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Evidence of Interaction Between CAV1 and ZAP70

The interaction score between CAV1 and ZAP70 is 6.25.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CAV1 and ZAP70 = -0.12

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.48E-3
Orthology
OrganismCAV1 OrthologueZAP70 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00010107 0.434 IPI00018597 0.402

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in CAV1 and ZAP70:
Domains in CAV1Domains in ZAP70
IPR001612 Caveolin
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR000980 SH2 motif
IPR012234 TyrPK_SYK.

The Chi square scores for co-occurrence of domains that are present in CAV1 and ZAP70 are listed below.

Domain 1Domain 2Chi Square
IPR001612 Caveolin IPR008266 Tyrosine protein kinase, active site 6.42878
IPR001612 Caveolin IPR001245 Tyrosine protein kinase 3.04421
IPR001612 Caveolin IPR011009 Protein kinase-like 1.50165
IPR001612 Caveolin IPR000719 Protein kinase 1.49972
IPR001612 Caveolin IPR000980 SH2 motif 0.243497

The background colour of the table refers to:

  • Blue Domain is only present in CAV1
  • Yellow Domain is only present in ZAP70
  • Green Domain is present in both CAV1 and ZAP70

 0.051
Post-translational Modifications

Protein: CAV1

PTMResidueReference
N-acetylalanine 32 PubMed, HPRD
N-acetylserine 1 PubMed, HPRD
Palmitoylation 156 PubMed, HPRD
Phosphorylation 6 PubMed, HPRD
Phosphorylation 14 PubMed, HPRD
Phosphorylation 80 PubMed, HPRD
Phosphorylation 88 PubMed, HPRD
Phosphorylation 168 PubMed, HPRD
Phosphoserine 36 HPRD
Phosphotyrosine 13 HPRD

Protein: ZAP70

PTMResidueReference
Dephosphorylation 292 PubMed, HPRD
Phosphorylation 69 PubMed, HPRD
Phosphorylation 126 PubMed, HPRD
Phosphorylation 178 PubMed, HPRD
Phosphorylation 289 PubMed, HPRD
Phosphorylation 292 PubMed, HPRD
Phosphorylation 293 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 319 PubMed, HPRD
Phosphorylation 474 PubMed, HPRD
Phosphorylation 492 PubMed, HPRD
Phosphorylation 493 PubMed, HPRD
Phosphorylation 494 PubMed, HPRD
Phosphoserine 289 HPRD
Phosphotyrosine 248 HPRD
Phosphotyrosine 292 HPRD
Phosphotyrosine 315 HPRD
Phosphotyrosine 319 HPRD
Phosphotyrosine 492 PubMed, HPRD
Phosphotyrosine 493 HPRD
Localisation

Protein: CAV1

LocalisationReference
Golgi HPRD
Peroxisome HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: ZAP70

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CAV1 and ZAP70 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CAV1 andZAP70. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CAV1 has 125 interactors and ZAP70 has 1506 interactors of which there are 111 common interactors.

Common InteractorName of Common InteractorScore for CAV1-Interactor (?)Score for ZAP70-Interactor (?)
MET MET: Hepatocyte growth factor receptor precursor 0.129 0.581
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.116 0.520
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.086 0.975
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.086 0.520
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.086 0.520
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.0782 0.975
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.070 0.655
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.070 0.655
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.061 0.037
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.061 0.037
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.059 0.859
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.059 0.581
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.059 0.030
IRS1 IRS1: Insulin receptor substrate 1 0.055 0.098
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.055 0.644
CAV2 CAV2: Caveolin-2 0.053 0.030
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.053 0.581
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.053 0.655
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.053 0.520
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.053 0.225
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.051 0.980
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.051 1.30
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.051 1.17
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.051 0.980
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.051 0.878
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.051 0.980
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.051 1.30
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.049 0.058
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.0479 0.028
GJA5 GJA5: Gap junction alpha-5 protein 0.047 0.030
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.047 0.039
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.046 0.878
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.046 563.00
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.046 1.17
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.046 0.878
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.046 0.484
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.046 0.036
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.046 0.878
FLT4 VEGFR3 long form 0.046 0.553
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.553
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.042 375.00
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.042 0.520
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.042 0.586
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.042 0.090
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.042 0.655
LIMK2 LIMK2: LIM domain kinase 2 0.0407 0.123
CTTN CTTN, EMS1: Src substrate cortactin 0.0407 0.110
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.0407 0.041
PHB2 PHB2, BAP, REA: Prohibitin-2 0.038 0.048
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.038 0.152
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.038 0.859
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.036 0.037
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.036 0.058
INSR INSR: Insulin receptor precursor 0.034 0.520
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.034 0.586
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.034 0.655
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.034 0.577
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.034 0.770
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.034 0.874
JAK1 0.0338 12.80
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.0338 0.654
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.0338 1.50
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.0338 12.80
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.0338 0.859
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.033 0.041
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.033 0.072
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.029
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.033 0.045
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.033 0.041
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.031 0.225
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.030 14.30
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.030 2.17
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.030 0.586
SYK SYK: Tyrosine-protein kinase SYK 0.030 1.07
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.0338
BMX N/A 0.030 0.775
ALK ALK: ALK tyrosine kinase receptor precursor 0.030 0.318
HCK N/A 0.030 0.874
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.030 0.694
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.030 0.520
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.030 0.644
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.030 0.520
KIT KIT: Mast/stem cell growth factor receptor precursor 0.030 0.577
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.030 370.00
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.030 0.136
SORBS3 SORBS3, SCAM1: Vinexin 0.030 0.088
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.030 0.110
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.030 0.097
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.030 0.058
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.030 0.110
DAB2 DAB2, DOC2: Disabled homolog 2 0.030 0.097
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.029 0.087
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.0273 650.00
LYN LYN: Tyrosine-protein kinase Lyn 0.0273 1.50
CSK CSK: Tyrosine-protein kinase CSK 0.0273 2.17
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.0273 1.78
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.0273 0.655
TNC TNC, HXB: Tenascin precursor 0.027 0.058
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.026 0.030
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.026 0.030
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.0253 0.0453
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0253 0.030
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.0253 0.045
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.0253 0.065
DAPK2 DAPK2: Death-associated protein kinase 2 0.0253 0.098
F3 F3: Tissue factor precursor 0.025 0.072
ANXA2 ANXA2, ANX2, ANX2L4, CAL1H, LPC2D: Annexin A2 0.025 0.0263
0.572
Total Score 6.25