SH2 domain analysis performed using the program AMAS [53]. The
aim of this analysis is to locate patterns of amino acid conservation
within each sub-group of related sequences and across all sequences in
the set. The sequences are clustered by their overall similarity,
then a set-based method is used to find the positions that have
conserved physico-chemical properties within each group and between
pairs of groups. The conservation is summarised by colour coding the
alignment (shown here as grey shading). Pair conservation is
summarised as a histogram. The histogram helps to locate conservation
patterns characteristic of - helix and
- strand. For full details
see [53]. For details of how to obtain AMAS and other programs
from the author's group please download the file README from
www.compbio.dundee.ac.uk.