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Evidence of Interaction Between PRG1 and ACTG1

The interaction score between PRG1 and ACTG1 is 2.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PRG1 and ACTG1 = 0.81

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between PRG1 and ACTG1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PRG1 andACTG1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PRG1 has 119 interactors and ACTG1 has 209 interactors of which there are 31 common interactors.

Common InteractorName of Common InteractorScore for PRG1-Interactor (?)Score for ACTG1-Interactor (?)
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.053 0.434
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.053 0.160
ARPC5 ARPC5, ARC16: Actin-related protein 2/3 complex subunit 5 0.053 1.31
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.053 209.00
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.053 0.051
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.053 69.60
TPP1 TPP1, CLN2, GIG1, UNQ267/PRO304: Tripeptidyl-peptidase 1 precursor 0.053 0.027
BID N/A 0.027 0.027
ITGAM ITGAM, CD11B, CR3A: Integrin alpha-M precursor 0.027 0.027
C1orf38 N/A 0.027 0.027
SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 0.027 0.090
ELF4 ELF4, ELFR, MEF: ETS-related transcription factor Elf-4 0.027 0.027
IER2 IER2, ETR101: Immediate early response gene 2 protein 0.027 0.027
C20orf24 N/A 0.027 0.027
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.025 0.081
PSCD4 PSCD4, CYT4: Cytohesin-4 0.025 0.081
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.025 0.038
ARPC4 ARPC4, ARC20: Actin-related protein 2/3 complex subunit 4 0.025 0.027
ARPC3 ARPC3, ARC21: Actin-related protein 2/3 complex subunit 3 0.025 6.52
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.025 0.789
ACTG1 ACTB: Actin, cytoplasmic 1 0.025 0.053
PLEK PLEK, P47: Pleckstrin 0.025 0.057
LCP1 LCP1, PLS2: Plastin-2 0.025 0.263
MSN MSN: Moesin 0.025 0.081
LRRFIP1 N/A 0.025 0.027
CDV3 CDV3, H41: Protein CDV3 homolog 0.025 0.0739
VAV1 VAV1, VAV: Proto-oncogene vav 0.025 0.263
STAT6 STAT6: Signal transducer and activator of transcription 6 0.025 0.081
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.025 0.0968
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.025 0.042
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.025 0.067
0.228
Total Score 2.50