Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 A 5 -4 -3 -4 3 -3 -4 -3 -4 -5 -5 -3 -4 -5 -4 5 -2 -6 -5 -4 52 0 0 0 7 0 0 0 0 0 0 0 0 0 0 42 0 0 0 0 1.24 1.41 2 K -4 3 2 -3 -7 0 -2 -4 -3 -6 -6 7 -5 -6 -4 -3 -3 -6 -3 -5 0 13 10 1 0 3 1 0 0 0 0 67 0 0 0 1 1 0 1 0 1.49 1.83 3 V -2 -5 -5 -7 -3 -6 -6 -6 -7 6 1 -5 -1 -3 -5 -4 -1 -6 -4 5 2 0 0 0 0 0 0 0 0 40 13 0 1 1 0 1 3 0 0 37 1.19 1.90 4 L 4 -5 -4 -6 -1 -4 -5 -3 -3 -1 4 -4 -1 -1 -5 -1 -1 -3 1 1 31 0 1 0 1 0 0 2 1 2 40 0 1 2 0 3 4 0 4 7 0.71 1.91 5 V -4 -6 -6 -7 -3 -5 -6 -5 -5 6 -1 -6 -1 -3 -5 -5 -3 -6 -5 5 1 0 0 0 0 0 0 1 0 48 4 0 1 1 0 0 0 0 0 42 1.48 1.92 6 L 0 -6 -5 -7 -2 -6 -6 -6 -6 5 3 -6 -1 -1 -3 -4 -3 -6 -4 5 9 0 0 0 1 0 0 0 0 26 22 0 1 2 2 1 1 0 0 35 0.97 1.93 7 Y -3 -5 -4 -6 -1 -4 -4 -6 1 -1 -2 -5 -3 4 -6 -4 -2 0 9 -2 2 0 1 0 2 0 1 0 3 4 3 0 0 13 0 1 2 1 66 2 1.85 1.95 8 Y -2 -4 -4 0 -3 -4 -3 -1 6 -4 -4 -5 -4 3 -6 -2 -3 4 7 -2 4 0 0 5 0 0 1 6 19 1 1 0 0 9 0 3 1 5 41 2 1.27 1.92 9 S -2 -3 -2 -3 -2 -4 -4 -3 -4 -6 -6 -4 -5 -6 -3 7 1 -6 -5 -4 2 1 1 1 1 0 0 1 0 0 0 0 0 0 1 84 9 0 0 1 1.66 1.93 10 M 2 3 -2 -3 -3 1 -2 1 -1 -3 -1 0 5 -4 -1 0 1 -1 -3 -3 14 14 1 2 1 5 2 12 2 1 5 4 13 1 4 8 8 1 1 2 0.32 1.98 11 Y -4 -3 0 -4 -3 -2 -3 -1 3 -4 -5 -3 -3 -1 -5 0 4 3 7 -4 1 2 4 1 1 2 1 5 7 0 0 1 0 2 0 8 28 4 34 0 1.01 1.98 12 G -3 -4 -2 -3 -6 -4 -3 7 -1 -6 -7 -3 -4 -5 -3 -2 -4 -6 -5 -7 1 1 1 1 0 1 1 85 2 0 0 1 0 0 2 2 1 0 0 0 1.91 2.00 13 H -1 -3 6 -3 -3 -3 -3 -2 8 -4 -5 -3 -4 -4 -4 0 2 -6 -1 -4 4 1 31 0 1 1 1 3 34 1 1 1 0 0 0 8 10 0 2 1 1.25 2.01 14 I -3 -5 1 -5 -1 -4 -4 -4 -4 2 -3 -5 -2 -5 -4 -1 7 -6 -4 2 1 0 5 0 1 0 1 1 0 10 1 0 1 0 1 2 62 0 1 12 1.23 2.01 15 E 3 2 -2 -2 -6 1 3 -2 3 -4 -4 2 -3 -3 -4 -2 -1 -3 2 -4 21 11 1 2 0 6 22 2 7 1 1 11 0 1 0 3 3 0 6 1 0.51 2.04 16 T 2 3 -2 -3 -3 3 0 -4 -1 -1 -2 3 -1 -2 -5 -2 2 -3 -2 -2 14 15 2 1 0 11 7 1 1 4 3 18 1 2 0 2 11 0 1 3 0.40 2.03 17 M -3 -4 -4 -6 -2 0 -4 -6 -5 2 4 -5 8 -3 -4 -4 -3 -5 -3 1 2 1 1 0 1 4 1 0 0 8 33 0 34 1 1 1 1 0 1 10 1.17 2.01 18 A 7 -4 -5 -5 -2 -4 -3 -2 -5 -2 -2 -4 -1 -4 -4 -1 -2 -6 -5 -1 77 1 0 0 1 0 1 2 0 2 5 0 1 1 0 2 1 0 0 3 1.34 2.01 19 R -2 2 1 1 -3 3 4 -3 1 -5 -3 2 -3 -5 -5 -2 -3 -2 -3 -4 3 9 6 7 1 14 30 1 3 1 3 13 1 1 0 2 1 1 1 1 0.62 2.12 20 A 4 -1 -2 -4 -1 1 1 -4 1 -2 -2 0 -2 -2 -4 -1 -1 3 0 -3 38 4 2 1 1 6 10 1 3 2 5 5 1 2 1 3 3 3 3 2 0.42 2.11 21 V 0 -4 -6 -4 -2 -3 -2 -6 -6 6 0 -5 0 0 -6 -4 -3 -6 -2 4 9 1 0 1 1 1 3 0 0 39 6 0 2 3 0 1 1 0 1 25 0.85 2.07 22 A 5 -2 -3 -4 -2 0 -1 -2 0 -3 0 1 -2 -3 -5 -2 -3 -2 -2 -1 50 2 1 1 1 4 4 2 2 1 8 8 1 1 0 3 1 1 2 3 0.61 2.12 23 E 1 2 -1 1 -2 2 4 -3 -1 -3 -4 2 -2 -4 -5 -1 -2 -6 -5 -3 13 12 2 6 1 7 27 2 1 1 2 10 1 1 0 4 3 0 0 1 0.45 2.10 24 G -1 -3 -2 -3 -2 -2 0 6 -1 -2 -4 -2 -2 -3 -3 -2 -2 -4 -2 -3 4 2 2 2 1 2 5 58 1 2 2 2 1 1 1 3 3 0 2 2 0.96 1.92 25 A 4 -3 -3 -3 0 -3 -3 -2 -2 3 0 -5 0 -2 -3 -3 -2 -5 -2 3 33 1 1 1 2 1 2 3 1 15 9 0 2 2 1 1 2 0 1 16 0.48 2.10 26 S 1 2 1 0 0 1 3 -1 0 -2 -2 1 0 -5 -2 -1 -1 -5 -5 -2 11 12 5 6 2 5 18 5 2 2 4 7 2 0 2 4 4 0 0 3 0.21 2.08 27 K -1 1 0 1 0 1 2 -2 0 -2 -3 1 -1 -2 -2 2 -1 -5 -1 -2 6 7 3 6 2 7 14 4 2 2 3 9 2 2 2 15 3 0 2 2 0.15 2.10 28 V 1 -1 -1 -1 1 0 0 -2 2 0 -2 -1 1 -1 -1 -1 0 2 0 2 12 3 3 3 3 4 6 3 4 5 4 4 3 3 3 5 5 2 3 15 0.06 2.07 29 D 0 -1 0 1 1 0 1 1 1 -2 -2 -1 0 -1 1 -1 -1 2 -1 -2 9 4 4 7 3 4 9 11 3 3 4 4 3 3 8 5 4 2 3 3 0.04 2.15 30 G -2 -2 0 0 2 -1 -2 4 1 -1 -2 -1 -5 -1 -1 -2 -2 2 -1 -1 3 3 4 5 4 3 3 34 3 5 4 4 0 3 3 3 3 2 3 4 0.33 2.19 31 A 1 -1 -1 -1 2 -1 0 -2 0 2 -2 -1 1 -1 -1 -1 1 2 0 2 13 3 3 4 4 3 5 3 3 10 3 4 3 3 3 4 7 3 3 12 0.06 2.17 32 E -1 -1 0 2 0 1 4 -3 0 -2 -2 0 -1 -2 -1 -1 1 -6 -2 -2 5 3 4 9 2 7 24 2 3 3 4 5 2 2 3 4 9 0 2 3 0.23 2.17 33 V -1 0 0 0 3 1 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.07 2.01 34 V -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 35 V -1 0 0 0 3 1 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.07 2.01 36 K -2 2 -1 -1 1 -1 -2 -2 1 1 -1 1 2 1 -2 -2 -1 3 2 0 3 13 3 3 3 3 3 3 3 9 7 9 4 6 3 4 4 4 8 6 0.17 2.13 37 R -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 38 V -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 39 P 0 -1 0 1 1 0 2 -1 1 -2 -1 -1 0 -1 3 0 -1 -5 0 -1 7 3 5 8 3 3 12 4 3 3 6 4 3 3 16 7 4 0 3 4 0.18 2.06 40 E -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 41 T -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 42 M 0 -1 0 1 0 0 0 -2 0 0 0 -1 1 -2 0 1 0 -5 0 0 9 3 4 9 2 4 5 4 2 6 11 4 4 2 4 11 5 0 3 6 0.05 2.06 43 P 0 -1 0 1 0 0 -1 -1 0 0 -2 -1 0 -1 4 0 1 1 -1 -1 8 3 5 8 2 4 4 4 2 5 4 3 2 2 20 7 8 2 3 4 0.23 2.04 44 P -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 45 Q -1 0 -1 2 3 0 3 -1 1 -1 -2 -1 0 0 -1 -1 0 2 0 -1 6 4 3 10 6 4 17 4 3 4 3 4 3 4 4 4 6 3 4 5 0.16 2.10 46 L 1 -2 -1 0 2 0 1 -1 0 1 -1 -1 1 0 -2 -1 -1 2 0 2 10 3 3 6 5 4 8 6 2 8 5 4 3 3 2 4 4 3 3 12 0.06 2.14 47 F -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 48 E -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 49 K -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 50 A -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 51 G 0 -1 0 0 2 0 0 2 4 -2 -2 -1 -1 0 1 -1 -2 1 0 -2 7 3 4 6 4 4 5 15 8 2 4 4 2 4 7 5 3 2 3 3 0.10 2.16 52 G 3 -1 -1 -1 1 -1 0 0 0 1 -3 -1 0 0 -1 -1 -2 2 0 0 20 4 3 4 3 3 7 6 2 8 3 4 2 4 3 4 3 3 3 6 0.08 2.17 53 K -1 0 0 -1 3 0 -1 -1 1 -1 -2 1 1 -1 2 -1 -1 4 0 -1 5 6 4 4 5 4 4 5 4 3 5 7 4 3 10 4 4 6 3 4 0.10 2.20 54 T -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 55 Q -1 0 -1 1 -1 3 1 -1 0 -2 -2 3 -1 -2 -1 -1 -1 -1 -2 -2 6 5 3 9 2 11 10 5 2 2 4 17 2 2 3 5 3 1 2 3 0.18 1.95 56 T -1 -1 2 4 -1 -1 0 1 2 -3 -3 -1 -2 -2 2 0 -1 -1 -2 -2 5 3 8 19 2 3 7 11 4 2 2 4 1 2 8 7 4 1 2 3 0.22 1.98 57 A 2 -2 -1 2 2 -1 0 -2 1 0 -2 -1 -1 -1 0 -1 -1 -1 0 1 18 2 3 11 3 2 7 3 3 6 4 3 2 3 5 4 4 1 3 9 0.11 1.99 58 P -1 -1 -1 0 0 0 0 -2 1 0 0 -1 2 -1 4 -1 -1 1 1 -1 5 4 3 6 2 4 5 3 3 5 8 3 5 3 21 4 3 2 5 4 0.20 1.98 59 V -1 -2 -1 0 0 -1 2 -2 0 3 -1 -1 0 -1 -1 -1 -2 -1 2 1 5 2 3 5 2 3 12 3 2 14 7 4 2 3 3 5 3 1 7 11 0.12 2.01 60 A 4 -2 -1 -1 2 -1 0 -2 -1 1 -2 -2 0 -1 -1 -2 -2 0 -2 1 31 2 3 4 3 3 5 3 2 9 4 3 2 3 3 3 3 1 2 9 0.25 2.03 61 T -1 -1 0 2 0 -1 1 -2 0 -1 -2 -1 0 -1 -1 0 3 1 -1 -2 4 3 4 12 2 3 10 3 2 4 4 4 2 3 3 8 19 2 2 3 0.19 2.02 62 P 0 0 -1 0 -5 -1 -1 -2 1 0 0 -1 2 0 3 -1 -1 3 0 1 8 5 3 5 0 3 4 4 3 5 9 4 5 3 13 4 4 4 3 8 0.13 2.01 63 Q 0 0 0 3 1 1 2 -2 1 -1 -2 0 1 -1 0 0 -1 2 0 -1 7 4 5 16 3 6 11 4 3 4 4 5 3 3 4 5 4 2 3 4 0.15 2.06 64 E -1 0 0 0 3 1 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.07 2.01 65 L -2 -1 -1 -1 1 -4 -1 -5 1 2 4 -5 3 0 -1 -4 -1 3 0 1 4 3 3 3 3 0 4 0 4 10 33 0 6 4 3 0 4 4 3 8 0.42 1.88 66 A -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 67 D -1 0 1 2 1 1 2 -1 2 -1 -3 0 0 -1 -1 -1 -1 5 0 -2 6 6 7 10 3 6 11 4 5 4 3 6 2 3 3 5 4 7 3 3 0.19 2.13 68 Y -1 0 -4 0 3 1 0 -1 2 0 -1 -4 2 1 0 -1 0 4 1 0 6 6 0 6 5 5 6 6 5 6 6 0 5 5 6 6 6 5 5 6 0.16 1.89 69 D -2 -1 1 5 1 0 1 -2 1 -1 -3 0 0 -5 -1 -1 -1 -6 -1 -2 3 3 7 36 3 4 7 3 3 3 3 5 3 0 3 4 3 0 3 3 0.53 1.95 70 A -1 0 0 0 3 1 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.07 2.01 71 I 0 1 -4 -4 3 1 0 0 -4 1 -1 -4 3 1 -5 0 0 5 2 0 7 7 0 0 6 7 7 7 0 7 7 0 6 6 0 7 7 6 6 7 0.24 1.56 72 I 0 -4 -4 -4 3 -4 0 0 -4 1 -1 0 3 1 1 0 0 -4 2 0 7 0 0 0 6 0 7 7 0 7 7 7 6 6 7 7 7 0 6 7 0.12 1.56 73 F -1 -3 -2 -5 -1 -4 -3 -1 1 2 2 -5 0 6 -1 -3 -1 2 0 0 5 2 2 0 2 0 2 6 3 9 16 0 2 29 3 2 4 2 2 7 0.48 1.58 74 G -1 -4 -3 -1 2 -4 -1 5 -4 -1 -1 0 1 0 -4 0 -1 -5 -4 -1 5 0 0 4 4 0 4 42 0 4 6 6 4 4 0 8 4 0 0 5 0.55 1.43 75 T 1 -4 -3 -4 3 -3 -1 0 1 0 0 -1 2 0 -4 2 2 -4 1 0 10 0 0 0 6 0 4 8 4 5 9 5 5 4 0 15 13 0 5 6 0.21 1.37 76 P 0 -4 1 -4 3 -3 0 0 3 -4 -1 0 -4 -4 1 0 0 5 2 0 7 0 7 0 7 0 7 7 7 0 7 7 0 0 7 7 7 7 7 7 0.26 1.45 77 T 0 -4 1 1 3 -3 0 0 -4 0 -1 0 3 -4 1 0 0 -5 2 0 7 0 7 7 6 0 7 7 0 7 7 7 6 0 7 7 7 0 6 7 0.15 1.56 78 R -2 2 1 -1 1 -1 -4 -1 3 -1 -2 -1 2 0 -5 -1 -1 6 4 -2 4 13 8 3 3 3 1 5 6 3 4 3 5 3 0 6 3 9 15 3 0.39 1.68 79 F -1 -4 4 -1 1 0 -1 -1 2 0 -2 -2 2 3 -5 -1 -1 5 2 -1 5 0 17 4 3 4 4 6 5 6 5 3 5 10 0 4 3 8 5 5 0.35 1.90 80 G 0 -1 1 0 1 -1 -2 4 1 -5 -2 -1 1 0 -5 -1 -1 3 1 -2 7 3 6 5 3 3 3 32 3 0 3 3 4 4 0 4 3 4 5 3 0.40 1.91 81 N -1 -1 3 1 -1 -1 0 1 1 -2 -3 -1 1 -3 -5 1 2 0 -1 -2 5 4 15 8 2 3 7 9 3 2 3 4 4 1 0 11 11 1 2 3 0.20 2.03 82 M -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 83 S 1 -5 -1 -1 1 -1 0 -2 1 -1 -1 -2 1 0 3 1 0 -5 0 0 11 0 4 3 3 3 5 3 3 4 6 3 3 5 16 9 6 0 3 6 0.14 2.12 84 G 1 -1 -1 -1 0 -1 -1 0 1 -2 0 -1 0 -1 2 -1 -1 5 0 -2 11 3 3 3 2 3 4 8 3 3 10 5 3 3 11 5 4 6 3 3 0.09 2.12 85 Q 0 -1 -1 0 -6 4 3 -1 0 -2 -3 -1 0 -2 3 -1 0 -6 -5 -2 9 3 3 4 0 18 18 5 2 3 3 4 2 2 12 4 6 0 0 3 0.36 2.04 86 M -1 0 0 0 3 1 0 -1 -4 0 -1 -4 2 1 0 -1 0 4 1 0 6 6 5 6 5 5 6 6 0 6 6 0 5 5 6 6 6 5 5 6 0.13 1.89 87 R -1 0 -1 0 1 0 -1 1 1 -2 -2 4 1 -1 -1 -1 -1 2 0 -2 5 4 3 6 3 4 4 11 3 3 3 24 3 3 3 5 4 3 3 3 0.24 1.99 88 T -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 89 F -1 0 -4 0 3 -4 0 -1 2 0 -1 0 2 1 -5 0 0 4 2 0 6 6 0 6 6 0 6 6 6 6 6 6 6 6 0 6 6 6 6 6 0.18 1.78 90 L 0 -4 -4 0 3 1 0 -5 3 0 -1 0 2 1 -5 0 0 4 2 0 6 0 0 6 6 6 6 0 6 6 6 6 6 6 0 6 6 6 6 6 0.25 1.67 91 D -2 -1 -1 4 1 0 2 -2 1 -2 -3 -1 2 -1 2 -1 -1 -5 0 -2 3 3 3 26 3 3 13 3 3 3 3 3 5 3 10 4 3 0 3 3 0.38 1.84 92 Q 1 1 0 -1 -5 1 1 -2 0 -2 -2 0 3 0 -1 1 1 1 1 -2 12 7 5 3 0 6 10 4 2 2 3 6 6 4 3 10 9 2 5 2 0.14 1.89 93 T 0 -3 -2 -2 0 -2 -3 -3 -1 -1 2 -3 2 2 0 0 3 1 -1 -1 8 2 2 2 2 2 2 2 2 3 20 2 5 9 6 8 18 2 2 4 0.27 1.93 94 G -1 0 1 1 0 -1 0 2 -1 -1 -1 0 0 1 -2 1 -1 1 0 -1 5 4 7 7 2 3 5 14 2 3 8 7 2 6 2 11 4 2 3 4 0.08 1.95 95 G -1 0 -1 1 -1 0 1 3 0 -2 -3 0 0 -1 2 0 -1 0 1 -2 6 5 3 6 2 3 9 18 2 2 3 7 2 3 10 7 3 2 5 3 0.17 1.92 96 L -1 0 0 -1 2 0 0 -3 0 2 2 -2 1 0 0 -2 -1 0 0 0 5 5 4 4 4 4 7 2 2 12 21 3 3 4 5 4 4 1 3 6 0.14 1.81 97 W -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 98 A 0 0 0 -1 1 -1 -1 -1 2 0 1 0 2 1 -1 -1 -1 2 1 0 8 5 4 3 3 3 4 4 4 5 14 5 5 6 3 4 4 2 4 8 0.07 2.12 99 S 0 1 1 0 1 1 2 0 2 -2 -3 2 -1 -5 -1 1 0 2 -1 -2 7 6 7 4 2 6 12 7 5 2 3 11 2 0 3 9 6 2 2 3 0.16 2.09 100 G -2 1 1 0 0 3 -1 3 1 -3 -1 0 0 0 -1 -1 0 0 -1 -2 4 7 6 5 2 12 3 21 3 2 6 5 2 4 4 4 5 1 2 3 0.21 2.06 101 A -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 102 L -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 103 Y -1 0 0 -1 1 0 -1 0 1 0 -1 2 0 0 -1 0 -1 3 0 0 6 5 4 4 3 5 4 8 3 6 7 12 3 4 3 6 4 4 3 6 0.07 2.12 104 G -1 0 1 0 3 1 0 -1 2 0 -1 0 2 -4 0 0 0 -5 1 0 6 6 5 6 5 5 6 6 5 6 6 6 5 0 6 6 6 0 5 6 0.10 1.89 105 K -1 0 0 0 3 1 0 -5 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 0 5 5 5 5 5 5 5 5 5 5 5 5 0.15 2.01 106 L -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 107 A 3 -5 -1 -1 2 -4 -2 1 -5 1 -1 -1 1 0 -1 -1 -1 -5 1 1 24 0 3 3 5 0 3 11 0 8 5 4 4 5 3 4 4 0 4 9 0.25 1.96 108 S 3 -2 -1 -5 3 -1 -2 3 0 0 -2 -4 1 0 -2 1 -1 -5 -1 0 23 2 2 0 5 2 2 21 2 6 4 0 3 4 2 9 4 0 3 5 0.34 1.93 109 V 1 -3 -3 -3 1 -2 -5 1 -5 2 1 -3 2 0 0 -1 -1 -5 0 3 12 2 2 2 3 2 0 10 0 9 15 2 5 4 5 4 4 0 3 18 0.25 1.90 110 F -2 -5 -3 -3 -1 -3 -4 -4 -2 -1 -1 -4 1 8 -6 -3 -2 1 1 -2 3 0 1 2 1 1 1 1 1 4 5 1 3 61 0 2 3 1 2 3 1.35 1.91 111 S 0 -2 -1 -3 2 -2 -2 2 -5 0 -2 -4 0 0 -3 0 3 3 0 1 8 2 3 1 4 1 3 16 0 4 4 0 2 4 1 5 21 4 4 11 0.32 1.91 112 S -1 0 1 0 3 -4 0 -1 2 0 -1 -4 2 1 0 0 0 -5 2 0 6 6 6 6 6 0 6 6 6 6 6 0 6 6 6 6 6 0 6 6 0.13 1.78 113 T -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 114 G 0 -1 0 -1 1 0 -2 4 0 -2 -3 -2 0 -1 -1 0 -1 2 0 -2 8 4 5 4 3 4 3 33 3 3 3 3 3 3 3 6 5 3 3 3 0.35 2.12 115 T -1 1 0 -1 0 1 0 0 1 -1 -2 -2 0 -1 -1 1 1 7 0 -2 6 7 4 4 2 6 5 7 3 4 4 2 3 3 4 9 8 13 4 4 0.27 2.13 116 G -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 117 G -1 -1 2 0 1 -1 -1 2 4 -1 -3 -1 0 -1 -1 0 0 2 1 -2 5 4 9 5 3 3 3 17 10 3 3 3 3 3 3 8 5 2 5 3 0.22 2.13 118 G -1 -2 1 -1 0 -2 -1 6 0 -3 -4 -2 -5 -5 -2 -2 -2 1 -1 -3 6 2 5 3 2 2 4 52 2 2 2 2 0 0 2 3 3 2 2 2 0.82 2.07 119 Q -1 0 0 0 -5 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.12 120 E -1 -1 -1 1 1 0 3 -2 0 -1 -2 1 0 0 -1 0 -1 2 -1 -2 5 3 3 6 2 4 21 3 2 3 4 9 2 4 3 6 3 3 3 4 0.14 2.11 121 Q -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 122 T 0 0 0 -1 1 0 -1 -2 1 -1 -2 -1 3 0 -1 0 3 -5 0 -1 8 6 5 4 3 4 4 4 3 3 4 3 6 4 3 6 17 0 3 4 0.09 2.17 123 I -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 124 T -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 125 S 0 -1 2 1 1 0 -1 -2 2 -1 -2 0 2 -1 -2 2 1 2 0 -2 7 4 8 8 3 5 5 3 4 3 3 5 4 3 3 12 8 2 3 3 0.07 2.23 126 T -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 127 W -2 -1 -1 -2 1 -1 -2 -2 2 2 2 -2 4 1 -5 -2 -2 4 1 -1 3 3 3 3 2 3 3 3 5 10 17 3 11 7 0 3 3 6 4 3 0.26 2.17 128 T -1 -1 2 -2 2 1 -1 -3 2 0 -1 -1 1 -1 0 0 2 1 0 -1 5 4 9 3 4 6 4 2 4 6 7 3 3 3 4 7 13 2 3 5 0.07 2.18 129 T -2 -1 0 -2 -1 0 -2 -2 0 -1 -1 -2 0 2 2 -1 3 1 0 -1 4 3 4 3 1 5 2 3 2 3 5 2 2 10 10 5 21 2 3 5 0.19 2.17 130 L 1 -3 -3 -2 0 -2 -3 -2 0 -1 3 -3 4 3 -2 -2 -2 4 0 -1 10 2 1 2 2 2 2 3 2 4 27 1 8 11 2 3 2 5 3 3 0.33 2.15 131 A -1 0 0 -4 3 1 0 -1 2 0 -1 0 2 1 -5 -1 0 4 1 -1 5 5 5 0 5 5 5 5 5 5 5 5 5 5 0 5 5 5 5 5 0.11 2.01 132 H -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 -5 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 5 5 5 0.07 2.12 133 H -2 -1 1 -2 1 1 -1 -2 6 -1 -2 -1 3 0 -5 -2 -1 5 1 -1 4 4 5 3 3 6 4 4 20 3 4 4 6 4 0 4 3 6 5 4 0.40 2.10 134 G -1 1 -1 0 1 1 0 3 1 -2 -2 0 2 0 -5 -1 -2 4 0 -2 4 8 2 5 2 7 5 23 3 2 4 5 4 3 0 4 2 5 3 3 0.22 2.11 135 M -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 -5 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 5 5 5 0.07 2.12 136 V -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 137 I -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 138 V -1 -1 -1 0 1 -1 -1 -2 0 1 0 0 2 -1 -1 -2 -1 -5 0 3 6 3 3 5 3 3 4 4 3 7 9 5 4 3 4 3 3 0 3 21 0.11 2.17 139 P -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 140 I -1 -1 0 0 2 -1 -1 -2 0 0 1 -1 1 0 3 0 -1 -5 0 -1 5 4 4 5 3 3 5 3 3 5 13 4 3 3 14 6 4 0 3 5 0.07 2.11 141 G -2 -1 0 0 2 -1 -2 4 -1 -3 -3 -2 0 -5 3 -1 0 -5 -1 -3 3 4 5 5 4 2 3 29 2 2 3 3 3 0 14 4 6 0 2 2 0.38 2.07 142 Y -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 143 A -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 144 A 0 -2 0 0 1 0 1 1 2 -1 -2 -1 0 1 2 -1 0 2 0 -1 8 3 4 6 3 3 10 10 4 4 3 3 2 5 9 4 5 2 3 5 0.05 2.23 145 Q 1 -1 0 -1 0 1 -1 1 0 -2 -3 0 0 -2 3 0 0 0 -1 -3 13 3 4 3 2 7 5 11 2 2 3 5 2 2 15 7 5 2 2 2 0.16 2.21 146 E 0 0 2 1 -1 0 1 1 0 -1 -2 -2 0 1 -1 -1 -1 4 0 -1 7 5 8 6 2 5 10 9 2 4 4 3 2 5 3 5 4 5 4 5 0.06 2.21 147 L -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 148 F -1 -2 1 2 0 -1 0 -1 1 -1 -1 -2 4 3 -2 0 0 1 0 -1 4 2 6 10 2 3 6 5 3 4 5 2 9 11 2 6 5 2 3 3 0.12 2.18 149 D 0 0 1 1 0 0 2 -1 2 -1 -1 -1 1 0 -2 0 0 -5 0 -1 7 5 6 9 2 4 12 5 4 4 5 4 4 4 2 7 5 0 3 5 0.05 2.16 150 V -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 151 S -1 1 1 1 -5 1 0 0 2 -1 -2 0 1 0 -1 0 0 2 0 -1 5 7 7 7 0 5 7 7 5 4 5 5 3 4 3 6 5 3 3 4 0.04 2.14 152 Q -1 0 0 0 2 0 -1 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.04 2.23 153 V -1 -1 -1 -2 2 -1 -1 3 0 0 -1 -2 1 0 -1 -1 0 3 0 0 5 4 3 3 4 3 4 21 3 5 6 3 4 3 3 4 5 4 3 6 0.11 2.22 154 T -1 0 0 0 3 0 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.02 2.12 155 P -1 -1 -1 0 1 -1 0 1 2 -2 -3 -2 -1 0 3 1 -1 1 0 -2 6 3 3 6 3 3 5 12 5 2 2 3 2 4 14 12 3 2 3 4 0.17 2.15 156 Y 0 -1 -1 -1 1 -1 0 -3 0 -1 1 -2 1 1 -2 -1 -2 5 4 0 8 3 3 3 2 3 6 2 2 4 15 3 3 5 3 4 3 6 15 6 0.26 2.13 157 G -1 0 0 0 -5 1 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.10 2.01 158 A 3 -1 0 -1 1 -1 -2 2 1 -1 -2 -1 1 0 -1 0 -1 2 -1 -1 22 3 5 3 3 3 3 13 3 4 4 3 3 5 4 6 4 2 3 4 0.16 2.05 159 T -1 -2 0 -2 0 2 -2 1 -1 -1 0 0 3 -1 0 1 1 1 -1 0 5 2 4 2 2 8 3 11 2 4 9 5 6 3 4 11 9 2 2 6 0.10 2.07 160 T 1 -2 -2 -2 1 -1 -2 -1 2 -1 0 -2 3 -2 -2 1 3 0 -1 1 12 2 2 2 3 2 3 5 5 3 7 2 6 2 2 9 17 1 2 11 0.21 2.06 161 I -1 0 0 0 2 0 0 -1 2 0 -1 0 2 1 0 -1 0 4 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0.09 2.12 162 A 3 -1 -1 -1 1 0 -1 -1 0 -1 -1 -1 0 -1 0 1 1 2 0 0 20 3 3 3 3 5 4 5 3 3 5 3 3 3 4 9 7 2 3 7 0.12 2.12 163 G -1 -2 0 2 0 -1 -1 4 0 -2 -3 -2 0 -2 2 0 -2 1 -2 -3 6 2 4 11 2 3 4 28 2 2 3 3 2 2 9 7 3 2 2 2 0.34 2.11 164 G -1 0 0 0 3 1 0 -1 2 0 -1 0 2 1 0 -1 0 -5 1 -1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 5 5 0.07 2.01 165 D -2 -1 1 4 1 0 0 -1 1 -1 -2 0 0 0 -1 -1 -1 2 0 -1 4 4 7 25 3 4 6 5 3 3 4 5 3 3 4 4 3 2 3 5 0.26 2.07 166 G 1 -1 1 0 1 0 -1 3 1 -2 -3 -1 -1 -2 0 0 -2 1 -5 -1 13 3 6 6 3 3 4 24 4 3 3 4 2 2 5 7 2 2 0 5 0.25 2.04 167 S 0 -1 2 3 -1 0 1 -2 0 -1 -3 0 -1 -3 0 2 -1 0 -2 -1 8 4 9 15 1 4 7 4 2 3 2 5 2 1 4 16 4 1 1 4 0.20 2.05 168 R 0 4 1 0 -1 0 2 0 0 -2 -1 -1 0 -2 0 -2 -1 0 -2 -1 7 20 6 5 1 5 11 6 2 2 6 4 3 2 6 3 3 1 2 5 0.20 2.07 169 Q 2 1 0 -1 -2 3 2 -2 0 -2 -3 1 0 -3 2 -1 0 -1 -2 -2 14 7 4 4 1 12 12 3 2 2 2 7 2 1 9 5 6 1 1 4 0.22 2.10 170 P -2 -4 -2 -3 -2 -2 -2 -4 -2 1 1 -3 1 -1 6 -3 -3 -6 -3 1 3 1 2 2 1 2 3 1 1 6 15 2 3 2 42 2 1 0 1 10 0.87 2.11 171 S -2 -2 1 4 -2 -2 -2 -2 2 -2 -3 -2 -3 -2 0 3 2 -2 -2 -2 3 2 5 23 1 1 2 3 4 3 2 2 1 2 6 25 12 1 1 2 0.49 2.12 172 Q 1 -2 -2 3 -3 1 5 -2 -1 -4 -4 0 -3 -4 1 -1 -2 -6 -4 -2 10 2 2 15 1 6 33 3 1 1 1 6 1 1 8 4 2 0 1 3 0.58 2.12 173 E 0 -3 1 3 -3 -1 3 1 1 -1 -2 -1 -1 -3 -3 0 -1 -2 -2 -2 7 1 7 17 1 3 19 10 3 3 5 4 2 1 2 6 5 1 1 4 0.29 2.14 174 E 0 -3 -2 5 -2 -1 5 0 -2 -4 -5 -3 -3 -3 -3 -2 -1 -1 -4 -2 7 1 1 27 1 1 36 8 1 1 1 1 1 1 1 2 3 1 1 3 0.81 2.11 175 L -2 1 -3 -4 -2 -1 -2 -4 -3 2 4 2 0 -2 -5 -3 -3 -1 -1 -1 3 7 1 1 1 3 2 1 1 11 44 11 2 1 0 2 2 1 2 4 0.58 2.08 176 S 3 0 0 1 -3 1 4 -3 -2 -3 -3 2 -3 -5 -4 -2 -1 -6 -3 -3 21 6 4 7 1 6 27 2 1 2 3 10 1 0 1 3 4 0 1 1 0.48 2.11 177 I 2 -2 -2 -2 -3 0 -1 -2 -2 1 2 -1 0 -3 -4 -2 4 -6 -3 -1 18 3 2 2 1 4 4 4 1 8 19 3 3 1 1 2 22 0 1 4 0.34 2.14 178 A 6 -5 -4 -6 7 -5 -4 -1 -3 -2 -2 -3 -2 -1 -4 -2 -3 -6 -5 0 55 0 0 0 18 0 1 4 1 2 3 1 1 3 1 2 1 0 0 7 1.16 2.11 179 R -1 5 -2 -2 -4 1 2 -4 1 -2 -4 3 -1 0 -4 -3 -2 -2 -1 -2 4 34 1 2 0 7 12 1 3 3 1 15 1 4 0 2 2 1 2 3 0.65 2.12 180 Y 2 -1 0 -2 -3 0 0 -3 5 1 -1 -2 -2 1 -5 -1 -2 -1 2 -1 20 4 4 2 0 5 6 2 15 7 7 3 1 7 0 4 2 1 7 3 0.36 2.12 181 Q -4 -3 -5 -5 -3 6 -3 -5 -1 -2 4 -4 0 4 -5 -4 -3 -2 2 -2 1 1 0 0 1 31 1 0 2 1 37 0 2 14 0 1 1 0 6 2 0.97 2.10 182 G 1 -6 -3 -5 -6 -5 -5 7 -6 -5 -6 -5 -4 -6 -6 -3 -3 -2 -6 -2 13 0 1 0 0 0 1 78 0 1 1 0 0 0 0 1 2 1 0 3 1.77 2.06 183 E 0 4 -2 -3 -4 2 2 -4 -1 -5 -4 5 -3 -5 -5 -2 -3 -3 -3 -3 7 23 2 1 0 9 14 1 1 1 1 32 1 0 0 2 1 0 1 2 0.84 2.07 184 Y -2 7 0 -2 -4 -1 -1 -5 4 -5 -4 0 -3 -4 -6 -2 -2 -1 1 -5 3 57 5 3 0 2 3 1 8 0 1 4 0 0 0 2 3 1 5 0 1.23 2.05 185 V -3 -6 -6 -7 -3 -4 -6 -7 -6 2 3 -6 2 4 -6 -5 0 -2 -3 4 2 0 0 0 0 1 0 0 0 11 26 0 5 14 0 1 6 1 0 32 0.90 2.01 186 A 6 -4 -4 -5 -3 -3 -5 -1 -4 -1 -3 -4 -3 -3 -5 -2 -2 -1 1 2 63 1 0 0 0 1 0 4 0 3 2 1 0 1 0 2 2 1 4 14 1.04 2.01 187 G -1 2 0 1 -5 2 5 -1 -2 -5 -3 2 -2 -5 -5 -1 1 -2 -3 -3 5 9 4 6 0 9 33 4 1 1 2 10 1 0 0 4 7 1 1 1 0.56 2.04 188 L -1 -4 -5 -6 -3 -3 -4 -6 -3 4 2 -1 1 -1 -6 -4 2 -1 -2 3 5 0 0 0 0 1 1 0 1 23 19 4 3 3 0 1 15 1 1 22 0.66 2.00 189 A 5 -5 -5 -5 -1 -4 -4 -2 -5 0 -1 -4 -2 -5 -5 -1 2 -6 -4 2 51 0 0 0 1 0 0 2 0 5 5 0 1 0 0 3 13 0 1 16 0.89 1.96 190 V 2 2 0 -2 -4 2 -1 -1 -2 -1 0 4 -1 -4 -5 0 -1 -6 -4 -1 15 10 4 2 0 7 4 4 1 3 11 23 1 0 0 8 3 0 0 4 0.34 1.95 191 K 1 4 -3 -4 -4 2 -1 -5 -3 -5 -3 6 -2 -5 -5 -2 -3 0 -4 -4 11 24 0 1 0 8 3 0 0 0 2 42 1 0 0 2 1 2 1 1 1.00 1.96 192 L -4 -6 -7 -7 -5 -5 -6 -7 -4 2 6 -6 2 3 -7 -5 -3 1 -2 0 0 0 0 0 0 0 0 0 0 9 66 0 3 10 0 0 1 2 1 6 1.24 1.91 193 N -1 2 3 -3 -4 -2 -2 -4 4 -4 -4 5 -3 0 -5 1 -2 -6 -3 -4 5 11 14 1 0 1 1 1 8 1 1 37 0 4 0 11 2 0 1 1 0.78 1.84 194 G -3 -5 3 -4 -6 -5 -5 7 -5 -7 -7 -5 -6 -7 -5 -3 -5 -6 -6 -7 0 0 12 0 0 0 0 88 0 0 0 0 0 0 0 0 0 0 0 0 2.08 1.66 K Lambda Standard Ungapped 0.1312 0.3145 Standard Gapped 0.0410 0.2670 PSI Ungapped 0.1115 0.3182 PSI Gapped 0.0341 0.2670