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Evidence of Interaction Between KIT and CTNNB1

The interaction score between KIT and CTNNB1 is 4.56.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between KIT and CTNNB1 = 0.08

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismKIT OrthologueCTNNB1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm O76698 0.132 O44326 1
worm Q21038 0.132 O44326 1
worm Q21041 0.132 O44326 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in KIT and CTNNB1:
Domains in KITDomains in CTNNB1
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.
IPR000225 Armadillo
IPR000357 HEAT
IPR011989 ARM-like.

The Chi square scores for co-occurrence of domains that are present in KIT and CTNNB1 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR011989 ARM-like. 29.0736
IPR000719 Protein kinase IPR000357 HEAT 16.1857
IPR001245 Tyrosine protein kinase IPR011989 ARM-like. 14.5319
IPR011009 Protein kinase-like IPR011989 ARM-like. 14.0209
IPR007110 Immunoglobulin-like IPR011989 ARM-like. 10.0676
IPR008266 Tyrosine protein kinase, active site IPR011989 ARM-like. 9.90485
IPR011009 Protein kinase-like IPR000357 HEAT 9.47388
IPR000719 Protein kinase IPR000225 Armadillo 8.2455
IPR001245 Tyrosine protein kinase IPR000357 HEAT 8.12971
IPR003599 Immunoglobulin subtype IPR011989 ARM-like. 5.12539
IPR008266 Tyrosine protein kinase, active site IPR000357 HEAT 4.8305
IPR011009 Protein kinase-like IPR000225 Armadillo 3.82973
IPR007110 Immunoglobulin-like IPR000357 HEAT 2.65461
IPR001245 Tyrosine protein kinase IPR000225 Armadillo 2.48682
IPR008266 Tyrosine protein kinase, active site IPR000225 Armadillo 1.62316
IPR007110 Immunoglobulin-like IPR000225 Armadillo 1.41591
IPR003599 Immunoglobulin subtype IPR000357 HEAT 1.25432
IPR003599 Immunoglobulin subtype IPR000225 Armadillo 0.229803

The background colour of the table refers to:

  • Blue Domain is only present in KIT
  • Yellow Domain is only present in CTNNB1
  • Green Domain is present in both KIT and CTNNB1

 0.049
Post-translational Modifications

Protein: KIT

PTMResidueReference
Dephosphorylation 570 PubMed, HPRD
N-linked 130 PubMed, HPRD
Phosphorylation 545 PubMed, HPRD
Phosphorylation 547 PubMed, HPRD
Phosphorylation 553 PubMed, HPRD
Phosphorylation 568 PubMed, HPRD
Phosphorylation 570 PubMed, HPRD
Phosphorylation 703 PubMed, HPRD
Phosphorylation 721 PubMed, HPRD
Phosphorylation 730 PubMed, HPRD
Phosphorylation 741 PubMed, HPRD
Phosphorylation 746 PubMed, HPRD
Phosphorylation 747 PubMed, HPRD
Phosphorylation 821 PubMed, HPRD
Phosphorylation 900 PubMed, HPRD
Phosphorylation 936 PubMed, HPRD
Phosphorylation 959 PubMed, HPRD

Protein: CTNNB1

PTMResidueReference
Acetylation 49 PubMed, HPRD
Dephosphorylation 654 PubMed, HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphorylation 37 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 45 PubMed, HPRD
Phosphorylation 86 PubMed, HPRD
Phosphorylation 102 PubMed, HPRD
Phosphorylation 112 PubMed, HPRD
Phosphorylation 142 PubMed, HPRD
Phosphorylation 393 PubMed, HPRD
Phosphorylation 654 PubMed, HPRD
Phosphoserine 23 PubMed, HPRD
Phosphoserine 29 PubMed, HPRD
Phosphoserine 33 PubMed, HPRD
Phosphoserine 37 PubMed, HPRD
Phosphoserine 45 HPRD
Phosphothreonine 41 PubMed, HPRD
Phosphotyrosine 86 PubMed, HPRD
Phosphotyrosine 654 PubMed, HPRD
Localisation

Protein: KIT

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD

Protein: CTNNB1

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between KIT and CTNNB1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between KIT andCTNNB1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , KIT has 1344 interactors and CTNNB1 has 1159 interactors of which there are 430 common interactors.

Common InteractorName of Common InteractorScore for KIT-Interactor (?)Score for CTNNB1-Interactor (?)
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 422.00 0.025
CRKL CRKL: Crk-like protein 388.00 0.038
NCK2 NCK2: Cytoplasmic protein NCK2 315.00 0.038
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 127.00 0.029
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 112.00 0.029
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 46.80 0.029
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 46.80 0.033
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 43.20 0.035
JUP JUP, CTNNG, DP3: Junction plakoglobin 15.80 0.188
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 11.10 0.040
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 2.08 0.344
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.028
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.028
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.025
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.028
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.980 0.025
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.165
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.902 0.038
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.902 0.038
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.902 0.0425
SYK SYK: Tyrosine-protein kinase SYK 0.902 0.029
STAT3 0.878 0.025
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.878 0.025
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.808 0.046
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.808 0.046
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.731 0.026
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.0425
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.731 0.0425
RIN1 RIN1: Ras and Rab interactor 1 0.655 0.029
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.655 0.069
CSK CSK: Tyrosine-protein kinase CSK 0.655 0.038
VAV1 VAV1, VAV: Proto-oncogene vav 0.655 0.029
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.644 0.026
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.644 0.026
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.644 0.032
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.617 0.051
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.581 0.052
STAT6 STAT6: Signal transducer and activator of transcription 6 0.577 0.038
LYN LYN: Tyrosine-protein kinase Lyn 0.577 0.029
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.355 0.036
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.275 0.027
IPO7 IPO7: Uncharacterized protein IPO7 0.202 0.251
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.181 0.026
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.181 0.114
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.171 0.072
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.171 0.041
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.166 0.032
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
FN1 N/A 0.165 0.049
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.109
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.878
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.152 0.032
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.152 0.127
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.152 0.057
PTPRZ1 N/A 0.152 0.064
ATRN N/A 0.148 0.036
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.148 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.044
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.148 0.098
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.127 0.0453
GAB2 N/A 0.126 0.026
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.123 0.033
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.123 0.0453
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.123 0.027
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.123 0.032
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.123 0.027
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.113 0.046
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.113 0.086
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.113 0.086
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.113 0.029
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.110 0.029
DCC DCC: Netrin receptor DCC precursor 0.110 0.029
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.110 0.041
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.110 0.041
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.110 0.026
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.110 0.058
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.110 0.090
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.090
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.028
NF2 NF2, SCH: Merlin 0.109 0.083
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.109 0.028
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.025
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.083
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.083
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.028
PPEF1 N/A 0.109 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.109 0.028
PSCD2 N/A 0.109 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.109 0.025
CNN2 CNN2: Calponin-2 0.109 0.028
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.109 0.028
F3 F3: Tissue factor precursor 0.109 0.091
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.037
IL9R IL9R: Interleukin-9 receptor precursor 0.109 0.032
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.075
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.075
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.109 0.037
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.109 0.033
ITGB4 N/A 0.109 0.036
CRLF3 N/A 0.109 0.057
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.0453
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.100 0.052
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.100 0.038
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.100 0.062
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.100 0.031
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.098 0.072
ELMO1 N/A 0.098 0.075
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.098 0.025
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.098 0.047
CDC25A CDC25A: M-phase inducer phosphatase 1 0.098 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.098 0.025
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.098 0.025
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.098 0.025
ARHGEF7 N/A 0.098 0.025
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 0.075
SNX3 N/A 0.098 0.025
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.098 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.098 0.025
ACTN4 ACTN4: Alpha-actinin-4 0.098 0.047
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.098 0.075
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.098 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.098 0.025
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.047
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.025
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.098 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.098 0.025
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.098 0.075
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.098 0.075
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.098 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.098 0.075
CDC25C CDC25C: M-phase inducer phosphatase 3 0.098 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.098 0.075
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.098 0.075
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.097 0.041
NEO1 NEO1, NGN: Neogenin precursor 0.097 0.029
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.097 0.032
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.097 0.027
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.097 0.0818
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.097 0.029
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.097 0.041
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.096 0.0333
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.094 0.041
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.091 0.032
RDX RDX: Radixin 0.090 0.114
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.090 0.054
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.090 0.038
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.090 0.038
THOP1 THOP1: Thimet oligopeptidase 0.090 0.046
CD2AP CD2AP: CD2-associated protein 0.090 0.046
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.090 0.086
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.090 0.086
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.090 0.049
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.090 0.044
DOK1 DOK1: Docking protein 1 0.090 0.038
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.090 0.029
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.090 0.171
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.088 0.029
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.088 0.029
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.086 0.078
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.083 0.04
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.049
OPTC OPTC, OPT: Opticin precursor 0.083 0.04
PCDHA2 PCDHA2: Protocadherin alpha 2 precursor 0.083 0.980
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.083 0.049
CDH6 CDH6: Cadherin-6 precursor 0.083 0.980
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.04
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.083 0.04
MUCDHL MUPCDH, MUCDHL, UNQ2781/PRO7168: Mucin and cadherin-like protein precursor 0.083 0.980
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.0818 0.046
XPO1 XPO1, CRM1: Exportin-1 0.0818 0.275
THOC1 THOC1, HPR1: THO complex subunit 1 0.0818 0.029
ROCK1 ROCK1: Rho-associated protein kinase 1 0.081 0.0425
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.081 0.096
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.025
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.081 0.096
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.081 0.029
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.081 0.052
GRLF1 N/A 0.081 0.062
IRS1 IRS1: Insulin receptor substrate 1 0.081 0.032
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.081 0.0425
SPTAN1 N/A 0.081 0.034
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.081 0.048
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.026
CNN3 CNN3: Calponin-3 0.081 0.032
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.0794 0.027
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.077 0.032
FADD FADD, MORT1: Protein FADD 0.077 0.036
DSG2 DSG2: Desmoglein-2 precursor 0.077 3.05
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.075 0.114
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.075 0.046
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.075 0.070
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.028
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.073 0.028
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.073 0.171
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.073 0.086
CHP CHP: Calcium-binding protein p22 0.073 0.038
MSN MSN: Moesin 0.073 0.139
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.073 0.114
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.073 0.054
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.073 0.038
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.073 0.071
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.073 0.038
FNBP1 N/A 0.073 0.139
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.073 0.275
PLD2 PLD2: Phospholipase D2 0.073 0.029
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.073 0.054
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.073 0.031
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.073 0.029
TLN1 TLN1: Uncharacterized protein TLN1 0.073 0.071
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.073 0.114
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.072 0.032
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.072 0.0425
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.031
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.072 0.096
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.0513
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.072 0.026
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.026
VASP VASP: Vasodilator-stimulated phosphoprotein 0.072 0.0425
S100A3 S100A3, S100E: Protein S100-A3 0.072 0.026
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.072 0.031
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.069 0.029
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.067 0.029
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.067 0.038
HSP90AA1 Hsp89-alpha-delta-N 0.067 0.038
CDK4 CDK4: Cell division protein kinase 4 0.067 0.046
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.067 0.372
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.067 0.063
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.067 0.038
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.067 0.046
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.065 0.070
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.065 0.032
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.065 0.026
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.064 0.063
TTN N/A 0.064 0.044
LCP1 LCP1, PLS2: Plastin-2 0.064 0.046
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.064 0.086
CXorf9 N/A 0.064 0.029
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.064 0.038
VIL2 N/A 0.064 0.114
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.064 0.046
GMIP GMIP: GEM-interacting protein 0.064 0.029
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.064 0.069
ACTN1 ACTN1: Alpha-actinin-1 0.064 0.087
TLN2 TLN2: Uncharacterized protein TLN2 0.064 0.031
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.063 0.032
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.063 0.037
CDH5 CDH5: Cadherin-5 precursor 0.062 0.731
SLITRK5 SLITRK5, KIAA0918, LRRC11: SLIT and NTRK-like protein 5 precursor 0.062 0.0263
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.062 0.044
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.058 0.069
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.058 0.049
PLD1 PLD1: Phospholipase D1 0.058 0.038
FUBP1 N/A 0.057 0.052
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.057 0.114
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.056 0.051
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.056 0.655
CDH17 CDH17: Cadherin-17 precursor 0.055 1.13
CDH2 CDH2, CDHN, NCAD: Cadherin-2 precursor 0.055 0.731
GP9 GP9: Platelet glycoprotein IX precursor 0.055 0.030
CD44 N/A 0.055 0.027
TLR4 TLR4: Toll-like receptor 4 precursor 0.055 0.027
CDH13 CDH13, CDHH: Cadherin-13 precursor 0.055 0.902
AREG AREG, SDGF: Amphiregulin precursor 0.055 0.036
PTPRA N/A 0.051 0.051
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.031
ETS2 ETS2: Protein C-ets-2 0.0513 0.075
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.051 0.029
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.051 0.029
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.051 0.038
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.051 0.038
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.051 0.038
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.051 0.110
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.051 0.063
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.051 0.029
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.051 0.063
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.051 0.063
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.051 0.086
SYMPK SYMPK, SPK: Symplekin 0.051 0.086
CTPS CTPS: CTP synthase 1 0.051 0.046
DSG3 DSG3: Desmoglein-3 precursor 0.049 0.731
DSC2 DSC2, DSC3: Desmocollin-2 precursor 0.049 0.731
PCDH7 PCDH7, BHPCDH: Protocadherin-7 precursor 0.049 0.581
MAPK15 N/A 0.049 0.028
MAP2K5 N/A 0.049 0.028
TSC2 TSC2, TSC4: Tuberin 0.049 0.075
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.028
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.049 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.049 0.052
MYO18A 0.049 0.047
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.027
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.049 0.067
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.047 0.044
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.046 0.0453
HD HD, IT15: Huntingtin 0.0453 0.127
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0453 0.210
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0453 0.032
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.0453 0.080
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0453 0.087
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0453 0.032
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.0453 0.077
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.0453 0.026
WEE1 WEE1: Wee1-like protein kinase 0.0453 0.029
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.044 0.025
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.044 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.044 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.044 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.047
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.047
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.044 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.044 0.025
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.044 0.047
NIPBL N/A 0.044 0.075
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.044 0.025
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.044 0.025
SEC24B SEC24B: Protein transport protein Sec24B 0.041 0.046
MAGED2 N/A 0.041 0.038
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.041 0.038
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.041 0.188
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.041 0.029
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.041 0.029
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.041 0.063
CDK2 CDK2: Cell division protein kinase 2 0.041 0.038
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.041 0.063
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.041 0.063
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.041 0.032
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.041 0.046
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.041 0.029
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.041 0.046
RPS6KB1 N/A 0.041 0.038
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.041 0.029
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.041 0.114
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.041 0.372
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.067
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.041 0.032
MYH9 MYH9: Myosin-9 0.041 0.067
COTL1 COTL1, CLP: Coactosin-like protein 0.04 0.025
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.04 0.083
DSP DSP: Desmoplakin 0.04 0.109
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.04 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.04 0.028
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.040 0.050
MYB MYB: Myb proto-oncogene protein 0.039 0.037
H1FX H1FX: Histone H1x 0.039 0.081
DBN1 DBN1, D0S117E: Drebrin 0.037 0.0425
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.037 0.026
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.037 0.0425
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.037 0.029
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.037 0.077
CFL2 CFL2: Cofilin-2 0.036 0.025
SVIL SVIL: Supervillin 0.036 0.025
GSN GSN: Gelsolin precursor 0.036 0.025
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.035 0.033
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.035 0.026
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.035 0.029
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.035 0.051
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.035 0.067
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.035 0.064
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.035 0.032
ANXA3 ANXA3, ANX3: Annexin A3 0.034 0.036
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.033 0.087
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.033 0.046
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.033 0.038
GMFB GMFB: Glia maturation factor beta 0.033 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.033 0.038
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.033 0.029
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.033 0.078
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.033 0.063
STK10 STK10: Uncharacterized protein STK10 0.033 0.029
FLII FLII, FLIL: Protein flightless-1 homolog 0.033 0.087
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.033 0.078
KIAA0690 N/A 0.033 0.069
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.033 0.078
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.033 0.038
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.033 0.029
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.033 0.026
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.033 0.078
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.032 0.060
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.032 0.0425
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.032 0.029
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.026
GAS2 GAS2: Growth arrest-specific protein 2 0.032 0.0425
FLNA FLNA, FLN, FLN1: Filamin-A 0.032 0.052
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.032 0.063
STK16 N/A 0.032 0.052
XRCC1 XRCC1: DNA-repair protein XRCC1 0.031 0.061
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.031 0.041
NPM1 NPM1, NPM: Nucleophosmin 0.031 0.032
TOM1L1 TOM1L1, SRCASM: TOM1-like protein 1 0.031 0.027
ANXA2 ANXA2, ANX2, ANX2L4, CAL1H, LPC2D: Annexin A2 0.031 0.036
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.0308 0.026
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.030 0.098
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.030 0.044
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.030 0.055
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.030 0.093
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.029 0.034
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.029 0.056
ATM ATM: Serine-protein kinase ATM 0.029 0.069
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.029 0.026
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.029 0.043
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.046
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.029 0.038
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.029 0.078
WASPIP N/A 0.029 0.038
CDK7 CDK7, MO15: Cell division protein kinase 7 0.029 0.078
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.052
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.054
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.029 0.028
DLG1 N/A 0.029 0.038
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.028 0.067
AP2M1 AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1 0.028 0.067
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.028 0.090
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.028 0.111
HDLBP HDLBP, HBP, VGL: Vigilin 0.027 0.046
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.027 0.038
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.027 0.029
DSTN DSTN, ACTDP, DSN: Destrin 0.027 0.038
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.026 0.0308
SPINT2 SPINT2, HAI2, KOP: Kunitz-type protease inhibitor 2 precursor 0.026 0.027
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.026 0.046
ERF ERF: ETS domain-containing transcription factor ERF 0.025 0.075
ETV1 ETV1, ER81: ETS translocation variant 1 0.025 0.029
MDM4 MDM4, MDMX: Mdm4 protein 0.025 0.037
0.347
Total Score 4.56