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Evidence of Interaction Between FIGF and F12

The interaction score between FIGF and F12 is 15.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between FIGF and F12 = -0.04

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in FIGF and F12:
Domains in FIGFDomains in F12
IPR000072 Platelet-derived growth factor (PDGF)
IPR004153 CXCXC repeat
IPR006209 EGF-like domain
IPR006210 Type I EGF
IPR000001 Kringle
IPR001254 Peptidase S1, chymotrypsin
IPR001314 Peptidase S1A, chymotrypsin
IPR009003 Peptidase, trypsin-like serine and cysteine proteases
IPR000562 Type II fibronectin collagen-binding domain
IPR000083 Fibronectin, type I
IPR000742 EGF_2.
IPR013032 IPR006209.

The Chi square scores for co-occurrence of domains that are present in FIGF and F12 are listed below.

Domain 1Domain 2Chi Square
IPR000072 Platelet-derived growth factor (PDGF) IPR006210 Type I EGF 21.4624
IPR000072 Platelet-derived growth factor (PDGF) IPR013032 IPR006209. 17.0799
IPR000072 Platelet-derived growth factor (PDGF) IPR000742 EGF_2. 15.7059
IPR000072 Platelet-derived growth factor (PDGF) IPR006209 EGF-like domain 11.6428

The background colour of the table refers to:

  • Blue Domain is only present in FIGF
  • Yellow Domain is only present in F12
  • Green Domain is present in both FIGF and F12

 0.165
Post-translational Modifications

Protein: FIGF

PTMResidueReference
Proteolytic Cleavage 88 PubMed, HPRD
Proteolytic Cleavage 99 PubMed, HPRD

Protein: F12

PTMResidueReference
Glycosylation 433 PubMed, HPRD
N-linked 249 PubMed, HPRD
N-linked 433 PubMed, HPRD
O-linked 109 PubMed, HPRD
Proteolytic Cleavage 376 PubMed, HPRD
Localisation

Protein: FIGF

LocalisationReference
Secreted HPRD

Protein: F12

LocalisationReference
Secreted HPRD
Transitive Score

The common interactors between FIGF and F12 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FIGF andF12. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FIGF has 498 interactors and F12 has 933 interactors of which there are 349 common interactors.

Common InteractorName of Common InteractorScore for FIGF-Interactor (?)Score for F12-Interactor (?)
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 283.00 0.032
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 127.00 0.077
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 71.40 0.032
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 35.00 0.037
KIT KIT: Mast/stem cell growth factor receptor precursor 30.80 0.032
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 27.80 0.037
C1S C1S: Complement C1s subcomponent precursor 0.307 0.251
THBD THBD, THRM: Thrombomodulin precursor 0.307 0.109
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.275 0.109
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.251 0.123
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.251 0.109
C1R C1R: Complement C1r subcomponent precursor 0.251 0.515
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.251 0.055
TNC TNC, HXB: Tenascin precursor 0.225 0.109
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.225 0.098
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.201 0.130
NOTCH4 N/A 0.191 0.109
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.191 0.109
SHBG SHBG: Sex hormone-binding globulin precursor 0.191 0.191
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.191 0.251
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.191 0.055
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.166 0.081
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.165 0.083
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.165 0.083
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.083
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.083
COL5A1 N/A 0.160 0.115
F7 F7: Coagulation factor VII precursor 0.156 0.174
BGLAP BGLAP: Osteocalcin precursor 0.152 0.174
LGALS3 LGALS3, MAC2: Galectin-3 0.152 0.109
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.152 0.055
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.152 0.109
CFI CFI, IF: Complement factor I precursor 0.152 0.123
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.152 0.055
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.152 0.109
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.148 0.081
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.148 0.124
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.083
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.148 0.165
PLAT PLAT: Tissue-type plasminogen activator precursor 0.148 0.165
BMP1 N/A 0.148 0.165
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.148 0.165
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.083
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.137 0.174
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.136 0.109
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.136 0.416
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.136 0.109
C6 C6: Complement component C6 precursor 0.136 1.81
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.136 0.152
C7 C7: Complement component C7 precursor 0.136 0.109
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.130 0.438
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.129 0.109
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.126 0.032
APCS APCS, PTX2: Serum amyloid P-component precursor 0.123 5.45
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.123 0.055
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.123 0.109
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.123 0.062
C8A C8A: Complement component C8 alpha chain precursor 0.123 1.81
F9 F9: Coagulation factor IX precursor 0.116 0.543
F10 F10: Coagulation factor X precursor 0.116 5.75
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.113 0.100
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.113 0.100
NEO1 NEO1, NGN: Neogenin precursor 0.113 0.072
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.113 0.065
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.110 0.109
C8B C8B: Complement component C8 beta chain precursor 0.110 1.81
ALK ALK: ALK tyrosine kinase receptor precursor 0.110 0.109
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.110 0.109
KIR3DL1 N/A 0.109 0.049
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.109 0.049
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.049
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.109 0.049
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.109 0.109
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.109 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.109 0.049
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.049
DLK1 DLK1, DLK: Delta-like protein precursor 0.109 0.109
TMPRSS9 N/A 0.109 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.109 0.049
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.049
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.109 0.109
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.109 0.123
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.109 0.055
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.109 0.055
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.109 0.152
MUC2 MUC2, SMUC: Mucin-2 precursor 0.109 0.109
UMOD UMOD: Uromodulin precursor 0.109 0.109
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.109 0.062
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.109 5.45
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.109 0.055
PROC PROC: Vitamin K-dependent protein C precursor 0.103 5.75
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.102 0.324
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.100 0.0453
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.100 0.032
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.100 0.037
PVR PVR, PVS: Poliovirus receptor precursor 0.100 0.100
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.100 0.037
GPA33 GPA33: Cell surface A33 antigen precursor 0.100 0.032
SELE SELE, ELAM1: E-selectin precursor 0.100 0.081
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.100 0.081
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.100 0.037
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.100 0.032
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.098 0.055
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.098 0.055
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.098 0.055
CSPG2 N/A 0.098 0.109
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.098 0.062
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.098 0.109
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.098 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.049
JAG2 JAG2: Jagged-2 precursor 0.098 0.109
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.109
BSG N/A 0.098 0.049
ATRN N/A 0.098 0.109
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.109
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.097 0.109
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.097 0.123
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.097 0.109
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.090 0.081
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.090 0.037
F2 F2: Prothrombin precursor 0.0898 5.75
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.087 0.109
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.081 0.081
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.081 0.057
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.081 0.081
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.081 0.081
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.081 0.065
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.081 0.037
EGF EGF: Pro-epidermal growth factor precursor 0.081 0.072
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.081 0.072
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.081 0.072
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.081 0.072
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0782 0.0338
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.078 0.109
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.073 0.072
DCC DCC: Netrin receptor DCC precursor 0.073 0.081
MEP1B MEP1B: Meprin A subunit beta precursor 0.073 0.100
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.073 0.081
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.073 0.072
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.073 0.081
LDLR LDLR: Low-density lipoprotein receptor precursor 0.073 0.081
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.073 0.081
SORL1 SORL1: Sortilin-related receptor precursor 0.0727 0.081
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.0727 0.032
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.0727 0.072
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.072 0.032
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.072 0.037
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.072 0.032
ITGB4 N/A 0.072 0.081
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.072 0.032
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.072 0.081
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.072 0.032
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.072 0.100
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.072 0.032
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.072 0.032
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.072 0.081
AREG AREG, SDGF: Amphiregulin precursor 0.072 0.072
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.072 0.0453
CD7 CD7: T-cell antigen CD7 precursor 0.072 0.032
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.072 0.032
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.072 0.032
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.072 0.072
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.070 0.123
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.070 0.191
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.0688 0.0688
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.065 0.032
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.065 0.081
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.065 0.032
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.065 0.081
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.065 0.032
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.065 0.072
MEP1A MEP1A: Meprin A subunit alpha precursor 0.064 0.072
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.064 0.100
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.064 0.072
VWF VWF, F8VWF: von Willebrand factor precursor 0.063 0.109
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.058 0.072
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.058 0.126
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.072
ITGB7 ITGB7: Integrin beta-7 precursor 0.058 0.072
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.052 0.160
EDN1 EDN1: Endothelin-1 precursor 0.052 0.109
LTBP1 LTBP1: Latent-transforming growth factor beta-binding protein, isoform 1S precur 0.051 0.051
CSPG5 N/A 0.051 0.051
PLAU PLAU: Urokinase-type plasminogen activator precursor 0.051 0.051
ELTD1 ELTD1, RP11-143H12.1-002: EGF, latrophilin and seven transmembrane domain contai 0.051 0.051
NULL Ig kappa chain V-I region CAR 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
NULL Ig lambda chain V-II region NEI 0.051 0.051
ITGB1 ITGB1, FNRB, MDF2, MSK12: Integrin beta-1 precursor 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
NULL Ig heavy chain V-III region WEA 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
MMRN1 MMRN1, ECM, EMILIN4, MMRN: Multimerin-1 precursor 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.051 0.032
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.050 0.056
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.049 0.859
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.038
CPM CPM: Carboxypeptidase M precursor 0.046 0.109
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.051
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.044
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.044 0.109
LUM LUM, LDC: Lumican precursor 0.0425 0.055
MGP MGP, MGLAP, GIG36: Matrix Gla protein precursor 0.0425 0.109
CCL14 CCL14, NCC2, SCYA14: Small-inducible cytokine A14 precursor 0.0425 0.251
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.0425 0.115
COL16A1 COL16A1: Collagen alpha-1(XVI) chain precursor 0.0416 0.037
LGALS1 LGALS1: Galectin-1 0.0416 0.0416
LMAN2 LMAN2, C5orf8: Vesicular integral-membrane protein VIP36 precursor 0.041 0.0794
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.038 0.109
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.038 0.098
CANX CANX: Calnexin precursor 0.037 0.041
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.036 0.033
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.036 0.067
LAMB2 LAMB2, LAMS: Laminin subunit beta-2 precursor 0.036 0.0308
TNN TNN: Tenascin-N precursor 0.034 0.038
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.033 0.072
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.033 0.037
CXCL10 CXCL10, INP10, SCYB10: Small-inducible cytokine B10 precursor 0.032 0.123
BGN BGN: Biglycan precursor 0.032 0.077
PZP PZP: Pregnancy zone protein precursor 0.032 0.152
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.032 0.109
CCL1 CCL1, SCYA1: Small-inducible cytokine A1 precursor 0.032 0.191
SERPINF1 SERPINF1, PEDF: Pigment epithelium-derived factor precursor 0.032 2.42
SLPI SLPI, WAP4, WFDC4: Antileukoproteinase precursor 0.032 0.109
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.032 0.109
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.032 0.416
SERPING1 SERPING1, C1IN, C1NH: Plasma protease C1 inhibitor precursor 0.032 14.30
C4BPA C4BPA, C4BP: C4b-binding protein alpha chain precursor 0.032 1.81
CFH CFH, HF, HF1, HF2: Complement factor H precursor 0.032 0.251
F8 F8, F8C: Coagulation factor VIII precursor 0.032 0.109
MASP1 MASP1, CRARF, CRARF1, PRSS5: Complement-activating component of Ra-reactive fact 0.0308 0.041
EGFL4 MEGF8, C19orf49, EGFL4, KIAA0817: Multiple epidermal growth factor-like domains 0.030 0.0338
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.030 0.034
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.030 0.034
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.030 0.034
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.030 0.034
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.030 0.067
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.029 0.072
INSR INSR: Insulin receptor precursor 0.029 0.072
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.029 0.055
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 0.029 0.123
SPARC SPARC, ON: SPARC precursor 0.029 0.109
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.029 0.123
COL4A1 N/A 0.029 0.109
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.027
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.027
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.028 0.165
PLTP PLTP: Phospholipid transfer protein precursor 0.028 0.028
IRF2BP2 IRF2BP2, RP4-781K5.1-002: Interferon regulatory factor 2-binding protein 2. 0.028 0.028
GUCA2A GUCA2A, GUCA2: Guanylin precursor 0.028 0.028
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.028 0.165
PTHLH N/A 0.028 0.028
PCGF6 N/A 0.028 0.028
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.028 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.028 0.083
DCN DCN: Decorin precursor 0.028 0.083
ACCN3 ACCN3, ASIC3, SLNAC1, TNAC1: Amiloride-sensitive cation channel 3 0.028 0.028
GRN GRN: Granulins precursor 0.028 0.165
PLAU Plasminogen activator, urokinase 0.028 0.028
GRP Gastrin-releasing peptide 0.028 0.028
F11 F11: Coagulation factor XI precursor 0.028 0.165
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.028 0.083
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.028 0.083
CST4 CST4: Cystatin-S precursor 0.028 0.028
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.028 0.174
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.028 0.165
PCSK6 N/A 0.028 0.028
CGN N/A 0.028 0.028
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.028 0.165
IL4 IL4: Interleukin-4 precursor 0.028 0.083
C4A C4A: Complement C4-A precursor 0.028 0.165
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.028 0.165
LECT1 LECT1, CHMI: Chondromodulin-1 precursor 0.028 0.028
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.028 0.083
LNX1 N/A 0.028 0.028
CD46 N/A 0.028 0.165
OPTC OPTC, OPT: Opticin precursor 0.028 0.083
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.028 0.083
THPO THPO, MGDF: Thrombopoietin precursor 0.028 0.083
CCL14 N/A 0.028 0.028
CSF1 CSF1: Macrophage colony-stimulating factor 1 precursor 0.028 0.028
TUBGCP6 TUBGCP6, GCP6, KIAA1669: Gamma-tubulin complex component 6 0.028 0.028
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.028 0.165
GHRL GHRL, MTLRP, UNQ524/PRO1066: Appetite-regulating hormone precursor 0.028 0.028
IFNG IFNG: Interferon gamma precursor 0.028 0.083
FN1 N/A 0.028 0.165
NOG NOG: Noggin precursor 0.028 0.028
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.028 0.165
C1QTNF4 C1QTNF4, CTRP4: Complement C1q tumor necrosis factor-related protein 4 precursor 0.028 0.083
MMRN2 MMRN2, EMILIN3: Multimerin-2 precursor 0.028 0.083
DSP DSP: Desmoplakin 0.028 0.028
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
MASP2 MASP2: Mannan-binding lectin serine protease 2 precursor 0.027 0.027
LAMC2 LAMC2, LAMB2T, LAMNB2: Laminin subunit gamma-2 precursor 0.027 0.027
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
IFRD2 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
FSTL5 FSTL5, KIAA1263: Follistatin-related protein 5 precursor 0.027 0.027
UNQ739 VWC2, UNQ739, hCG_2045125, tcag7.1302: von Willebrand factor C domain-containing 0.027 0.027
CSPG3 CSPG3, NCAN, NEUR: Neurocan core protein precursor 0.027 0.027
CILP2 CILP2: Cartilage intermediate layer protein 2 precursor 0.027 0.027
CFC1 CFC1: Cryptic protein precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
NTNG2 N/A 0.027 0.027
HHIP HHIP, HIP, UNQ5825/PRO19644: Hedgehog-interacting protein precursor 0.027 0.027
NETO1 N/A 0.027 0.027
MUC13 MUC13, DRCC1, UNQ6194/PRO20221, RECC: Mucin-13 precursor 0.027 0.027
ROBO1 N/A 0.027 0.027
GP2 GP2: Pancreatic secretory granule membrane major glycoprotein GP2 precursor 0.027 0.027
SCARF2 SCARF2, SREC2, SREPCR: Scavenger receptor class F member 2 precursor 0.027 0.027
SEPP1 SEPP1, SELP: Selenoprotein P precursor 0.026 0.032
EPO EPO: Erythropoietin precursor 0.026 0.062
CXCL9 CXCL9, CMK, MIG, SCYB9: Small-inducible cytokine B9 precursor 0.026 0.152
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.026 0.109
C2 C2: Complement C2 precursor 0.026 0.852
C3 0.026 1.81
SLC14A2 SLC14A2, HUT2, UT2: Urea transporter, kidney 0.026 0.109
NDP NDP: Norrin precursor 0.026 0.055
AGRP AGRP, AGRT, ART: Agouti-related protein precursor 0.026 0.026
ASPN ASPN: ASPN protein 0.026 0.062
TFF2 TFF2, SML1: Trefoil factor 2 precursor 0.026 0.032
DSPG3 EPYC, DSPG3, PGLB: Epiphycan precursor 0.026 0.077
CXCL11 CXCL11, ITAC, SCYB11, SCYB9B: Small-inducible cytokine B11 precursor 0.026 0.123
WNT2B WNT2B, WNT13: Protein Wnt-2b precursor 0.026 0.152
APOE APOE: Apolipoprotein E precursor 0.026 0.430
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.026 0.109
IL3 IL3: Interleukin-3 precursor 0.026 0.055
BMX N/A 0.025 0.025
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.025 0.165
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.025 0.165
VNN1 VNN1: Pantetheinase precursor 0.025 0.028
LOC641705 AMY2A: Pancreatic alpha-amylase precursor 0.025 0.028
CPB2 CPB2: Carboxypeptidase B2 precursor 0.025 0.165
CA11 CA11, CARP2, UNQ211/PRO237: Carbonic anhydrase-related protein 11 precursor 0.025 0.028
SCRIB N/A 0.025 0.028
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.028
UNC5D N/A 0.025 0.028
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.025 0.165
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.025 0.165
COL18A1 N/A 0.025 0.165
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.025 0.165
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.025 0.165
ITM2C ITM2C, BRI3, hucep-14, NPD018, PSEC0047: Integral membrane protein 2C 0.025 0.028
0.347
Total Score 15.00