>QUERY >UniRef90_UPI000467989E >UniRef90_R9VTK9 >UniRef90_G9YB30 >UniRef90_D3V678 >UniRef90_V3TXA3 >UniRef90_Q7N984 >UniRef90_A6F8J6 >UniRef90_E8XYH4 >UniRef90_H5V767 >UniRef90_C4L792 >UniRef90_C9P7D7 >UniRef90_I2BDX7 >UniRef90_F7YSK1 >UniRef90_X3X6R1 >UniRef90_D4E0J8 >UniRef90_UPI0002F689B8 >UniRef90_D6YQJ3 >UniRef90_U3BJX7 >UniRef90_Q74RF9 >UniRef90_T0QJW8 >UniRef90_D8MLH2 >UniRef90_A6CUL9 >UniRef90_UPI0002FCA92E >UniRef90_UPI000376198A >UniRef90_Q8D3U8 >UniRef90_V5E7C0 >UniRef90_UPI0002D3BD05 >UniRef90_D0Z9W6 >UniRef90_U3CNL1 >UniRef90_UPI00046AAF11 >UniRef90_W0L7S1 >UniRef90_W1DZQ0 >UniRef90_L0MNS2 >UniRef90_Q9KL06 >UniRef90_D4GEH0 >UniRef90_E6WIV1 >UniRef90_F0LZU9 >UniRef90_C6AN86 >UniRef90_U1TD64 >UniRef90_Q65QT4 >UniRef90_UPI0002FB4105 >UniRef90_UPI00034AFE3B >UniRef90_E7V2Y5 >UniRef90_D0Z2X2 >UniRef90_L8JE58 >UniRef90_UPI000395C446 >UniRef90_W1IS43 >UniRef90_N6WRM9 >UniRef90_UPI000394359F >UniRef90_U4K7Q4 >UniRef90_UPI0002D47270 >UniRef90_UPI0003B3D55E >UniRef90_U3HNV4 >UniRef90_S2KIP8 >UniRef90_M9X1I5 >UniRef90_UPI00047A89DE >UniRef90_UPI0003C78CFD >UniRef90_M4R405 >UniRef90_I3D846 >UniRef90_A3N1N8 >UniRef90_U7NZ43 >UniRef90_F7SPJ5 >UniRef90_B9Z7Z8 >UniRef90_W8RSB9 >UniRef90_C9PPE8 >UniRef90_H0J3K0 >UniRef90_W5YKH1 >UniRef90_W5YTE1 >UniRef90_W9B195 >UniRef90_T2LD71 >UniRef90_A4VQ62 >UniRef90_E1V8B2 >UniRef90_Q2SPS3 >UniRef90_UPI0004780EEE >UniRef90_B8F3M5 >UniRef90_N9VJD8 >UniRef90_D9P655 >UniRef90_S6EH14 >UniRef90_R9PTQ0 >UniRef90_I7AC92 >UniRef90_V8FB61 >UniRef90_UPI00034BF354 >UniRef90_UPI000476071C >UniRef90_UPI00045EB527 >UniRef90_UPI0003808290 >UniRef90_UPI0003B4D646 >UniRef90_UPI00028A354D >UniRef90_UPI00047AC811 >UniRef90_A4XX18 >UniRef90_I0HKS0 >UniRef90_G8PQB0 >UniRef90_A0A031GG29 >UniRef90_F4DHN9 >UniRef90_W7Q8A7 >UniRef90_UPI00035F92B1 >UniRef90_G4RAA6 >UniRef90_UPI0004783D8A >UniRef90_UPI0003645C74 >UniRef90_F1VV19 >UniRef90_UPI0003652BE0 >UniRef90_R5EDT0 >UniRef90_K5VDI0 >UniRef90_A4B998 >UniRef90_UPI0004760862 >UniRef90_U2YJI6 >UniRef90_UPI000476D1AB >UniRef90_D5EHQ4 >UniRef90_Q2CC96 >UniRef90_W0J525 >UniRef90_S2VNY7 >UniRef90_D0LWJ2 >UniRef90_UPI00025561A9 >UniRef90_UPI00039CB85C >UniRef90_B5YD23 >UniRef90_D1BF31 >UniRef90_UPI00047C88C0 >UniRef90_X1G6K8 >UniRef90_X4R0P8 >UniRef90_K9F0S3 >UniRef90_UPI0003B6077F >UniRef90_L1PH07 >UniRef90_UPI000302AD02 >UniRef90_S2WFX3 >UniRef90_R1H2W5 >UniRef90_A0A011SP74 >UniRef90_F8A2D0 >UniRef90_D1BUG6 >UniRef90_E6KR01 >UniRef90_F6FXF4 >UniRef90_D5UG42 >UniRef90_UPI0003B40363 >UniRef90_C7R504 >UniRef90_UPI0003B40515 >UniRef90_D7BMI6 >UniRef90_UPI00034613C5 >UniRef90_A1R398 >UniRef90_U1QF71 >UniRef90_C0W248 >UniRef90_I0HZS4 >UniRef90_UPI0003B3D1CA >UniRef90_UPI0003632C3D >UniRef90_A0A021VTV5 >UniRef90_F4H2U1 >UniRef90_UPI0003B5777C >UniRef90_UPI000346462B >UniRef90_U1RH09 >UniRef90_UPI00031BFB72 >UniRef90_UPI000344C461 >UniRef90_K0YV80 >UniRef90_F6EJU9 >UniRef90_I6WT72 >UniRef90_UPI0003619BE7 >UniRef90_J7LB23 >UniRef90_A0A031FQN8 >UniRef90_UPI00034D3016 >UniRef90_E1VV69 >UniRef90_UPI0003474099 >UniRef90_UPI000255D17A >UniRef90_UPI00036541E0 >UniRef90_D7AYF3 >UniRef90_C5BZZ2 >UniRef90_F6FTM1 >UniRef90_U1S0Q1 >UniRef90_M2XSE4 >UniRef90_UPI000376BCCB >UniRef90_U1MWQ4 >UniRef90_UPI000378F0B5 >UniRef90_UPI00042067BB >UniRef90_C5C4R0 >UniRef90_C5C7M3 >UniRef90_C7NK69 >UniRef90_UPI00037707CE >UniRef90_Q9XDA1 >UniRef90_UPI00046D098F >UniRef90_C8X7V9 >UniRef90_UPI00037C1524 >UniRef90_A0A022KUF2 >UniRef90_U2YIG0 >UniRef90_UPI00047A4B69 >UniRef90_D3PZ89 >UniRef90_A0A010NQ33 >UniRef90_UPI0003B4B096 >UniRef90_S5DQS1 >UniRef90_Q8FR92 >UniRef90_D2B814 >UniRef90_UPI000346393B >UniRef90_K6VHZ1 >UniRef90_UPI00036771AF >UniRef90_A4AJ16 >UniRef90_D4TXD1 >UniRef90_T5K262 >UniRef90_G8S2Q3 >UniRef90_E6DR58 >UniRef90_UPI00047CD1DA >UniRef90_C4RP02 >UniRef90_F8A1Z0 >UniRef90_UPI0003B32003 >UniRef90_UPI00045EA581 >UniRef90_I0KWJ9 >UniRef90_U1YZH2 >UniRef90_C5C2Q4 >UniRef90_UPI000478CF0A > > > >lupas_21 >lupas_14 >lupas_28 >jnet >conf >sol25 >sol5 >sol0 >jhmm >jpssm * iteration 1 W WW W W W W 9 Q QS Q RK K Q R KK K K K Q 9 S SH H SG N S S KN K S G S 2 H D DP S AS V E L VV V V S S D H1 H A IV AF MI L VMLM FF F F V A V L H3 HH L LL LI FL I VALI II I I L L V L L H8 HH K KK KK TK K KKKK KK K K K K K K K H9B HH W WW WW RW W WWSW WW W W W W W W W H9B HH S IF LC SA A LGVS GA A A A S L S A H9 HH V VG AT LV L CLLL LL L L T L T A V H9B HH L IV VL LL L ILIL LL L L L L L I V H9BBBHH G AS ST GS G GSGA GG G G G G L G A H9 B HH L AL LL LA T LALT SS T S L M A L I H9 HH L MC CI VV V LICV VV V L V I V L I H9BB HH G CL VG AG G SACG GG G G G G S C V H9BBBHH L LF LL VI I LALI LI L I I V L L L H9 HH L FF FM LV V MILV VI I V I V L L V H9B HH V TT TN NN N TNVN NN N N N N N V N H9B HH G GG GG GG G CGGG GG G G G G G G L H9B HH Y YY YY YY Y YYYY YY Y Y Y Y Y Y Y H9BB HH L LL LA LT A LVLA AA A A A A A L A H9BBBHH V TI VS IT T ICLT TT T T T T S V D H9B HH V IV VV VI I VVVI II I I V V V V I H9BBBHH L VL LL QL L LLLL LL L L L L L L C H8BB HH M MM MM MM M MMMM MM M M M M M M M H7BB HH Y YY YY YY Y YYYY YY Y Y Y Y Y Y Y Y Y H3B HH A AA SS AS S ASAS SS S S S A A A V L Q 1B H Q QQ QR QR R QRQR RR R R R Q QR RK Q Q Q S N S S 8 G GG GG RG G GGGG GG G G G G GG GG G G G G G G G 8B EEEEEEEEE EE E EEEE EEE E E E E EE EEE E E EE E E D Q E 0 H YYYYYYYTY YL L YTYI YLL V L V Y YF YYI Y F YY W W I V W H5B HH LLLLLLLSL LA A LALA LAA A A A L LA LAA L A AL V V A A V H8BB HH FFFFFFFFF FF F FFFF FFF F F F F FF FFF F F FF F F Y I F H9BB HH AAAAAAAAA AA A AAAA AAA A A A A AA AAA A A AA A A P A A H9BBBHH IIIMMMMVV MM L IMLL IMM M L L I IL ILL M I LI L L L L L H9B HH TMTLLLVLL LL L MLLL LLL L L L L LL MLL L L LM L L L T L L H9BB HH TTTTTTTTT TT T TTTT TTT T T T T TT TTT T T NT D D D M D S H9B HH LLLLLLLLL LL L LLLL LVV V V L L LL LLV L V LL L L L L L L H9BBBHH IMVVVLVII LV I IVII LII I I I V VV IVV V V VI V V V C L I H9BB HH LLLLLLLLL LL L LLLI LLL L L L I IL LLL L L IL V V L M V T H9B HH SSSLLSLTS AT T ITST STT T T T L LA STT L T VS V V V T V L H9B HH SGSGGSGSG GV A SSAA SAT A A A T TS SSA G A AS S S G G S I H9B HH ATASSVMLV TL L ALTL LLL L L L S SM ALL S L SA V V V L V A H9BB HH GGGGGGGAG GA A GAGA GAA A A A G GG GGA G A GG G G G F G V H9B HH LLLLILILL IL L LVLL LLL L L L V VV LVL I V VL L L V V L D H8BB HH YYYYYYYYY YY Y YYWF FYY Y Y Y Y YY YYF Y A YY Y Y Y Y Y Y Y H8B HH IIIIVIVII LI I VVII III V I I I VV IVI I I VI V I V V V V V H8BB HH FFFFFYFFY FF F FFFF YFF F F F F FF FFF F F FF F F F F Y F Y H6BB HH AAAAATSGG AG G AGAG GGG G G G S TA AAG V G TA M T M V L M F H3B HH NRNNNNNSN SS S NSNS NSS S S S N NR NRS N N SN N S N S N N S 5B RRRRRRRKRRRKRK RKRKRRRKKRKRKRKR RRRRRKKRKKRRKK S RR R KR Q K S R K K A K K R KP K K K 8 KKKKKRNKRRKKKH RKRKRNRKKRKRKRKR KRKRRKKRNRRKSR R KK R RK S K R R K K K RR K R RR R R R 8 ATAASATTAAATAT ATATATATTATATATA AATAATTAATATMT A TA T AA T T A A T M A MA T A MT M T A 5B YYYYYYYYYYYYYY YYYYYYYYYYYYYYYY YYYYYYYYYYSYYY Y YY Y YY Y Y Y Y Y Y Y LL Y I LL I I L H1B HE AAAAASAASASAAA AAAAAAAAAAAAAAAS AAAAAAAAAAAAAA A AA A AA R A A A A A T AP A P PA P P P H1B HE WWWWWWWHWWWHWH WYWHWWWHHWHWHWHW WWHWWHWWWHWWHH W HH H HW W H Y H H Q Y AA H G AL A A L H2B HE RRRRRRRRRRRRRR RRRRRRRRRRRRRRRR RRRRRRRRRRRRRR R RR R RR R R R R R R R KK R K K KK K K K H2B HE YYYYYYYYYYYYYY YYYYYYYYYYYYYYYY YYYYYYYYYYYYYY Y YY Y YY Y Y Y Y Y Y Y FY Y Y Y YY Y Y Y H2B HE VVVVTVTIVVVIVI VTVIVAVIIVIVIVIV VVIVVIVVVIVVII T II I IV V I L I I A L LL I L L LL L L M H3B HE YYYYYYYYYYYYYY YYYYYYYYYYYYYYYY YYYYYYYYYYWYFF Y YY Y YY Y F F Y F F F VL F V Y VT V V L H1B H PPPPPPPPPPPPPP PPPPPPPPPPPPPPPP PPPPPPPPPPPPPP P PP P PP P P P P P P P PP P P P PP P P P H1B H GGGGGGGGGGGGGG GGGGGGGGGGGGGGGG GGGGGGGGGGGGGG G GG A GG G G G A G S G GG G G G GG G G G H1B H MLVLILVVLLLVMI VIVIVILIILIVILIL LIIMIVILIVLLVI I II V MV V V V L V V L LM V M L ML M M L H1B H AAAAAAAAAAVAAA AAAAAAAAAAAAAAAA AAAAAATAMAAAAA A AA A AA S A A A A A L VV A V L VV V V A H2B H GGGGGGGGGGGGGG GGGGGGGGGGGGGGGG GGGGGGGGGGGGGG G GG G GG A G A G G G G FF G F F FF F F F H3B H MMMMMMMMMMMMMM MMMMMMMMMMMMMMMI MMMMMMMMMMMMMM M MM M MM M M V M M M F LL M L L LL L L L H3B H GGGGSSGISGGIGI GIAIGGAIIGIGIGIG GGIMAIIATIGGIL A II L VG G V M L V T G CL V L F LL L L V H0B HH LLLLLLLLLLLLLL LLLLLLLLLLLLLLLL LLLLLLILILLLLI L LL V ML I V V V V A V VI V I T VT I I I H1B HH FFFFFFFFFFFFFF FFFFFFFFFFFFFFFF FFFFFFFFFFFFFF F FF F FF F F F F F F F YY F Y Y YF Y Y Y H1B HH VVVVVVVIVVVIVI VIVIVVVIIVIVIVIV VVIVVIIVIIVVII V II V IV V I V V I I V V QQ I Q Q QQ Q Q Q H0B HH LLLLLLLILLLLLL LILLLLLLLLLLILLL LLLLLLLLLILLII L MI I IL L I L I I I I I LL I V L VV V V V H2B H FFFFFFFFFFFFFF FFFFFFFFFFFFFFFF FFFFFFFFFFFFFF F FF F FF F F L F F F F Y FF F F F FF F F F H1B H PPPPPPPPPPPPPP PPPPPPPPPPPPPPPP PPPPPPPPPPPPPP P PP P PP P P P P P P P P TV P V T VV V V T H1B H LLLLLLLLLLLLLL LLLLLLLLLLLLLLLL LLLLLLLLLLLLLL L LL L LL L L L L L L L I MM L M M MI M M I H2B H VVVIIVIVIIFAIA IMAAIIVAAVAIVIAV IIAAVAVAVIAVMI I VV L LI I A V L A I I F AG A G V GG G G G H1 HH CCCCCCCYCCCYCY CYCYCCCYYAYCYCYC CCYCCYACAYCCYY C YY Y YC C Y Y Y Y Y Y Y YY Y Y Y YY Y Y Y H2BB HH TTTTTTTTTTTTTT TTTTTTTTTTTTTTTT TTTTTTTTTTTTTT T TT T TT T T T T T T T T TT T T T TT T T T H1B EH IIIIVIIVIIIVIV IIIVIIIVVIVIVIVI IIVVVVIVIIIIIV I IV V VI V I V V I V F I GG I G G GG G G G E1B EH AAAAAFAGAAGNAG AGAGAAAGGAGAGANA AAGGANAAAGAAGG A GG G GA V G S G G W V F YY G Y Y YY Y Y Y E2B EH IIIIIIIIIIILILIILILIIILLILILILI IILIILIIILIILL I LL I II I I I I I I I V VV I V V VV V V V I E3BBBEH AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAA A SA G AA A A G G A S G S AS A S A SA S S A AA A E0BBBEE FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF FFFFFFFFFFFFFF F FF F FF F F F F F F F F FL F F F LF F F F F FF F 1BB TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTT T TT T TT T T T T T TTT T T T TTT TT T TT T T TT TT T TTTTT T T TT T T T TT T T TT TT T 5B NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNN NNN NN NNNNNN NNN NNN N N N N NN NNNNN NN NN N R NN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNN NNNNNNN NNNNNNNNNN 7B YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY YYY YY YYYYYY YYY YYYYYYYY Y F YY YFYYF YY YY K Y YY YYYYYYYYYYYYYFYYYYYYYMYYYYYYYYYYYYLYYYYMYHYMYYLYYYYYYYYYYTYFYYYFYYLYYWYYMYYYYY YYFYYYFYYY 8B SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS SSS SS SSSSSS SSSSSSSSSSSS SSSSSSSSSSSSSSSSSSS SS S SSE SG S GGGGGGGGGGSGGGGGGGGGGSGGGGGGGGGGGGSGGGGSGGGSSGSGGGGGGGGGGGGGGGGGGGGGGSGGSGGGGG GGGGGGGGGG 8B SSSSSSSASSAASASSASASSSAASASASASSSSASSAGSGGSSGAASAAAAAGS GS GGSSSG SAAASGSASGGGSGGSSSSAGSSGSSSGSSSG SSG NSSSASSD A TDQTHDTDDHGSDDQDDTDTHDDQDDSDDDTDQADSDDDDADSDTDDTTQDDDDDDAADDDTSDADDTTTDDDDDTQT DDDTDDDTDD 8 TTTTTTIKTTVKTKTTTTKTTVKKTKSKTKTTTTKTTKTTSATTTSSTSKKTKSSSTTSSSSSTTTTSSTDSSSTSASTTTTKRTSTSSSSFRSSSFSSSNS LFFRTFAR K GGGGQRGGGGAGGGGGGGGGQGGGRGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGG 7 NNNNNNNNNNHNNNNNNNNNNHNNNNNNNNHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNHNNNNHH HNNNHNNH NNHHHHHHHHHHNHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHHHHHHHHH HHHHHHHHHH 7B QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQQQQLLQLQQQQLLLLQLLLQLLLLLQLQQLLQLLLLQLLLLLLLLLLQILLV LLLLLLLM LLIINITMINNILVNNNNNNNNTRNNLLNNNNNRNNRNNNNRIRNRNNRNNNNNNNNNNQNRRLNRVNRNLINNRLMNNN NNRNNNRNQN 7B LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLM LLLLLLLL FFLLSLLLGSSLLSSSSSSSSGLGSSLLSLSSGGSSGSSDSGGGSGSSGSSSGASSSSSLSGLDSGGSGSGLSGGDGSSG GSGVSSGSGS 6B TTTTTTTSTTSSTSTTSTSTTTSSTSTSSTSTTTTTTSASSSTTSSSTSSSSSSSSTAASNSSTSASSSTSSSSSASSSSSTTSTTTSESSSTSSPTTTSSN SSSSSSRT TTTNTSDTTTTTSTTTTTTTTSDTTTDTDTTTSTTDDTSSTSSTDDSDDTTTSTTSTTDTSDDSTTSTTTSTTTTTDTST STSSTTSTAT 2 FQQFFFFFFFFFFLFFLFFFFFLLFLFFQLLFFFLQLYFEFFFFLLFLFLFFIQEFLQFYFEEFFYEFFLQQEQLFMFFLFFFFFFFEYFYHYVEFFFFFLV FYYFYKFK LLKKKKKKKKKKVKKKKKKKKKKKKKKKKKKQKKKKKKKKKKQKKKKKKQRKKKKKKKKKKKKKKKQKKKMKKKKKKKKK RKKKKKKKIK H7B HH EEEEEEEEEEEEEEEEEEEEEEDEEDEEEDEEEEEEEEEAEQEEEEEEEEEEEEEEEEEEKEESEEEGEEEAEEQEEEEEQEEESDEEEEEEEEDQEEEEED DEEESPPE EETTSEAEEAAEEDSEEEEEAESEDDAQAEQAEEEPDEEQEEDEDEEPEEEEDDDEDEADEEDDEEDAEDQSDQEEDAAD DEDEQSDEDE H8 HH RRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRQRRRRRQQRRRQRRQQRRQRRRRQQRRQRRRRRRRRQRRRQRRRRRRRS QRRRRRQR RRQDDQQAADDAQDDQDQHDDQTQDDSVDQDDQQDARDDAQQQEDQDDQQQDEADADQAEAQGADQQDEHQQDDQVDDDQ DDDQDHDQAA H9 HH AAAAAAAAAAAAAAAASAAAAAATAAAAAAVAAAAAAAAAATAAATAAVAAAAVVAVAAVVVVAAAVVVTVVVVVVAVAVVAAAAVVVAVAVAAVSAVAAVA AATSVTVA AAVAAVAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATAAAAAAAAVAAAAAAAAAAA AAAAAAAAAA H9BB HH QQQQQQQQQQQQRQQQQQQQQQQQQQQQQQQQQQQQQQVQLQQQQQQKQQQQQKRVETVLVRRTQLRQKQRERLKVRLLEQQTTTQQRKQTRTRRTQQRTRM KVITKVVT TEIIIIITIIVIRVVVIVVVIVIIIVAIVVVVVIVIIVIIIIVIIIIVIVVVIIIVIVIVIIIIVIVVIIVVIVIVIVVI VIIVIIIVLV H9B HH EQQSTSSSSQSTDTQSAQSSSSSSQSSTSSNSQSSQQSSQSGQQSSSTESSSSQASRQTKRDGARSSEDSARAEENERNQREQAAEKAQRAEQDGENSHQAA SEERAERE KEEAEENSEEEENNAQSEENSSEASNERSAEESASEAARTEAAASNEAADDAATSRAEEEGADVNNANDHDNTAAQSSAS AAVDQEVSAR H9 HH VVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVQVVVVYQVMVVQQQQYYVQNNIQYQQIQYNVLYVYYYQQQYYYIYYQVVQYYIF YVVYDVYA FFQSIQAQAVAIYAASAAAASSISQSSQAAFASQAIAAAQASARASAASAASQQAAQAIIQAAAASAAYAAIAASQVLSS AQAAAAAAQA H9B HH LLLLLLLLLLILLLLLHLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILLLLHFLHLLLLLLLHLLLLLLHFLHLHLLHHLLLLLFLFHLHLHLLLFHLHH FLLLFLFL HHLILFLLNAILHLILILLLILLILIILLVLILIIIIILILISILIIIIALILLIILLIILITILIAILIALIIIILLIL ILILILILHL H8BB HH LLLMMMMLMMLLMLMMLLLLMMMLMLLLLVMMMMMLLMTLTLMMLHLMLLLLILLTLLSQQLMLLLMLMETLLLLQLQTILLLLLLLLLLLLLLLLLLLLLL LLILLLQL TLEEMEVVLLLLLLLLLLLILMLETLLELLLLMELQETVLLELELEMLELLLTTVVTLQQTEIQLVLQEMLEELEVILLL QTQLELQL V H8B HH DDDQSDSDGDDNSDDQSGDDSDQDDDQDQNDQDQDSSDDSEEDDQQESADADDNEEADESNSSDNESSDQNSESASKSTQGDDDDASADREADKANSASDAQ DSSEQSDT EQKEQNVRASEQKQEEEEEQSAQAAERRQAENAAESAAQDEAEAQSQSAEIEEEGSAESAEAAAQSEQALESDSAAESQQ QASSQESEES H5 HH RRRRRRRSRRRRRRRRKRRRRRRRRRRQRRRRRRQRRRQRQQRRQRRRRQQRRQQQRRQQQRQQQQQRRRQQRQKQKQQKQREEQQKREQQKEKRRSQQEKK QRREQREQ KKEKNQQSQRRKKQQRQRRQKENYQQQEEQREEAQSSKQRRSRSNTEEYRQQQQQEQRSQQYQSQQRQKQQREEYNKSQE EQQQGKKRRE 1 SQSQQQQTEQQTQTSQTTTQQQTTQTQTMTQQSQTQQTRQRSQSTTTQTTTTTTTRTSRTTTTTTRTTTTTTTRTRTTKTTSTTTQTTTTTKTTTTRNTTTT TGGKTGTR TKTRQYNSRQRRSRRRRRRRRRSSKRRMRRRTRSRSVYRRRVRRRRRTSRSRRRNTKRSQRSRNRQRRQTRTPTSSRQRRTRQQKSRQRRT 5 WYYFYFYYFYFYYYYFFFYFYFFYYFFYFFYFFFFYYFYYYFFYYFFYYYFFFYYYYYYYYFYYYYYYYFYYYFYYYYYYYWQYYYYYYYTIQYYNIYYRWY YTTMYTYV YYFVRY QVRVVYVVVAVVVVVTVRAVYVVVRVVVITTRVVVVTVTVRVVEAVITRRVIVVVDVVTIVRQVFVRVVVNAVRVRVIFVVVVR 7B QQQTQQQQQQQQQQQQQQQQQSQQQQQQTQLQQQQQQQFQFQQQQQQQQQQQQLQFTQFAAQQSLFQQQQQLQQEFKALMLQRQSQQQTLPVRKQSIERGRK IVVPKVLE RRLERL REVEEKEEEPEEPEE VVEELEEELEAPRRRVEEREAEAPVSERPEEQVVEREERPEEADLEPEQPVREPREEVPVPPEEPEEV 8 AAATAASSGASSAGATSSSTSASSASTSSSETATSDDSSAASSASSGTSSSSRAAAAASAAAESAADSSAAAATTSQASAAATAGTQESAEDVAETDKEETS ADDTPDAG EEPGAS VGEGGADGGGGGDGD SPGGPGGGPDQGVDVDGGEGDGDDPSGAGGGRDPGVGGTDGDDTDDDDQDPDEDVGDPNPGDEGGGGE 8 GGGGGEGGGGGGGGGGGGGGGDGGGGGGGGGGGGGGGGGGGGGGGGGGEGGGGGGGGGGGGGGGGGDEDGGGGGGGGGGGGGDGGGPEGGGKEGEGEPGGGG DPPGEPSS GGESQE PTGSSGSSTASSSTS ADATESSSDSGAPPGGTSDAGSSSDPSVASSVGDSPSSPSGSASSASSGAGA SAASGADSSSSSSSG 7 KKKKQKQDKKNDAEKKKEEKQNEEKEKEQDKKKKEAAEDDDDSKDDDEAQEDEEVDGKDDDANDEDDASKAESEGEGEEGEKGREDNSDEHESGSEEDQSEG QDEVDDDA AGNADD DPAPPGAANVPAAAP DSPAGPADSPEADDPTSPDPRAEPSDEDEPGESSEEEPDPTPPPPPPPIPSD PDPPSPSTPKAAAEA 7 TSATTTASVTTSTSTTSASTTASSASTSTSTTATSGGSKAKSGTSSSSRNSSSRAKTTKRHAAPRKARRSARARSRERKSRTGTPRSTKRGSAETGTSNNSD STTEATAQ DETSSS SATAEEAAANATTGA EATEAGAASTGNSSVQTSSTEGETPETTNEAGSASSRQSTEARSATTSESAS ASSTTAAESESQSAN 6 YYYYLYLYLFLYYYYFYVYFFWFFLYFYYYWFYFYLLYYMYYYYVYYFYYYYYYFYFFYLLFFLFFFYYYFFFYYYYLYFFYYYLYYFLYWRYFFMRYYYFY YEEYYEYY FYFYVY YYVYYFYYYVAYYYY YYVYFYYYYYYTYPVFYSRLFYYYVYYYLRYYYYFYYYYYYYYYYYYYFRQR YYLYYYYYYYYYSLF 4B NSNGNPTKNNNPPPNTPNPTTNSPNPGPAPSTNTANNSDNNTNNKKPDGPPRPRDQDNNDNDDQGDDDNNSRDDGDDDDDGNADKKQGAGGDADGAPKDASS EPPATPPP RKKPDTSPPQPPDPPPTPPDPP TKPPEPPQPPVTPEPPPPEPAPAPPTPPPAPQRKPDAETLAPNPRAQPDPPE DRPPQNRTPPPPAPR 3 FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFYFFFFFFFFFFFFFLLFFLYYFYFFFFFFFFFFFMFLFFFFFFFMFFFFFFMFY IFFFYFFL FFYLLYFLLTLLFMLVALLLIV LATLWVLVLVLAVYAIVLFLLVLLALLLAVVVITLILVLYVVMLVLLLLVIF MLAVLSVLLLLLLTI E2BB EE GGGGKGKDAGTTATGSTSTGRADTGTETSQANTGQSNHKAKEAGSDSKETQDNSQTAGSKKATSSKTEEESTRKSKTKKQSGTAAKEQTSASTTQTADSTKK GAATKATA NSETSQKKAATATSTAATATTTKTSATTKTSTTTASVKSTTATTSTTSTTTATTQAAVTSTTAVTTASTTAYART VTATKSASTTASTVA E7 EE LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLMLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLVVLLLLVLLML LVVLLVLV IIIVIARVVVVILVIVVVVVVVRVVVVAVVVVVLVVLVVVVLVIIVVVVVIIVVVVVVVVVVVPIVVIVVVVVVL VVVVIVVVIVVVVVV E8BB EE YYYYYYYYFYLHYYYYMFYYYYYYYYYYYLYYIYYLIYYYYRWYYYYYYYHYYHYYLYYLLYYYHYYYFYYHYYYLVIYHHYYLYYYHHHHWHLHHVYYHYF YAAHYAYV IVYLLFVVVVVVLLVVVVVLLVVALVVYYLVIVAVLAVVVVTVALAAVAVVVLLVFLVLVLAGILAVLAIVFIVTVLLVVLALAVLVAVVV E8B EE PPPPPPPRPPGKAKPADPKPPPKKPKPSPKPPPPKPASPSPQPPDKQPQHSRKARPEPPEQRQAQPAKNKQPRPQESEPQQPGSPPQSKRPQAGAQAQAAQE EERARPRD KEKSDKESSEAEKETEEEEDEEETTEEPSMELDAEEPTQEAPEAETEAPEEEREEQASEPSAEEEPEEYERQSEPPEEEEAEESERETELK E6 EE ASAEEAKSADSADTSAQATSKDTTATATDTATATTEATQQQHQTDVTETTISTSEQSAQNTDEHNQETTAESETNTEAQENADDRELSHEDQDGTDELADEL EGDLQEAA HSSDRNGRSDQQEKQSDSRQDRNTKNKQGRQSQRDQDSSKDDREGTRRERRDSGSAKDEEKDSQQTQRDRENGREGRQDQKKQEQDGKDDN 3 GGGGSGSEGNDDGEGAGGEDSGDDEDDEGADDGAEGGEAGDDGGNDDAEQDEQPGDGGDGNGGGDAGNDGGPGDGDNNTSDGGGGGDDRDGGNDEGGDGGGQ GDGGEGGG DSKDGNSGDGGGNDDGGDGLAGSGGGDGDGDGGGGGTIEDGTGGQGFGTLDSDALDDGGGDGSNGEGDGSDQDGTSFLSFGDNGDGDGGDD 8 DNDNEDDNDEGDDSDNNDQNDDNNDSQNDGENDDQDEDDDNDDDGNKEQNSEQEDNEDNEEEEKEDDAAGEDEDENNNEEDDKQKENEDEQDKNENDNENPD SGEQSDEG DNIDTYPGDSDNNGGGSADGDGPDNDGDDSGDGDAGGSGGDGGDDDGDGGGSDDADNGGTGTEGNGGGSGGEDGGEGGNGDGGDGNSDDDG 8 EAAQQRLGRKHGKGEQGRGQLRGGKGQGQGKQEQGRRGGRQVQEKGGRGGRGGGRKGEQQQRLNGRLGGGLGRKSQQQGGGEQRKQ GGERTEGGKQ TANG AGVDGLGE TKGGTGQEEEEEQADDGGEAGEQGGKA GDGETGGDEKGETDDGGSQRETEGGGGGSEEGEGGTEPEDGEELGEERQESTQKEPELGAAEG 0 E WWWWWWWYWWWYWYWWYWHWWWHHWHWHWHWWWWYWWYYWYYWWVHAWYYYYYDIYYWYYYAIYMWVYYYVEVFYYFYYYLWFHWYDVYLLYY LYYDYFFY YYYYYYLL YYD LDYL LLLYLLLLLLYNLYEFLLYLFLLLDLLLT LLLLE LLVLVVLD L FL D DDVFFYFDLIQLLLYLLLYLLVLLYLLLL E5B EE QQQRVRVRQRQRQRQQ QRRVQRRQRRRRIQQKQRRQRKQKSIQHQRVVRRRRRRQVKRQQRRQRQRIVQRRWVQQQQQVRQRIQIQRQRRRRQHQRKRRRD RRRRRREG TSI GLPGQGAGQFGGGGGS GPLYQGLVGGGGLGHVGEGGVGL VSGVGGG GSYG L LLSFEGHLGGFGGVRSSGGAASVGFGVGGQ E8B EE LLLLLLLLLLLILILL LILLLILLILILILLLLLLLILLIILLILLLILILILLILLLILLLLLLLVIILLLMLLLIILLLILLLILLLLLLFIFVILVLL VIIILVLF LLLLLKLFLLFFLFFLLFFFILLVLLFLMFLFLVLLFLLFFFFVLFFLFFFLLLLLLFLVLVLMFLFLVFFYLFFAFFLLFLLFFLFFFLL E9BBBEE AAAQAVAAAAQAAAAQAVVQAAYSAVRAQATQALLVVSAAVAAAAVVAYVYAFRYAQAVAAYYRRARHYIYRYRNALAGASAKRAQQYKRVYRQYAFQARMV VWWRFWAA VVLAAVTAGVAALLAAVAALALVFLVAWLAAALFV LAGAALAFALALLAAAAALALAYYAFLLLWALFAAYA LSLLALLILLAVALAAG E9B EE LLLLLLLILLLVLILLLLILLLVILILVLLLLLLILLILLLLLLLIVLLIVVIVLLLLLLLLLLVLLLLILILLLLLLLLVLLLLLLLLVLILLLFLLLLLL LLLLLLDI LLLFVILVFIVVLVIIIVIVFVVLFIILIIVVVLVLLVFVILVLMLVVLIVILLALFILLLLLVTLIALVILVLLLVVVAIVFVI IIVVF E8BB EE STTASKSKTTQQTETTTNNTDTKDSKTQTQTTTTESSEHSTKTTQNESERKKTDETVTVTSHESDHEKE EDEEQEKTSSDTEQSQHESDATELETPHTQSQ E EE AVSDTFALLKVAAVFTTAVSVITGTKLTRIEE VVTLQTTVAVVTVLLTVTTVVAAATATVLLALTTTLVTLTNALVTTTTVTTITTVTITDVT E6B EE DDDDVAIDSDDDDDDHIDDNASDTEDAKDDSHDHDEEDNTNQGD AMK NQDDKANQDNNNGNNRNNGG SKQSKNQS QKDRASLFRNKPGSLRSQFAQKQ S DS SNQATKIDYDNIDQDQTQADDDDIDDTDDDSR TDDTNVDKTDSS AIDDQGD DATSADDTTTTNDDDDDTTNDHNDTEEDDDDDDQDDDDVT E1B E GGGSPPPGAGSGTGGPKGGPPPGGGGPGAGPPGPGGAGKGPDAG PI GGGGGKPDGPKPGA GKEKKDDGGPGKGK DGGAP PEEEGGKPTE GSKATGK PPARPADGPGDVKSG LPDG PDGPEGPVPGDPAGPEIGTPGPRA AGPP GEPPPPG SVVPQPAEDVATPAPDPDEDIDGSGTPTPPPPPDPGPGDS 7 EDDDDDS DEEDAEEDDKEDGEDDDDDEQEEDEDDSEDTEADDEE ESGEDEEEETDENTNDDEENRHHDGEE DNDEHDEEDDE KGDEQEDQDDEK DSSKEDEAEEDDAEGERDLEEDTG DGDAS DDEEDSKDEGESEDDADE GHDEEEREADEDESEREQDDRNEAAADEGDADGDDPEDDDAEKGEAGEDEEDD 8 TSSNSSQ NST S TSAD DQN T S N NSSS NN TNT NTGNASQ N QGT STSSATAQT DDLGANV SN QTTSASQA RANTDGDGDTSTTGQASTGSPGRTQNDSNLDDSQ DGVVTG GDGLDGTDTQKGGGDTGGDSAGGDDD DRG GTDDGQGGDEDDDTSTEGDGVEDGGLGGTSTTGTVQTTVEA 8 GGGDSGTASGN G GGGN GTG E G GGGG SG NSA AGNG SN GAE GEQQSTGGD GNGAGKQ QG GGNGGGGP GDGGDDDGGGEDSDGGGGTGAAGGTNGGDGGGGA GTACGDGDGDGGKGVG GDEEGGQNGGEADGGGGGSREGGDGDGKDGGGGDNSGIGGEVQRGNSTSGGGKDGAGVGEVG 7 KKKQQAKQEKQEKQKEQ QSKAQQ VQQQQDQKEEQQKQ QHQKKE NQQ QQ RQKKQKKQQQ QQQQKD SEHKQKEK KEEKEESK D EQSK EELEDET KQ KVAKENQEEFDAEQ HAQVTVDIQAFQAKKE RVAARTAAKEAVTQEQAQVAVRAEQV VVQAKTSQEDKVKVQNVAALAVADKKAAKARAAQQ E2 E NHNLLIQLTNTWYTHRL LLQVLIHLRLRTLLNSRTTLD TW HWLRINLWLLVRTVTTNNGRVVYRNNLRVRSSTANYYVNLVTMRRVVS VSRY ERVHKLL VR TLFKVIPVSAVVLL HEVGLRVSSLAAQLVK IRQSVFVYVTGQYLVQTVRYRVVVVL SEPHVVRVLVASFLVILRYLMSIAVVFVVMVVGVS E5 EE YYYYLLLLLYLYYLYLLFLFLMLLYLLLYLLLYLLWFYFFFLFYYLYLFLLLLFLFLYLYYFFWWFWLLLLFLWYYFYFFWYFFWVYFYFLYLFFYLFFYYKLFLLYFLYVFFYYLLYVLLKT FITT VLVKVVYLMGY LVVVLQLAYVTAALYLYLWAVLKLLV LAVFLYWRVFGVYL LAVALVIRLSHLS IGSTT E7B EE LLVIVVVVVVLIVALMAVAIVVVAVSIALVVILLAVVALLVVVLQAAVQAAVSVIVVIVLLVVQIIMTVSLVIATLILLVVLLLLGSVTVVLLIVILVIVLLAILLLWLRGVAKKVILIAVLA VGAV GVGVGVAGITI VGG AIGGVLQGGAALAVAGGVVIVG GGLAVAVIVAATAGGFAGGVGGVLLAGAGGTVAAG E6B EE SSSSSSSTSSSTSTSSTSTSSSTTSTSTSTSSSSTSSTSSSSSSTSTSSTSTSSSSSSSSSTSSSSSSSTSSSSTSSSSTSSSTSTTSSSTSTSTSSTSTTTTTSSSSSTTSSSVDGCDTDTETSSDE SGNGTDGSGEA STT G GTGVNTTDG TGGTTD DGT STGGGGGGGETDGSTGTSTDSG GGNGTSAGETS E0B E DDDEDAEDPDAEEDDEEPPEEKPKEPDDGRKEDAAPAPEAEQADPDKKPPPDDDEESDDEEPSAAQSAAGAPEAEAHDERADGPDSPRTPPEQQGEEPEPEEPEDAPEEAEESSESDEDESKEEPAQD A AAEPDSDER EAE D AEEGAAEDD DQHEAE QEASSAGSQDDTGQDADAEKTAEEDE DTNDASEDREA 1 ATAPPPPEPAPSSVAPSPTPPPEEPEPHPEPPAPPLPADPSPPAAVPPPAATDPPPPAKPPPPDPPPPPLAPPPDPPPPPPAPAEAVPPPPPPPPPPEPAPKTAPPEPPAPPAEDPA GPPPPVQPPP E EDPDSEAPP PEP A DEATPPEPA GPPEEP PPEPEDALPANNAPPPEEEAGPEAGP APEADDPPPPP 3 FFFFFFFIFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFIFILFFYFFFFFIFFLLILFFLLLLVLILMLILLLFFLLLVVLFLIVFILILLFLVISAIVLFAFLVVFFLVFVIIKL KLFLLKLLLL Q TTLKEDKF LEL D ESLGLLNLE LLLTSL LLQLARDDLDEEELLLTAEVEL FKL NT SEMLLL 4B KTKSSESNATAPTSSSDAQSSADVSVTDTNASKSSSSSKTASRSDDDSSSDDTTGSSKNVVNNKEQNEADNTVSYASVPEQKADKGNSDTAEASSAPTEAPKQPESATAAVAQDKE IEQQAVAEAV P PAANGPTE QHPH G PDENAEESG EREEPT AAPKPPQGAGGGQEEEGPPTEEGVPK QS APVDSET 5 FFPFLFLLFFLLPLFLLFLFLFILFLLLLLFLFLLFFILLLLFFLIFLLLFLMPKLPFLLLLFLVFLLLFLGDFLLLLLVGFLLLMLLLGLKLLLLLLLLETLLLLLLLLPLLMLVQ KKP PGLAAVKL LLEVLLKK LELR L LLP EPLVL DPPLLP APLFLL LPLLL QVDLLLNLPLGLD VL LLEPVEF 6 GGGSGNSTNGDTGNGDNGDTTNSEGGGASSTSGNSDGTSG SDGKAASGGTTDNAAIGAGDDADETAADNTESSMAGNAVEGREGSSQGDGNKNQNDDTHTGDTITAADEADAA ATNVIASASMAVAEETNEAAETDV IVRT E ASAAVVIVT LAVDAV ELEISA DATDT VVAKEEETVTTEV ETGAHAGVVV 6 GGGAEAEQAGNGGGGAQAGGEASGGSGSQKPEGNGTGNDGKDKGPNAENPQTKAGTEGINANNGGDNGGNNPEEGDEDPAPGRDAAAEEAGVRTDKGNAKSAGHEVADGKKEKK SPEGDPVEADSQDGAADNSGEEVE GPTDGDGPGPAQDGGGGGDEGAPGEEEGGGEGAPSEPDGDPAANPADKPNGG GEGDAPADPG 7 EEEEETEPPEPSELEADDLEETPGTAPLSDTTEPNAEPAEAEEETPASAAPPTEKGSEEEPPHAEKVED SDSLALAAATEEKAAESGAAATAQAEENPKETFVGEAESPNLDE DLKTGEKGENDDGTAEADGTLVDG DGVDTANEAGFGGAPADGDQAADNSGVTAVLVDLLVLADALAVNEALDANDT AVLAVGAGET 7 QQQQVTTEQQQVQSQEAQSQTTKTQSQTDKEQQQVGQSQQAGQQEFQEEKPATEGTSQKGAEEQPQETTKEPGQEKKSQKQQVWQEEEQGQQVQAVPNIPPTSEEEQLEEAVAT AEKAAAGAQKAAAVPQEAAEPPGV ESEANSEADAQAAQARAAAPTPASAAAEGDEEADPPESAIAPASATVGEASS EPRASATAAP 7 KTQRIPTNTTRPHVKPETDKTPENTDTDQDPTKQPPTD QDHTKPATKAQATEPKNEKNEEPTTL QTSSRQSNGEEE RPKPPTEKHHEEHPVHRANEPKDAPEESRETQART TAIHTTTTPAETVDGPTPESGEQKGNTDTETDQVKPVSVPTDTAVVDAEQTERKDPTQPDAPDSTEGGNTGGLDQEE LDRDGVITSE 7 LLLLLQLRLLLALTLVRLLVLQYLLLLMILQLLVTLLLILVLLLIDLLVLQLFLLVVLIVLVRVGVLAAVVALNLIVIVILLLSLVVVIPITLVVLSIIVLVTIE LF IVVVI VVITVVVVLRFVVTALDNFHAASRQDSGVQGTMDVVVVDAGEVVYEATTTAGSDAVTVD GVVGDSAAFVGAEALTQGNALAAVAVVT 5B QATTPTHRDKNDADQKTKDMRTDDEDKDSSTKATDKKDTSPKTQSPAPPAARNAAVKAAAAGQTMNGPPKPPAADKSTNKEQKSAATATLKINEQKLADTKNDSAEKENPSPQP APKPKATEKNTDQPTTADDKDGTAPAATEPPPDAKAADPSPPDEDPSDPDADGSSESSD DDTSADVVAEDQPKEPPGSEDTTTPEDG 3 E LLLMLLVLMLMLLMLLLMLVLLLLMLLLMLLLLLLMLLVLVLLLLMLLLLIFLMVVLLVVVLILTVLVVLTLVLALLVLLMLVVLLLILALKVLILALLVALLLAVALAAGLVVIGGVLGDAGKLGGNLVVAGGLVKAGVLGAGLTLGADGGASGTFPGASVGLGDVLTVAAGL VGVGTVVVMDAVLFGLLLLRAVMDGDGL 0B E KKKKHTYVLSVYRDKTTTTAYMSAKSTSAMAGKTLVTATTSTSKTTTHRTQDMQRTSKTKTQQHLTQLLKQTHAIEQNTQSKDAREAQSLEAEQHQATTAY DTPAEDATKSHEKAANHTGMDVAGGGRSEGADTDDTNEATSGDGHAGGATGGAGAAGGGDEHDGTQGDLGTTSQAAAGEQDHGSDTEGHEKGDATEGGGTQ E2 E EEEPKLELPEPLELEALPPPEAEPAPVIPVMVEAESQPEPEPKEELPEPPLLLPPEHEEEEAAEEEAPPPSLPVQEPEQEPEVAELSPERPEVPPSEPALIVLELLLSLEREEKISTLTQAGRG RKREVPTRVEKSAIPPRRREKDEKQEKRR RPSERKRRERRRVKVMKTIERTRPRARTEQGEPRVEEPKSDVQAKRTP E6 EE TAAEQAQAQAKAAQTAAAVTQAAVAVEVAVTETDVAAIQAQATTVRVRAIESAATQVAQVVVVAAGALAVVQAAVVVVQVVSAAAETAAAAAAFAVQSIESAAIAEQAAVILVVAVLSVVIIVA AVAVAVGIAVVAIIAVVVVVVVAVIAVVVAVVVIAVAVVVVALAIQIVVTVAVTATVAPVGVIAAVVVIAVVAVVAIV E0B EE TDDSEPDTTATPAPDAPTTNDQQPPDNEDDPNDAIPTDP TDD DDTAEPPVEDNEP EEDDSDMSSSVDPQPTTTEDDGAPPAATEDESAPTDTVTDPTSPQPPNPPSTPPDETDDKETTTT ATTSTTITVDTNTGEDTTTDTDVTVVTTTTLDTVVASTTTATANTDTEDDTTTDVSIISTVTEVVSDDKITTIATTTS 4 AAATKANDAAALGIAGV STTTSSATESGASSATGA A AAEAAAVSVSSTIDDA QASQQRAVVADGDETASASTDQ AATLAVSLGEHGPVGETEATLHGTSAGAEAAEASSGANSGEAEGE AEEEDEGDSGESSKGPSEAAEAAESSEAGEDPEAAEDSAAEADAAGASAVGGE ESEELAGDQGGAAGNGVQGQAEAA 7 QLLEVPLD LDDLELEEPVAALQVLVQAANAPLAG P ELELALVD GAPEDQVPRKLLLLPSAD AQKAPEPEELEFLLVLDALSEENEFIDEVLRAPAAEEEDEEADGVVVNDVIRKVVVVV LVVVVVLIATALVIEAVVVEAQVAVVVLAVAAALAAVLVAAVILVEAVEDVVVVLAVVKVATNLLVQVLVAVLVAVVV 7 PPPLFPEVPPTPPIPPIP QQP P PPPIPPPPIPTMPPPPPPPVIFPQQAVAPPPPPPPPPPDPPPPFPDPPPPVPPPDPPQPPKPSPKPPAAPAMPQPTAPEATLAAPT YFPPFIPPPAD PPPEPPPDDFFPNPPSPPEMDIDFPPPPLPDGFGPFPPDDPAPDPPEA ASPPPEEPPQEGLPDDDFPPEPPKPDPPP 7 EGAAEQNVSAGLDEGTRADTSESSQSA QQTVEADEASQAT AGSQSETGRTVDPTEEDENSAVLETRAGEVADVETADSDEPQASTVSGPSVATFPQDTTSTDPPATPGGPNQPGGGDGGGGG GGGGGGGGGSGGGGPLGGGEGSGGDGGGGGGLGGGGGGGGGGGGGVGGGEGGQGGGDGNGGGAGGGEAGGGGGGGGGG 7 GGGGSGGGAGAGGGGTGGGSGTGGGGGGGGSGGGGGGGGTGGGGGGGHGWGGGGGGLGGAIGQGGVAGGGGGGAGSAGISGGGPGAGGGGGTASGAQGQGGGGLAAPGAAYEGPSYEYGFYYWW YWWYWAYYWGYYHWSGFFWGYGYYWYWYYWYGYHWYWWYYYWYYFGYYYGYYGWYYHWGYWYGYYYGGYYGWYYYYWY 7B EEEEDEESEETEETEEKEDEEEEKETEDSDEEEEEEEEEAEKEEDEESETTTEKEEEEEKSEEDKADEEKEEEQEKANSEKEQPEAEEDEEEAKEETEPAAKDPAADQAPEDNTEDTKQEEKQK TETKTTTTNTTEKEQETTEGTTTTKENDTNTDTDLTDETEETTRETQETDQNENRTEDEERTKETKGTRNKETETTQT 7 RRRRAKAKKRKPKKRRKRKPAKKKRARKAKKRRRVRRKARIKRRKKKAPKKKKAAVVRKVVPPRASPAPKPAVPKVAVTKARPQKPKPAAPKPASATKPPELKQLLAALEIAVPYVIKRIVVTV TVIVVVTITIVTIVIYVITKLVTLVVVVIVPYIIAIVVVVISATLTLVVASTVVTPVVIVTVVTTVKVVTVVAVVVVV 7 AAAAAAAAAAAEAEXAAAEAAAEEAEAEAEAAAAEAAEAAAAAAAEAALEEAQLLAAAVAALLALALLLLLLLLLAAAAALALLALALILLLLALLLVLLLVEALLLLLALLCCALLLLLLLLL LLLLLLLLLVLLLVDLALLALLLLALLLLVLLLLLLVVLLLLLLVLLLLELLLVLLLVVLLLLLLLALLLLVLLLLLL 6BB NTNTAGTKGTPPSPNTKTQSTGKSTPTKTPGTNTPNSPPSPPMNPKTAASKKKPGPQNPPPPGSPPPGAPPPGAAPPPPPPNGAGGPSPAPSGPSPEKAGPPPEATQKEATSSGGTTDPGTDDS NDDQDDNDQPSKTNGTGEQSTTRSDDSETPTATDTSAGKDDGSNDRDDTGNADPQTSPPSTSNDGTPNPDTGGANPGT 2 LLLLLLLILLLVLILLIFILLLIILILILILLLLILLILLLLLLLILLMLIIILLLILLLLMMFLLMIIIMVMIILILLILLLLLLLMMLLMIIMLMIVILMIRPPVLRAPRIIYFFKAMFLFI FFLIRRFFFLPFFIYFQRFFAVFPFFPYPRAFPFYPYRLYYMSFRFSRTYLLMRFGFRPAYPAFFILAFLFKMRFRFE H7B HH RRRRRRRKRRKRRKRRKRKRRRKKRKRKRKRRRRKRRKKKRKRRKKRRRKKKKRRKRRKKKRRRRKRRRKRRRKKKRKKKRRKRKKRRGRGRKRRRRRKRRKKRRRRPRRAIRKKAKISQEAAA AAGAAGNAASNQDGRAQGAAATGAAPAAANAAAGSTQRNAGQSQQGKEARAGRGGEAAKQSTGSQAAGSGGNRAGDAD H8 HH VIIVTVIEVIVTVTIVQATIIVATVTITTSAVVVTVVTVTIAVIQAAIDTTEADEVAIFVTEAEDVDDDDADEDETEATEDLDEEDFEQEADDAEKDFEDEKTADDEEDDQECCLEEQSEEAAE QTQDQEDQDEEEQKQDDAQDEDDEDDDAQQQDQEQQRLEGGDEEGDQRQESDETEEEEDDEQQQDETEEQQADDQQDE H9 HH IIIIIIIIVIIIIIIIIIIIIIIIIIIIVIVVIIIIIIIIIVVIVIVIIVVIIVVIIIIIIVIVVIIIIIAVVVLIIIIIVIVLVIIVVVVTIIVIVLLLVLITAALIAIILKTLVIILVILLL LIIIVVIIVLVIILLLVIVVALLVVVVVVIALVRIVLLVVVIVIVLVIIVLIVFVILLQAIVAMIIVAVIAVLVAVLI H9BBBHH TTTTTTTITTTVTITTITVTTTIITVTVTITTTTITTITTTITTIVITIIIVIIITTTTTTIIIITVIIVIIIIITVTTIIPIIIVIIIILIIVIIVVVIIMVIIIITIIGITMPAVITTLAAG VAILLLVALGNVVGSLFLLIGLLNVIQLNINLNIANLGLVVLLVLLNNNNSLNLLGVTIMVNNLLLFSSLSLFLSLLL H9B HH QQQQQQQKQQQGQNQQATKQQQQKQSQQQKQQQQGTSSQQQQQQAKQQKQKTKQAQQQQQQAQARQQQQKQQAKKQGQQSRQERAKQAKQKKAEAEAKRAKSKTPAAKAKAKEKQQAQQAQSQA AQQKEANAENAAADRGAEEAENSADAAEEGGGTEGAEDQSAQAAEQEAEEGAAGAEDAAAAAAAGQTAQATSGQAQES H9 HH NNNNYNNNNNNYNHNHKHNSNNNSNNNNHANNNHYHNNNNNNNNNNNNNHYNNRNNNNNNNAAQQNALLNARELLNHNNHLNQLELNYLRNLLHALLNLQKYNYLLLPLLRRFFTRRSRQQRRR NRRRRRNNRRRNRRLRHRRRRRRRNRRRRDRRRRRRDPRAARVNRRRSRRNNVDNRRLNRRRRQRTLRRNRDMRRRRQ H9 HH RRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRSRRRRRRRRRRQRRRRRRRRRKRRRRRRRRQQQKRRRRRRQRRERRRQRRRRRRQKRRQRRRQQQLQQQQQQ QQQQQQQQTQSQQQRQQAQTSQQSQQQQSQGQSQQS QQSAQQQQQSSSIPQY QDQQSQQSSQQQSSSQS QQSQQQ H8B HH QQQQQQQALQQSQALQPHSQQQSPQTESQPQQTQTQQSNQSNQLKSDQQDKTADDAQQAQTGDAKTSESSDKEEQQSQQQNQAPANKAEAQKKTDADEGPSNSNGSPLSAADDDSATNKAEEES AADKQSEDDDDQDAHQQDDDESDDMDKQGAAQDEKDQLTEGQEQDDKEDDDKNPEAQETQADASSQERNDQAQDKATQ H8 HH AAAAAAATAAATATAAYAAAAAAIAATSTVAAAAEAAAAAAVAAANAIATTTMQRAFAIVKASAQAALEQAARDGQDNAFQAERAETASEASDHAPPAVGTTAEGGGAGAEAYFKEEEEEEEEE TEDDEEAEEEEDEEAEEEEEEEQEQSDEETEEEEEEAQEDEEDQEQEDEELAEADEEQTEEEDQAKEEEKEAREDEEQ H6 HH LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILLLLLLLLLFLLLLLLLLILLLLLLILLMLLLLLLLLLLLILLLLVLLIIIVVV IILVVVIVVVLIVVQVVVVIIVVLIIVVLQVVLIILLEVLLIVIVVLLIVKILLIILVLVILLIIVLIIVILVVIVVI H3BB HH SNNNGGNNGGGSNSNSNSGSNSNGSSSSNSGNNSSASGQSQNANSSSGGSSTNQQQNTQQQQQKEQQSSSQEQKKQNQQNESKRKRGQKEAGKSQKSSQKKKSDQQKRGQTQQKQTKQILTS T S AATTAVTTQLALNTTTFTSTTQTSLTQQSTETSQQDFEAAALTTNMAEAAQQLATVQLTQSAASETSLTATTTTTA H1 H DQQNQEQTQQQGQSQHLQQSQQTADSQRSKQLQQGKQGSQAQRQDKAKAGDKLQASSQSSAGGAQAGQESAQRSKTRSASQNMSAQQNKQAELDGNRKNVQTSSTSLDAHARLTNSTNDSTQ Q S DGTSANAKEKKGLSSEAEEGQEQEEKEAGSEEEAEVAQDAQGAQEADAQAQEAKSEDDARNASAKDQGDDATDEEE E1 E IILILLLVIILILIILILVLLLIIIIIVLILILLILILMLMLLIIVLILLLFIWLMLLILILLLWILVLLLWLLVVLVMIWILLLVLLLWLILLLVILVLLFVLLLVYAVLVIVLLLLLLLLVL MVLLLLLLLLFILMVLLLLLMLLFMLLLFILLFLLFLLLLLLLTLLFLFIWLLVVFLLLVLFFMIILFLQLLMLLLLL E4BB EE TTTVVTVDSTTDVDTVSRDVVSDDTDVDVDTVTSDRHDRTKETTTEEVTKTDYVTKVTKQKRRTVQRTDIRVVSQNNKTVVTTTEETVNVKSTDRIEAVTNTDQTTSETTRSTKKRTIRRRTDR ADRTRRSRARATQRAKRRRAASKARRRRADATAARAEASRRQRTRKARAADAAETASRSRRAASSKSARVVAQRVRRR E8 EE AAAATAVLAAALALAALALAAALLALALALAAAALAALVAVVAALLLVLLFLLMLVLAVVVLLLMVLLLLLLLVIALLLLLALILLILLLLVLLLAVIALILLLLLVFLIVVIVIVVFVVVVLV VLIVVVVVVVVVVVLVVVVVVVVVLVVVVLVVVVVVLLVVVVVVVVVVVVAVVLVVVVLVVVVVVVVVVIVLVVVVVI E8BB EE IRLVVKVVKQVHEHVQSEHIVRHHVHSHLIEKVQHVQHTRIQLVIVKIEVNTAREVVVIVLVLYRIIILEQQTNTIRIIVRIVATKIAARVQIVVVTQHTVHHVTNVQTEPRDSEEPKPPGPRP PRPPPAPPPPPPPPEPPPPPPPPPPPNPPRPPPPPPRRPPPPPPPPPPPPLPPRPPPPVLPPPPPPPPPPPRPDPPPP E8 EE LLLLLLLLLLMFLFLLLLMLLLMTMFLLLKLLLLFLLFLLLTMLGTRLTTVLMGTLTLLLLTTLGLTTTLTATILLLLLTGLMMLTSTLSLLLLTTLTLLLVLLTTLIALMFLLIFVKLFFVVL FVVVVFLIAITVVLFVFLFFAVLTAMLVTVTFTFVTVVAVVLVVVLVATTSLVVFVLVISVTTLLAFTVFTVVATVVL E6B EE PPPPPPPPPPPPPPPPPPPPPAPPPAPPPPPPPPPPPPPPPPPPAPSPEPPPPPPPPPPPPPPPHPPEEPPPPEPPPPPPNPPPPTSPPTPPPPPPPVPPPPPPPPPPPPSP GPS SSGSPS SPSSSSSSSSGSSSGSSPSPESSGADSSDPGTDPTGPPSSASPSSSDPGDPNDPSDPSDPPDASPSPASDAPSEAPSG 4 DDDQDDDNDDDSASDGSDDDDDDSDNDTDSDEDDDDDSSDNDDDEEDDDDDNEDDNEDNTSEDGEDEDDDGDEGDSDTNNDDNDGEDENDDDNDAEDSDDNNSDEDDDDDDDNDNEDDDDDDDE DDDDDDDDDDDDDDQDSEDNEDDDDGDDDDDDSNDSDDDDEDSDDDDQDDEDDDDDNDQDGDDENDNAAEGDDDGEDA 8 GDGNGGGGGEGGQGEGGGGGGGGGEGGGGGGGDGGGGGGGDGGEGGDGGEGGGGGNGEHEEGGSGNGGGGGGGGGEGEGQGDKGAGGGGGGGKGGGQGHGDSGGGEGGGGGDGSGGGEGGGGGG GGGGGGGGGGGGGDPGGEGDGGGGGDDGGGGGGDGGGGGGGGGGDGGDGGGGTGGGAGNGEGGGDGDGGGGGGGGDGA 8 NSSSSENNESSIEESGERDAQTAQSDGEAETGSGERRDNRNESSNEQSRQANDNTNDSNEQLANQRTRRNTSVATEVQSDHNITTKFLQEAVITLNTESSTEDTVVVPTTFSTNISFYSASFSA TSSYSSTSAAATHPPTSGSGTFTAASPSSSATAGSTSSHSVFATATGGTGTYSSSGGSTDGAGAGSGAFSASISAGST 4 KEKEKTRETQEDQDKEQQDELQDAKDEDAATEKIDEQDEEEAQKNKIKMTSENLEEE ERIEEELTEEEEELESGMMKSELKETPSPEQLAIEHEELQDAGKDVEATLVLIWDEFLYFIIIYLL LIIYIVLLIIGLYEQLVSVAGYLGAF VGIGLGVLGIIYLLLSLELIAGGYLAIL AIRVSGGLMYS IL ILI SLT E5 EE VLVLLLLILLLILVVLILILLLIILILILVLLVLILLILLLLLVLIILLILIILLLL LLVLLYLLLLLILLLLLLLLLLLVLVYLLLLLLLLLLLLLLLLLILLLLVLAGALLLRVIGGRLRG QRRKRRRRRGIRKGVRRLRLIKEIWL RIRIRILRIRRKRRRLRIEKLIILRIRRILRAVLIIRLRLIRQLRRRLIRL E8B EE MVARRRKRRVVRVRIRKRRRRRRRIRRRRRHRIRRVVRTVTVRIKRRRTRTRRRSTV TSTRRRRTRSSRRRRSATTTTVRMRRRRTRGRSKRTRRRMRRASRARRGAMTTVSSQTTKTTTTTT TTTTTTTTTTRTTTFTTRTRRTTRRRTTRTRTRRTRTTSTTTRTRTARRNRTRTTRRTQRRRKTRSRRTTRTTTRRTG E7 EE MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMLMMM MMMMMLLMMQMMMLMLMMMMMMLMMMLLMMMLYNMLMMAMMSMMMKNNMINNQKYMMQNLQQQTQQ RQQDQQPTPQSATQRSQTPTADRSTTQQSRASSQASRREEDTNATRLTSVATPRSTQRLTTSMPTDASTASGKQSTPM E1 E SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSVNNSSYVSS SSSAAVYSAAASAYAATSSSSNYSVSSASAQFASVSASSGSTTSSSSATDATTDTISDDVTNTDDN DDDDDDDDDTSDDNVDNQDDSDDSDNGDSDQDSDDSEEDDDNDDTDGDSQIDLDDKDEFNSSQDDDDATDSDEDSTDA 4 SSSSSSSGSSSGSGSSGSGSSSGGSGSGSGSSSSGSSGSSSGSSGGGSGGGGGGGSG SSSGGSGSGSSGGGGGGSSSSGGSSSSGGGGGGGGSGSGGGGSGGKGGGGGGAKGDDAGSGAGGGG GAGGAAGAGGGGGASGGDGGGGGGGDWAGGGGGAGGGGGGGAGGDGLDGGSGSGGGGGKDDGGGGGGGGGGAGAGDGG 7 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL LLLLLLLLILLLLLLLLLLLLLLLLLLLLLLLVLLLLMLLMLLLLLLLLLLLTLLLLSSLTSSTTM SSTARRSTSTLSTSERTASSLSSLEGLRLSLRLQILTTSRRSYSASSGLFISVSSLQSIAALLASSQLSSLTSRLARL 8B RRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRR RRRRRSRRRRRRRRRRRRRRRRRRRRSRRRRRRRRRRRRRRRRRRRRRRRRRTSHHNNTTTTTSTT TTNSTTSNSVNTHTRTIRTSSSRSHRRTTSSTTSSTTRTTTQWNRRQRMTTTNTSNRTSRVSTKSTKRQNRIRNRRTR 8 QQQQQLQKQQQQQKQQKQKQQQKKQKQKQKQQQQKQQKQQQKQQTKKQDRKKKESQK QQQHQGEQQSAKQEHNSQKQQKEQEQEDEHREEKEKHRESQQKSKESSRQTDGITTNGAEGGGGAG AGAAGGAAGGAAGGQAGNGAAAAAAATGAGAAAAAAGAAAAAAATGATAARAQGAEAGVTTAAAAAGAAAAGAGATAQ 6 FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFMFFVFFF FFFFFFVFFFFFFVFFFFFFFFVFFFFFFYFVFFFFFFFFFFFFFYFFFFFFFFFFFFYFFFFYYF YYFYYFYYYYFYYYMYYYYYYYYFYFYYFAYYFYAFATYYYFYYYYFAYFAYFAYYYAFAAFFYFYYYFYYASYYYYW 1B SSSASSSASSSASASAASASSSAASASAAASSSSASSASSSASSAAASASGAAAASA SAAAAAASAAAAAAAAGSAASSAAGAAASAAAAAGAASASSAGSASAAVSAAVLGGSVRKQVLLVQ QVALVLLVLQEQLVAQLVVLELVELVVVETEQEQAEIVLAAVEQVVVYEERLVVVEVVGTAEEVLLLEEIEVLVEVLA E6B EE GGGGGAGAGGAGAAGGAGAGGGSAGGAAAGAGGGAGGAEGEQGGEAAGGASAAAPEA EEEPPPAEPAAAPAPPAQAEAAAGPPPASPLAPAPAPMYEAAAAAQRSPTSPFPAATFAVFFYAYF YYFAFAYYYFGFAFEYYFYYGAYGSYAFGYGYGYYGYYAWYFYFYYGAGGEFGYYGYYATPGGYYAYGFFGYYYGYYY E7B EE TTTTISVVTTIVTVTTVTVTVTVVTVTVSVTTTTVTTVQTQVTTIEIIIIVVVVMQQ QQQMMVVQMIIDMVIMIQQQQMVTIVAMTMSVLQVQMMVSTTIQVNVVLQVRQQVMYAVYTRQKQT VERKQVLRVTTKKEYTKRVLRKSSREKTTLRTSVRTLRKEEEMKESEYQTATTLRVTSTYYSRSTKVKIARRTRKTQV E6 EE QRRSHQHQQRKVRSRSGQVKHQQNRVSVRERSQGKRRVKRKKQ EAQHQFAKAQLKA KKKLVSEKLHNYIELQASKKSKEQARQSTLSKVMAKLKQSREACVYTTQLQHSTKRKPSSSSPSSS SSSSPPSSSSAPSTESSSSSASPASQSSASASASSASSSPPSPPSPANASRSTSPASSSISATASSSASPASPSASSS 1 E PPPPPPPPPPPPAPPPPPPPPPPSPPPPPPPPPPPPPPPPAPP PPPSPPPPPPPPP APTDDPPADPAPDPPSPHSAPPPPHKRPPDPPPPHQEPPPPKKEPPPPSPPPTAKKQTLKTTSATT TVSAVTDVTSQAITQSTATNTARVSGATVTASVQTTTSRTTTGAVRQPTSSTVTSTRSQSTVTSSRTVTTIVTIVATP 0 LLLLLLQLLLLLLLLLLLLLQLLLLLLLLLLLLLLLLLRLRLL VLLLLKRLLLRRL RRRRRLLRRQQLRVRLVRQRRLLLVLLALRLLTEVHRAELLVVKLLEDLLDLLLKKRLLKLMLFII LLLYLLLLLIRLYMRLFLMLRFLRMLLLRMRIRYLRLLYLLFLLLLITRRGLLLLRFLLTLRIMLYLRMMRLLMRLMG 0 E YYYYYYYYYYYYYYYYFYYYYYFYYYYYYFYYYYYYYYYYYYY YFYYYYYYYYYYF YYYYYYYYYFFFYYYYYFYYYYYYYYYYYYYYFFYYFFYYFWYFYWYFYWYWKYFFYATYSSSTVR VVESEEVEETVNSEYKTEEEVSEVKVTTVTVKVVVAEESSVVTTVETLTSFAQTSKVTYMSVTKDNEATTAEVVAEVL E4B EE TTQSSKSSKTTTRTTHTRTTSQKTTTTTTTQTTTTVLTTVQST TTSTEQSNTRQQT QRTEERRTESTTERTGQSSTHTQTAVRTEEKRTRKTESEAQQRKTTRVKKEQHTRTKYYQYYYYYY WYFYYWYYYYHYYWTYYYWYYYYYYYYYYWYYYYYYWWYYHYYYYYYVYYTWYWFYYWTRYYYYYYYFYYYWYYYWYT E5 EE LLLLIKLVLLLVLMLVLALLLLIMLMLLLLQLLLLVLMFLFLL LLLLLLLLMQEFK DYFAAQLYTQLMMQELVFRYYRLLARQLLAVLREQRARLLVRPLLERRQNLHDQIKYDDFDDDDDD DDDDDDDDDDDDDDYDDDDDDDDDDNDDDDDDDDDDDDDDDDKDDDDYQDYDDDDEDDFYDDDDNDDDDDDDDDDDDY E1 EE DAEEGSGEGAQQDQAAQGQGGSEQAQGQGQSDGAQTSQNDDDG EQQSSLLSQANDL NEDRRARNQHHQRDNRGDLDDLQGANAQQRSLETLLRNVQLLDDQNTTVLLNANLLPEEDEKEEEE AEEAAAAEEAPAAADEAEEEAAEEAEAAQADEAEHAPPQEEESAEEEDEADPEAEAEPDDGQAEEEEPKEAAQERAAN 5 GDQKEAEKEKEEADDDEAGAESGADAKEDGEKEDDDDEEAEAD KEDEEDEKSDSED EDEDEADDEDDSDGPDDTTEEEDDAAAEEDEEAPPMEAEAPPDSDPGGGGDAAPSEEAASAAAAAQ AAAQEDSSADGAKNAAASAAGDAAGAAAAEGTESDGDDADAASAAASEDEEAEDADSAEERTAADAAAKEGERDGAAP 7 DDDDDDDDDDDDDDDDDQDDDDTDDDDDDDDDDDDQDDTPNDN DDDDNDDDDNDEK NSNDDDDNDNNDNPDDNQDNADDDDDDDDDGGEEDDDDDDDDHDDDEEKGPDADNDETAETTTAAT AAAAAAARAACTSAQAAEAACAQCKTASCSCACAACAAATAAQAARAACCAARATCAATAACTTAAATATCARTCATD 8 GGGEGGGGKGDGNGGGGDGGGNDGGGGGGGGGGGGQGGNENGG GGGGGGGGGGGND RQQGGGGQGGGNGGGGDQGEHGGGGGGGQGEGGGKGGGEQGRIFGDENNSDDDQGGDDDDDQGDDD GDGDDDDDGDDDDEDDGGGGDDDDQDDDDQDDDDDDQGDGDDDDDDDQDDDDDQSDDRDQDDDDGDDDGDDDDLDDDT 7 TATTTKSTKKRTTTLTTETKKLDTLTTTTTSTVTTTRTLQITA TTTTATSTTVSKR VDISSRSITSSTSVSSTIAIQVATNSSTTSTDVVTASTKSSNAVSQTE RTTTTTKVTTRTTATTT TTTTTTTVTTCTKTVTTVTTCTTCTTTTCTCTCTTCTTTSATATTTTNCCATVTTCTTSDTCQTTTTSTTCTATCTTD 3B LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL LMLLLLLLLLLLL LLLLLLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLFLLLLLFMLMMLLMM MMMLMMMMMMIFLLMMMMIMIIFIMMFMIIIMVMIIMMLMMMMFMFLAIIMMIIFILLLAVVLFMLIIMFILFDVMLV E6BB EE TTLKTTTITTRFTVTTFILITTLITKTVTLTITTTRKYTRRVT IIITTRHIIITLR VTTYYTTTYTTLYVTVITRTVRLTKTTYVYILKIKRFTRVVKIWFTETVERKTVELITTLTTTTTV TTTTTTTTTTETTTITTRTTTTTTTTTTETTTTTTTTTTVVTTTTTTMVTITVTTVTTTMTETIRTTRTTTTVTKTTM E7 EE NNNNNNDNNNNNNNNNNNNNNDNNNNDSDNNDNNNNNNNNNND NNNNNNNNNNDNN NNNDDNNNDDNNDDDNDNDNNNNNKNNDSDNNQSKDDDHSNNDDNNRRNNRNDNDDDNNDNDDNDN NNDDDDNNDDDDNDDDDSNNDDDDD DDDDDDDNDDDDD D DDDDVDDNDDDDDNDNIDDDDDDDDDNDNDDDDDV E5B EE NNNNNVNNVNNNNNNNNQNQNSNNNNNNNNNNNNNQQNNQNNK HNNNQQNNNNLNN NLNRRLNNRNNNRTLQSHNNNNN LQQQLRMTTNITRNVQQSNNNQTSQQTLINQNNIALTHTTTT TTVSTVAVLVTTTLNQTLTLTTLSTAPTTSSKTTRATVTAASATTLQSSSTTTTLATANAPTTLKTTTKIRTQTSTTA 3 QQQQQKQQQQQRQQQQKQRQQQKEQQQEQEQQQQQQQREQEQQ QKQQRQEQEKREQ EEERRKQERQQQQRRQREQEEQQ ARQRLRQRALAQRSEVQARERKEARESVTRQQLEEKEATEEE QVTASTTESEEEHKAKLVADSSEEQAETEAEAEDAGAETEDAEDTEREVAATAAEKAESARERENTTTKEEDRDDTTQ 7 STSTTTTDTSTTTTSTTSTTTSTSNTTTSTNTTTSSSTNNNTS KTTTTNNSTTDTT TTSDDTTTDTTTESDTSTSTNTT TDTNDDTSTDTNDSTDTSTTTDDDTDDTTTNTTDTNNTTTTD TTTTTTTTTTTTTTTTTDTTTTSTTD TTTTTTTGTTSTDDSNSTSTDTTTTSSTTSTTDTTTTTTTT TSTDTSTTD 8 GGGGGGGKGGGGHGGQEGDGGGGGGGQGGGGQHQGGGGGGGAG EQGGGGQQGGGGG GGGDDGGGDGDDDGGGSNGQGGG GGGQGDNNGGGGDGGGKGGNQGGGGGGGGGGQGGGGGGGGGG GGGGGGDGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGNGGGGGGGGGGGGGGAGGGG 5 VVATTVTTTAEETEVVQTEVTKEENEIAIEKIVVQVVEKAKQV IQEVVELEEEGKE KKERREEKRTVQQATVAEQEKEE ESAVSLTEVSEERKETEAEKETALDRAEKEKKETVITKVVTT VVTTVTVVTTATADKLTTDTETVEKTKVTLTVRTVIVVVTTITAVATTVEEVTVTHETVTVIKAIVTKTMRVDTKTVT E5 EE KVKLETLVIVLWQIKQYRTKLVTTRLQIATIQKQVSTTIRLVV TITQTLTVNRVRL LVRVIVRVLTTLVRRVVRLRRLR LVVAVLIRVRLLVIIVRLTLLVTTVILTVVLLKVVIVQVVVV VVVVVVVEVVVEVVIVVVVVVVVVVVVTVVVVVVVVVVVVVVEVVEVVTVVVEVTRIVTVVVTVTVVVVTTVVVTVVE E8 EE YYYYYYYLYYYLYLYYFYLYYYFLYLYLYFYYYYLYYLYYYLW LFLYYLYLLLLYM YYYLILLYLYYYLLLYLYMYYML ILLYLLILFLVMLLLLILIFLLLLLILIYLFFLYYYFYYYYY YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYWYYYYYWYYCYYYFYYYYWYYWYYYWYYY E9BB EE RQRRRRRIRAQRRRRRKRKWRRRKRKRRRMRRRRRRRRKQKKW KMKRFKKLKTTQM RRKTTRTRTFFKTTTATKLKALV KRRYKTTVRFTLTKTKAVYMRNTTVETRHTAMVTTYKVRKTK TTHTTRTTSHTRQTRKTSTSTTRTKTHTHTTKTVRHRATSARRRARV TTLSQNTTTSLTRHASSTSKRVTARTTTHR E8B EE PPPPPPPPPPPPPPPPAVPPPPPPPPPPPPPPPPPAAPAAAPP PPPPPPPPPPPAP AAPPPPAAPPPPPAPPPPPAAPA PPAPPAPAAPPPPAPPPPPPPAAAPPAPAPPPPPAPAADAPA DPPAPAAP AADAAP APA AADAAATPAAA ADPAAPADN PDPDPAAAA KA A PAP AP A AD AAAPAPDP E6B EE NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNDNN NNNDDNNNDDDNDDDNDNNNNNN NNNNNDNDNNNNDDNNDDDNNSDNDDNDDNDD DSINDNNDD NDNNNTDSDDDNDNVDS DDDDNDT DNDSDDDETDN DSN DNNN DDNNDITDD D NDD DDNDDN D RNDNNS 3 NNNTMMTVMADMSMNQHPRPTMMMDMSMMMMPNDMPAMNRDYD MMDMHMFMMLQDM DDDQPFDQHHHMNMRQHDQDFMN FFFDMSFHRSFGRMHFMFMMMFHHFKPDSFMM DS DDGNSD G DNDSPDTDDGNDRTDSQLDEGNDTEDDPDTDGSNDSGGG DGDGSNNNNIDDTD D DDD EINTDG ETS SDGD 7 QHEDDKDEDDEEHDDEEQDSDDEETDEDQDTEDNEDAEDDEES DEEEDDDEEEEEE EADQAEEDTEDDDEEDADEEDED QQKDEEDGDKKEEAEERKAEDESEKERTSDNEQRS DSEQHT NARKEDRRGDEKKE GHEEGEKEDDESDE EGEDDEDEKEEDGKDEEGVDDGDDGA RETGEQGGKGGRDKEDDAERT 8 IIIITSTTTIMVTVSIITETTSVVIVITSVTTVTITSLITTIT IIITTIITVTNTT IIIIITITITTTIRHITVTITTI TVTITTTITTTTTGIILSTTVDVTLLTLDTIRNGEETV K V GT T SGVARGTT VGDVTRA R TV RTRVLG RGDVGGLG DENRDTTGEV GIGHRDTTIDQGGADGNL GG 8 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGNGGGGGGGG SGGGGGGNGGGAGGGGQGGGGGGGGGGGGGGGGAGGQGGSAGNGGGAGGGGGEQGG NDSGGGGGGGGNGGGRGGGNN 7B FFYFFFFFFFFFFFYFFFYFFFFYFFFFFFFFFFFFFFFFFYY FYYFFFYFFFFFF FFFFFFFFFFFFFFFFFFFFFYF FFFFFFFFFFFFFYFNFFYYYFFFFYFRFFYYFFAYFFMVSS FNQVQWAFAFAFVFTAFFSAANRAANAQANVAAFVAFRAFFNFAQQRASAAAYFSS FNFRARAAAAAFGSQFQAQFF E2BB E YYFYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYFYFYY YYYYYYYYYYFFY FFFFFYYFFYYYFYFYYFYFFYY YYYYYFFYYYYYFWYYYYYYYFFFYFFYYYFFF YFFFFFFF FFFFFF FFF FFFF FFFFFFFFFFFFFFYF FF FF G FFFWFFFFFF FF F FFYFFFFF GFF FFF E6BB EE QEQQQQQQQQQQEQQQQQQQQQQQEQQQQQQQQQQQQQQQQQQ QQQQQQQQQ QQ QQQVVE QVRRQV E EQQQQ QQEQQVE ETEQVK QRRTQQ TEV EVRERRV V EVAER RE ERT TK KETT V T KQ TVVE VAT A VV Q AEQVVV IT Q V A VVT TV NVV QVE E7B EE SSVAAASTAAAVSPSAEAPASAPPAAAPAAQASAPVTPAQAPS QPASSPPTP SY AEPTAT EASSPT G QYKQY STT NT NMYSY AQ NYP TTN T A YYR A AAA A AA ASA AA GSAA S S SA ASAA AAA A AA F AAAPGS NA S C A ASS AA YAA ASA E6B EE IVIVTVVIVVVIVVIVIVVVVIIIVMIVVVVIIVIIIIVIVVK VVVI VYIIVVII IIIDD IVDA VEVVPIIIIIIV P IE V PIDPVVI SAVYPPQV D IIPVSVEED EI AEEVPDEV DYA DDVPVDY DYAASAYDDEVVPYSPPVVEVSEAQPDYAEVVAV V APYTDDV TVVAPVSAPAV 1B E NNNNNNNDNNDDNDNNNNNNNDNSDDDDNDDN NNDNDNNNDD DDNN DEDNDTDD DDDDN DDDD DNDD DDDDDDD NDDDDDEDDDDRDNDDNDD KD DNSDNSDSDDDDDS SDDDDDNS DDD DDSDS S DNDDDDDD DDSDDSDDSSSSNDDDDDNTDNSDD S S DDDND DSDDDDDDDDS 4 WWAWAAAAAAAEWEAADWEWAWTDFFAEAFWA AFAAFEAEAW FFDAAQYGDSEEF WFF AGQ AF EG EFEAAGA EAAE ESGM E EAAS EES SE AFF A E S E A A AE EAAK P E EA E E EA ED EAGA G E EA D S E EG AE AE D DA 7 GADEENEEQDKQASDDNDQEEENTTVDMDVQD DVKDVTDSDS VVAKEHVANDSNV LVT ADQ EV TEQRTQQQDE EAAEN NHAT Q DDEAGSNEEETEA AEE D Q A D D D DG DNSS D DQDA D D G EV DD ADDD D DT ED K DNSGDS DG SN Q DD 7 DGGNGGGGGGGGGGGGGNGNGTGGGGGGGGTG GGGGGGGGGG GGGGGGGGGGGGG DGGGGGGGGGGGGGGGGGGNGGG GGGGGGKGGGGGGGGGGGSGGGGGGGG GGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGDGGGGGGGGGGGGGGGG 7 EDEEGEEDEEEEEQEEEEEEEEEEENQQEQED EEEENEEEQD EKEEEQDNEKEEN EENEEEQEQEQEEKEEEKQNEEQ EEEETEQNEETQQTSEEIEEQEEEENE EEEEQQTETSSNTN QTSNTQEEESEEVESTKETERESQTESTRTESDETEETTEEQQESSNEQQQTQAEE QKEARETQNEEKQETKTESES 3 KKKQTKTPKKRTQTKTPTTKTVTTQTTTRTVT TRRTTTQTYK PPTTRPPPTARTR KRRSRQATRTTHRARTRRSRTRR SNKTERQKRHKFRNRAGAQKTYRATTR TFSNERQRTTTQAA TARETREEQTRTEKTQAQEERSTRAEQTRTRQRERRTAQEAVRTTTPERRRERAQK REEVRAEEQQRSARAAVRTTM E2 EE LLLLLLLILLMVLVLLILVLLLVVLVLVLVLL LVLLVLLLIL LIVLLIVVILLLV LLLVIIVLILLIIVLLLVVLLLV LVVLIILVLVLVIAVLIVIFVYVVMVV LVVYILLLLLLLLL LLLLLLLLLLLLLLLLLLLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLALMLLLL LILLLFLLILLLILLLLLLLL E0B EE SSSSSSTSSSSSSSSSSSSSTSSSSSSASSSS SSSSSESETS SSSSSSSSSATET EEETTAAETSSSTPTSSEAEEAT EPASSTTAQSEATETSAQGASTPPTGP NRTTLTSAPDRPTG ATGTANRSLNAAKERMASGLSDQASSTPAPSMPMSAPPDRRGTTAQPKLLNLSPSA ADLSPSMLDLAENAPEPAAQT 4B PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP PPPPPPPPPP PPPPPPPPPPPPP PPPPPPPPPPPPPPPPPPPPPPP PPPPPPPPPPPPPPPPPPPPPPPPPFP TPPPPPPPVTVTPV TPTPVVPPPVQTPTPPTVTPQPTQPPPVQTQPQPPQVVPPPTPTVTQPQAPPQTTQ APPPQQPPPPQPPQVQVQVTP 2 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGG GGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGSGGG GGGGGGGGGGGGGGGGGGGGG E1B E YYYFFFFFFYYFYFYYFFFFFFFFYFYFFFFF YFFFFFFYFY FFYFWFFFFFWYF YYYWWFYFWWWFWFWWFYFYFFY FFFWFWFFFWFFWFWFFFFFFFWWFFW WFFFFWWFWWWWWW WWWWWWWWWWWWWYFWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW WWWWWWWWWWWWWWWWWWWWW E8B EE TTTTTTTTTTTITVTTVTITTTIVTVTITITT TVTTVTTTIT IVVTTIISVAPTT TTTPPRTTPTTVPTPTTTVTTTS KQRTVPKTKRKVPRRVSKTKVQRRKRR RRRRVQRRRRRRRR QKRRRRKRQRQKRRRSRRKQRRRQRTRRQVRSQRKQRIRRRQQKRRKRRKTQLVKE YRRKQLKKRQKKKKRKRKRVQ E8 EE VVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVV VVVVVVVVVV VVVVVVVVVVVVV VVVVVVVVVVVVVVVVVVVVVVV VVVVVVVVVVVVVSVVVVIVVVVVVTV VVVVTVVVVVVDVV VVVVVVVVIVVIVVVIVVVIVVVVVAVVVVVIVIVVVVVEVIVIVVQVVVVVQVVV VVVVVQIIVTVVIVVVVVVTV E8B EE TTTSSNTVGTTSTKTTNNGSSGDQTQTDTGST VSGNSTGGNT NGQSNKTVNFATN TGSANNYSNNNDNFATYTATSGY NNNTSASFGNNSAYFNFNYNNNGGGWT TLGGYTFSGTPFNG WAGFSMEFTVGDFWVNMVFVGFFGANFLGNGNNAFGGGFFFVNDVFNFNNGVNNNN PFNFGNDEFTNTDNFFANPVN E4 EE TIIIVIIIITIIIIITITVIIIIIIIIITIIT SIATIVASIV IVIITIIIVTVSI TVVVVVATVIIVVAVITIVTIVA VIVITVIAIVVVVVITVVTIIIIVVSV VVVVVVKIVVVVVV VVVVVVVVVVVVVVIVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVVV VVVVVVVVVVVVVVVVVVVIV 7 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGG GGGGGGGG GGGG GGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGG 9 *