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Evidence of Interaction Between MCM5 and TFDP1

The interaction score between MCM5 and TFDP1 is 13.70.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MCM5 and TFDP1 = 0.60

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 6.27E-3
Orthology
OrganismMCM5 OrthologueTFDP1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm Q21902 1 Q22703 1
fly Q9VGW6 1 Q24318 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in MCM5 and TFDP1:
Domains in MCM5Domains in TFDP1
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008048 MCM protein 5
IPR003316 Transcription factor E2F/dimerisation partner (TDP)
IPR011991 Wing_hlx_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in MCM5 and TFDP1 are listed below.

Domain 1Domain 2Chi Square
IPR001208 MCM IPR011991 Wing_hlx_DNA_bd. 5.30628
IPR008994 Nucleic acid-binding OB-fold IPR011991 Wing_hlx_DNA_bd. 1.13582

The background colour of the table refers to:

  • Blue Domain is only present in MCM5
  • Yellow Domain is only present in TFDP1
  • Green Domain is present in both MCM5 and TFDP1

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: MCM5

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: TFDP1

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between MCM5 and TFDP1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM5 andTFDP1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM5 has 251 interactors and TFDP1 has 116 interactors of which there are 24 common interactors.

Common InteractorName of Common InteractorScore for MCM5-Interactor (?)Score for TFDP1-Interactor (?)
MCM3 MCM3: DNA replication licensing factor MCM3 209.00 0.060
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 209.00 0.123
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 69.60 0.074
MCM6 MCM6: DNA replication licensing factor MCM6 69.60 0.060
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.263 0.060
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.263 0.074
RFX5 RFX5: DNA-binding protein RFX5 0.137 0.0308
CCNF CCNF: G2/mitotic-specific cyclin-F 0.137 0.881
CCNB1 Cyclin B1 0.123 0.123
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.123 0.123
RB1 RB1: Retinoblastoma-associated protein 0.083 0.050
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.083 0.083
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.074 0.074
E2F3 E2F3, KIAA0075: Transcription factor E2F3 0.060 0.028
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.060 0.028
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.059 0.059
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.044 0.242
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.044 0.081
CCND3 CCND3: G1/S-specific cyclin-D3 0.044 0.044
H1F0 H1F0, H1FV: Histone H1.0 0.036 0.081
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.036 0.081
E2F2 E2F2: Transcription factor E2F2 0.0308 0.137
NUSAP1 NUSAP1, ANKT, BM-037, PRO0310: Nucleolar and spindle-associated protein 1 0.027 0.027
TMPO N/A 0.027 0.027
0.572
Total Score 13.70