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Evidence of Interaction Between SNRPD3 and POLE

The interaction score between SNRPD3 and POLE is 17.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPD3 and POLE = 0.65

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismSNRPD3 OrthologuePOLE OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YLR147C 1 YNL262W 1
worm Q17348 1 O62218 1
fly O44437 1 Q95R46 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains No domains were used in calculating likelihood of interaction 0.027
Post-translational Modifications

Protein: SNRPD3

PTMResidueReference
Methylation 110 PubMed, HPRD
Methylation 112 PubMed, HPRD
Methylation 114 PubMed, HPRD
Methylation 118 PubMed, HPRD

Protein: POLE

PTMResidueReference
Localisation

Protein: SNRPD3

LocalisationReference
Nucleus HPRD
Nucleolus HPRD

Protein: POLE

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between SNRPD3 and POLE that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPD3 andPOLE. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPD3 has 1151 interactors and POLE has 87 interactors of which there are 37 common interactors.

Common InteractorName of Common InteractorScore for SNRPD3-Interactor (?)Score for POLE-Interactor (?)
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 3.41E3 0.074
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 3.41E3 0.074
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 2.07E3 0.074
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 2.07E3 0.074
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.59E3 0.074
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 691.00 0.123
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 691.00 0.074
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 323.00 0.074
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 205.00 0.074
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 12.80 0.074
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 10.30 0.074
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.137
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.137
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.036
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.308 0.083
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.276 0.038
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.276 1.10
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.276 6.05
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.137 0.041
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.129 0.108
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.129 1.82
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.129 0.060
PCNA PCNA: Proliferating cell nuclear antigen 0.129 0.123
CDK2 CDK2: Cell division protein kinase 2 0.129 0.038
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.129 0.038
MDN1 MDN1, KIAA0301: Midasin 0.078 0.060
H2AFX H2AFX, H2AX: Histone H2A.x 0.078 1.10
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.078 0.038
EXOSC4 EXOSC4, RRP41, SKI6: Exosome complex exonuclease RRP41 0.067 0.029
POLA POLA1, POLA: DNA polymerase alpha catalytic subunit 0.060 0.890
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.065
DKC1 DKC1, NOLA4: H/ACA ribonucleoprotein complex subunit 4 0.0479 3.05
XRCC5 XRCC5, G22P2: ATP-dependent DNA helicase 2 subunit 2 0.044 0.074
GAPD GAPDH, GAPD, CDABP0047, OK/SW-cl.12: Glyceraldehyde-3-phosphate dehydrogenase 0.032 0.060
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.029 0.408
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.071
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.071
0.572
Total Score 17.00