[Jalview-discuss] distance initialized to zero in average seq id tree?

Daron Standley standley at protein.osaka-u.ac.jp
Mon Dec 15 13:03:58 GMT 2008


Dear Jalview experts,

I recently tried to draw a tree from an MSA in which some of the  
sequences were completely unaligned (e.g. a sequence fragment that  
aligned only to the N-terminal region and one that aligned only to  
the C-terminal region).  Oddly, these two sequences were placed  
together on the (average distance % id) tree, even though their  
distance would be undefined. This suggests that there is a bug in the  
Jalview tree code that (perhaps) initializes the distance to zero.  
Attached is the MSA that cases the problem. Two of the sequences that  
should not be close together are 1w0tA and MOUSEAkirin2.

Best regards,

Daron



Daron M. Standley, Ph.D.
Systems Immunology Laboratory
Immunology Frontier Research Center
Osaka University
Tel:   +81-(0)6-6879-4311
FAX: +81-(0)6-6879-8636




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