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Evidence of Interaction Between KIT and PTPN11

The interaction score between KIT and PTPN11 is 4.46.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between KIT and PTPN11 = 0.38

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology
OrganismKIT OrthologuePTPN11 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00018335 0.132 IPI00477552 0.365
human IPI00021396 0.132 IPI00477552 0.365
human IPI00018335 0.132 IPI00515044 0.111
human IPI00021396 0.132 IPI00515044 0.111
worm O76698 0.132 Q21055 1
worm Q21038 0.132 Q21055 1
worm Q21041 0.132 Q21055 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains No domains were used in calculating likelihood of interaction 0.014
Post-translational Modifications

Protein: KIT

PTMResidueReference
Dephosphorylation 570 PubMed, HPRD
N-linked 130 PubMed, HPRD
Phosphorylation 545 PubMed, HPRD
Phosphorylation 547 PubMed, HPRD
Phosphorylation 553 PubMed, HPRD
Phosphorylation 568 PubMed, HPRD
Phosphorylation 570 PubMed, HPRD
Phosphorylation 703 PubMed, HPRD
Phosphorylation 721 PubMed, HPRD
Phosphorylation 730 PubMed, HPRD
Phosphorylation 741 PubMed, HPRD
Phosphorylation 746 PubMed, HPRD
Phosphorylation 747 PubMed, HPRD
Phosphorylation 821 PubMed, HPRD
Phosphorylation 900 PubMed, HPRD
Phosphorylation 936 PubMed, HPRD
Phosphorylation 959 PubMed, HPRD

Protein: PTPN11

PTMResidueReference
Phosphorylation 62 PubMed, HPRD
Phosphorylation 542 PubMed, HPRD
Phosphorylation 576 PubMed, HPRD
Phosphorylation 580 PubMed, HPRD
Localisation

Protein: KIT

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD

Protein: PTPN11

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between KIT and PTPN11 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between KIT andPTPN11. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , KIT has 1344 interactors and PTPN11 has 779 interactors of which there are 319 common interactors.

Common InteractorName of Common InteractorScore for KIT-Interactor (?)Score for PTPN11-Interactor (?)
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 487.00 0.038
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 422.00 0.025
CRKL CRKL: Crk-like protein 388.00 0.063
NCK2 NCK2: Cytoplasmic protein NCK2 315.00 0.029
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 43.20 0.038
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 11.10 0.040
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 2.08 0.078
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.028
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.028
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.025
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.028
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.980 0.025
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.028
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.902 0.046
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.902 0.063
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.902 0.0425
SYK SYK: Tyrosine-protein kinase SYK 0.902 0.038
STAT3 0.878 0.025
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.878 0.025
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.808 0.046
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.808 0.029
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.808 0.038
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.731 0.026
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.032
JAK1 0.731 0.038
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.731 0.0425
RIN1 RIN1: Ras and Rab interactor 1 0.655 0.038
CSK CSK: Tyrosine-protein kinase CSK 0.655 0.046
VAV1 VAV1, VAV: Proto-oncogene vav 0.655 0.038
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.644 0.026
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.644 0.026
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.644 0.026
STAT6 STAT6: Signal transducer and activator of transcription 6 0.577 0.038
LYN LYN: Tyrosine-protein kinase Lyn 0.577 0.029
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.577 0.029
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.577 0.029
IPO7 IPO7: Uncharacterized protein IPO7 0.202 0.087
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.191 0.027
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.181 0.046
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.181 0.078
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.166 0.052
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.152 0.032
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.152 0.027
ITGAE ITGAE: Integrin alpha-E precursor 0.152 0.027
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.148 0.046
GAB2 N/A 0.126 0.0425
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.123 0.027
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.123 0.027
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.113 0.046
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.113 0.046
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.113 0.129
STMN1 STMN1, LAP18, OP18: Stathmin 0.113 0.046
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.113 0.063
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.028
NF2 NF2, SCH: Merlin 0.109 0.028
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.109 0.028
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.025
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.028
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.028
PPEF1 N/A 0.109 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.109 0.028
PSCD2 N/A 0.109 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.109 0.025
CNN2 CNN2: Calponin-2 0.109 0.028
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.109 0.028
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.105 0.027
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.100 0.026
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.100 0.063
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.100 0.032
ELMO1 N/A 0.098 0.025
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.098 0.025
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.098 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.098 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.098 0.025
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.098 0.025
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.098 0.025
ARHGEF7 N/A 0.098 0.025
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 0.025
SNX3 N/A 0.098 0.025
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.098 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.098 0.025
ACTN4 ACTN4: Alpha-actinin-4 0.098 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.098 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.098 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.098 0.025
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.025
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.025
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.098 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.098 0.025
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.098 0.025
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.098 0.025
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.098 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.098 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.098 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.098 0.025
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.098 0.025
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.096 0.027
CDK6 CDK6: Cell division protein kinase 6 0.091 0.029
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.091 0.144
RDX RDX: Radixin 0.090 0.046
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.090 0.046
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.090 0.046
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.090 0.038
THOP1 THOP1: Thimet oligopeptidase 0.090 0.046
CD2AP CD2AP: CD2-associated protein 0.090 0.063
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.090 0.046
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.090 0.078
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.090 0.063
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.090 0.038
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.090 0.029
DOK1 DOK1: Docking protein 1 0.090 0.029
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.090 0.029
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.090 0.029
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.090 0.038
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.0818 0.063
XPO1 XPO1, CRM1: Exportin-1 0.0818 0.129
THOC1 THOC1, HPR1: THO complex subunit 1 0.0818 0.078
ROCK1 ROCK1: Rho-associated protein kinase 1 0.081 0.0425
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.081 0.032
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.081 0.032
GAB1 GAB1: GRB2-associated-binding protein 1 0.081 0.032
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.081 0.038
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.081 0.026
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.081 0.029
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.081 0.026
SPTAN1 N/A 0.081 0.032
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.081 0.0425
S100B S100B: Protein S100-B 0.081 0.032
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.026
SNCB SNCB: Beta-synuclein 0.081 0.032
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.081 0.026
CNN3 CNN3: Calponin-3 0.081 0.026
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.0794 0.036
ATP2B1 N/A 0.077 0.027
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.075 0.063
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.075 0.063
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.075 0.078
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.075 0.087
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.073 0.038
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.073 0.063
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.073 0.038
PSD TYL: TYL protein 0.073 0.029
CHP CHP: Calcium-binding protein p22 0.073 0.038
MSN MSN: Moesin 0.073 0.038
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.073 0.046
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.073 0.029
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.073 0.038
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.073 0.038
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.073 0.038
FNBP1 N/A 0.073 0.063
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.073 0.046
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.073 0.038
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.073 0.029
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.073 0.029
TLN1 TLN1: Uncharacterized protein TLN1 0.073 0.029
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.073 0.046
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.072 0.026
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.072 0.0425
VASP VASP: Vasodilator-stimulated phosphoprotein 0.072 0.026
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.040
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.071 0.032
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.069 0.063
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.067 0.046
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.067 0.063
HSP90AA1 Hsp89-alpha-delta-N 0.067 0.129
CDK4 CDK4: Cell division protein kinase 4 0.067 0.063
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.067 0.046
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.067 0.078
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.067 0.063
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.065 0.032
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.065 0.026
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.064 0.038
LCP1 LCP1, PLS2: Plastin-2 0.064 0.046
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.064 0.038
PSCD4 PSCD4, CYT4: Cytohesin-4 0.064 0.029
CXorf9 N/A 0.064 0.029
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.064 0.029
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.064 0.029
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.057 0.032
FUBP1 N/A 0.057 0.070
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.057 0.046
PLEK PLEK, P47: Pleckstrin 0.051 0.027
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.051 0.038
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.051 0.046
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.051 0.046
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.051 0.063
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.051 0.063
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.051 0.063
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.051 0.063
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.051 0.029
MDN1 MDN1, KIAA0301: Midasin 0.051 0.063
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.051 0.078
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.051 0.078
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.051 0.078
SYMPK SYMPK, SPK: Symplekin 0.051 0.038
CTPS CTPS: CTP synthase 1 0.051 0.063
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.051 0.040
MAPK15 N/A 0.049 0.028
MAP2K5 N/A 0.049 0.028
TSC2 TSC2, TSC4: Tuberin 0.049 0.025
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.028
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.049 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.049 0.028
MYO18A 0.049 0.025
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.046 0.040
HD HD, IT15: Huntingtin 0.0453 0.087
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0453 0.070
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0453 0.032
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.0453 0.0425
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0453 0.087
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0453 0.0425
COBL N/A 0.0453 0.032
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.0453 0.026
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.0453 0.026
WEE1 WEE1: Wee1-like protein kinase 0.0453 0.029
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.044 0.025
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.044 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.044 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.044 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.025
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.044 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.044 0.025
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.044 0.025
NIPBL N/A 0.044 0.025
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.044 0.025
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.044 0.025
SEC24B SEC24B: Protein transport protein Sec24B 0.041 0.078
MAGED2 N/A 0.041 0.029
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.041 0.046
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.041 0.078
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.041 0.063
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.041 0.078
CDK2 CDK2: Cell division protein kinase 2 0.041 0.038
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.041 0.078
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.041 0.063
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.041 0.029
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.041 0.078
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.041 0.063
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.041 0.063
CDK5 CDK5: Cell division protein kinase 5 0.041 0.063
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.041 0.038
RPS6KB1 N/A 0.041 0.063
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.041 0.063
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.041 0.063
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.041 0.063
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.041 0.032
COTL1 COTL1, CLP: Coactosin-like protein 0.04 0.025
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.04 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.04 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.04 0.028
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.039 0.027
DBN1 DBN1, D0S117E: Drebrin 0.037 0.052
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.026
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.037 0.0425
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.037 0.0425
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.037 0.052
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.037 0.038
CFL2 CFL2: Cofilin-2 0.036 0.025
SVIL SVIL: Supervillin 0.036 0.025
GSN GSN: Gelsolin precursor 0.036 0.025
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.035 0.032
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.035 0.032
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.035 0.032
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.035 0.032
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.035 0.040
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.033 0.063
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.033 0.046
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.033 0.038
GMFB GMFB: Glia maturation factor beta 0.033 0.078
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.033 0.038
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.033 0.029
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.033 0.046
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.033 0.038
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.033 0.038
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.033 0.046
STK10 STK10: Uncharacterized protein STK10 0.033 0.038
FLII FLII, FLIL: Protein flightless-1 homolog 0.033 0.029
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.033 0.029
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.033 0.078
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.033 0.029
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.033 0.046
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.033 0.038
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.033 0.029
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.033 0.063
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.032 0.026
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.032 0.032
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.032 0.029
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.032
GAS2 GAS2: Growth arrest-specific protein 2 0.032 0.032
FLNA FLNA, FLN, FLN1: Filamin-A 0.032 0.032
STK16 N/A 0.032 0.026
XRCC1 XRCC1: DNA-repair protein XRCC1 0.031 0.027
NPM1 NPM1, NPM: Nucleophosmin 0.031 0.032
ATM ATM: Serine-protein kinase ATM 0.029 0.029
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.029 0.046
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.063
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.029 0.029
WASPIP N/A 0.029 0.046
CDK7 CDK7, MO15: Cell division protein kinase 7 0.029 0.046
DLG1 N/A 0.029 0.078
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.028 0.032
AP2M1 AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1 0.028 0.032
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.028 0.032
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.028 0.040
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.027 0.038
HDLBP HDLBP, HBP, VGL: Vigilin 0.027 0.029
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.027 0.029
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.027 0.029
DSTN DSTN, ACTDP, DSN: Destrin 0.027 0.029
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.026 0.029
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.026 0.063
0.572
Total Score 4.46