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Evidence of Interaction Between RBL1 and CCND2

The interaction score between RBL1 and CCND2 is 1.37E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismRBL1 OrthologueCCND2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00304028 0.4 IPI00025817 0.503
  • Y2H

Get References From PubMed
worm O01682 0.4 Q9U2M5 1
fly Q24472 1 Q24158 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in RBL1 and CCND2:
Domains in RBL1Domains in CCND2
IPR002719 Retinoblastoma-associated protein, B-box
IPR002720 Retinoblastoma-associated protein, A-box
IPR006670 Cyclin
IPR011028 Cyclin-like
IPR006670 Cyclin
IPR006671 Cyclin, N-terminal
IPR004367 Cyclin, C-terminal
IPR013763 Cyclin-related

The Chi square scores for co-occurrence of domains that are present in RBL1 and CCND2 are listed below.

Domain 1Domain 2Chi Square
IPR002719 Retinoblastoma-associated protein, B-box IPR004367 Cyclin, C-terminal 55.1463
IPR002720 Retinoblastoma-associated protein, A-box IPR004367 Cyclin, C-terminal 55.1463
IPR002719 Retinoblastoma-associated protein, B-box IPR006671 Cyclin, N-terminal 52.0127
IPR002720 Retinoblastoma-associated protein, A-box IPR006671 Cyclin, N-terminal 52.0127
IPR002719 Retinoblastoma-associated protein, B-box IPR006670 Cyclin 33.4354
IPR002720 Retinoblastoma-associated protein, A-box IPR006670 Cyclin 33.4354
IPR006670 Cyclin IPR004367 Cyclin, C-terminal 14.1195
IPR006670 Cyclin IPR006671 Cyclin, N-terminal 12.1572
IPR002719 Retinoblastoma-associated protein, B-box IPR011028 Cyclin-like 9.40312
IPR002720 Retinoblastoma-associated protein, A-box IPR011028 Cyclin-like 9.40312
IPR002719 Retinoblastoma-associated protein, B-box IPR013763 Cyclin-related 9.10115
IPR002720 Retinoblastoma-associated protein, A-box IPR013763 Cyclin-related 9.10115
IPR006670 Cyclin IPR006670 Cyclin 5.24887
IPR006670 Cyclin IPR011028 Cyclin-like 3.61869
IPR006670 Cyclin IPR013763 Cyclin-related 3.42244

The background colour of the table refers to:

  • Blue Domain is only present in RBL1
  • Yellow Domain is only present in CCND2
  • Green Domain is present in both RBL1 and CCND2

 0.027
Post-translational Modifications

Protein: RBL1

PTMResidueReference
Phosphorylation 332 PubMed, HPRD
Phosphorylation 340 PubMed, HPRD
Phosphorylation 369 PubMed, HPRD
Phosphorylation 385 PubMed, HPRD
Phosphorylation 615 PubMed, HPRD
Phosphorylation 640 PubMed, HPRD
Phosphorylation 650 PubMed, HPRD
Phosphorylation 749 PubMed, HPRD
Phosphorylation 762 PubMed, HPRD
Phosphorylation 964 PubMed, HPRD
Phosphorylation 975 PubMed, HPRD
Phosphorylation 988 PubMed, HPRD
Phosphorylation 997 PubMed, HPRD
Phosphorylation 1009 PubMed, HPRD
Phosphorylation 1041 PubMed, HPRD
Phosphoserine 640 PubMed, HPRD
Phosphoserine 762 PubMed, HPRD
Phosphoserine 964 PubMed, HPRD
Phosphoserine 975 PubMed, HPRD
Phosphoserine 988 PubMed, HPRD
Phosphoserine 1009 PubMed, HPRD
Phosphothreonine 332 PubMed, HPRD
Phosphothreonine 369 PubMed, HPRD
Phosphothreonine 385 PubMed, HPRD
Phosphothreonine 997 PubMed, HPRD

Protein: CCND2

PTMResidueReference
Localisation

Protein: RBL1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: CCND2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between RBL1 and CCND2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RBL1 andCCND2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RBL1 has 1002 interactors and CCND2 has 177 interactors of which there are 109 common interactors.

Common InteractorName of Common InteractorScore for RBL1-Interactor (?)Score for CCND2-Interactor (?)
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 11.50 0.044
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.165 0.027
RB1 RB1: Retinoblastoma-associated protein 0.165 0.041
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.165 0.027
GTF2F2 N/A 0.165 0.0308
ELF1 ELF1: ETS-related transcription factor Elf-1 0.165 0.050
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.165 0.041
IRF3 IRF3: Interferon regulatory factor 3 0.165 0.050
ERF ERF: ETS domain-containing transcription factor ERF 0.165 0.0308
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.165 0.027
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.148 0.060
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.148 0.036
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.148 0.044
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.148 0.028
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.148 0.036
ETS1 ETS1, EWSR2: Protein C-ets-1 0.148 0.036
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.148 0.044
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.148 0.028
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.148 0.036
CCNH CCNH: Cyclin-H 0.148 0.036
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.148 0.044
ARID3A ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein 0.148 0.028
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.148 0.036
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.148 0.028
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.148 0.028
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.148 0.028
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.148 0.036
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.148 0.028
MCM3 MCM3: DNA replication licensing factor MCM3 0.148 0.060
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.148 0.044
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.148 0.044
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.148 0.028
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.148 0.044
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.148 0.044
CCNB1 Cyclin B1 0.148 0.036
PHB2 PHB2, BAP, REA: Prohibitin-2 0.109 0.039
MAPK15 N/A 0.083 0.027
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.083 0.041
FBXO4 FBXO4, FBX4: F-box only protein 4 0.083 0.027
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.083 0.137
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.027
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.083 0.0255
ROCK1 ROCK1: Rho-associated protein kinase 1 0.083 0.041
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.083 0.0308
STK16 N/A 0.083 0.041
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.083 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.027
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.083 0.067
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.083 0.067
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.083 0.0308
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.083 0.041
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.075 0.044
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.075 0.044
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.075 0.036
CDK7 CDK7, MO15: Cell division protein kinase 7 0.075 0.060
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.075 0.036
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.075 0.036
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.075 0.074
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.075 0.028
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.075 0.028
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.060
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.075 0.044
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.075 0.044
CDK5 CDK5: Cell division protein kinase 5 0.075 0.028
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.075 0.028
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.075 0.028
CDK2 CDK2: Cell division protein kinase 2 0.075 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.036
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.075 0.028
STK10 STK10: Uncharacterized protein STK10 0.075 0.036
CDK4 CDK4: Cell division protein kinase 4 0.075 28.90
RPS6KB1 N/A 0.075 0.060
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.075 0.028
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.075 0.036
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.075 0.028
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.075 0.028
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.075 0.036
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.044
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.075 0.044
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.075 0.028
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.075 0.028
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.075 0.060
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.075 0.028
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.075 0.028
CUL2 CUL2: Cullin-2 0.050 0.060
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.044 0.029
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.044 0.035
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.044 0.029
IRF7 IRF7: Interferon regulatory factor 7 0.027 0.027
CCNF CCNF: G2/mitotic-specific cyclin-F 0.027 0.0308
HILS1 HILS1: Spermatid-specific linker histone H1-like protein 0.027 0.027
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.027 0.067
SPIC SPIC: Transcription factor Spi-C 0.027 0.027
HSFY1 HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked 0.027 0.027
ELF4 ELF4, ELFR, MEF: ETS-related transcription factor Elf-4 0.027 0.050
FOXQ1 FOXQ1, HFH1: Forkhead box protein Q1 0.027 0.027
IRF4 IRF4, MUM1: Interferon regulatory factor 4 0.027 0.067
C20orf116 C20orf116: Uncharacterized protein C20orf116 precursor 0.027 0.027
ARID1B ARID1B, DAN15, KIAA1235, OSA2: AT-rich interactive domain-containing protein 1B 0.027 0.027
RNF31 ISGF3G, IRF9: Transcriptional regulator ISGF3 subunit gamma 0.027 0.041
JARID2 JARID2, JMJ: Protein Jumonji 0.027 0.041
IRF2 IRF2: Interferon regulatory factor 2 0.027 0.041
IRF5 IRF5: Interferon regulatory factor 5 0.027 0.041
RFX5 RFX5: DNA-binding protein RFX5 0.027 0.050
CDC25B CDC25B, CDC25HU2: M-phase inducer phosphatase 2 0.027 0.027
IRF1 IRF1: Interferon regulatory factor 1 0.027 0.0308
PAX3 PAX3, HUP2: Paired box protein Pax-3 0.027 0.027
FBXO24 N/A 0.027 0.027
0.299
Total Score 1.37E3