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Evidence of Interaction Between RAF1 and NPR3

The interaction score between RAF1 and NPR3 is 3.78.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RAF1 and NPR3 = 0.20

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction 0.014
Post-translational Modifications

Protein: RAF1

PTMResidueReference
Dephosphorylation 340 PubMed, HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 43 PubMed, HPRD
Phosphorylation 233 PubMed, HPRD
Phosphorylation 259 PubMed, HPRD
Phosphorylation 268 PubMed, HPRD
Phosphorylation 269 PubMed, HPRD
Phosphorylation 289 PubMed, HPRD
Phosphorylation 296 PubMed, HPRD
Phosphorylation 301 PubMed, HPRD
Phosphorylation 338 PubMed, HPRD
Phosphorylation 339 PubMed, HPRD
Phosphorylation 340 PubMed, HPRD
Phosphorylation 341 PubMed, HPRD
Phosphorylation 491 PubMed, HPRD
Phosphorylation 494 PubMed, HPRD
Phosphorylation 499 PubMed, HPRD
Phosphorylation 621 PubMed, HPRD
Phosphorylation 642 PubMed, HPRD
Phosphoserine 43 HPRD
Phosphoserine 259 PubMed, HPRD
Phosphoserine 338 PubMed, HPRD
Phosphoserine 499 PubMed, HPRD
Phosphoserine 621 HPRD
Phosphothreonine 268 PubMed, HPRD

Protein: NPR3

PTMResidueReference
Disulfide Bridge 136 PubMed, HPRD
Disulfide Bridge 261 PubMed, HPRD
Glycosylation 86 PubMed, HPRD
Glycosylation 293 PubMed, HPRD
Glycosylation 394 PubMed, HPRD
Localisation

Protein: RAF1

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: NPR3

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between RAF1 and NPR3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RAF1 andNPR3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RAF1 has 1538 interactors and NPR3 has 228 interactors of which there are 113 common interactors.

Common InteractorName of Common InteractorScore for RAF1-Interactor (?)Score for NPR3-Interactor (?)
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 501.00 0.026
CDK2 CDK2: Cell division protein kinase 2 0.275 0.027
CDK4 CDK4: Cell division protein kinase 4 0.275 0.036
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.227 0.032
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.225 0.027
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.188 0.026
CDC23 CDC23: Cell division cycle protein 23 homolog 0.188 0.027
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.171 0.026
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.148 0.028
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.139 0.027
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.139 0.036
CTPS CTPS: CTP synthase 1 0.139 0.027
FADD FADD, MORT1: Protein FADD 0.124 0.0425
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.028
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.109 0.028
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.028
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.109 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.109 0.028
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.028
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.028
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.098 0.028
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.028
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.091 0.0425
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.087 0.027
WEE1 WEE1: Wee1-like protein kinase 0.086 0.027
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.032
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.074 0.026
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.072 0.026
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.071 0.027
GNA13 GNA13: Guanine nucleotide-binding protein alpha-13 subunit 0.067 0.026
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.067 0.026
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.026
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.064 0.026
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.058 0.026
EPOR EPOR: Erythropoietin receptor precursor 0.057 0.026
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.054 0.026
CHUK N/A 0.052 0.027
UBAP2 N/A 0.052 0.027
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.051 0.032
KIT KIT: Mast/stem cell growth factor receptor precursor 0.051 0.052
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.051 0.026
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.028
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.028
GPRC5A GPRC5A, GPCR5A, RAI3, RAIG1: Retinoic acid-induced protein 3 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.028
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.028
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.028
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.049 0.028
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.046 0.027
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.046 0.027
GHR GHR: Growth hormone receptor precursor 0.0453 0.0425
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.0446 0.032
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.028
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.028
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.044 0.028
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.028
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.044 0.028
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.044 0.028
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.044 0.028
AQP4 AQP4: Aquaporin-4 0.044 0.028
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.028
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.028
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.0425 0.0425
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.041 0.026
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.041 0.026
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
C3AR1 C3AR1, AZ3B, C3R1, HNFAG09: C3a anaphylatoxin chemotactic receptor 0.04 0.028
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.04 0.028
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.04 0.028
DRD2 DRD2: D(2) dopamine receptor 0.04 0.028
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.040 0.026
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.040 0.026
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.038 0.036
HSPD1 0.038 0.027
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.037 0.0425
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.037 0.026
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.052
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.026
ITGAE ITGAE: Integrin alpha-E precursor 0.036 0.026
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.036 0.026
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.036 0.028
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.036 0.028
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.033 0.032
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.033 0.026
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.033 0.032
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.033 0.032
EGF EGF: Pro-epidermal growth factor precursor 0.032 0.052
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.032 0.026
F2R F2R, CF2R, PAR1, TR: Proteinase-activated receptor 1 precursor 0.030 0.026
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.029 0.026
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.029 0.032
RHO RHO, OPN2: Rhodopsin 0.029 0.026
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.029 0.026
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.029 0.032
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.027 0.032
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.027 0.026
KCNJ1 KCNJ1, ROMK1: ATP-sensitive inward rectifier potassium channel 1 0.0263 0.052
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.026
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.0263 0.026
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.026 0.026
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.026 0.026
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.051
0.572
Total Score 3.78