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Evidence of Interaction Between KIT and TOM1L1

The interaction score between KIT and TOM1L1 is 7.11.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between KIT and TOM1L1 = 0.13

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology N/A N/A
Domains Domains present in KIT and TOM1L1:
Domains in KITDomains in TOM1L1
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.
IPR002014 VHS
IPR008942 ENTH/VHS
IPR004152 GAT domain

The Chi square scores for co-occurrence of domains that are present in KIT and TOM1L1 are listed below.

Domain 1Domain 2Chi Square
IPR008266 Tyrosine protein kinase, active site IPR002014 VHS 3.42159
IPR001245 Tyrosine protein kinase IPR002014 VHS 1.3629
IPR011009 Protein kinase-like IPR002014 VHS 0.0560293
IPR000719 Protein kinase IPR002014 VHS 0.0125758

The background colour of the table refers to:

  • Blue Domain is only present in KIT
  • Yellow Domain is only present in TOM1L1
  • Green Domain is present in both KIT and TOM1L1

 0.034
Post-translational Modifications

Protein: KIT

PTMResidueReference
Dephosphorylation 570 PubMed, HPRD
N-linked 130 PubMed, HPRD
Phosphorylation 545 PubMed, HPRD
Phosphorylation 547 PubMed, HPRD
Phosphorylation 553 PubMed, HPRD
Phosphorylation 568 PubMed, HPRD
Phosphorylation 570 PubMed, HPRD
Phosphorylation 703 PubMed, HPRD
Phosphorylation 721 PubMed, HPRD
Phosphorylation 730 PubMed, HPRD
Phosphorylation 741 PubMed, HPRD
Phosphorylation 746 PubMed, HPRD
Phosphorylation 747 PubMed, HPRD
Phosphorylation 821 PubMed, HPRD
Phosphorylation 900 PubMed, HPRD
Phosphorylation 936 PubMed, HPRD
Phosphorylation 959 PubMed, HPRD

Protein: TOM1L1

PTMResidueReference
Phosphorylation 460 PubMed, HPRD
Localisation

Protein: KIT

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD

Protein: TOM1L1

LocalisationReference
Golgi HPRD
Lysosome HPRD
Endosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between KIT and TOM1L1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between KIT andTOM1L1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , KIT has 1344 interactors and TOM1L1 has 348 interactors of which there are 216 common interactors.

Common InteractorName of Common InteractorScore for KIT-Interactor (?)Score for TOM1L1-Interactor (?)
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 422.00 0.049
CRKL CRKL: Crk-like protein 388.00 0.030
NCK2 NCK2: Cytoplasmic protein NCK2 315.00 0.030
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 127.00 0.031
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 112.00 0.025
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 43.20 0.100
JUP JUP, CTNNG, DP3: Junction plakoglobin 15.80 0.036
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.049
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.04
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.04
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.049
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.049
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.980 0.04
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.04
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.902 0.029
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.902 0.072
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.902 0.057
SYK SYK: Tyrosine-protein kinase SYK 0.902 0.032
STAT3 0.878 0.04
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.878 0.049
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.808 0.037
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.808 0.032
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.808 0.091
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.808 0.065
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.037
JAK1 0.731 0.072
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.731 0.0263
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.731 0.030
RIN1 RIN1: Ras and Rab interactor 1 0.655 0.037
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.655 0.037
CSK CSK: Tyrosine-protein kinase CSK 0.655 0.029
BMX N/A 0.654 0.032
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.644 0.032
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.644 0.0263
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.644 0.029
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.644 0.0263
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.644 0.081
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.581 0.075
STAT6 STAT6: Signal transducer and activator of transcription 6 0.577 0.0263
LYN LYN: Tyrosine-protein kinase Lyn 0.577 0.032
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.577 0.029
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.577 0.029
HCK N/A 0.577 0.029
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.577 0.0263
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.520 0.037
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.355 0.049
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.275 0.025
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.181 0.072
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.171 0.039
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.034
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.034
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.165 0.028
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.034
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.034
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.152 0.0263
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.148 0.034
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.034
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.148 0.034
SORL1 SORL1: Sortilin-related receptor precursor 0.123 0.072
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.123 0.025
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.113 0.098
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.113 0.152
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.110 0.0513
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.110 0.031
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.110 0.039
INSR INSR: Insulin receptor precursor 0.110 0.025
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.04
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.028
NF2 NF2, SCH: Merlin 0.109 0.109
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.04
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.109
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.04
PPEF1 N/A 0.109 0.04
S100A16 S100A16, AAG13: Protein S100-A16 0.109 0.04
PSCD2 N/A 0.109 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.04
CGN N/A 0.109 0.028
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.109 0.04
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.109 0.04
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.085
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.100 0.032
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.098 0.04
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 0.109
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.098 0.04
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.098 0.034
EEF2K EEF2K: Elongation factor 2 kinase 0.098 0.049
ACTN4 ACTN4: Alpha-actinin-4 0.098 0.04
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.109
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.098 0.04
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.098 0.109
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.098 0.109
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.098 0.049
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.098 0.109
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.098 0.04
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.097 0.0513
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.097 0.063
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.097 0.025
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.097 0.025
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.097 0.025
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.097 0.031
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.097 0.031
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.094 0.025
RDX RDX: Radixin 0.090 0.126
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.090 0.0453
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.090 0.037
CD2AP CD2AP: CD2-associated protein 0.090 0.0453
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.090 0.065
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.090 0.065
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.090 0.030
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.090 0.0263
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.090 0.037
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.088 0.039
GRLF1 N/A 0.081 0.037
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.081 0.032
IRS1 IRS1: Insulin receptor substrate 1 0.081 0.036
SPTAN1 N/A 0.081 0.027
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.081 0.037
S100B S100B: Protein S100-B 0.081 0.0263
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.081 0.030
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.081 0.027
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.075 0.037
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.073 0.0263
CHP CHP: Calcium-binding protein p22 0.073 0.037
MSN MSN: Moesin 0.073 0.081
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.073 0.029
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.073 0.037
FNBP1 N/A 0.073 0.0263
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.073 0.0263
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.073 0.027
TLN1 TLN1: Uncharacterized protein TLN1 0.073 0.072
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.072 0.046
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.072 0.032
MMP9 MMP9, CLG4B: Matrix metalloproteinase-9 precursor 0.072 0.045
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.072 0.0263
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.057
S100A3 S100A3, S100E: Protein S100-A3 0.072 0.037
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.072 0.032
S100A7 S100A7, PSOR1: Protein S100-A7 0.072 0.0263
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.067 0.030
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.065 0.046
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.064 0.0263
ALK ALK: ALK tyrosine kinase receptor precursor 0.064 0.051
STAM2 STAM2: Signal transducing adapter molecule 2 0.064 0.152
SORBS3 SORBS3, SCAM1: Vinexin 0.064 0.0453
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.064 0.065
CXorf9 N/A 0.064 0.027
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.064 0.0263
VIL2 N/A 0.064 0.081
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.064 0.046
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.064 0.030
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.064 0.100
ACTN1 ACTN1: Alpha-actinin-1 0.064 0.046
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.064 0.051
TLN2 TLN2: Uncharacterized protein TLN2 0.064 0.065
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.064 0.045
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.062 0.052
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.058 0.0453
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.058 0.081
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.058 0.030
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.056 0.0794
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.055 0.063
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.051 0.0453
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.051 0.030
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.051 0.037
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.051 0.037
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.051 0.045
MAPK15 N/A 0.049 0.04
TSC2 TSC2, TSC4: Tuberin 0.049 0.028
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.049 0.063
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.049 0.041
PKD1 PKD1: Polycystin-1 precursor 0.047 0.034
EPB41 EPB41, E41P: Protein 4.1 0.046 0.051
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0453 0.037
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0453 0.030
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0453 0.0263
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.0453 0.037
ST8SIA2 ST8SIA2, SIAT8B, STX: Alpha-2,8-sialyltransferase 8B 0.045 0.032
LDLR LDLR: Low-density lipoprotein receptor precursor 0.044 0.105
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.044 0.04
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.044 0.04
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.044 0.04
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.041 0.027
RPS6KB1 N/A 0.041 0.030
RYR1 0.041 0.0263
FKBP10 FKBP10, FKBP65, PSEC0056: FK506-binding protein 10 precursor 0.041 0.037
FKBP9 FKBP9, FKBP60, FKBP63: FK506-binding protein 9 precursor 0.041 0.046
RAP1GA1 N/A 0.039 0.026
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.034 0.059
SYTL4 Endocrine transmitter regulatory protein 0.034 0.0688
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.033 0.0263
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.033 0.027
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.033 0.061
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.033 0.037
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.033 0.027
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.033 0.0263
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.033 0.063
CFI CFI, IF: Complement factor I precursor 0.032 0.0794
F12 F12: Coagulation factor XII precursor 0.032 0.063
COL17A1 COL17A1, BP180, BPAG2: Collagen alpha-1(XVII) chain 0.032 0.027
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.032 0.030
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.0263
STK16 N/A 0.032 0.046
C8A C8A: Complement component C8 alpha chain precursor 0.032 0.063
GGA3 GGA3, KIAA0154: ADP-ribosylation factor-binding protein GGA3 0.030 0.165
C6 C6: Complement component C6 precursor 0.029 0.063
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.029 0.030
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.029 0.027
C7 C7: Complement component C7 precursor 0.029 0.051
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.027
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.029 0.065
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.028 0.026
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.028 0.123
C8B C8B: Complement component C8 beta chain precursor 0.026 0.063
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.026 0.030
TMPRSS9 N/A 0.025 0.0688
0.572
Total Score 7.11