 0 0 12 0 0.52 0.32 88 E -2 -2 2 4 -4 0 4 -3 -1 -4 -4 -1 -3 -4 3 -1 -2 -5 -3 -4 0 0 14 30 0 0 42 0 0 0 0 0 0 0 15 0 0 0 0 0 0.81 0.32 89 T -1 -2 4 -1 -2 -1 -1 -2 -2 -2 -3 -1 -2 -3 -2 2 5 -4 -3 -2 0 0 29 0 0 0 0 0 0 0 0 0 0 0 0 17 54 0 0 0 0.68 0.32 90 I -2 -4 -4 -4 -2 -3 -4 -5 -4 5 2 -4 0 -1 -4 -3 -1 -4 -2 4 0 0 0 0 0 0 0 0 0 42 14 0 0 0 0 0 0 0 0 44 0.68 0.32 91 M -2 -3 -4 -4 -2 -2 -3 -4 -3 2 2 -3 7 -1 2 -3 -2 -3 -2 0 0 0 0 0 0 0 0 0 0 16 17 0 54 0 13 0 0 0 0 0 0.70 0.32 92 L -2 -3 -3 -2 -3 -1 3 -4 -2 3 1 -2 -1 3 -3 -2 -2 -2 3 0 0 0 0 0 0 0 31 0 0 28 12 0 0 16 0 0 0 0 13 0 0.40 0.32 93 K -2 1 -1 -2 -4 1 0 -3 -2 -4 -3 6 -2 -4 -2 -1 -2 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 1.03 0.32 94 I -2 -4 -4 -4 -2 -4 -4 -5 -4 6 2 -4 0 -1 -4 -3 -2 -3 -2 3 0 0 0 0 0 0 0 0 0 70 16 0 0 0 0 0 0 0 0 14 0.75 0.32 95 A 1 -2 -1 -2 -2 -1 -2 2 6 -1 -1 -2 3 -2 -2 -1 -1 -3 -1 1 13 1 1 1 0 1 1 15 32 1 1 1 14 1 1 1 1 0 1 15 0.37 0.27 96 S 0 -1 0 -1 -2 4 0 2 -1 -3 -3 0 -2 -3 -2 3 0 -3 -2 -2 1 1 1 1 0 31 1 15 0 1 1 1 0 1 1 42 1 0 1 1 0.46 0.27 97 L -2 -2 -3 -3 -2 -2 -3 -3 -2 0 4 -2 4 0 -3 -2 -2 -1 3 0 1 1 1 1 0 1 1 1 0 1 58 1 14 1 1 1 1 0 14 1 0.49 0.27 98 L -2 -2 -3 -3 -2 -2 -3 -3 -3 2 5 -3 1 0 -3 -3 -2 -2 -2 0 1 1 1 1 0 1 1 1 0 14 72 1 0 1 1 1 1 0 1 1 0.56 0.27 99 L -1 2 -2 -2 5 -1 2 -2 -2 -1 2 -1 -1 -2 -2 1 -1 -2 -2 -1 1 15 1 1 17 1 16 1 0 1 27 1 0 1 1 15 1 0 1 1 0.27 0.27 100 I -1 -2 -1 -2 5 -1 -2 -2 4 1 -1 -2 -1 -2 -2 2 -1 -3 -1 1 1 1 1 1 17 1 1 1 14 13 1 1 0 1 1 29 1 0 1 16 0.32 0.27 101 S 2 -2 2 -1 -2 -1 -1 -1 -2 1 -2 -1 -1 -2 -2 4 0 -3 -2 -1 16 1 15 1 0 1 1 1 0 14 1 1 0 1 1 44 1 0 1 1 0.33 0.27 102 N -2 -1 5 -1 -2 -1 -1 -2 -1 1 -2 2 -1 -2 -2 -1 -1 -3 -2 1 1 1 40 1 0 1 1 1 0 14 1 18 0 1 1 1 1 0 1 16 0.36 0.27 103 N 1 -1 4 3 -3 2 2 -2 4 -4 -4 -1 -3 -4 -2 -1 -1 -4 -2 -3 17 0 27 16 0 13 14 0 14 0 0 0 0 0 0 0 0 0 0 0 0.52 0.32 104 K -2 -1 -1 4 -4 -1 0 -3 4 -4 -4 3 -3 -2 3 -2 -2 -2 3 -3 0 0 0 28 0 0 0 0 14 0 0 28 0 0 13 0 0 0 17 0 0.58 0.32 105 G -2 -2 3 2 -3 -2 -1 3 -2 -3 -3 1 -3 2 -3 -1 1 -3 -2 -3 0 0 17 13 0 0 0 26 0 0 0 15 0 16 0 0 14 0 0 0 0.37 0.32 106 H -2 -2 2 2 -4 2 -1 -2 4 -4 -4 -1 -3 -2 3 1 -1 -3 3 -3 0 0 14 17 0 16 0 0 12 0 0 0 0 0 15 14 0 0 13 0 0.48 0.32 107 W -3 -3 -4 -4 -3 2 -2 -3 -3 -3 -2 -3 -2 3 -4 -3 -3 11 1 -3 0 0 0 0 0 16 0 0 0 0 0 0 0 13 0 0 0 71 0 0 2.04 0.32 108 L -2 -2 -3 -3 -2 -2 -3 -3 -3 1 4 -2 4 0 -3 -2 -2 -2 -2 0 1 1 1 1 0 1 1 1 0 1 72 1 14 1 1 1 1 0 1 1 0.57 0.27 109 T -2 -2 -2 -2 -2 -2 -2 -3 -1 2 -1 -2 -1 3 -2 -1 3 0 5 0 1 1 1 1 0 1 1 1 0 17 2 1 0 14 1 1 27 0 29 1 0.42 0.27 110 F -2 -3 -3 -3 -3 -3 -3 -4 -3 -1 1 -3 -1 5 3 -2 3 -1 0 -1 0 0 0 0 0 0 0 0 0 0 14 0 0 43 16 0 27 0 0 0 0.61 0.32 111 D 1 -2 0 5 -4 -1 0 2 -2 -4 -4 2 -3 -4 -2 -1 -2 -5 -4 -3 13 0 0 56 0 0 0 15 0 0 0 17 0 0 0 0 0 0 0 0 0.71 0.32 112 P -2 -3 -3 -3 -4 -2 -2 -3 -3 -2 0 -2 -2 -4 8 -2 -2 -4 -4 -3 0 0 0 0 0 0 0 0 0 0 16 0 0 0 84 0 0 0 0 0 1.86 0.32 113 Q -1 2 -1 2 -2 2 0 -2 -1 -1 -2 0 -1 -2 -1 1 -1 -2 -2 1 2 17 1 16 1 13 2 2 1 1 2 2 1 1 1 16 2 0 1 18 0.20 0.24 114 A 2 -2 -2 -1 -2 -1 3 2 -2 -1 -2 -1 -2 -3 -2 -1 -1 -3 -2 1 27 1 1 1 0 1 32 15 0 1 1 1 0 1 1 1 1 0 0 17 0.31 0.28 115 E -2 0 -1 -1 -3 4 2 -3 -1 1 1 2 -1 -2 -2 -1 -1 -3 -2 -1 1 1 1 1 0 31 13 1 0 15 15 17 0 1 1 1 1 0 0 1 0.32 0.28 116 K -1 0 -1 -1 -2 0 0 -1 -1 -1 -1 4 3 -2 -1 1 -1 -2 -2 -1 2 2 1 2 1 1 2 2 1 2 3 42 17 1 2 16 2 0 1 2 0.31 0.23 117 N -1 -1 4 -1 -2 -1 -1 -1 -1 -2 -2 2 -2 -2 3 0 2 -2 -2 -2 2 2 27 2 1 1 2 2 1 2 3 16 1 1 15 2 18 0 1 2 0.36 0.23 118 A 1 -2 -2 -2 -1 -1 -1 -2 -2 0 1 -1 -1 -2 3 -1 2 -2 -2 2 14 1 1 2 1 1 2 2 1 1 16 2 1 1 15 2 18 0 1 16 0.22 0.23 119 N -1 -1 2 2 -2 -1 0 -1 -1 -1 -1 -1 -1 3 -1 2 -1 -1 0 -1 3 2 14 16 1 2 3 3 1 2 4 2 1 18 2 18 3 1 1 3 0.19 0.18 120 N -1 0 2 3 -2 0 2 -1 -1 -2 -2 2 -1 -2 -1 0 -1 -2 -1 -2 3 2 14 19 1 2 17 3 1 2 4 16 1 2 2 3 3 1 1 3 0.26 0.18 121 Q -1 0 3 -1 -2 4 0 -1 -1 -1 1 0 0 -1 -1 -1 -1 -1 -1 -1 3 2 16 2 1 30 3 3 1 2 20 2 1 2 2 3 2 1 1 3 0.23 0.19 122 R -1 2 -1 -1 -2 -1 -1 -2 4 2 -1 -1 -1 3 -1 -1 -1 -1 0 -1 3 14 2 2 1 2 3 3 18 18 4 2 1 16 2 3 2 1 1 3 0.19 0.19 123 D -1 -1 0 4 -2 0 0 2 -1 -2 -2 2 -2 -2 -1 -1 -1 -2 -2 -2 3 2 2 28 1 2 3 19 1 2 4 19 1 2 2 3 2 1 1 3 0.28 0.19 124 S 0 -2 -1 2 -2 -1 -1 2 -2 -3 -3 -1 -2 -3 3 3 0 -3 -3 -3 1 1 1 15 0 1 1 15 0 1 1 1 0 1 17 42 1 0 0 1 0.49 0.28 125 I -2 -3 -3 -3 -2 -3 -3 -3 -3 4 3 -3 0 3 -3 -3 -2 -2 -1 1 1 1 1 1 0 1 1 1 0 45 28 1 0 14 1 1 1 0 0 1 0.46 0.28 126 S -1 -2 -1 -2 -2 -1 -2 -2 -1 1 -1 -1 -1 -1 -2 3 3 -2 3 -1 1 1 1 1 0 1 1 1 0 14 1 1 0 1 1 29 31 0 14 1 0.34 0.28 127 G 1 -3 2 -2 -3 -2 -2 5 -2 -4 -4 -2 -3 -4 -3 2 -1 -4 -3 -3 15 0 13 0 0 0 0 56 0 0 0 0 0 0 0 16 0 0 0 0 0.78 0.32 128 W -2 -3 -3 -4 5 -3 -3 -4 -1 -2 -2 -3 -2 3 -4 -2 1 6 6 -2 0 0 0 0 17 0 0 0 0 0 0 0 0 16 0 0 14 12 42 0 0.89 0.32 129 F -3 -4 -4 -5 -3 -4 -4 -4 -1 -1 -1 -4 -1 7 -5 -3 -3 0 4 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 83 0 0 0 0 17 0 1.27 0.32 130 D 1 -2 0 5 -3 -1 0 -2 -2 -4 -4 -1 -3 -4 -2 3 -1 -5 -3 -3 16 0 0 54 0 0 0 0 0 0 0 0 0 0 0 30 0 0 0 0 0.75 0.32 131 Q -2 0 4 0 -4 2 2 -2 -1 -4 -4 3 -3 -4 -2 1 -1 -4 -3 -3 0 0 31 0 0 12 15 0 0 0 0 30 0 0 0 13 0 0 0 0 0.57 0.32 132 N -1 -2 4 -1 -2 -1 -2 -2 -1 -2 -3 -2 -2 -2 -2 0 5 -2 3 -2 0 0 27 0 0 0 0 0 0 0 0 0 0 0 0 0 60 0 14 0 0.66 0.32 133 E -2 -2 -2 -1 -4 -1 4 -4 -1 -2 1 -2 -1 5 -3 -2 -2 -1 4 -2 0 0 0 0 0 0 41 0 0 0 14 0 0 30 0 0 0 0 16 0 0.57 0.32 134 P 1 -2 -2 -2 -3 2 -1 -3 6 -4 -4 -1 -3 -3 6 -1 -2 -4 -1 -3 17 0 0 0 0 14 0 0 29 0 0 0 0 0 40 0 0 0 0 0 0.98 0.32 135 N -3 -1 7 1 -4 -1 -1 -1 0 -4 -4 -1 -3 -4 -3 0 -1 -5 -3 -4 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.31 0.32 136 C -1 -5 -4 -5 10 -4 -5 -4 -4 -2 -2 -4 -2 -3 -4 -2 -2 -3 -3 -2 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.05 0.32 137 L -3 -4 -4 -5 -3 -4 -4 -5 -3 2 3 -4 0 6 -4 -3 -2 -1 1 0 0 0 0 0 0 0 0 0 0 14 40 0 0 46 0 0 0 0 0 0 0.75 0.32 138 I -1 -3 -2 -3 -2 -3 -3 -3 -3 4 0 -3 0 -2 -3 2 -1 -4 -2 3 0 0 0 0 0 0 0 0 0 43 0 0 0 0 0 29 0 0 0 28 0.47 0.32 139 L -3 -4 -4 -5 -3 -4 -4 -5 -3 3 2 -4 0 5 -4 -3 -2 -1 1 0 0 0 0 0 0 0 0 0 0 31 26 0 0 43 0 0 0 0 0 0 0.71 0.32 140 K -1 0 -2 -2 -3 3 0 -3 -2 -1 -2 5 -1 -3 -2 -1 -1 -4 -3 2 0 0 0 0 0 16 0 0 0 0 0 56 0 0 0 0 0 0 0 29 0.54 0.32 141 T -2 2 -2 -3 -3 -2 -2 -3 -2 -2 -1 -1 3 3 -3 1 1 6 3 -2 0 17 0 0 0 0 0 0 0 0 0 0 16 14 0 13 12 15 14 0 0.49 0.32 142 P -1 -1 2 -1 -3 4 0 -2 -1 -4 -4 2 -2 -4 2 3 -1 -4 -3 -3 0 0 15 0 0 27 0 0 0 0 0 14 0 0 12 33 0 0 0 0 0.54 0.32 143 T -1 -2 2 2 -3 2 -1 3 -2 -3 -4 -1 -3 -4 -3 0 3 -4 -3 -3 0 0 14 14 0 17 0 30 0 0 0 0 0 0 0 0 25 0 0 0 0.51 0.32 144 G -1 -3 -2 -3 -3 -3 -3 6 -3 1 -2 -3 3 -3 -3 -2 -2 -3 -3 -2 0 0 0 0 0 0 0 71 0 14 0 0 15 0 0 0 0 0 0 0 0.89 0.32 145 I -2 -2 -2 -2 -3 -1 3 -4 -2 3 -1 -2 -1 2 -3 -2 2 -3 -1 2 0 0 0 0 0 0 29 0 0 29 0 0 0 14 0 0 15 0 0 14 0.34 0.32 146 R -2 1 -2 -3 -3 -2 -2 -3 4 1 -2 -2 -2 0 -3 -1 3 -1 5 -1 0 12 0 0 0 0 0 0 15 14 0 0 0 0 0 0 31 0 29 0 0.49 0.32 147 K -2 3 -1 -2 -4 0 -1 -3 7 -4 -4 4 -2 -3 -3 -1 -2 -4 -1 -4 0 14 0 0 0 0 0 0 46 0 0 41 0 0 0 0 0 0 0 0 0.90 0.32 148 I -1 -4 -3 -4 7 -3 -4 1 -4 2 -1 -3 -1 -2 -4 -2 -1 -4 -3 4 0 0 0 0 29 0 0 15 0 12 0 0 0 0 0 0 0 0 0 44 0.65 0.32 149 W -3 -3 -4 -4 -3 -3 -3 -4 0 -2 -2 -3 -2 4 -4 -3 -3 8 7 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 14 0 0 0 26 60 0 1.44 0.32 150 N -3 -1 7 1 -4 -1 -1 -1 0 -4 -4 -1 -3 -4 -3 0 -1 -5 -3 -4 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.31 0.32 151 K -2 2 -2 -3 -3 3 -1 -4 4 -1 3 1 0 -2 -3 -2 -2 -3 -2 -2 0 14 0 0 0 17 0 0 14 0 44 12 0 0 0 0 0 0 0 0 0.40 0.32 152 P -2 -3 -3 -3 -3 -2 -2 -3 -3 -2 -3 -2 -3 -4 8 -2 -2 -5 -4 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 86 0 0 0 0 14 1.93 0.32 153 L -3 -2 4 -2 -3 -2 -2 -3 4 -1 3 -2 0 3 -4 -2 -2 -2 0 -2 0 0 29 0 0 0 0 0 16 0 39 0 0 17 0 0 0 0 0 0 0.47 0.32 154 I -2 -4 -4 -4 -2 -4 -4 -4 -4 4 0 -4 0 3 -4 -3 -1 -3 -1 4 0 0 0 0 0 0 0 0 0 39 0 0 0 17 0 0 0 0 0 44 0.65 0.32 155 E 1 -2 -1 2 -3 3 2 2 -2 -4 -4 -1 -3 -4 -2 3 -1 -4 -3 -3 14 0 0 14 0 17 12 16 0 0 0 0 0 0 0 28 0 0 0 0 0.42 0.32 156 A 3 -2 -1 -2 -2 -1 -1 2 -2 -3 -3 -1 -2 -3 -2 4 0 -4 -3 -2 26 0 0 0 0 0 0 17 0 0 0 0 0 0 0 58 0 0 0 0 0.61 0.32 157 T -1 -2 -1 2 -3 -2 -1 -2 -2 -3 -3 -2 -2 2 3 3 3 -3 -2 -2 0 0 0 15 0 0 0 0 0 0 0 0 0 14 17 27 28 0 0 0 0.48 0.32 158 G 3 -3 -2 -2 -2 -2 -2 4 -3 -2 -3 -2 -2 -3 -2 1 -1 -4 -3 1 29 0 0 0 0 0 0 40 0 0 0 0 0 0 0 15 0 0 0 17 0.53 0.32 159 Q 1 -1 3 -1 -3 2 -1 2 -2 -3 -3 2 -2 -4 -2 2 2 -4 -3 -3 13 0 16 0 0 12 0 17 0 0 0 14 0 0 0 15 14 0 0 0 0.35 0.32 160 Y -3 -3 -3 -4 -3 -3 -3 -4 1 -2 -2 -3 -2 4 -4 -3 -3 1 8 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 83 0 1.37 0.32 161 L -2 -3 -4 -5 -2 -3 -4 -5 -4 1 5 -3 1 -1 -4 -3 -2 -3 -2 3 0 0 0 0 0 0 0 0 0 0 72 0 0 0 0 0 0 0 0 28 0.71 0.32 162 M -2 -2 -3 -4 -2 2 -2 -4 -3 1 0 -2 3 3 -3 -2 -1 -2 -1 4 0 0 0 0 0 16 0 0 0 0 0 0 12 17 0 0 0 0 0 55 0.47 0.32 163 D 1 -2 3 6 -4 -1 0 -2 -2 -4 -4 -2 -4 -4 -2 -1 -2 -5 -4 -3 15 0 16 70 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.97 0.32 164 E -2 -1 -1 1 -5 3 6 -3 -1 -4 -4 0 -3 -4 -2 -1 -2 -4 -3 -3 0 0 0 0 0 14 86 0 0 0 0 0 0 0 0 0 0 0 0 0 1.08 0.32 165 N 1 -2 5 4 -3 -1 -1 -1 -1 -4 -4 -1 -3 -4 -2 2 -1 -5 -3 -3 15 0 40 29 0 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0.67 0.32 166 G -1 -3 2 4 -4 -2 -1 5 -2 -5 -5 -2 -4 -4 -3 -1 -2 -4 -4 -4 0 0 14 31 0 0 0 56 0 0 0 0 0 0 0 0 0 0 0 0 0.92 0.32 167 E -1 -1 2 0 -3 0 3 -2 4 -2 -2 2 -2 -3 -2 -1 -1 -3 -1 1 1 1 15 1 0 1 29 1 14 1 1 17 0 1 1 1 1 0 0 14 0.35 0.28 168 K -2 2 3 -1 -4 2 2 -3 -1 -3 -3 2 -2 -2 -3 -1 2 -2 3 -3 0 16 17 0 0 14 14 0 0 0 0 12 0 0 0 0 15 0 13 0 0.40 0.32 169 Y -3 -3 -4 -4 -3 -3 -4 -4 -1 -1 -1 -4 -1 7 -4 -3 -3 1 6 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 61 0 0 0 0 39 0 1.21 0.32 170 D 1 0 3 4 -4 3 0 -2 -1 -4 -4 3 -3 -4 -2 -1 -1 -4 -3 -3 14 0 17 26 0 16 0 0 0 0 0 28 0 0 0 0 0 0 0 0 0.52 0.32 171 S 0 -2 0 -1 -2 -1 -1 -1 -2 -3 -3 -1 -2 -3 -2 5 3 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 83 17 0 0 0 0.78 0.32 172 W -4 -4 -5 -5 -3 -3 -4 -4 -3 -4 -3 -4 -2 0 -5 -4 -3 12 1 -4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 3.05 0.32 173 D -2 -1 -1 2 -3 0 4 -3 4 -3 -3 -1 -3 -4 -2 -1 3 -4 -2 -3 0 0 0 12 0 0 41 0 17 0 0 0 0 0 0 0 30 0 0 0 0.62 0.32 174 K 1 0 -1 2 -3 3 2 -2 -2 -3 -2 3 3 -3 -2 -1 -2 -4 -3 -2 17 0 0 15 0 14 14 0 0 0 0 25 16 0 0 0 0 0 0 0 0.38 0.32 175 Y 1 -3 -3 -4 -3 -3 -3 -3 -1 0 -1 -3 3 4 -4 -2 -2 0 5 2 16 0 0 0 0 0 0 0 0 0 0 0 13 28 0 0 0 0 27 17 0.55 0.32 176 F -3 -4 -4 -5 -3 -4 -4 -4 -3 2 2 -4 0 6 -4 -3 -2 -1 1 1 0 0 0 0 0 0 0 0 0 15 16 0 0 56 0 0 0 0 0 13 0.77 0.32 177 E -2 0 -1 0 -4 6 4 -3 -1 -4 -3 0 -2 -4 -2 -1 -2 -3 -3 -3 0 0 0 0 0 58 42 0 0 0 0 0 0 0 0 0 0 0 0 0 0.98 0.32 178 M 1 -2 -2 -2 -2 -1 -2 -2 -2 2 0 -2 5 -2 -2 3 0 -3 -2 0 15 0 0 0 0 0 0 0 0 16 0 0 34 0 0 35 0 0 0 0 0.39 0.28 179 K -2 -1 5 -1 -3 -1 -1 -2 -1 -2 1 2 -1 -3 -2 0 2 -4 -2 -2 0 0 40 0 0 0 0 0 0 0 21 19 0 0 0 0 21 0 0 0 0.38 0.23 180 P -1 -2 -1 -2 -3 -1 -1 -2 7 -4 -4 -1 -3 -3 5 2 -1 -4 -1 -3 0 0 0 0 0 0 0 0 40 0 0 0 0 0 39 21 0 0 0 0 1.00 0.23 181 I -2 -3 -4 -4 -2 -3 -4 -4 -3 5 1 -3 4 3 -4 -3 -2 -2 0 1 0 0 0 0 0 0 0 0 0 60 0 0 20 19 0 0 0 0 0 0 0.58 0.23 182 L -2 -1 -3 -4 -2 -2 -2 -4 -3 3 4 2 1 -1 -3 -3 -2 -3 -2 0 0 0 0 0 0 0 0 0 0 21 59 20 0 0 0 0 0 0 0 0 0.44 0.23 183 T -1 -1 -1 -2 -2 3 -1 -3 -2 2 -1 -1 -1 -2 -2 0 4 -3 -2 0 0 0 0 0 0 26 0 0 0 25 0 0 0 0 0 0 49 0 0 0 0.38 0.18 184 A 3 -1 -1 -1 -2 4 0 -1 -1 -3 -3 0 -1 -3 -1 3 0 -3 -2 -2 32 0 0 0 0 33 0 0 0 0 0 0 0 0 0 36 0 0 0 0 0.42 0.14 185 Y -2 0 -1 0 -4 4 3 -3 0 -3 -2 0 -2 0 -2 -1 -1 0 4 -2 0 0 0 0 0 36 33 0 0 0 0 0 0 0 0 0 0 0 32 0 0.56 0.14 186 P -1 -2 -2 -2 -2 -2 -2 -2 -3 -2 -3 -1 -2 -4 7 0 3 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 64 0 36 0 0 0 1.31 0.14 187 T 0 -2 0 -1 -2 -1 -1 4 -2 -3 -3 -1 -2 -3 -2 3 3 -3 -3 -2 0 0 0 0 0 0 0 36 0 0 0 0 0 0 0 33 32 0 0 0 0.50 0.14 188 F -2 -3 -4 -4 -3 -3 -4 -4 -2 0 2 -3 0 6 -4 -3 -2 0 2 -1 0 0 0 0 0 0 0 0 0 0 33 0 0 67 0 0 0 0 0 0 0.72 0.14 189 A 4 -1 -2 -2 0 -1 -1 0 -2 -1 -1 -1 -1 -2 -1 1 0 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 K Lambda Standard Ungapped 0.1327 0.3165 Standard Gapped 0.0410 0.2670 PSI Ungapped 0.1572 0.3171 PSI Gapped 0.0481 0.2670