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Evidence of Interaction Between RAD21 and CSPG6

The interaction score between RAD21 and CSPG6 is 2.90E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RAD21 and CSPG6 = 0.85

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismRAD21 OrthologueCSPG6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL003W 1 YJL074C 1
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS
  • AffinityCaptureWestern
  • CoLocalization

Get References From PubMed
worm Q21306 1 Q9U2C1 1
fly O96689 1 Q24098 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains No domains were used in calculating likelihood of interaction 4.85E-3
Post-translational Modifications

Protein: RAD21

PTMResidueReference
Proteolytic Cleavage 279 PubMed, HPRD

Protein: CSPG6

PTMResidueReference
Phosphorylation 1065 PubMed, HPRD
Phosphorylation 1067 PubMed, HPRD
Phosphorylation 1074 PubMed, HPRD
Phosphorylation 1083 PubMed, HPRD
Phosphoserine 1065 HPRD
Phosphoserine 1067 HPRD
Phosphoserine 1074 HPRD
Phosphoserine 1083 HPRD
Localisation

Protein: RAD21

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: CSPG6

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between RAD21 and CSPG6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RAD21 andCSPG6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RAD21 has 95 interactors and CSPG6 has 993 interactors of which there are 67 common interactors.

Common InteractorName of Common InteractorScore for RAD21-Interactor (?)Score for CSPG6-Interactor (?)
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 12.60 431.00
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 1.15 6.64
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 1.15 6.64
SMARCA4 SMARCA4: SMARCA4 isoform 2 0.593 0.593
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.430 0.046
NIPBL N/A 0.218 19.80
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.138 0.082
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.133 0.804
SMC1L2 SMC1B, SMC1L2: Structural maintenance of chromosomes protein 1B 0.119 1.27
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.078 0.047
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.053 0.923
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.053 0.053
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.0479 0.276
CBX3 CBX3: Chromobox protein homolog 3 0.0479 0.827
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.0479 0.827
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 0.0479 0.129
NUP153 N/A 0.0479 0.827
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.0479 0.129
XPO1 XPO1, CRM1: Exportin-1 0.0479 128.00
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.0479 0.276
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0479 0.0479
HDAC3 HDAC3: Histone deacetylase 3 0.0479 0.276
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.0479 0.141
HNRPK N/A 0.0479 0.141
SLBP SLBP, HBP: Histone RNA hairpin-binding protein 0.0479 0.0479
MCM3 MCM3: DNA replication licensing factor MCM3 0.0479 0.276
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.0479 0.276
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.0479 0.276
PCNA PCNA: Proliferating cell nuclear antigen 0.0479 0.129
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.0479 0.276
GGCX GGCX, GC: Vitamin K-dependent gamma-carboxylase 0.039 0.046
CEP57 CEP57, KIAA0092, TSP57: Centrosomal protein of 57 kDa 0.027 0.082
SERBP1 N/A 0.027 0.027
HNRPD N/A 0.027 0.027
SMC4L1 N/A 0.027 0.027
BUB3 N/A 0.027 0.027
TMPO N/A 0.027 0.027
CTA-126B4.3 CGI-96: Gastric cancer antigen Zg14 0.027 0.027
LOC642558 N/A 0.027 0.049
NBN NBN, NBS, NBS1, P95: Nibrin 0.025 1.81
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.025 0.087
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.025 0.0446
KIAA0157 KIAA0157: Uncharacterized protein KIAA0157 0.025 0.025
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.025 0.308
DNMT1 DNMT1, AIM, DNMT: DNA 0.025 0.087
RB1 RB1: Retinoblastoma-associated protein 0.025 0.144
CENPA CENPA: Histone H3-like centromeric protein A 0.025 0.087
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.025 0.144
GMNN GMNN: Geminin 0.025 0.025
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.025 0.144
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.025 0.025
TCOF1 N/A 0.025 0.087
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.025 0.087
ABCF1 N/A 0.025 0.144
DDX21 DDX21: Nucleolar RNA helicase 2 0.025 0.308
C11orf58 SMAP, C11orf58: Small acidic protein 0.025 0.053
PTMA N/A 0.025 0.308
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.025 0.0446
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.025 0.144
MATR3 MATR3, KIAA0723: Matrin-3 0.025 0.144
ESPL1 N/A 0.025 0.087
GTSE1 GTSE1: G2 and S phase-expressed protein 1 0.025 0.025
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.025 0.144
MKI67 MKI67: Antigen KI-67 0.025 0.087
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.025 0.430
RBM14 RBM14, SIP: RNA-binding protein 14 0.025 0.144
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.025 0.308
0.572
Total Score 2.90E3