PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between POLR2H and POLR2C

The interaction score between POLR2H and POLR2C is 49.0.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between POLR2H and POLR2C = 0.31

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

3.80E-3

Orthology

Organism	POLR2H Orthologue		POLR2C Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YOR224C	1	YIL021W	1	Other AffinityCaptureMS CoPurification Get References From PubMed
worm	Q19826	1	Q93338	1
fly	Q9VNZ3	1	O97183	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

No domains were used in calculating likelihood of interaction

1.48E-3

Post-translational Modifications

Protein: POLR2H

PTM	Residue	Reference
N-acetylalanine	1	HPRD

Protein: POLR2C

PTM	Residue	Reference

Localisation

Protein: POLR2H

Localisation	Reference
Cytosol	HPRD
Nucleus	HPRD
Nucleolus	HPRD
Nucleoplasm	HPRD

Protein: POLR2C

Localisation	Reference
Nucleus	HPRD

Transitive Score

The common interactors between POLR2H and POLR2C that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between POLR2H andPOLR2C. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , POLR2H has 295 interactors and POLR2C has 54 interactors of which there are 11 common interactors.

Common Interactor	Name of Common Interactor	Score for POLR2H-Interactor (?)	Score for POLR2C-Interactor (?)
POLR2G	POLR2G: DNA-directed RNA polymerase II subunit RPB7	19.70	0.538
POLR2A	POLR2A: Uncharacterized protein POLR2A	7.16	0.326
POLR2B	POLR2B: DNA-directed RNA polymerase II subunit RPB2	1.82	0.538
POLR2D	POLR2D: DNA-directed RNA polymerase II subunit RPB4	1.10	0.408
POLR2E	POLR2E: DNA-directed RNA polymerases I, II, and III subunit RPABC1	1.10	0.538
C1orf82	RPAP2, C1orf82: RNA polymerase II-associated protein 2	0.902	0.685
POLR2L	POLR2L: DNA-directed RNA polymerases I, II, and III subunit RPABC5	0.890	0.408
SUPT5H	SUPT5H: Uncharacterized protein SUPT5H	0.593	0.593
GTF2F2	GTF2F2: Uncharacterized protein GTF2F2	0.593	0.593
SETD2	SETD2, HIF1, HSPC069, HYPB, KIAA1732, SET2: Histone-lysine N-methyltransferase S	0.593	0.593
POLR2I	POLR2I: DNA-directed RNA polymerase II subunit RPB9	0.354	0.354

0.228

Total Score

49.0