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Evidence of Interaction Between KIT and STIP1

The interaction score between KIT and STIP1 is 2.44.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between KIT and STIP1 = 0.08

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology N/A N/A
Domains Domains present in KIT and STIP1:
Domains in KITDomains in STIP1
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.
IPR006636 Heat shock chaperonin-binding
IPR008940 Protein prenyltransferase
IPR001440 TPR repeat
IPR011990 TPR-like_helical.
IPR011595 TPR_related.
IPR013026 TPR_region.

The Chi square scores for co-occurrence of domains that are present in KIT and STIP1 are listed below.

Domain 1Domain 2Chi Square
IPR001245 Tyrosine protein kinase IPR011990 TPR-like_helical. 10.3965
IPR000719 Protein kinase IPR011990 TPR-like_helical. 10.106
IPR000719 Protein kinase IPR001440 TPR repeat 9.7158
IPR000719 Protein kinase IPR013026 TPR_region. 7.83558
IPR011009 Protein kinase-like IPR011990 TPR-like_helical. 7.27847
IPR008266 Tyrosine protein kinase, active site IPR011990 TPR-like_helical. 7.22179
IPR011009 Protein kinase-like IPR001440 TPR repeat 5.4727
IPR011009 Protein kinase-like IPR013026 TPR_region. 4.50191
IPR000719 Protein kinase IPR008940 Protein prenyltransferase 1.68697
IPR011009 Protein kinase-like IPR008940 Protein prenyltransferase 0.165645

The background colour of the table refers to:

  • Blue Domain is only present in KIT
  • Yellow Domain is only present in STIP1
  • Green Domain is present in both KIT and STIP1

 0.014
Post-translational Modifications

Protein: KIT

PTMResidueReference
Dephosphorylation 570 PubMed, HPRD
N-linked 130 PubMed, HPRD
Phosphorylation 545 PubMed, HPRD
Phosphorylation 547 PubMed, HPRD
Phosphorylation 553 PubMed, HPRD
Phosphorylation 568 PubMed, HPRD
Phosphorylation 570 PubMed, HPRD
Phosphorylation 703 PubMed, HPRD
Phosphorylation 721 PubMed, HPRD
Phosphorylation 730 PubMed, HPRD
Phosphorylation 741 PubMed, HPRD
Phosphorylation 746 PubMed, HPRD
Phosphorylation 747 PubMed, HPRD
Phosphorylation 821 PubMed, HPRD
Phosphorylation 900 PubMed, HPRD
Phosphorylation 936 PubMed, HPRD
Phosphorylation 959 PubMed, HPRD

Protein: STIP1

PTMResidueReference
N-acetylmethionine 1 HPRD
Phosphotyrosine 354 HPRD
Localisation

Protein: KIT

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD

Protein: STIP1

LocalisationReference
Golgi HPRD
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between KIT and STIP1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between KIT andSTIP1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , KIT has 1344 interactors and STIP1 has 1002 interactors of which there are 345 common interactors.

Common InteractorName of Common InteractorScore for KIT-Interactor (?)Score for STIP1-Interactor (?)
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 487.00 0.0425
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 422.00 0.028
CRKL CRKL: Crk-like protein 388.00 0.070
NCK2 NCK2: Cytoplasmic protein NCK2 315.00 0.032
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 35.00 0.026
JUP JUP, CTNNG, DP3: Junction plakoglobin 15.80 0.096
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 11.10 0.026
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 11.10 0.138
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 8.99 0.072
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 2.08 0.475
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 1.57 0.029
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.028
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.028
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.028
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.980 0.083
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.028
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.902 0.052
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.902 0.070
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.902 0.0425
SYK SYK: Tyrosine-protein kinase SYK 0.902 0.0425
STAT3 0.878 0.028
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.878 0.028
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.808 0.052
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.808 0.032
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.808 0.032
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.052
JAK1 0.731 0.026
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.731 0.070
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.655 0.032
CSK CSK: Tyrosine-protein kinase CSK 0.655 0.052
VAV1 VAV1, VAV: Proto-oncogene vav 0.655 0.0425
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.644 0.026
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.644 0.096
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.644 0.032
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.644 0.026
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.577 0.026
STAT6 STAT6: Signal transducer and activator of transcription 6 0.577 0.052
LYN LYN: Tyrosine-protein kinase Lyn 0.577 0.032
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.577 0.026
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.577 0.026
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.361 0.027
IPO7 IPO7: Uncharacterized protein IPO7 0.202 0.191
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.191 0.027
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.181 0.070
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.166 0.032
OSM OSM: Oncostatin-M precursor 0.166 0.063
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.165 0.028
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.152 0.052
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.148 0.032
IL3 IL3: Interleukin-3 precursor 0.126 0.051
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.113 0.052
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.113 0.026
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.113 0.251
STMN1 STMN1, LAP18, OP18: Stathmin 0.113 0.0425
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.113 0.191
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.0453
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.083
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.028
NF2 NF2, SCH: Merlin 0.109 0.028
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.109 0.028
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.028
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.083
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.109 0.028
PSCD2 N/A 0.109 0.028
CGN N/A 0.109 0.028
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.109 0.028
GHR GHR: Growth hormone receptor precursor 0.109 0.036
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.105 0.036
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.100 0.087
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.100 0.077
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.098 0.0446
ELMO1 N/A 0.098 0.052
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.098 0.028
CDC25A CDC25A: M-phase inducer phosphatase 1 0.098 0.028
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.098 0.083
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.098 0.028
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.098 0.028
ARHGEF7 N/A 0.098 0.028
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 0.028
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.098 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.098 0.083
ACTN4 ACTN4: Alpha-actinin-4 0.098 0.028
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.098 0.028
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.098 0.028
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.098 0.083
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.028
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.028
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.098 0.028
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.098 0.083
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.098 0.083
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.098 0.028
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.098 0.028
CDC25C CDC25C: M-phase inducer phosphatase 3 0.098 0.028
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.098 0.028
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.098 0.028
ITGB7 ITGB7: Integrin beta-7 precursor 0.097 0.124
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.097 0.036
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.097 0.0453
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.096 0.0333
CDK6 CDK6: Cell division protein kinase 6 0.091 0.026
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.091 0.155
RDX RDX: Radixin 0.090 0.0425
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.090 0.062
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.090 0.077
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.090 0.127
THOP1 THOP1: Thimet oligopeptidase 0.090 0.087
CD2AP CD2AP: CD2-associated protein 0.090 0.070
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.090 0.080
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.090 0.032
DOK1 DOK1: Docking protein 1 0.090 0.052
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.090 0.127
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.090 0.049
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.090 0.127
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.086 0.055
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.086 0.087
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.0818 0.070
XPO1 XPO1, CRM1: Exportin-1 0.0818 0.515
THOC1 THOC1, HPR1: THO complex subunit 1 0.0818 0.052
ROCK1 ROCK1: Rho-associated protein kinase 1 0.081 0.127
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.081 0.251
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.081 0.032
GRLF1 N/A 0.081 0.096
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.081 0.032
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.081 0.055
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.081 0.026
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.0794 0.036
FADD FADD, MORT1: Protein FADD 0.077 0.036
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.075 0.155
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.075 0.052
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.075 0.0425
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.075 0.515
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.028
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.073 0.026
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.073 0.032
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.073 0.0425
CHP CHP: Calcium-binding protein p22 0.073 0.026
MSN MSN: Moesin 0.073 0.0425
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.073 0.132
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.073 0.127
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.073 0.052
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.073 0.127
FNBP1 N/A 0.073 0.087
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.073 0.052
PLD2 PLD2: Phospholipase D2 0.073 0.026
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.073 0.0425
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.073 0.0425
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.073 0.056
TLN1 TLN1: Uncharacterized protein TLN1 0.073 0.0425
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.073 0.0425
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.072 0.032
VASP VASP: Vasodilator-stimulated phosphoprotein 0.072 0.032
IL6 IL6, IFNB2: Interleukin-6 precursor 0.072 0.063
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.072 0.026
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.027
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.071 0.027
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.069 0.052
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.067 0.041
HSP90AA1 Hsp89-alpha-delta-N 0.067 0.416
CDK4 CDK4: Cell division protein kinase 4 0.067 0.087
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.067 0.287
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.067 0.096
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.067 0.052
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.067 0.087
EPO EPO: Erythropoietin precursor 0.065 0.045
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.065 0.026
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.065 0.032
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.065 0.026
STAM2 STAM2: Signal transducing adapter molecule 2 0.064 0.191
LCP1 LCP1, PLS2: Plastin-2 0.064 0.070
SORBS3 SORBS3, SCAM1: Vinexin 0.064 0.026
PSCD4 PSCD4, CYT4: Cytohesin-4 0.064 0.032
CXorf9 N/A 0.064 0.0425
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.064 0.026
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.064 0.052
VIL2 N/A 0.064 0.032
GMIP GMIP: GEM-interacting protein 0.064 0.032
RASA3 RASA3: Ras GTPase-activating protein 3 0.064 0.077
ACTN1 ACTN1: Alpha-actinin-1 0.064 0.026
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.058 0.026
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.058 0.055
PLD1 PLD1: Phospholipase D1 0.058 0.070
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.057 0.0446
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.057 0.027
FUBP1 N/A 0.057 0.087
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.057 0.155
GLRB GLRB: Glycine receptor subunit beta precursor 0.056 0.065
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 0.055 0.032
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.052 0.166
PLEK PLEK, P47: Pleckstrin 0.051 0.027
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.051 0.032
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.051 0.127
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.051 0.155
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.051 0.127
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.051 0.174
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.051 0.026
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.051 0.030
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.051 0.032
MDN1 MDN1, KIAA0301: Midasin 0.051 0.127
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.051 0.087
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.051 0.144
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.051 0.096
SYMPK SYMPK, SPK: Symplekin 0.051 0.155
CTPS CTPS: CTP synthase 1 0.051 0.087
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.051 0.340
GABRR1 N/A 0.049 0.065
MAPK15 N/A 0.049 0.028
TSC2 TSC2, TSC4: Tuberin 0.049 0.052
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.083
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.028
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.049 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.049 0.083
MYO18A 0.049 0.028
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.049 0.065
GLRA1 N/A 0.049 0.065
ST6GAL1 ST6GAL1, SIAT1: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltrans 0.046 0.026
HD HD, IT15: Huntingtin 0.0453 0.210
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0453 0.260
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0453 0.032
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0453 0.087
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0453 0.0425
WEE1 WEE1: Wee1-like protein kinase 0.0453 0.0425
ST8SIA4 ST8SIA4, PST, PST1, SIAT8D: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransfe 0.045 0.0425
TP73 TP73, P73: Tumor protein p73 0.045 0.037
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.044 0.032
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.044 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.044 0.028
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.044 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.044 0.028
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.028
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.028
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.044 0.028
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.044 0.028
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.044 0.028
SEC24B SEC24B: Protein transport protein Sec24B 0.041 0.052
WWC2 WW and C2 domain containing 2 0.041 0.055
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.041 0.026
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.041 0.027
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.041 0.0513
MAGED2 N/A 0.041 0.026
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.041 0.087
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.041 0.025
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.041 0.026
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.041 0.032
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.041 0.144
CDK2 CDK2: Cell division protein kinase 2 0.041 0.087
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.041 0.055
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.041 0.144
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.041 0.087
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.041 0.087
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.041 0.032
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.041 0.070
CDK5 CDK5: Cell division protein kinase 5 0.041 0.032
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.041 0.077
RPS6KB1 N/A 0.041 0.260
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.041 0.052
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.041 0.155
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.041 0.087
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.041 0.036
MYH9 MYH9: Myosin-9 0.041 0.036
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.04 0.083
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.04 0.083
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.039 0.340
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 0.038 0.081
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.037 0.0425
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.037 0.087
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.037 0.104
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.037 0.026
CFL2 CFL2: Cofilin-2 0.036 0.028
SVIL SVIL: Supervillin 0.036 0.028
GSN GSN: Gelsolin precursor 0.036 0.028
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.035 0.0453
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.035 0.124
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.035 0.027
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.035 0.036
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.035 0.036
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.033 0.054
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.033 0.087
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.033 0.087
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.033 0.070
GMFB GMFB: Glia maturation factor beta 0.033 0.026
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.033 0.127
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.033 0.070
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.033 0.210
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.033 0.0425
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.033 0.032
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.033 0.077
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.033 0.070
STK10 STK10: Uncharacterized protein STK10 0.033 0.0425
DYRK3 N/A 0.033 0.026
FLII FLII, FLIL: Protein flightless-1 homolog 0.033 0.052
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.033 0.0425
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.033 0.144
KIAA0690 N/A 0.033 0.077
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.033 0.0425
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.033 0.0425
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.033 0.096
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.033 0.096
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.033 0.087
PRKAA1 N/A 0.032 0.032
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.032 0.070
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.026
FLNA FLNA, FLN, FLN1: Filamin-A 0.032 0.032
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.032 0.032
STK16 N/A 0.032 0.070
XRCC1 XRCC1: DNA-repair protein XRCC1 0.031 0.074
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.031 0.061
NPM1 NPM1, NPM: Nucleophosmin 0.031 0.036
TOM1L1 TOM1L1, SRCASM: TOM1-like protein 1 0.031 0.062
GGA3 GGA3, KIAA0154: ADP-ribosylation factor-binding protein GGA3 0.030 0.083
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.030 0.049
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.029 0.055
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.029 0.049
ATM ATM: Serine-protein kinase ATM 0.029 0.032
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.029 0.062
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.029 0.026
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.070
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.029 0.0425
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.029 0.096
WASPIP N/A 0.029 0.0425
CDK7 CDK7, MO15: Cell division protein kinase 7 0.029 0.087
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.096
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.077
DLG1 N/A 0.029 0.032
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.028 0.127
CANX CANX: Calnexin precursor 0.028 0.027
AP2M1 AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1 0.028 0.052
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.028 0.027
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.028 0.157
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.028 0.307
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.027 0.026
HDLBP HDLBP, HBP, VGL: Vigilin 0.027 0.0425
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.027 0.070
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.027 0.032
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.026 0.056
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.026 0.032
TFRC TFRC: Transferrin receptor protein 1 0.026 0.027
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 2 0.026 0.026
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.026 0.052
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.025 0.049
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.025 0.049
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.025 0.044
0.572
Total Score 2.44