PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between FXR2 and MAPK1

The interaction score between FXR2 and MAPK1 is 3.45.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between FXR2 and MAPK1 = 0.24

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3

Orthology

Organism	FXR2 Orthologue		MAPK1 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
fly	Q9NFU0	1	P40417	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.22E-3

Domains

Domains present in FXR2 and MAPK1:

Domains in FXR2

Domains in MAPK1

IPR008994	Nucleic acid-binding OB-fold
IPR004087	KH
IPR008395	Agenet
IPR004088	KH, type 1

IPR000719	Protein kinase
IPR002290	Serine/threonine protein kinase
IPR011009	Protein kinase-like
IPR008271	Serine/threonine protein kinase, active site
IPR003527	MAP kinase
IPR008349	ERK1/2 MAP kinase

The Chi square scores for co-occurrence of domains that are present in FXR2 and MAPK1 are listed below.

Domain 1		Domain 2		Chi Square
IPR008994	Nucleic acid-binding OB-fold	IPR000719	Protein kinase	8.03577
IPR008994	Nucleic acid-binding OB-fold	IPR011009	Protein kinase-like	3.26757
IPR008994	Nucleic acid-binding OB-fold	IPR008271	Serine/threonine protein kinase, active site	1.487
IPR004087	KH	IPR000719	Protein kinase	0.0439971
IPR004087	KH	IPR011009	Protein kinase-like	0.0380864
IPR004088	KH, type 1	IPR000719	Protein kinase	0.0239433
IPR004088	KH, type 1	IPR011009	Protein kinase-like	0.0157401

The background colour of the table refers to:

Blue Domain is only present in FXR2
Yellow Domain is only present in MAPK1
Green Domain is present in both FXR2 and MAPK1

0.028

Post-translational Modifications

Protein: FXR2

PTM	Residue	Reference
Phosphorylation	601	PubMed, HPRD
Phosphorylation	603	PubMed, HPRD
Phosphotyrosine	519	HPRD

Protein: MAPK1

PTM	Residue	Reference
Acetylation	2	PubMed, HPRD
Dephosphorylation	187	PubMed, HPRD
N-acetylalanine	1	HPRD
Phosphorylation	29	PubMed, HPRD
Phosphorylation	41	PubMed, HPRD
Phosphorylation	181	PubMed, HPRD
Phosphorylation	185	PubMed, HPRD
Phosphorylation	187	PubMed, HPRD
Phosphorylation	202	PubMed, HPRD
Phosphothreonine	184	PubMed, HPRD
Phosphotyrosine	186	HPRD

Localisation

Protein: FXR2

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD
Ribosome	HPRD

Protein: MAPK1

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD
Cytoskeleton	HPRD

Transitive Score

The common interactors between FXR2 and MAPK1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FXR2 andMAPK1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FXR2 has 695 interactors and MAPK1 has 1694 interactors of which there are 559 common interactors.

Common Interactor	Name of Common Interactor	Score for FXR2-Interactor (?)	Score for MAPK1-Interactor (?)
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	127.00	0.038
SPTAN1	N/A	0.210	0.062
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.171	0.038
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.166	0.052
HNRPK	HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K	0.165	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.165	0.028
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.148	0.063
G3BP2	G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2	0.148	0.025
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.148	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.148	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.148	0.025
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.144	0.344
MAPK8IP1	MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1	0.139	0.097
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.136	0.046
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.136	0.118
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.136	0.063
MDN1	MDN1, KIAA0301: Midasin	0.136	0.038
MATR3	MATR3, KIAA0723: Matrin-3	0.126	0.087
FUBP1	N/A	0.123	0.052
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.123	0.026
SRPR	SRPR: Uncharacterized protein SRPR	0.123	0.052
MAP3K10	MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10	0.114	0.044
WWOX	WWOX, FOR, WOX1: WW domain-containing oxidoreductase	0.114	0.029
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.113	0.063
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.113	0.063
HTATSF1	HTATSF1: HIV Tat-specific factor 1	0.113	0.038
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.113	0.046
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.113	0.063
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.113	0.129
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.113	0.046
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.113	0.029
PCBP2	PCBP2: Poly(rC)-binding protein 2	0.110	0.046
PRKG1	PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme	0.110	0.069
PCBP1	PCBP1: Poly(rC)-binding protein 1	0.110	0.063
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.110	0.123
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.109	0.028
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.109	0.028
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.109	0.028
RBM14	RBM14, SIP: RNA-binding protein 14	0.100	0.052
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.100	0.0425
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.100	0.052
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.100	0.052
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.098	0.025
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.098	0.025
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.098	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.098	0.025
ABCC1	ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1	0.098	0.044
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.098	0.025
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.098	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.098	0.025
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.098	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.098	0.025
RAPGEF6	RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6	0.097	0.139
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.097	0.038
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.097	0.038
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.0971	0.026
CTTN	CTTN, EMS1: Src substrate cortactin	0.096	0.044
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.090	0.038
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.090	0.046
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.090	0.114
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.090	0.046
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.090	0.038
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.090	0.063
EIF2S2	EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2	0.090	0.038
SSB	SSB: Lupus La protein	0.090	0.046
PCTK1	PCTK1: Serine/threonine-protein kinase PCTAIRE-1	0.087	0.056
CASKIN2	CASKIN2, KIAA1139: Caskin-2	0.086	0.044
RIN1	RIN1: Ras and Rab interactor 1	0.086	0.171
CRKL	CRKL: Crk-like protein	0.086	0.461
STAM	STAM, STAM1: Signal transducing adapter molecule 1	0.086	0.114
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.086	0.137
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.086	0.137
ABL2	ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2	0.083	0.165
PTPN6	PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6	0.083	0.165
TRIM39	TRIM39, RNF23, TFP: Tripartite motif-containing protein 39	0.083	0.028
ITSN1	ITSN1, ITSN, SH3D1A: Intersectin-1	0.083	0.165
MATK	MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase	0.083	0.165
SLA2	SLA2, C20orf156, SLAP2: Src-like-adapter 2	0.083	0.165
LNK	SH2B3, LNK: SH2B adapter protein 3	0.083	0.165
STAT3		0.083	0.148
ABI1	ABI1, SSH3BP1: Abl interactor 1	0.083	0.083
AMPH	AMPH, AMPH1: Amphiphysin	0.083	0.083
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.0818	0.046
PPARGC1A	PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1: Peroxisome proliferator-activated receptor	0.081	0.026
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.081	0.070
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.081	0.070
RBM6	RBM6, DEF3: RNA-binding protein 6	0.081	0.032
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.077	0.077
PLEKHA5	PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member	0.077	0.109
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	0.077	0.152
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	0.075	0.148
RASA1	RASA1, RASA: Ras GTPase-activating protein 1	0.075	0.148
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.075	0.075
SPAST	SPAST, KIAA1083, SPG4: Spastin	0.075	0.025
BAIAP2	BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2	0.075	0.075
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.075	0.148
SH3KBP1	SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1	0.075	0.075
BIN1	BIN1, AMPHL: Myc box-dependent-interacting protein 1	0.075	0.075
ITSN2	ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2	0.075	0.148
NEDD9	NEDD9, CASL: Enhancer of filamentation 1	0.075	0.075
GRB2	GRB2, ASH: Growth factor receptor-bound protein 2	0.075	0.148
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.073	0.046
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.073	0.063
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.073	0.063
RBM7		0.073	0.029
MCM3	MCM3: DNA replication licensing factor MCM3	0.073	0.071
TIAL1	TIAL1: Nucleolysin TIAR	0.073	0.063
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.073	0.029
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.073	0.063
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.073	0.038
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.073	0.029
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.073	0.063
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.073	0.046
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.073	0.046
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.073	0.063
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.073	0.078
PTK2	PTK2, FAK, FAK1: Focal adhesion kinase 1	0.071	0.056
PEA15	PEA15: Astrocytic phosphoprotein PEA-15	0.070	0.062
PDE4A	N/A	0.070	0.0425
SNCB	SNCB: Beta-synuclein	0.070	0.152
PIK3R2	PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta	0.069	0.099
CSK	CSK: Tyrosine-protein kinase CSK	0.069	0.372
FNBP1	N/A	0.069	0.188
APS	SH2B2, APS: SH2B adapter protein 2	0.069	0.110
NCK2	NCK2: Cytoplasmic protein NCK2	0.069	0.171
ABCB9	ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor	0.0688	0.030
ELK1	ELK1: ETS domain-containing protein Elk-1	0.067	0.110
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.065	0.032
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.064	0.043
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.064	0.046
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.064	0.063
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.064	0.054
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.064	0.043
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.064	0.046
CKAP1	TBCB, CG22, CKAP1: Tubulin folding cofactor B	0.063	0.063
CALM2	CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca	0.063	0.063
PRKCZ	PRKCZ, PKC2: Protein kinase C zeta type	0.063	0.136
DPYSL2	DPYSL2, CRMP2: Dihydropyrimidinase-related protein 2	0.063	0.029
STUB1	STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1	0.063	0.038
AHCYL1	AHCYL1, DCAL, XPVKONA: Putative adenosylhomocysteinase 2	0.063	0.029
PITPNM1	PITPNM1: Uncharacterized protein PITPNM1	0.063	0.086
CDK5	CDK5: Cell division protein kinase 5	0.063	0.114
IQSEC1	IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein	0.063	0.372
BLNK	BLNK, BASH, SLP65: B-cell linker protein	0.062	0.191
LYN	LYN: Tyrosine-protein kinase Lyn	0.062	0.372
SOCS3	SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3	0.062	0.123
SH2D2A	SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A	0.062	0.307
NCF4	NCF4, SH3PXD4: Neutrophil cytosol factor 4	0.062	0.251
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.062	0.077
PLCG1	PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1	0.062	0.152
BMX	N/A	0.062	0.110
PTK6	PTK6, BRK: Tyrosine-protein kinase 6	0.062	0.098
INSL3	JAK3: Tyrosine-protein kinase JAK3	0.062	0.110
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	0.062	0.152
NCF1	Neutrophil cytosolic factor 1 variant (Fragment)	0.062	0.096
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.057	0.032
ETV1	ETV1, ER81: ETS translocation variant 1	0.057	0.098
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.057	0.052
FRK	FRK, PTK5, RAK: Tyrosine-protein kinase FRK	0.056	0.110
CXorf9	N/A	0.056	0.188
MAP3K11	MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11	0.056	0.069
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.056	0.233
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.056	0.275
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.056	0.188
VAV1	VAV1, VAV: Proto-oncogene vav	0.056	0.461
FER	FER, TYK3: Proto-oncogene tyrosine-protein kinase FER	0.056	0.097
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.056	0.461
SYK	SYK: Tyrosine-protein kinase SYK	0.056	0.275
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	0.056	0.372
HCLS1	HCLS1, HS1: Hematopoietic lineage cell-specific protein	0.056	0.233
TEC	TEC, PSCTK4: Tyrosine-protein kinase Tec	0.056	0.088
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.056	0.171
JAK1		0.056	0.461
ARHGAP12	ARHGAP12: Rho GTPase-activating protein 12	0.056	0.171
IQGAP1	IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1	0.056	0.385
SORBS3	SORBS3, SCAM1: Vinexin	0.056	0.049
ARHGEF6	ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6	0.056	0.372
SPTA1	SPTA1, SPTA: Spectrin alpha chain, erythrocyte	0.055	0.077
YES1	YES1, YES: Proto-oncogene tyrosine-protein kinase Yes	0.055	0.110
LCK	LCK: Proto-oncogene tyrosine-protein kinase LCK	0.055	0.251
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	0.055	0.416
SLA	SLA, SLAP, SLAP1: SRC-like-adapter	0.055	0.307
PSTPIP1	PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1	0.055	0.260
CDK5R1	CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor	0.054	0.086
SIPA1L1	SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein	0.052	0.114
COBL	N/A	0.052	0.062
VSNL1	VSNL1, VISL1: Visinin-like protein 1	0.052	0.026
YWHAH	YWHAH, YWHA1: 14-3-3 protein eta	0.052	0.032
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.051	0.046
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.051	0.046
POLR2A	POLR2A: Uncharacterized protein POLR2A	0.051	0.029
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.049	0.028
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.049	0.052
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.049	0.165
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.049	0.028
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.049	0.052
C20orf18	N/A	0.049	0.028
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.049	0.225
HCK	N/A	0.049	0.275
JAK2	JAK2: Tyrosine-protein kinase JAK2	0.049	0.372
ZAP70	ZAP70: Uncharacterized protein ZAP70	0.049	0.372
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.049	0.029
GRAP2	GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2	0.049	0.225
CD2AP	CD2AP: CD2-associated protein	0.049	0.139
NCK1	NCK1, NCK: Cytoplasmic protein NCK1	0.049	0.372
DNMBP	DNMBP, KIAA1010: Dynamin-binding protein	0.049	0.044
STAT6	STAT6: Signal transducer and activator of transcription 6	0.049	0.372
TXK	TXK, PTK4: Tyrosine-protein kinase TXK	0.049	0.275
STAM2	STAM2: Signal transducing adapter molecule 2	0.049	0.056
PTK2B	PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta	0.047	0.075
MAP2K4	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k	0.046	0.139
DLG1	N/A	0.046	0.046
TSC1	TSC1, KIAA0243, TSC: Hamartin	0.046	0.038
CLASP1	CLASP1, KIAA0622, MAST1: CLIP-associating protein 1	0.046	0.046
BRAF	BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase	0.046	0.275
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.046	0.029
GPI	GPI: Glucose-6-phosphate isomerase	0.046	0.029
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.046	153.00
PPP2CB	PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	0.046	0.029
EPB41L3	EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3	0.046	0.136
MAPRE2	MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2	0.046	0.063
PMM1	PMM1, PMMH22: Phosphomannomutase 1	0.046	0.029
SNTA1	SNTA1, SNT1: Alpha-1-syntrophin	0.046	0.088
GMFB	GMFB: Glia maturation factor beta	0.046	0.038
ABCB1	ABCB1, MDR1, PGY1: Multidrug resistance protein 1	0.046	0.028
STAT2	STAT2: Signal transducer and activator of transcription 2	0.0453	0.191
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.0453	0.032
IRF3	IRF3: Interferon regulatory factor 3	0.0453	0.080
ERF	ERF: ETS domain-containing transcription factor ERF	0.0453	0.152
GTF2F2	N/A	0.0453	0.060
MAPK8IP3	MAPK8IP3, JIP3, KIAA1066: C-jun-amino-terminal kinase-interacting protein 3	0.0446	0.032
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.044	0.075
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.044	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.044	0.075
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.044	0.047
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.044	0.025
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.044	0.025
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.044	0.148
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.044	0.148
SUPT5H	SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5	0.044	0.054
CP110	N/A	0.0425	0.032
USP21	USP21, USP23: Ubiquitin carboxyl-terminal hydrolase 21	0.0425	0.026
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.0425	0.052
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.0425	0.096
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.0425	0.070
SNCG	SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein	0.0425	0.109
GFAP	GFAP: Glial fibrillary acidic protein	0.0425	0.039
NEFL	NEFL, NF68, NFL: Neurofilament light polypeptide	0.0425	0.048
HSPB8	HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8	0.0425	0.044
NEF3	NEFM, NEF3, NFM: Neurofilament medium polypeptide	0.0425	0.039
RGS4	RGS4: Regulator of G-protein signaling 4	0.0425	0.026
DCAMKL1	DCLK1, DCAMKL1, DCDC3A, KIAA0369: Serine/threonine-protein kinase DCLK1	0.0425	0.026
PAK6	PAK6, PAK5: Serine/threonine-protein kinase PAK 6	0.0425	0.056
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.0425	0.155
EIF5	EIF5: Eukaryotic translation initiation factor 5	0.042	0.061
CCNH	CCNH: Cyclin-H	0.041	0.225
MYCBP2	MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2	0.041	0.111
ETS1	ETS1, EWSR2: Protein C-ets-1	0.041	0.275
RFX1	RFX1: MHC class II regulatory factor RFX1	0.041	0.028
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.041	0.063
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.041	0.044
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.041	0.038
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.041	0.136
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.041	0.118
AXL	AXL, UFO: Tyrosine-protein kinase receptor UFO precursor	0.04	0.049
HPCAL1	HPCAL1, BDR1: Hippocalcin-like protein 1	0.038	0.029
BAP1	BAP1, KIAA0272, hucep-6: Ubiquitin carboxyl-terminal hydrolase BAP1	0.038	0.038
HIPK2	HIPK2: Homeodomain-interacting protein kinase 2	0.038	0.069
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.038	0.029
CFL1	CFL1, CFL: Cofilin-1	0.038	0.038
PSD	TYL: TYL protein	0.038	0.171
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.038	0.114
GSK3A	GSK3A: Glycogen synthase kinase-3 alpha	0.038	0.044
STK39	STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase	0.038	0.086
PTPN11	N/A	0.038	0.063
FKBP8	DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment)	0.038	0.029
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.038	0.114
GAPD	GAPDH, GAPD, CDABP0047, OK/SW-cl.12: Glyceraldehyde-3-phosphate dehydrogenase	0.038	0.029
EPS15	EPS15, AF1P: Epidermal growth factor receptor substrate 15	0.038	0.063
STMN1	STMN1, LAP18, OP18: Stathmin	0.038	0.136
DYNC1I2	N/A	0.038	0.038
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.038	0.114
PLCB1	PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-	0.038	0.136
ELMO2	ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2	0.038	0.461
PAK7	PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7	0.038	0.056
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.038	0.233
TRAP1	TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor	0.038	0.056
PRKCA	PRKCA, PKCA, PRKACA: Protein kinase C alpha type	0.038	0.086
MDM4	MDM4, MDMX: Mdm4 protein	0.037	0.062
DDX21	DDX21: Nucleolar RNA helicase 2	0.037	0.052
ETS2	ETS2: Protein C-ets-2	0.037	0.152
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.037	0.048
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.037	0.171
CBLC	CBLC, CBL3, RNF57: Signal transduction protein CBL-C	0.037	0.109
H1FX	H1FX: Histone H1x	0.037	0.155
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.037	0.070
ELF1	ELF1: ETS-related transcription factor Elf-1	0.037	0.416
CCNT2	CCNT2: Cyclin-T2	0.036	0.148
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.036	0.148
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.0333	0.174
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.033	0.114
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.033	0.063
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.033	0.275
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.033	0.225
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.033	0.063
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.033	0.046
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.033	0.063
CCNB1	Cyclin B1	0.033	0.136
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.033	0.078
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.033	0.046
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.033	0.139
FOXO1A	FOXO1A, FKHR: Forkhead box protein O1A	0.033	0.035
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.032	0.416
FOXL2	FOXL2: Forkhead box protein L2	0.032	0.028
STAT4	STAT4: Signal transducer and activator of transcription 4	0.032	0.225
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.032	0.060
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.032	0.052
MAPK4	MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4	0.032	0.077
HD	HD, IT15: Huntingtin	0.032	0.155
GRLF1	N/A	0.032	0.062
GAB2	N/A	0.032	0.251
MCF2	MCF2, DBL: Proto-oncogene DBL	0.032	0.109
YWHAQ	YWHAQ: 14-3-3 protein theta	0.032	0.052
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.032	0.127
SCRIB	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4	0.032	0.032
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.032	0.032
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.032	0.0425
DBN1	DBN1, D0S117E: Drebrin	0.032	0.026
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.032	0.127
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.032	0.026
SQSTM1	SQSTM1: Uncharacterized protein SQSTM1	0.032	0.123
APBA2	APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2	0.032	0.171
RB1	RB1: Retinoblastoma-associated protein	0.030	0.127
TP73	TP73, P73: Tumor protein p73	0.030	0.055
ERG	ERG: Transcriptional regulator ERG	0.029	0.123
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.029	0.078
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	0.029	0.097
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.029	0.054
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.029	0.088
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.029	0.049
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.029	0.372
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	0.029	0.049
CDC34	CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1	0.029	0.038
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.029	0.029
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.029	0.078
PREP	PREP, PEP: Prolyl endopeptidase	0.029	0.046
PSMB7	PSMB7: Proteasome subunit beta type-7 precursor	0.029	0.372
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.029	0.038
HSPH1	HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa	0.029	0.046
STMN2	STMN2, SCG10, SCGN10: Stathmin-2	0.029	0.110
CARS	CARS: Cysteinyl-tRNA synthetase, cytoplasmic	0.029	0.063
COPE	COPE: Coatomer subunit epsilon	0.029	0.046
YWHAZ	YWHAZ: 14-3-3 protein zeta/delta	0.029	0.078
EHBP1	EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1	0.029	0.029
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.029	0.275
CNKSR2	CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2	0.029	0.136
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.029	0.029
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.029	0.038
LIMK1	LIMK1, LIMK: LIM domain kinase 1	0.029	0.044
AKR7A2	AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2	0.029	0.043
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.029	3.35
SYMPK	SYMPK, SPK: Symplekin	0.029	0.029
DNAJC7	DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7	0.029	0.038
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.029	0.063
FRS3	FRS3: Fibroblast growth factor receptor substrate 3	0.029	0.110
YWHAB	YWHAB: 14-3-3 protein beta/alpha	0.029	0.078
AIP	AIP, XAP2: AH receptor-interacting protein	0.029	0.029
CAMK1	CAMK1: Calcium/calmodulin-dependent protein kinase type 1	0.029	0.069
APC	N/A	0.029	0.038
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.029	0.139
LNX1	N/A	0.028	0.028
SH2D3A	SH2D3A, NSP1, UNQ175/PRO201: SH2 domain-containing protein 3A	0.028	0.028
NLN	NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor	0.028	0.025
GOPC	GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein	0.028	0.025
MAPK15	N/A	0.028	0.083
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.083
SNCA	SNCA, NACP, PARK1: Alpha-synuclein	0.028	0.165
STAP2	Uncharacterized protein ENSP00000317912	0.028	0.028
SIVA	SIVA1, SIVA: Apoptosis regulatory protein Siva	0.028	0.028
UACA	UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats	0.028	0.028
SPAG6	SPAG6, PF16: Sperm-associated antigen 6	0.028	0.028
CACNB2	N/A	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.083
PDZD2	CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.083
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
AXIN1		0.028	0.028
KRT6E	KRT6C, KRT6E: Keratin, type II cytoskeletal 6C	0.028	0.083
EEF2K	EEF2K: Elongation factor 2 kinase	0.028	0.148
CNN2	CNN2: Calponin-2	0.028	0.075
AKAP12	AKAP12, AKAP250: A-kinase anchor protein 12	0.028	0.083
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.028	0.075
AHSA2	AHSA2, DKFZp564C236, hCG_15158: Putative uncharacterized protein DKFZp564C236	0.028	0.028
NCF4	N/A	0.028	0.028
CASP1	CASP1, IL1BC, IL1BCE: Caspase-1 precursor	0.028	0.083
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.028	0.075
PHLDB2	N/A	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.165
ABLIM1	ABLIM1, RP11-317F20.1-001: Actin binding LIM protein 1	0.028	0.028
WRNIP1	WRNIP1, WHIP: ATPase WRNIP1	0.028	0.025
RGS18	RGS18, RGS13: Regulator of G-protein signaling 18	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
SH3PX3	SH3PX3, DKFZp666B159, hCG_1731072: SH3 and PX domain-containing protein 3.	0.028	0.025
CASP8	CASP8, MCH5: Caspase-8 precursor	0.028	0.083
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.028	0.075
S100A16	S100A16, AAG13: Protein S100-A16	0.028	0.028
PKP4	PKP4: Plakophilin-4	0.028	0.028
PPEF1	N/A	0.028	0.028
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.028	0.083
CDC42	N/A	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.083
PDE5A	PDE5A, PDE5: cGMP-specific 3',5'-cyclic phosphodiesterase	0.028	0.028
MAP2K5	N/A	0.028	0.165
CDC2	CDC2: Cell division control protein 2 homolog	0.028	0.075
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
PSCD1	PSCD1, D17S811E: Cytohesin-1	0.028	0.165
CASP14	CASP14: Caspase-14 precursor	0.028	0.028
C9orf88	N/A	0.028	0.028
MATK		0.028	0.028
SLC9A3R2	SLC9A3R2: SLC9A3R2 protein (Fragment)	0.028	0.028
NASP	NASP: Nuclear autoantigenic sperm protein	0.028	0.028
DNM3	DNM3: Uncharacterized protein DNM3	0.028	0.165
RASGRP2	RASGRP2: RAS guanyl-releasing protein 2	0.028	0.075
MAPKAPK5	N/A	0.028	0.083
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.028	0.083
FASN	FASN, FAS: Fatty acid synthase	0.028	0.028
CASP9	CASP9, MCH6: Caspase-9 precursor	0.028	0.083
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.028	0.075
DNAJC13	DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13	0.028	0.028
AP1GBP1	AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1	0.028	0.025
PTPN7	N/A	0.028	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.028	0.083
PSCD2	N/A	0.028	0.165
CASP6	CASP6, MCH2: Caspase-6 precursor	0.028	0.028
YWHAG	YWHAG: 14-3-3 protein gamma	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.083
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
CAPN3	CAPN3, CANP3, CANPL3, NCL1: Calpain-3	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.083
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.028	0.028
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.027	0.208
KIT	KIT: Mast/stem cell growth factor receptor precursor	0.027	0.041
EPHA1	EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor	0.027	0.026
TP53	TP53, P53: Cellular tumor antigen p53	0.027	0.086
CSF1R	CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor	0.027	0.067
DUSP3	DUSP3, VHR: Dual specificity protein phosphatase 3	0.027	0.975
TSPYL2	TSPYL2, CDA1, HRIHFB2216, DENTT, TSPX: Testis-specific Y-encoded-like protein 2	0.027	0.077
ADAM23	ADAM23, MDC3: ADAM 23 precursor	0.027	0.032
FLT3	FLT3, STK1: FL cytokine receptor precursor	0.0263	0.041
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.026	0.233
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.026	0.127
FTH1	FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain	0.026	0.0425
CIB1	CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1	0.026	0.026
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.026	0.087
IPO7	IPO7: Uncharacterized protein IPO7	0.026	0.032
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.026	0.191
MAP2K5	N/A	0.026	0.032
MPG	N/A	0.026	0.0425
API5	N/A	0.026	0.052
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.026	0.210
EPN1	N/A	0.026	0.026
TRRAP	N/A	0.026	0.026
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.026	0.127
GSTP1	GSTP1, FAEES3, GST3: Glutathione S-transferase P	0.026	0.029
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.026	0.127
IRS2	IRS2: Insulin receptor substrate 2	0.026	0.251
UBAP2	N/A	0.026	0.032
AGTPBP1	AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein	0.026	0.078
DNM2	N/A	0.026	0.052
RHOB	RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor	0.026	0.0308
GRK1	GRK1, RHOK: Rhodopsin kinase precursor	0.026	0.055
ABCF1	N/A	0.026	0.070
PHB2	PHB2, BAP, REA: Prohibitin-2	0.026	0.026
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.026	0.052
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.026	0.155
NEFH	NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide	0.026	0.034
DES	DES: Desmin	0.026	0.031
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.026	0.052
LRRC7	LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7	0.025	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
ACTN4	ACTN4: Alpha-actinin-4	0.025	0.025
SPTBN1	SPTBN1, SPTB2: Spectrin beta chain, brain 1	0.025	0.148
COTL1	COTL1, CLP: Coactosin-like protein	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.075
MYO18A		0.025	0.025
DCP1B	DCP1B: mRNA-decapping enzyme 1B	0.025	0.025
UBE2A	UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A	0.025	0.025
TSC2	TSC2, TSC4: Tuberin	0.025	0.075
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.075
EPB41L1	EPB41L1, KIAA0338: Band 4.1-like protein 1	0.025	0.148
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.075
RAC1	N/A	0.025	0.025
GSN	GSN: Gelsolin precursor	0.025	0.025
CFL2	CFL2: Cofilin-2	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
DCTN1	DCTN1: Dynactin subunit 1	0.025	0.025
RSU1	RSU1, RSP1: Ras suppressor protein 1	0.025	0.025
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.025	62.30
CAMK4	CAMK4: Calcium/calmodulin-dependent protein kinase type IV	0.025	0.075
NIPBL	N/A	0.025	0.025
CAMKK1	N/A	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.075
SVIL	SVIL: Supervillin	0.025	0.025
GRK6	N/A	0.025	0.025
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.148
SNX3	N/A	0.025	0.075
BCR	N/A	0.025	0.025
PARD6A	PARD6A, PAR6A: Partitioning defective 6 homolog alpha	0.025	0.148
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.075
KCNAB2	KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2	0.025	0.047
HSPA8	HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein	0.025	0.025
ARHGEF7	N/A	0.025	0.148
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.075
UBE2R2	UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2	0.025	0.025
PRKCB1	N/A	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
LMO6	LMO6: LIM domain only protein 6	0.025	0.025
DBNL	N/A	0.025	0.025
CAMK2A	N/A	0.025	0.025
DPP8	DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8	0.025	0.025
RASGRP3	RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3	0.025	0.075
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.075
MAP2K3	N/A	0.025	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.025	62.30
CASP7	N/A	0.025	0.025
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.075
RAB5B	RAB5B: Ras-related protein Rab-5B	0.025	0.047
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.075
PDE4B	PDE4B, DPDE4: cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0.025	0.025
SCRIB	N/A	0.025	0.025
CHTF18	RUVBL, CHTF18: Protein CTF18 homolog.	0.025	0.025
GART	GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include	0.025	0.075
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.148
BCOR	N/A	0.025	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.148
EPN2	N/A	0.025	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.148
KCNIP3	KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.075
GIT2	N/A	0.025	0.075
KIAA0031	EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component	0.025	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.075
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
ELMO1	N/A	0.025	0.148
RAD50	RAD50: DNA repair protein RAD50	0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.075
NDNL2	NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1	0.025	0.025
EHD4	EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4	0.025	0.025
NCOA5	NCOA5, KIAA1637: Nuclear receptor coactivator 5	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
RASD1	RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor	0.025	0.025
USP16	USP16: Ubiquitin carboxyl-terminal hydrolase 16	0.025	0.025
LTA4H	LTA4H, LTA4: Leukotriene A-4 hydrolase	0.025	0.025
DGKD	DGKD, KIAA0145: Diacylglycerol kinase delta	0.025	0.148
RSN	CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1	0.025	0.025

0.299

Total Score

3.45