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Evidence of Interaction Between SNRPD3 and TSSC1

The interaction score between SNRPD3 and TSSC1 is 14.70.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPD3 and TSSC1 = 0.75

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismSNRPD3 OrthologueTSSC1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm Q17348 1 Q9U1Q0 1
fly O44437 1 Q9VTY5 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in SNRPD3 and TSSC1:
Domains in SNRPD3Domains in TSSC1
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat

The Chi square scores for co-occurrence of domains that are present in SNRPD3 and TSSC1 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041

The background colour of the table refers to:

  • Blue Domain is only present in SNRPD3
  • Yellow Domain is only present in TSSC1
  • Green Domain is present in both SNRPD3 and TSSC1

 0.027
Post-translational Modifications

Protein: SNRPD3

PTMResidueReference
Methylation 110 PubMed, HPRD
Methylation 112 PubMed, HPRD
Methylation 114 PubMed, HPRD
Methylation 118 PubMed, HPRD

Protein: TSSC1

PTMResidueReference
Localisation

Protein: SNRPD3

LocalisationReference
Nucleus HPRD
Nucleolus HPRD

Protein: TSSC1

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between SNRPD3 and TSSC1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPD3 andTSSC1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPD3 has 1151 interactors and TSSC1 has 67 interactors of which there are 39 common interactors.

Common InteractorName of Common InteractorScore for SNRPD3-Interactor (?)Score for TSSC1-Interactor (?)
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 3.41E3 0.074
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 3.41E3 0.123
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 2.07E3 0.074
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 2.07E3 0.123
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.59E3 0.074
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 691.00 0.074
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 691.00 0.123
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 323.00 0.074
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 205.00 0.123
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 12.80 0.074
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 10.30 0.074
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.137
SF3B3 N/A 3.89 0.074
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.137
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 1.81 0.0278
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 1.81 0.0278
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.060
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 1.10 0.038
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.881 0.0278
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.294 0.0278
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.276 0.038
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.276 0.053
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.276 0.038
DNMT1 DNMT1, AIM, DNMT: DNA 0.144 0.0255
NBN NBN, NBS, NBS1, P95: Nibrin 0.144 0.0255
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.140 0.028
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.129 0.060
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.129 0.038
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.129 0.074
CENPA CENPA: Histone H3-like centromeric protein A 0.087 0.041
CUL5 CUL5, VACM1: Cullin-5 0.078 0.074
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.078 0.060
H2AFX H2AFX, H2AX: Histone H2A.x 0.078 0.044
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 0.063 0.044
SOS1 SOS1: Son of sevenless homolog 1 0.046 0.060
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.038 0.036
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.038 0.028
TBCE TBCE: Tubulin-specific chaperone E 0.032 0.047
DGUOK N/A 0.027 0.027
0.299
Total Score 14.70