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Multiple sequence alignment

So far I have only considered methods to align two sequences. However, when the sequence data is available, a multiple alignment is always preferable to pairwise alignment.

Techniques for the alignment of three or more sequences may be divided into four categories.

Of these, the second is by far the most practical and widely used method. Consensus methods are not greatly used for protein sequence alignment and so are not discussed further.



geoff.barton@ox.ac.uk