The interaction score between RBL1 and CCNE2 is 1.37E3.
This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins
The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.
| Feature | Evidence | Score (?) |
|---|
| Gene Expression |
N/A
|
N/A |
| Orthology |
The Inparalog Score is calculated by InParanoid
The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.
|
1.07 |
| Domains |
Domains present in RBL1 and CCNE2:
| Domains in RBL1 | | Domains in CCNE2 |
|---|
|
|
|
The Chi square scores for co-occurrence of domains that are present in RBL1 and CCNE2 are listed below.
| Domain 1 | Domain 2 | Chi Square |
|---|
| IPR002719 |
Retinoblastoma-associated protein, B-box |
IPR004367 |
Cyclin, C-terminal |
55.1463 |
| IPR002720 |
Retinoblastoma-associated protein, A-box |
IPR004367 |
Cyclin, C-terminal |
55.1463 |
| IPR002719 |
Retinoblastoma-associated protein, B-box |
IPR006671 |
Cyclin, N-terminal |
52.0127 |
| IPR002720 |
Retinoblastoma-associated protein, A-box |
IPR006671 |
Cyclin, N-terminal |
52.0127 |
| IPR006670 |
Cyclin |
IPR004367 |
Cyclin, C-terminal |
14.1195 |
| IPR006670 |
Cyclin |
IPR006671 |
Cyclin, N-terminal |
12.1572 |
The background colour of the table refers to: - Blue
Domain is only present in RBL1- Yellow
Domain is only present in CCNE2- Green
Domain is present in both RBL1 and CCNE2
|
0.027 |
| Post-translational Modifications |
Protein: RBL1
| PTM | Residue | Reference |
|---|
| Phosphorylation |
332 |
PubMed, HPRD |
| Phosphorylation |
340 |
PubMed, HPRD |
| Phosphorylation |
369 |
PubMed, HPRD |
| Phosphorylation |
385 |
PubMed, HPRD |
| Phosphorylation |
615 |
PubMed, HPRD |
| Phosphorylation |
640 |
PubMed, HPRD |
| Phosphorylation |
650 |
PubMed, HPRD |
| Phosphorylation |
749 |
PubMed, HPRD |
| Phosphorylation |
762 |
PubMed, HPRD |
| Phosphorylation |
964 |
PubMed, HPRD |
| Phosphorylation |
975 |
PubMed, HPRD |
| Phosphorylation |
988 |
PubMed, HPRD |
| Phosphorylation |
997 |
PubMed, HPRD |
| Phosphorylation |
1009 |
PubMed, HPRD |
| Phosphorylation |
1041 |
PubMed, HPRD |
| Phosphoserine |
640 |
PubMed, HPRD |
| Phosphoserine |
762 |
PubMed, HPRD |
| Phosphoserine |
964 |
PubMed, HPRD |
| Phosphoserine |
975 |
PubMed, HPRD |
| Phosphoserine |
988 |
PubMed, HPRD |
| Phosphoserine |
1009 |
PubMed, HPRD |
| Phosphothreonine |
332 |
PubMed, HPRD |
| Phosphothreonine |
369 |
PubMed, HPRD |
| Phosphothreonine |
385 |
PubMed, HPRD |
| Phosphothreonine |
997 |
PubMed, HPRD |
Protein: CCNE2
|
| Localisation |
Protein: RBL1
| Localisation | Reference |
|---|
| Nucleus |
HPRD |
| Cytoplasm |
HPRD |
Protein: CCNE2
| Localisation | Reference |
|---|
| Nucleus |
HPRD |
|
| Transitive Score |
The common interactors between RBL1 and CCNE2 that are considered by the Transitive module are listed below. The Scores listed are the values used by the transitive module to calculate the final interaction Score between RBL1 andCCNE2. The values listed are therefore not the final Score value for the listed interactions. With a Score value ≥0.025 , RBL1 has 1002 interactors and CCNE2 has 86 interactors of which there are 35 common interactors.
| Common Interactor | Name of Common Interactor | Score for RBL1-Interactor (?) | Score for CCNE2-Interactor (?) |
|---|
| RB1 |
RB1: Retinoblastoma-associated protein |
0.165 |
0.027 |
| CDKN1A |
CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi |
0.165 |
0.027 |
| MAPK15 |
N/A |
0.083 |
0.027 |
| PASK |
PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase |
0.083 |
0.027 |
| MAPK4 |
MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 |
0.083 |
0.027 |
| FBXO4 |
FBXO4, FBX4: F-box only protein 4 |
0.083 |
0.027 |
| MAPK6 |
MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 |
0.083 |
0.027 |
| ICK |
ICK, KIAA0936: Serine/threonine-protein kinase ICK |
0.083 |
0.027 |
| MINK1 |
MAP4K6, MINK1, MINK: Misshapen-like kinase 1 |
0.083 |
0.027 |
| PRKAA1 |
N/A |
0.083 |
0.027 |
| MAPKAPK2 |
MAPKAPK2: MAP kinase-activated protein kinase 2 |
0.083 |
0.027 |
| ROCK1 |
ROCK1: Rho-associated protein kinase 1 |
0.083 |
0.027 |
| RIPK1 |
RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 |
0.083 |
0.027 |
| STK16 |
N/A |
0.083 |
0.027 |
| SGK2 |
SGK2: Serine/threonine-protein kinase Sgk2 |
0.083 |
0.027 |
| MAPK9 |
MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 |
0.083 |
0.027 |
| NEK3 |
NEK3: Serine/threonine-protein kinase Nek3 |
0.083 |
0.027 |
| MAP3K8 |
MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 |
0.083 |
0.027 |
| GRK1 |
GRK1, RHOK: Rhodopsin kinase precursor |
0.083 |
0.027 |
| MAP4K1 |
MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 |
0.083 |
0.027 |
| NEK1 |
NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 |
0.083 |
0.027 |
| TLK1 |
TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 |
0.083 |
0.027 |
| SRPK2 |
SRPK2: Serine/threonine-protein kinase SRPK2 |
0.083 |
0.027 |
| MAP3K5 |
MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 |
0.083 |
0.027 |
| ZAK |
MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT |
0.083 |
0.027 |
| PKN1 |
PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 |
0.083 |
0.027 |
| CDKL5 |
N/A |
0.083 |
0.027 |
| GSK3A |
GSK3A: Glycogen synthase kinase-3 alpha |
0.075 |
11.50 |
| CDK2 |
CDK2: Cell division protein kinase 2 |
0.075 |
11.50 |
| RELA |
RELA, NFKB3: Transcription factor p65 |
0.075 |
0.642 |
| CCNF |
CCNF: G2/mitotic-specific cyclin-F |
0.027 |
0.027 |
| RCBTB1 |
CLLD7, RCBTB1, E4.5: RCC1 and BTB domain-containing protein 1 |
0.027 |
0.027 |
| RCBTB2 |
RCBTB2, CHC1L, RLG: RCC1 and BTB domain-containing protein 2 |
0.027 |
0.027 |
| CDC25B |
CDC25B, CDC25HU2: M-phase inducer phosphatase 2 |
0.027 |
0.027 |
| FBXO24 |
N/A |
0.027 |
0.027 |
|
0.299 |
| Total Score |
|
1.37E3 |
