Contents

• Contents
• Summary
• Abbreviations
• Introduction
• Methods
  • Source of Sequences and Multiple Alignment
  • Conservation Analysis and Secondary Structure Prediction
• Results
  • Clustering of sequences
  • Similarity to Bacteriophage Protein Phosphatases and E. coli Tetra-Phosphatase
  • Invariant residues, secondary structure and insertions/deletions
    • Loop Predictions
    • Helix Predictions
    • Beta Strand Predictions
    • Ambiguous Predictions
• Discussion
  • Invariant Residues Suggest a Common Catalytic Mechanism
  • Change in charge sign
  • Phosphate binding site
  • Phosphoryl-Enyzme Intermediate
  • Are metal ions present at the catalytic centre?
  • Secondary Structure Prediction and Domain Structure
• Acknowledgements
• Figure Legends
  • Legend to Figure 1
  • Legend to Figure 2
• Tables
  • Table 1
  • Table 2
  • Table 3 - Changes in sign of potential charge
• References
• About this document ...