PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between CSK and SMAD3

The interaction score between CSK and SMAD3 is 3.85.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between CSK and SMAD3 = 0.55

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

6.27E-3

Orthology

Organism	CSK Orthologue		SMAD3 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00552347	0.145	IPI00019548	0.72
human	IPI00552347	0.145	IPI00019549	0.219
worm	Q9BL77	1	Q02330	0.219
fly	Q9VGK8	1	O96660	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.22E-3

Domains

Domains present in CSK and SMAD3:

Domains in CSK

Domains in SMAD3

IPR000719	Protein kinase
IPR001245	Tyrosine protein kinase
IPR008266	Tyrosine protein kinase, active site
IPR011009	Protein kinase-like
IPR001452	SH3
IPR000980	SH2 motif

IPR008984	SMAD/FHA
IPR003619	Dwarfin protein, domain A
IPR001132	Dwarfin protein
IPR013019	MAD_MH1.

The Chi square scores for co-occurrence of domains that are present in CSK and SMAD3 are listed below.

Domain 1		Domain 2		Chi Square
IPR011009	Protein kinase-like	IPR003619	Dwarfin protein, domain A	12.3099
IPR011009	Protein kinase-like	IPR001132	Dwarfin protein	12.1698
IPR011009	Protein kinase-like	IPR013019	MAD_MH1.	12.1698
IPR000719	Protein kinase	IPR003619	Dwarfin protein, domain A	6.02148
IPR000719	Protein kinase	IPR001132	Dwarfin protein	5.86622
IPR000719	Protein kinase	IPR013019	MAD_MH1.	5.86622
IPR000719	Protein kinase	IPR008984	SMAD/FHA	5.66869

The background colour of the table refers to:

Blue Domain is only present in CSK
Yellow Domain is only present in SMAD3
Green Domain is present in both CSK and SMAD3

0.014

Post-translational Modifications

Protein: CSK

PTM	Residue	Reference
Phosphorylation	184	PubMed, HPRD
Phosphorylation	304	PubMed, HPRD
Phosphorylation	364	PubMed, HPRD
Phosphotyrosine	184	HPRD
Phosphotyrosine	304	PubMed, HPRD

Protein: SMAD3

PTM	Residue	Reference
Phosphorylation	8	PubMed, HPRD
Phosphorylation	179	PubMed, HPRD
Phosphorylation	204	PubMed, HPRD
Phosphorylation	208	PubMed, HPRD
Phosphorylation	213	PubMed, HPRD
Phosphorylation	422	PubMed, HPRD
Phosphorylation	423	PubMed, HPRD
Phosphorylation	425	PubMed, HPRD

Localisation

Protein: CSK

Localisation	Reference
Plasma membrane	HPRD
Cytoplasm	HPRD

Protein: SMAD3

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between CSK and SMAD3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CSK andSMAD3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CSK has 1875 interactors and SMAD3 has 962 interactors of which there are 557 common interactors.

Common Interactor	Name of Common Interactor	Score for CSK-Interactor (?)	Score for SMAD3-Interactor (?)
STAT6	STAT6: Signal transducer and activator of transcription 6	12.80	0.032
VAV1	VAV1, VAV: Proto-oncogene vav	12.80	0.111
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	4.07	0.027
BLNK	BLNK, BASH, SLP65: B-cell linker protein	4.07	0.027
LCP2	LCP2: Lymphocyte cytosolic protein 2	3.05	0.127
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	2.73	0.087
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	2.20	0.029
STAT2	STAT2: Signal transducer and activator of transcription 2	1.81	0.0425
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	1.81	0.210
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	1.81	0.070
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	1.62	0.032
LCP1	LCP1, PLS2: Plastin-2	1.62	0.067
FNBP1	N/A	1.62	0.046
CXorf9	N/A	1.62	0.139
PLEK	PLEK, P47: Pleckstrin	1.19	0.052
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	1.07	0.118
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.964	0.046
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.878	0.025
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.852	0.052
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.763	0.046
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.763	0.038
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.763	0.063
STK10	STK10: Uncharacterized protein STK10	0.763	0.046
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.763	0.046
SNX17	SNX17, KIAA0064: Sorting nexin-17	0.763	0.032
IQGAP1	IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1	0.763	0.0818
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.763	0.046
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.763	0.139
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.763	0.046
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.763	0.038
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	0.655	0.043
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.561	0.052
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.515	0.0971
ROCK1	ROCK1: Rho-associated protein kinase 1	0.515	0.052
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.503	0.046
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.503	0.046
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.484	0.046
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.461	0.038
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.461	0.087
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.461	0.046
ARHGEF6	ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6	0.461	0.0818
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.461	0.038
TAGLN2	TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein	0.461	0.111
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.461	0.114
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.461	0.046
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.461	0.038
RPS6KB1	N/A	0.461	0.046
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.461	0.063
FUBP1	N/A	0.430	0.027
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.416	0.0425
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.416	0.0425
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.416	0.052
NCF4	NCF4, SH3PXD4: Neutrophil cytosol factor 4	0.416	0.075
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.385	0.114
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.372	0.038
ATM	ATM: Serine-protein kinase ATM	0.372	0.114
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.372	0.046
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.372	0.086
DOK1	DOK1: Docking protein 1	0.372	0.046
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.372	0.046
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.372	0.038
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.372	0.038
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.340	0.0425
TGFB1	TGFB1, TGFB: Transforming growth factor beta-1 precursor	0.318	0.076
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.307	0.052
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.307	0.026
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.307	0.032
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.307	0.032
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.307	0.032
LPXN	LPXN, LDLP: Leupaxin	0.276	0.032
EIF3S6	EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6	0.276	0.032
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.276	0.067
QARS	QARS: Glutaminyl-tRNA synthetase	0.276	0.032
KIAA1012	KIAA1012: Protein TRS85 homolog	0.276	0.063
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.275	0.038
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.275	0.038
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.275	0.029
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.275	0.038
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.275	0.038
CDK7	CDK7, MO15: Cell division protein kinase 7	0.275	0.038
CDK2	CDK2: Cell division protein kinase 2	0.275	0.029
PTPN12	PTPN12: Tyrosine-protein phosphatase non-receptor type 12	0.275	0.029
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.275	0.063
CDK4	CDK4: Cell division protein kinase 4	0.275	0.029
RAPGEF6	RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6	0.275	0.067
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.260	0.036
CFLAR	CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec	0.260	0.027
HD	HD, IT15: Huntingtin	0.260	0.061
PHB2	PHB2, BAP, REA: Prohibitin-2	0.260	0.027
IRF3	IRF3: Interferon regulatory factor 3	0.253	0.155
STK16	N/A	0.251	0.0425
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.251	0.026
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.251	0.032
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.246	0.038
SOS1	SOS1: Son of sevenless homolog 1	0.246	0.071
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.246	0.114
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.246	0.029
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.246	0.139
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.227	0.046
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.227	0.046
MAP3K11	MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11	0.225	0.038
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.225	0.029
SGK3	SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3	0.225	0.029
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.225	0.029
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.210	0.096
GAB2	N/A	0.191	0.026
PRKAA1	N/A	0.191	0.032
DUSP1	DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1	0.181	0.038
SSH1	SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1	0.181	0.046
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.181	0.038
ARHGAP12	ARHGAP12: Rho GTPase-activating protein 12	0.171	0.033
SGK	SGK, SGK1: Serine/threonine-protein kinase Sgk1	0.171	0.029
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.171	0.086
MAP2K6	MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki	0.171	0.029
PSKH1	PSKH1: Serine/threonine-protein kinase H1	0.171	0.038
CENPA	CENPA: Histone H3-like centromeric protein A	0.166	0.026
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.166	0.032
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.165	0.049
MAPKAPK5	N/A	0.165	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.165	0.083
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.165	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.165	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.165	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.165	0.028
MAP2K5	N/A	0.165	0.049
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.165	0.028
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.165	0.049
NF2	NF2, SCH: Merlin	0.165	0.028
CNN2	CNN2: Calponin-2	0.165	0.049
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.165	0.028
MAPK15	N/A	0.165	0.083
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.165	0.028
PPEF1	N/A	0.165	0.028
NCOA3	N/A	0.157	0.087
ELF1	ELF1: ETS-related transcription factor Elf-1	0.157	0.210
NBN	NBN, NBS, NBS1, P95: Nibrin	0.157	0.155
IFI16	N/A	0.157	0.070
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.152	0.152
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.152	0.062
SQSTM1	SQSTM1: Uncharacterized protein SQSTM1	0.152	0.057
ARHGEF7	N/A	0.148	6.17
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.148	0.025
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.148	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.148	0.025
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.148	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.148	0.025
SPTBN1	SPTBN1, SPTB2: Spectrin beta chain, brain 1	0.148	0.036
DGKD	DGKD, KIAA0145: Diacylglycerol kinase delta	0.148	0.044
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.148	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.148	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.148	0.025
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.148	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.148	0.025
CDC2	CDC2: Cell division control protein 2 homolog	0.148	0.025
ELMO1	N/A	0.148	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.148	0.025
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.148	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.148	0.025
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.148	0.025
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.148	0.025
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.148	0.047
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.148	0.025
ACTN4	ACTN4: Alpha-actinin-4	0.148	0.036
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.148	0.025
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.148	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.148	0.025
EEF2K	EEF2K: Elongation factor 2 kinase	0.148	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.148	0.025
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.148	0.047
FLII	FLII, FLIL: Protein flightless-1 homolog	0.146	0.032
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.146	0.046
IFI35	N/A	0.144	0.036
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.141	0.063
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.141	0.063
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.141	0.046
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.141	0.046
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.137	0.038
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.137	0.046
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.137	0.038
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.137	0.046
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.137	0.114
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.136	0.051
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.136	0.056
PRKCI	PRKCI, DXS1179E: Protein kinase C iota type	0.136	0.051
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.136	0.035
DNMBP	DNMBP, KIAA1010: Dynamin-binding protein	0.136	0.041
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.132	0.0425
EEF2	EEF2, EF2: Elongation factor 2	0.129	0.246
KLHDC4	N/A	0.129	0.038
MAD1L1	MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1	0.129	0.032
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.129	0.038
RPL3	RPL3, OK/SW-cl.32: 60S ribosomal protein L3	0.129	0.032
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.129	0.188
RAP1B	RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor	0.129	0.181
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.129	0.063
RPS10	RPS10: 40S ribosomal protein S10	0.129	0.032
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.129	0.038
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.129	0.032
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.129	0.038
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.129	0.087
EEF1B2	EEF1B2, EEF1B, EF1B: Elongation factor 1-beta	0.129	0.032
DIAPH1	Diaphanous 1	0.129	0.038
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.129	0.086
RPL8	RPL8: 60S ribosomal protein L8	0.129	0.032
RPS3	RPS3, OK/SW-cl.26: 40S ribosomal protein S3	0.129	0.032
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.127	0.075
NFATC1	N/A	0.125	0.070
H1FX	H1FX: Histone H1x	0.124	0.096
NEK3	NEK3: Serine/threonine-protein kinase Nek3	0.123	0.026
MAPK4	MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4	0.123	0.026
GAB1	GAB1: GRB2-associated-binding protein 1	0.123	0.032
PLEKHA5	PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member	0.123	0.055
GRLF1	N/A	0.123	0.152
TGFBR2	TGFBR2: TGF-beta receptor type-2 precursor	0.113	0.114
TP53	TP53, P53: Cellular tumor antigen p53	0.112	0.087
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.111	0.139
NPM1	NPM1, NPM: Nucleophosmin	0.111	0.029
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.111	0.114
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.111	0.114
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.110	26.80
PRKG1	PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme	0.110	0.056
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.110	0.056
CNN3	CNN3: Calponin-3	0.110	0.029
NSBP1	NSBP1: Nucleosome-binding protein 1	0.109	0.028
MCF2	MCF2, DBL: Proto-oncogene DBL	0.109	0.0263
DAPK2	DAPK2: Death-associated protein kinase 2	0.109	0.026
IRS1	IRS1: Insulin receptor substrate 1	0.109	0.026
ETS2	ETS2: Protein C-ets-2	0.100	0.077
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.100	0.096
TAGLN	TAGLN, SM22, WS3-10: Transgelin	0.099	0.041
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.098	0.025
ACVR1B	ACVR1B, ACVRLK4: Activin receptor type-1B precursor	0.098	29.60
CETN1	CETN1, CEN1, CETN: Centrin-1	0.098	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.098	0.025
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.098	0.075
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.098	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.098	0.025
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.098	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.098	0.025
ACTN1	ACTN1: Alpha-actinin-1	0.097	0.041
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.093	0.208
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.091	0.052
MCM3	MCM3: DNA replication licensing factor MCM3	0.090	0.029
TGFBR1	TGFBR1: TGF-beta receptor type-1 precursor	0.090	27.30
PRKCZ	PRKCZ, PKC2: Protein kinase C zeta type	0.088	0.029
DAB1	DAB1: Disabled homolog 1	0.088	7.14
SRPR	SRPR: Uncharacterized protein SRPR	0.087	0.036
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.087	0.032
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.087	0.052
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.087	0.052
RHOA	RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor	0.087	0.274
CIITA	CIITA, MHC2TA: MHC class II transactivator	0.087	0.027
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.087	0.0425
DAPP1	N/A	0.087	0.027
ABCF1	N/A	0.087	0.0425
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.087	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.083	0.028
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.0818	0.038
CAMK2D	CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain	0.078	7.92
XPO1	XPO1, CRM1: Exportin-1	0.078	0.054
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.078	0.067
TPT1	TPT1: Translationally-controlled tumor protein	0.078	0.032
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.078	0.046
ACTG1	ACTB: Actin, cytoplasmic 1	0.078	0.032
RAP1A	RAP1A, KREV1: Ras-related protein Rap-1A precursor	0.078	0.148
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.078	0.038
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.078	0.114
AIP	AIP, XAP2: AH receptor-interacting protein	0.078	0.038
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.078	0.038
EEF1A1	EEF1A1: Elongation factor 1-alpha	0.078	0.032
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.075	0.026
PARD6A	PARD6A, PAR6A: Partitioning defective 6 homolog alpha	0.075	0.044
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.074	0.052
GNB2L1	Lung cancer oncogene 7	0.074	0.210
DDX21	DDX21: Nucleolar RNA helicase 2	0.074	0.052
SP100	N/A	0.074	0.210
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.074	0.087
PTMA	N/A	0.074	0.052
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.074	0.0425
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.074	0.052
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.074	0.127
TGIF2	TGIF2: Homeobox protein TGIF2	0.074	0.210
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.074	0.052
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.074	0.0425
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.074	0.052
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.074	0.127
TP73	TP73, P73: Tumor protein p73	0.072	0.055
MVP	MVP, LRP: Major vault protein	0.070	0.027
LIMS1	N/A	0.070	0.027
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.070	0.032
CHUK	N/A	0.070	0.032
MPG	N/A	0.070	0.027
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.070	0.070
MARK2	N/A	0.070	0.052
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.070	0.0425
TRRAP	N/A	0.070	0.032
JUP	JUP, CTNNG, DP3: Junction plakoglobin	0.069	19.80
EIF4G3	EIF4G3: Eukaryotic translation initiation factor 4 gamma 3	0.067	0.054
CDC20	CDC20: Cell division cycle protein 20 homolog	0.067	0.056
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.066	0.114
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.066	0.038
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.066	0.046
PPP1R8	N/A	0.066	0.114
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.066	0.046
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.066	0.046
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.066	0.087
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.066	0.087
WBSCR20A	N/A	0.066	0.046
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.066	0.071
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.066	0.046
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.066	0.139
TIAL1	TIAL1: Nucleolysin TIAR	0.066	0.038
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.066	66.70
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.066	0.038
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.066	0.046
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.066	0.038
YY1	YY1: Transcriptional repressor protein YY1	0.066	0.139
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.066	0.188
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.066	0.046
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.066	0.046
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.066	0.038
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.066	0.046
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.066	0.038
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.066	0.139
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.066	0.046
TIAM1	TIAM1: T-lymphoma invasion and metastasis-inducing protein 1	0.064	0.028
SAPS3	N/A	0.063	0.046
COPA	COPA: Coatomer subunit alpha	0.063	0.188
RAN	RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran	0.063	0.113
AGTPBP1	AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein	0.063	0.029
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.063	0.038
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.063	0.029
NRAS	NRAS, HRAS1: GTPase NRas precursor	0.063	0.148
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	0.063	0.148
GSK3B	N/A	0.063	0.038
MDN1	MDN1, KIAA0301: Midasin	0.063	0.029
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.063	0.029
COPE	COPE: Coatomer subunit epsilon	0.063	0.038
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.063	0.038
ARHGEF12	ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12	0.058	0.0277
ERF	ERF: ETS domain-containing transcription factor ERF	0.057	0.127
KIF23	N/A	0.057	0.026
NAT1	NAT1, AAC1: Arylamine N-acetyltransferase 1	0.052	0.027
API5	N/A	0.052	0.032
FLNA	FLNA, FLN, FLN1: Filamin-A	0.052	0.074
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.052	0.026
UBAP2	N/A	0.052	0.026
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.052	0.032
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.052	0.0425
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.052	0.052
HES6	HES6: Transcription cofactor HES-6	0.049	0.028
BID	BID: BH3-interacting domain death agonist	0.049	0.028
RAC2	RAC2: Ras-related C3 botulinum toxin substrate 2 precursor	0.048	0.100
UBA52	UBA52, UBCEP2: 60S ribosomal protein L40	0.048	0.030
EIF3S5	N/A	0.0479	0.116
BRPF1	BRPF1, BR140: Peregrin	0.046	0.086
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.046	0.038
SYMPK	SYMPK, SPK: Symplekin	0.046	0.054
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.046	0.038
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.046	0.029
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.046	0.029
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.046	0.069
MYB	MYB: Myb proto-oncogene protein	0.046	0.062
BCAR1	BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1	0.046	2.09
RAB32	RAB32: Ras-related protein Rab-32	0.046	0.076
BTG1	BTG1: Protein BTG1	0.045	0.086
MATR3	MATR3, KIAA0723: Matrin-3	0.0446	0.096
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.0446	0.0425
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.0446	0.127
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.0446	0.032
RBM14	RBM14, SIP: RNA-binding protein 14	0.0446	0.0425
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.0446	0.070
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.0446	0.155
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0446	0.052
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.0446	0.060
ARFGAP1	N/A	0.0446	0.052
RBM6	RBM6, DEF3: RNA-binding protein 6	0.0446	0.0425
TCOF1	N/A	0.0446	0.0425
SET	SET: Protein SET	0.0446	0.0425
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.0446	0.210
TOP2B	N/A	0.0446	0.032
SREBF2	N/A	0.0446	0.0425
DNMT1	DNMT1, AIM, DNMT: DNA	0.0446	0.032
WDR1	N/A	0.0446	0.210
KIAA0853	N/A	0.0446	0.052
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.044	0.075
CREB1	CREB1: cAMP response element-binding protein	0.044	0.075
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.044	0.025
CCNT2	CCNT2: Cyclin-T2	0.044	0.025
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.044	0.025
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.0425	0.096
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	0.041	0.069
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.04	0.028
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.04	0.028
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.040	0.038
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.040	0.046
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.040	0.046
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.040	0.038
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.040	0.114
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.040	0.038
JUND	JUND: Transcription factor jun-D	0.040	0.114
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.040	0.038
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.040	0.046
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.040	0.046
NUP153	N/A	0.040	0.029
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.040	0.038
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.040	0.029
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.040	0.038
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.040	0.046
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.040	0.139
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.040	0.114
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.040	0.046
MTA1	MTA1: Metastasis-associated protein MTA1	0.040	0.038
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.040	0.038
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	0.040	0.038
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.040	0.038
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.040	0.038
NOL1	N/A	0.040	0.038
EP300	N/A	0.040	0.038
CBX3	CBX3: Chromobox protein homolog 3	0.040	0.038
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.040	0.029
SSB	SSB: Lupus La protein	0.040	0.038
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.040	0.029
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.040	0.114
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.040	0.038
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.040	0.114
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.040	0.038
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.040	0.029
HDAC3	HDAC3: Histone deacetylase 3	0.040	0.038
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.040	0.139
SP3	SP3: Transcription factor Sp3	0.040	0.086
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.040	0.038
JUNB	JUNB: Transcription factor jun-B	0.040	0.139
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.040	0.046
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.040	0.038
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.040	0.029
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.040	0.038
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.040	0.038
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.040	0.038
EDD1	EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1	0.040	0.094
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.040	0.029
FKBP1A	FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A	0.038	0.038
UBE2E3	UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3	0.038	19.50
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.038	0.046
DYNC1LI1	DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1	0.038	0.136
SNRK	SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase	0.038	0.029
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.038	0.041
CLASP1	CLASP1, KIAA0622, MAST1: CLIP-associating protein 1	0.038	0.035
MAPRE2	MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2	0.038	0.027
TERT	TERT, EST2, TCS1, TRT: Telomerase reverse transcriptase	0.037	0.026
CDKN1A	CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi	0.037	0.0425
AKR1A1	AKR1A1, ALDR1, ALR: Alcohol dehydrogenase [NADP+]	0.037	2.68
HSPG2	HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec	0.037	0.035
BACH1	BACH1: Transcription regulator protein BACH1	0.036	0.127
RGS14	N/A	0.036	0.052
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.036	0.032
ZNF267	ZNF267: Zinc finger protein 267	0.036	0.077
ID2	ID2: DNA-binding protein inhibitor ID-2	0.036	0.032
RB1	RB1: Retinoblastoma-associated protein	0.036	0.060
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.036	0.048
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.036	0.096
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.036	0.032
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.033	0.086
ETV1	ETV1, ER81: ETS translocation variant 1	0.033	0.049
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.032	0.032
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.032	0.060
CUL4B	N/A	0.032	0.046
SRF	SRF: Serum response factor	0.032	0.139
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.032	0.086
RELA	RELA, NFKB3: Transcription factor p65	0.032	0.046
ZNF335	ZNF335: Zinc finger protein 335	0.032	0.114
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.032	0.029
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.032	0.029
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.032	0.086
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.032	0.038
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.032	0.029
CREBBP	CREBBP, CBP: CREB-binding protein	0.032	41.40
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.032	0.038
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.032	0.069
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.032	0.029
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.032	0.114
PHF10	N/A	0.032	0.038
POLA2	POLA2: DNA polymerase subunit alpha B	0.032	0.038
YEATS2	KIAA1197, YEATS2: YEATS domain-containing protein 2	0.032	0.029
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.032	0.029
EIF2S2	EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2	0.032	0.046
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.032	0.029
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.032	0.139
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.032	0.114
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.032	0.029
ETS1	ETS1, EWSR2: Protein C-ets-1	0.032	0.139
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.032	0.054
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.032	0.029
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.032	0.038
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	0.032	0.038
CUL5	CUL5, VACM1: Cullin-5	0.032	0.038
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.032	0.038
MRE11A	MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A	0.032	0.038
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.032	0.038
NUAK1	NUAK1, ARK5, KIAA0537: NUAK family SNF1-like kinase 1	0.031	1.24
KCNH2	KCNH2, ERG, ERG1, HERG, HERG1: Potassium voltage-gated channel subfamily H membe	0.030	0.030
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.030	0.025
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.030	0.025
HMGA2	HMGA2, HMGIC: High mobility group protein HMGI-C	0.029	0.026
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.029	0.056
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.029	0.038
KIAA0690	N/A	0.029	0.054
MICAL-L1	MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1	0.029	0.041
DNAJC7	DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7	0.029	0.029
CDC34	CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1	0.029	0.033
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.029	0.114
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.029	0.027
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.165
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.028	0.083
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
AXIN1		0.028	0.049
PHLDB2	N/A	0.028	0.028
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.027	0.032
MEF2A	N/A	0.027	0.096
GTF3C1	N/A	0.027	0.026
XRCC1	XRCC1: DNA-repair protein XRCC1	0.027	0.032
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.027	0.026
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.027	0.077
HIVEP1	N/A	0.027	0.127
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.027	0.0425
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.027	0.077
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.027	0.032
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.027	0.060
SMARCC2	N/A	0.027	0.032
GAS2	GAS2: Growth arrest-specific protein 2	0.026	0.030
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.062
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.025	0.025
CAMKK1	N/A	0.025	0.025
CAMK2A	N/A	0.025	0.025
RASD1	RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor	0.025	0.098
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.025
KIAA0031	EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component	0.025	0.098
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
MAP2K3	N/A	0.025	0.025
NIPBL	N/A	0.025	0.047
BCOR	N/A	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
GIT2	N/A	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.148
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
GRK6	N/A	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
PRKCB1	N/A	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.148
RAB5B	RAB5B: Ras-related protein Rab-5B	0.025	0.098
UBE2A	UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A	0.025	0.044

0.299

Total Score

3.85