PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between POLG and LSM5

The interaction score between POLG and LSM5 is 0.032.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between POLG and LSM5 = 0.63

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

7.78E-3

Orthology

Organism	POLG Orthologue		LSM5 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YOR330C	1	YER146W	1
worm	Q9U208	1	O18694	1
fly	Q27607	1	Q9VRT7	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.22E-3

Domains

No domains were used in calculating likelihood of interaction

0.012

Post-translational Modifications

Protein: POLG

PTM	Residue	Reference

Protein: LSM5

PTM	Residue	Reference
N-acetylalanine	1	HPRD

Localisation

Protein: POLG

Localisation	Reference
Mitochondrion	HPRD

Protein: LSM5

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

No Transitive data was used in the prediction of this interaction.

N/A

Total Score

0.032