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Evidence of Interaction Between FIGF and SIRPD

The interaction score between FIGF and SIRPD is 3.70.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in FIGF and SIRPD:
Domains in FIGFDomains in SIRPD
IPR000072 Platelet-derived growth factor (PDGF)
IPR004153 CXCXC repeat
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like

The Chi square scores for co-occurrence of domains that are present in FIGF and SIRPD are listed below.

Domain 1Domain 2Chi Square
IPR000072 Platelet-derived growth factor (PDGF) IPR007110 Immunoglobulin-like 20.1534

The background colour of the table refers to:

  • Blue Domain is only present in FIGF
  • Yellow Domain is only present in SIRPD
  • Green Domain is present in both FIGF and SIRPD

 0.027
Post-translational Modifications

Protein: FIGF

PTMResidueReference
Proteolytic Cleavage 88 PubMed, HPRD
Proteolytic Cleavage 99 PubMed, HPRD

Protein: SIRPD

PTMResidueReference
Localisation

Protein: FIGF

LocalisationReference
Secreted HPRD

Protein: SIRPD

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between FIGF and SIRPD that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FIGF andSIRPD. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FIGF has 498 interactors and SIRPD has 676 interactors of which there are 207 common interactors.

Common InteractorName of Common InteractorScore for FIGF-Interactor (?)Score for SIRPD-Interactor (?)
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 283.00 0.027
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 127.00 0.027
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 71.40 0.027
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 35.00 0.027
KIT KIT: Mast/stem cell growth factor receptor precursor 30.80 0.027
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 27.80 0.027
THBD THBD, THRM: Thrombomodulin precursor 0.307 0.027
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.275 0.027
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.251 0.027
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.251 0.027
TNC TNC, HXB: Tenascin precursor 0.225 0.027
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.191 0.027
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.166 0.027
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.165 0.027
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.165 0.027
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.027
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.027
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.152 0.027
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.152 0.027
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.152 0.027
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.148 0.027
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.027
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.148 0.027
BMP1 N/A 0.148 0.027
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.027
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.137 0.027
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.136 0.027
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.136 0.027
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.129 0.027
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.126 0.027
APCS APCS, PTX2: Serum amyloid P-component precursor 0.123 0.027
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.123 0.027
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.123 0.027
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.113 0.027
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.113 0.027
NEO1 NEO1, NGN: Neogenin precursor 0.113 0.027
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.113 0.027
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.110 0.027
ALK ALK: ALK tyrosine kinase receptor precursor 0.110 0.027
KIR3DL1 N/A 0.109 0.027
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.109 0.027
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.027
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.027
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.109 0.027
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.109 0.027
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.109 0.027
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.027
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.109 0.027
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.027
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.109 0.027
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.109 0.027
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.109 0.027
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.109 0.027
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.109 0.027
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.102 0.027
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.100 0.027
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.100 0.027
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.100 0.027
PVR PVR, PVS: Poliovirus receptor precursor 0.100 0.027
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.100 0.027
GPA33 GPA33: Cell surface A33 antigen precursor 0.100 0.027
SELE SELE, ELAM1: E-selectin precursor 0.100 0.027
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.100 0.027
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.100 0.027
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.098 0.027
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.098 0.027
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.098 0.027
CSPG2 N/A 0.098 0.027
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.098 0.027
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.098 0.027
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.098 0.027
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.027
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.027
BSG N/A 0.098 0.027
ATRN N/A 0.098 0.027
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.027
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.097 0.027
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.097 0.027
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.090 0.027
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.087 0.027
CRTAC1 CRTAC1, ASPIC1, CEP68: Cartilage acidic protein 1 precursor 0.083 0.027
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.081 0.027
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.081 0.027
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.081 0.027
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.081 0.027
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.081 0.027
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.078 0.027
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.073 0.027
DCC DCC: Netrin receptor DCC precursor 0.073 0.027
MEP1B MEP1B: Meprin A subunit beta precursor 0.073 0.027
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.073 0.027
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.073 0.027
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.073 0.027
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.0727 0.027
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.0727 0.027
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.072 0.027
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.072 0.027
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.072 0.027
ITGB4 N/A 0.072 0.027
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.072 0.027
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.072 0.027
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.072 0.027
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.072 0.027
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.072 0.027
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.072 0.027
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.072 0.027
CD7 CD7: T-cell antigen CD7 precursor 0.072 0.027
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.072 0.027
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.072 0.027
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.072 0.027
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.070 0.027
VSIG4 VSIG4, Z39IG, UNQ317/PRO362: V-set and immunoglobulin domain-containing protein 0.065 0.027
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.065 0.027
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.065 0.027
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.065 0.027
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.065 0.027
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.065 0.027
MEP1A MEP1A: Meprin A subunit alpha precursor 0.064 0.027
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.064 0.027
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.058 0.027
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.027
ITGB7 ITGB7: Integrin beta-7 precursor 0.058 0.027
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.056 0.027
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.053 0.027
CEACAM5 CEACAM5, CEA: Carcinoembryonic antigen-related cell adhesion molecule 5 precurso 0.051 0.027
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.050 0.027
CILP CILP, UNQ602/PRO1188: Cartilage intermediate layer protein 1 precursor 0.050 0.027
ITGBL1 ITGBL1, RP11-397O8.1-003, hCG_29594: Integrin beta-like protein 1 precursor 0.050 0.027
MET MET: Hepatocyte growth factor receptor precursor 0.0453 0.027
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.0453 0.027
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.027
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.044 0.027
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.027
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.0425 0.027
CCL14 CCL14, NCC2, SCYA14: Small-inducible cytokine A14 precursor 0.0425 0.027
CD248 CD248, CD164L1, TEM1: Endosialin precursor 0.041 0.027
ISLR ISLR, UNQ189: ISLR precursor 0.041 0.027
MCAM MCAM, MUC18: Cell surface glycoprotein MUC18 precursor 0.039 0.027
TREM2 TREM2: Triggering receptor expressed on myeloid cells 2 precursor 0.039 0.027
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.038 0.027
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.036 0.027
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.036 0.027
LAMB2 LAMB2, LAMS: Laminin subunit beta-2 precursor 0.036 0.027
B2M B2M, CDABP0092, HDCMA22P: Beta-2-microglobulin precursor [Contains: Beta-2-micro 0.033 0.027
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.033 0.027
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.033 0.027
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.033 0.027
CXCL10 CXCL10, INP10, SCYB10: Small-inducible cytokine B10 precursor 0.032 0.027
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.032 0.027
CCL1 CCL1, SCYA1: Small-inducible cytokine A1 precursor 0.032 0.027
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.032 0.027
ITGB5 ITGB5: Integrin beta-5 precursor 0.032 0.027
SLAMF8 SLAMF8, BLAME: SLAM family member 8 precursor 0.032 0.027
SEMA7A SEMA7A, CD108, SEMAL: Semaphorin-7A precursor 0.0308 0.027
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.030 0.027
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.029 0.027
INSR INSR: Insulin receptor precursor 0.029 0.027
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.029 0.027
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 0.029 0.027
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.029 0.027
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.028 0.027
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.028 0.027
IL4 IL4: Interleukin-4 precursor 0.028 0.027
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.028 0.027
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.028 0.027
THPO THPO, MGDF: Thrombopoietin precursor 0.028 0.027
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.028 0.027
IFNG IFNG: Interferon gamma precursor 0.028 0.027
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.028 0.027
TLL1 TLL1, TLL: Tolloid-like protein 1 precursor 0.028 0.027
FCAR FCAR, CD89: Immunoglobulin alpha Fc receptor precursor 0.027 0.027
LILRB3 LILRB3, ILT5, LIR3: Leukocyte immunoglobulin-like receptor subfamily B member 3 0.027 0.027
PSG6 PSG5: Pregnancy-specific beta-1-glycoprotein 5 precursor 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
CEACAM7 CEACAM7, CGM2: Carcinoembryonic antigen-related cell adhesion molecule 7 precurs 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
FSTL5 FSTL5, KIAA1263: Follistatin-related protein 5 precursor 0.027 0.027
PSG4 PSG4, CGM4, PSG9: Pregnancy-specific beta-1-glycoprotein 4 precursor 0.027 0.027
HLA-DRB5 N/A 0.027 0.027
HLA-DRB5 N/A 0.027 0.027
MGC33530 N/A 0.027 0.027
CSPG3 CSPG3, NCAN, NEUR: Neurocan core protein precursor 0.027 0.027
PSG6 PSG6, CGM3, PSGGB: Pregnancy-specific beta-1-glycoprotein 6 precursor 0.027 0.027
HFE HFE, HLAH: Hereditary hemochromatosis protein precursor 0.027 0.027
CILP2 CILP2: Cartilage intermediate layer protein 2 precursor 0.027 0.027
C20orf102 N/A 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
HLA-DQA1 HLA-DQA2, HLA-DXA: HLA class II histocompatibility antigen, DQ(6) alpha chain pr 0.027 0.027
PSG7 PSG7: Pregnancy-specific beta-1-glycoprotein 7 precursor 0.027 0.027
PSG11 PSG11, PSG13, PSG14: Pregnancy-specific beta-1-glycoprotein 11 precursor 0.027 0.027
MADCAM1 MADCAM1: Mucosal addressin cell adhesion molecule 1 precursor 0.027 0.027
NEGR1 NEGR1, UNQ2433/PRO4993: Neuronal growth regulator 1 precursor 0.027 0.027
NTNG2 N/A 0.027 0.027
SIGLEC11 N/A 0.027 0.027
IGLL1 IGLL1, IGL1: Immunoglobulin lambda-like polypeptide 1 precursor 0.027 0.027
ROBO1 N/A 0.027 0.027
SIGLEC6 N/A 0.027 0.027
LILRB1 N/A 0.026 0.027
EPO EPO: Erythropoietin precursor 0.026 0.027
CXCL9 CXCL9, CMK, MIG, SCYB9: Small-inducible cytokine B9 precursor 0.026 0.027
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.026 0.027
CXCL11 CXCL11, ITAC, SCYB11, SCYB9B: Small-inducible cytokine B11 precursor 0.026 0.027
IL3 IL3: Interleukin-3 precursor 0.026 0.027
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.025 0.027
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.025 0.027
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.025 0.027
0.347
Total Score 3.70