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Evidence of Interaction Between BCL2L1 and BMF

The interaction score between BCL2L1 and BMF is 56.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in BCL2L1 and BMF:
Domains in BCL2L1Domains in BMF
IPR000712 Apoptosis regulator Bcl-2 protein, BH
IPR003093 Apoptosis regulator Bcl-2 protein, BH4
IPR004725 Apoptosis regulator Bcl-X protein
IPR002475 BCL2_family.
IPR012238 Bcl2_apop_reg.
IPR000712 Apoptosis regulator Bcl-2 protein, BH
IPR002475 BCL2_family.

The Chi square scores for co-occurrence of domains that are present in BCL2L1 and BMF are listed below.

Domain 1Domain 2Chi Square
IPR000712 Apoptosis regulator Bcl-2 protein, BH IPR002475 BCL2_family. 743.951
IPR000712 Apoptosis regulator Bcl-2 protein, BH IPR000712 Apoptosis regulator Bcl-2 protein, BH 692.691
IPR012238 Bcl2_apop_reg. IPR000712 Apoptosis regulator Bcl-2 protein, BH 620.677
IPR003093 Apoptosis regulator Bcl-2 protein, BH4 IPR000712 Apoptosis regulator Bcl-2 protein, BH 408.947
IPR004725 Apoptosis regulator Bcl-X protein IPR000712 Apoptosis regulator Bcl-2 protein, BH 289.862
IPR002475 BCL2_family. IPR002475 BCL2_family. 245.195
IPR012238 Bcl2_apop_reg. IPR002475 BCL2_family. 211.111
IPR003093 Apoptosis regulator Bcl-2 protein, BH4 IPR002475 BCL2_family. 103.541
IPR004725 Apoptosis regulator Bcl-X protein IPR002475 BCL2_family. 42.0488

The background colour of the table refers to:

  • Blue Domain is only present in BCL2L1
  • Yellow Domain is only present in BMF
  • Green Domain is present in both BCL2L1 and BMF

 0.617
Post-translational Modifications

Protein: BCL2L1

PTMResidueReference
Proteolytic Cleavage 42 PubMed, HPRD
Proteolytic Cleavage 61 PubMed, HPRD

Protein: BMF

PTMResidueReference
Phosphorylation 74 PubMed, HPRD
Phosphorylation 77 PubMed, HPRD
Localisation

Protein: BCL2L1

LocalisationReference
Nucleus HPRD
Mitochondrion HPRD
Cytoplasm HPRD

Protein: BMF

LocalisationReference
Mitochondrion HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between BCL2L1 and BMF that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between BCL2L1 andBMF. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , BCL2L1 has 370 interactors and BMF has 50 interactors of which there are 44 common interactors.

Common InteractorName of Common InteractorScore for BCL2L1-Interactor (?)Score for BMF-Interactor (?)
MCL1 MCL1: Induced myeloid leukemia cell differentiation protein Mcl-1 1.30 0.617
BID BID: BH3-interacting domain death agonist 1.30 0.617
BCL2 BCL2: Apoptosis regulator Bcl-2 1.30 0.617
BAD BAD, BBC6, BCL2L8: Bcl2 antagonist of cell death 0.617 0.617
BCL2L11 BCL2L11, BIM: Bcl-2-like protein 11 0.617 0.617
BCL2A1 BCL2A1, BCL2L5, BFL1, GRS, HBPA1: Bcl-2-related protein A1 0.265 0.0288
BCL2L2 BCL2L2, BCLW, KIAA0271: Apoptosis regulator Bcl-W 0.265 0.0288
BAX BAX: Apoptosis regulator BAX, membrane isoform alpha 0.265 0.0288
BOK BOK: Bcl-2-related ovarian killer protein 0.265 0.0288
BAX BAX: Apoptosis regulator BAX, cytoplasmic isoform beta 0.265 0.0288
BAX BAX: BAX protein, cytoplasmic isoform delta 0.265 0.0288
BAK1 N/A 0.265 0.0288
BCL2L13 BCL2L13, MIL1, CD003: Bcl-2-like 13 protein 0.265 0.0288
HRK HRK, BID3: Activator of apoptosis harakiri 0.265 0.0288
BIK BIK, NBK: Bcl-2-interacting killer 0.265 0.0288
BCL2L14 BCL2L14, BCLG: Apoptosis facilitator Bcl-2-like 14 protein 0.265 0.0288
RTN2 RTN2, NSPL1: Reticulon-2 0.165 0.051
VDAC1 VDAC1, VDAC: Voltage-dependent anion-selective channel protein 1 0.165 0.051
RTN1 RTN1, NSP: Reticulon-1 0.165 0.051
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0688 0.051
CASP9 CASP9, MCH6: Caspase-9 precursor 0.0688 0.051
MAPK15 N/A 0.0688 0.051
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.0688 0.051
CASP6 CASP6, MCH2: Caspase-6 precursor 0.0688 0.051
CASP14 CASP14: Caspase-14 precursor 0.0688 0.051
CASP3 CASP3, CPP32: Caspase-3 precursor 0.0688 0.051
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.0688 0.051
BAG3 BAG3, BIS: BAG family molecular chaperone regulator 3 0.0688 0.051
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.0688 0.051
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.0688 0.051
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.0688 0.051
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.0688 0.051
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.0688 0.051
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.0688 0.051
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.0688 0.051
VDAC3 VDAC3: Voltage-dependent anion-selective channel protein 3 0.056 0.051
FASN FASN, FAS: Fatty acid synthase 0.056 0.051
BAG2 BAG2: BAG family molecular chaperone regulator 2 0.051 0.051
RTN4 RTN4, KIAA0886, My043, NOGO, SP1507: Reticulon-4 0.051 0.051
BAK1 BAK1: BAK1 protein 0.0288 0.0288
BBC3 BBC3, PUMA: Bcl-2-binding component 3 0.0288 0.0288
BCL2L12 BCL2L12, BPR: Bcl-2-related proline-rich protein 0.0288 0.0288
BCL2L10 BCL2L10, BCLB: Apoptosis regulator Bcl-B 0.0288 0.0288
BCL2L7P1 DKFZp686D0345: Putative uncharacterized protein DKFZp686D0345 0.0288 0.0288
0.228
Total Score 56.20