Methods

• Database of unique protein 3D structural domains
• Alignment of secondary structures
• Filters
  • Removing un-compact structures
  • Loop length distance restraints
  • Poor sheets
  • Adjacent parallel structures
  • Distance restraints
  • Consistency &Redundancy
  • Maps removed by each filter
• Fitting sequences on to 3D structures
• Protein Structure Patterns for Evaluation
• Cross-validation
• Computational details