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Evidence of Interaction Between KIT and CSH2

The interaction score between KIT and CSH2 is 16.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between KIT and CSH2 = -0.02

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in KIT and CSH2:
Domains in KITDomains in CSH2
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.
IPR001400 Somatotropin hormone
IPR012351 Cytokine_4_hlx.

The Chi square scores for co-occurrence of domains that are present in KIT and CSH2 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR012351 Cytokine_4_hlx. 5.70849
IPR008266 Tyrosine protein kinase, active site IPR001400 Somatotropin hormone 3.72814
IPR003598 Immunoglobulin C-2 type IPR012351 Cytokine_4_hlx. 3.54173
IPR007110 Immunoglobulin-like IPR012351 Cytokine_4_hlx. 3.25711
IPR011009 Protein kinase-like IPR012351 Cytokine_4_hlx. 2.23773
IPR001245 Tyrosine protein kinase IPR001400 Somatotropin hormone 2.19853
IPR013151 Immunoglobulin. IPR012351 Cytokine_4_hlx. 2.11896
IPR003599 Immunoglobulin subtype IPR012351 Cytokine_4_hlx. 1.0039
IPR000719 Protein kinase IPR001400 Somatotropin hormone 0.324812

The background colour of the table refers to:

  • Blue Domain is only present in KIT
  • Yellow Domain is only present in CSH2
  • Green Domain is present in both KIT and CSH2

 0.109
Post-translational Modifications

Protein: KIT

PTMResidueReference
Dephosphorylation 570 PubMed, HPRD
N-linked 130 PubMed, HPRD
Phosphorylation 545 PubMed, HPRD
Phosphorylation 547 PubMed, HPRD
Phosphorylation 553 PubMed, HPRD
Phosphorylation 568 PubMed, HPRD
Phosphorylation 570 PubMed, HPRD
Phosphorylation 703 PubMed, HPRD
Phosphorylation 721 PubMed, HPRD
Phosphorylation 730 PubMed, HPRD
Phosphorylation 741 PubMed, HPRD
Phosphorylation 746 PubMed, HPRD
Phosphorylation 747 PubMed, HPRD
Phosphorylation 821 PubMed, HPRD
Phosphorylation 900 PubMed, HPRD
Phosphorylation 936 PubMed, HPRD
Phosphorylation 959 PubMed, HPRD

Protein: CSH2

PTMResidueReference
Deamidated asparagine 178 HPRD
Deamidated glutamine 163 HPRD
Disulfide Bridge 191 PubMed, HPRD
Disulfide Bridge 215 PubMed, HPRD
Phosphorylation 132 PubMed, HPRD
Phosphorylation 176 PubMed, HPRD
Phosphoserine 132 HPRD
Phosphoserine 176 HPRD
Localisation

Protein: KIT

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD

Protein: CSH2

LocalisationReference
Secreted HPRD
Transitive Score

The common interactors between KIT and CSH2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between KIT andCSH2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , KIT has 1344 interactors and CSH2 has 503 interactors of which there are 368 common interactors.

Common InteractorName of Common InteractorScore for KIT-Interactor (?)Score for CSH2-Interactor (?)
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 422.00 0.034
CRKL CRKL: Crk-like protein 388.00 0.025
NCK2 NCK2: Cytoplasmic protein NCK2 315.00 0.025
STAT5B STAT5B: Signal transducer and activator of transcription 5B 214.00 0.031
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 127.00 0.152
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 112.00 0.081
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 46.80 0.072
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 46.80 0.100
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.034
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.034
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.034
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.034
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.034
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.980 0.034
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.034
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.902 0.025
STAT3 0.878 0.034
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.878 0.034
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.808 0.025
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.031
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.655 0.025
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.644 0.025
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.644 0.025
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.577 0.025
STAT2 STAT2: Signal transducer and activator of transcription 2 0.497 0.031
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.484 0.034
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.355 0.025
STAT4 STAT4: Signal transducer and activator of transcription 4 0.318 0.025
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.307 0.644
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.275 0.081
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.191 0.072
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.731
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.171 0.081
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.171 0.100
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.165 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.165
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.165 0.028
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
FN1 N/A 0.165 0.174
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.980
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.165 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.980
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 1.30
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.165
KIR3DL1 N/A 0.165 0.109
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.049
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.152 0.072
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.152 0.032
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.152 0.072
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.152 0.731
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.152 0.072
EPOR EPOR: Erythropoietin receptor precursor 0.152 0.644
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.152 0.731
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.152 0.100
PTPRZ1 N/A 0.152 0.072
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.152 0.072
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.148 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.148 0.049
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.148 0.109
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.165
BSG N/A 0.148 0.109
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.148 0.049
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.165
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.123 0.109
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.123 0.037
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.123 0.109
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.123 0.072
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.123 0.081
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.123 0.081
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.123 0.072
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.123 0.109
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.123 0.109
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.123 0.126
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.123 0.644
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.123 0.072
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.126
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.123 0.109
SORL1 SORL1: Sortilin-related receptor precursor 0.123 0.081
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.123 0.109
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.123 0.126
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.123 0.109
GPA33 GPA33: Cell surface A33 antigen precursor 0.123 0.065
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.123 0.081
F10 F10: Coagulation factor X precursor 0.123 0.137
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.113 0.045
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.110 0.109
DCC DCC: Netrin receptor DCC precursor 0.110 0.072
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.110 0.0453
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.110 0.081
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.110 0.100
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.110 0.072
INSR INSR: Insulin receptor precursor 0.110 0.126
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.110 0.109
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.110 0.100
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.034
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.109 0.028
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 1.30
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.034
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.034
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.034
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.109 0.028
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.109 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.034
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.109 0.028
CGN N/A 0.109 0.028
IL4 IL4: Interleukin-4 precursor 0.109 0.028
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.109 0.165
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.109 0.028
C4A C4A: Complement C4-A precursor 0.109 0.028
THPO THPO, MGDF: Thrombopoietin precursor 0.109 0.028
IFNG IFNG: Interferon gamma precursor 0.109 0.028
CD7 CD7: T-cell antigen CD7 precursor 0.109 0.072
F3 F3: Tissue factor precursor 0.109 0.081
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.065
THBD THBD, THRM: Thrombomodulin precursor 0.109 0.026
IL9R IL9R: Interleukin-9 receptor precursor 0.109 0.644
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.0453
GHR GHR: Growth hormone receptor precursor 0.109 0.644
PVR PVR, PVS: Poliovirus receptor precursor 0.109 0.081
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.109 0.072
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.109 0.072
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.072
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.072
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.109 0.081
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.109 0.072
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.109 0.072
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.109 0.109
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.109 0.072
LILRB1 N/A 0.109 0.072
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.109 0.109
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.109 0.072
ITGB4 N/A 0.109 0.081
CRLF3 N/A 0.109 0.109
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.072
PRLR PRLR: Prolactin receptor precursor 0.109 0.731
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.100 0.109
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.098 0.065
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.098 0.072
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.098 0.072
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.098 0.109
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.098 0.098
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.098 0.072
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.098 0.072
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.098 0.072
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.072
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.098 0.072
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.098 0.081
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.098 0.109
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.098 0.072
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.098 0.028
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.098 0.028
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.098 0.028
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.098 0.165
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.034
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.098 0.034
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.098 0.165
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.098 0.165
BMP1 N/A 0.098 0.028
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.098 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.098 0.034
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.098 0.034
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.098 0.034
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.097 0.072
NEO1 NEO1, NGN: Neogenin precursor 0.097 0.072
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.097 0.109
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.097 0.072
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.097 0.081
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.097 0.072
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.097 0.081
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.097 0.037
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.097 0.081
TNC TNC, HXB: Tenascin precursor 0.097 0.109
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.096 0.032
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.090 0.025
CD2AP CD2AP: CD2-associated protein 0.090 0.025
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.090 0.109
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.088 0.072
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.088 0.081
F7 F7: Coagulation factor VII precursor 0.087 0.209
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.086 0.174
EDA N/A 0.083 0.109
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.083 0.028
OPTC OPTC, OPT: Opticin precursor 0.083 0.028
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.083 0.028
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 1.00
PRG2 PRG2, MBP: Bone marrow proteoglycan precursor 0.081 0.032
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.080 0.114
DLG2 DLG2: Disks large homolog 2 0.073 0.055
MMP11 MMP11, STMY3: Stromelysin-3 precursor 0.073 0.0425
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.073 0.025
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.073 0.031
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.072 0.032
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.072 0.052
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.072 0.0425
PRL PRL: Prolactin precursor 0.072 0.923
CP CP: Ceruloplasmin precursor 0.072 0.026
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.072 0.109
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.130
CSPG2 N/A 0.072 0.109
CGA CGA: Glycoprotein hormones alpha chain precursor 0.072 0.923
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.025
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.072 0.109
TSHB TSHB: Thyrotropin subunit beta precursor 0.072 0.308
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.109
FSHB FSHB: Follitropin subunit beta precursor 0.072 0.308
LHB LHB: Lutropin subunit beta precursor 0.072 0.923
F5 F5: Coagulation factor V precursor 0.065 0.026
ALK ALK: ALK tyrosine kinase receptor precursor 0.064 0.062
TTN N/A 0.064 0.045
STAM2 STAM2: Signal transducing adapter molecule 2 0.064 0.045
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.064 0.109
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.064 0.109
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.064 0.152
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.058 0.025
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.058 0.025
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.057 0.156
PROC PROC: Vitamin K-dependent protein C precursor 0.057 0.137
COL5A1 N/A 0.057 0.130
FUBP1 N/A 0.057 0.045
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.056 0.115
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.056 0.032
HPN HPN, TMPRSS1: Serine protease hepsin 0.055 0.032
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.055 0.055
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
NULL Ig heavy chain V-III region WEA 0.051 0.051
IGHG1 N/A 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
NULL TCRA: T-cell receptor alpha chain V region CTL-L17 precursor 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
FCGR2A FCGR2A, CD32, FCG2, FCGR2A1, IGFR2: Low affinity immunoglobulin gamma Fc region 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
IGHE IGHE: Ig epsilon chain C region 0.051 0.051
HLA-DRB2 HLA class II histocompatibility antigen, DW2.2/DR2.2 beta chain (Fragment) 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
NCAM1 N/A 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
IGHM N/A 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
IGHG3 N/A 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
NULL Ig kappa chain V-I region CAR 0.051 0.051
IGHA1 N/A 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
HLA-A N/A 0.051 0.051
IGHD N/A 0.051 0.051
NULL Ig lambda chain V-II region NEI 0.051 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-27 alpha chain precursor 0.051 0.051
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
IFNAR2 IFNAR2, IFNABR, IFNARB: Interferon-alpha/beta receptor beta chain precursor 0.051 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-68 alpha chain precursor 0.051 0.051
HLA-DQB1 HLA-DQB1: HLA class II histocompatibility antigen, DQB1*0602 beta chain precurso 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.027
IGHA2 IGHA2: Ig alpha-2 chain C region 0.051 0.051
HLA-DRA HLA-DRA, HLA-DRA1: HLA class II histocompatibility antigen, DR alpha chain precu 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
TRB@ TCRB: T-cell receptor beta chain V region CTL-L17 precursor 0.051 0.051
MAPK15 N/A 0.049 0.034
CD46 N/A 0.049 0.028
COL18A1 N/A 0.049 0.165
PLAT PLAT: Tissue-type plasminogen activator precursor 0.049 0.083
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.049 0.028
DCN DCN: Decorin precursor 0.049 0.028
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.049 0.174
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.049 0.028
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.049 0.032
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.049 0.032
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.049 0.0453
F9 F9: Coagulation factor IX precursor 0.0462 0.137
FLT4 VEGFR3 long form 0.046 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.046 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.051
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0453 0.031
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.044 0.034
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.044 0.034
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.044 0.034
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.041 0.055
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.041 0.025
DSP DSP: Desmoplakin 0.04 0.028
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.038 0.038
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.038 0.038
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.037 0.026
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.0338 0.0338
BGLAP BGLAP: Osteocalcin precursor 0.0333 0.152
B2M B2M, CDABP0092, HDCMA22P: Beta-2-microglobulin precursor [Contains: Beta-2-micro 0.033 0.109
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.033 0.031
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.033 0.025
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.033 0.100
CFI CFI, IF: Complement factor I precursor 0.032 0.062
F12 F12: Coagulation factor XII precursor 0.032 0.055
COL1A1 COL1A1: Collagen alpha-1(I) chain precursor 0.032 0.130
COL17A1 COL17A1, BP180, BPAG2: Collagen alpha-1(XVII) chain 0.032 0.152
COL3A1 COL3A1: Collagen alpha-1(III) chain precursor 0.032 0.130
COL16A1 COL16A1: Collagen alpha-1(XVI) chain precursor 0.032 0.109
C1S C1S: Complement C1s subcomponent precursor 0.032 0.055
CFB CFB, BF, BFD: Complement factor B precursor 0.032 0.062
IGF2 IGF2, PP1446: Insulin-like growth factor II precursor 0.032 0.026
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.032 0.191
HP HP: Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta c 0.032 0.055
COL5A2 N/A 0.032 0.123
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.032 0.160
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.032 0.115
BGN BGN: Biglycan precursor 0.032 0.026
C1R C1R: Complement C1r subcomponent precursor 0.032 0.062
C8A C8A: Complement component C8 alpha chain precursor 0.032 0.100
TNN TNN: Tenascin-N precursor 0.030 0.030
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.030 0.034
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.030 0.032
DSPG3 EPYC, DSPG3, PGLB: Epiphycan precursor 0.029 0.026
C2 C2: Complement C2 precursor 0.029 0.062
C6 C6: Complement component C6 precursor 0.029 0.100
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.029 0.026
COL4A1 N/A 0.029 0.152
C7 C7: Complement component C7 precursor 0.029 0.114
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.027 0.114
HLA-DQA1 HLA-DQA2, HLA-DXA: HLA class II histocompatibility antigen, DQ(6) alpha chain pr 0.027 0.027
IL22RA2 IL22RA2, UNQ5793/PRO19598/PRO19822: Interleukin-22 receptor alpha-2 chain precur 0.027 0.027
C20orf102 N/A 0.027 0.027
CSF3R CSF3R, GCSFR: Granulocyte colony-stimulating factor receptor precursor 0.027 0.217
MADCAM1 MADCAM1: Mucosal addressin cell adhesion molecule 1 precursor 0.027 0.027
IL5RA N/A 0.027 0.265
HLA-DRB5 N/A 0.027 0.027
PSG11 PSG11, PSG13, PSG14: Pregnancy-specific beta-1-glycoprotein 11 precursor 0.027 0.027
TRIM42 TRIM42: Tripartite motif-containing protein 42 0.027 0.027
HFE HFE, HLAH: Hereditary hemochromatosis protein precursor 0.027 0.027
SIGLEC11 N/A 0.027 0.027
FCAR FCAR, CD89: Immunoglobulin alpha Fc receptor precursor 0.027 0.027
IL5RA IL5RA, IL5R: Interleukin-5 receptor alpha chain precursor 0.027 0.217
SIRPD N/A 0.027 0.027
SIGLEC6 N/A 0.027 0.027
ROBO1 N/A 0.027 0.027
LILRB3 LILRB3, ILT5, LIR3: Leukocyte immunoglobulin-like receptor subfamily B member 3 0.027 0.027
CNTN6 CNTN6: Contactin-6 precursor 0.027 0.027
NEGR1 NEGR1, UNQ2433/PRO4993: Neuronal growth regulator 1 precursor 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.265
CSF2RA CSF2RA, CSF2R, CSF2RY: Granulocyte-macrophage colony-stimulating factor receptor 0.027 0.217
MGC33530 N/A 0.027 0.027
PSG4 PSG4, CGM4, PSG9: Pregnancy-specific beta-1-glycoprotein 4 precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
HLA-DRB5 N/A 0.027 0.027
PSG6 PSG6, CGM3, PSGGB: Pregnancy-specific beta-1-glycoprotein 6 precursor 0.027 0.027
PRTN3 PRTN3, MBN: Myeloblastin precursor 0.027 0.055
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.0263 0.0425
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.0263 0.0425
CFP CFP, PFC: Properdin precursor 0.0263 0.100
CEACAM5 CEACAM5, CEA: Carcinoembryonic antigen-related cell adhesion molecule 5 precurso 0.026 0.0416
C8B C8B: Complement component C8 beta chain precursor 0.026 0.100
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.026 0.114
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.026 0.031
SPINT2 SPINT2, HAI2, KOP: Kunitz-type protease inhibitor 2 precursor 0.026 0.032
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.025 0.083
TMPRSS9 N/A 0.025 0.049
0.572
Total Score 16.40