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Evidence of Interaction Between KIT and GAB1

The interaction score between KIT and GAB1 is 18.60.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between KIT and GAB1 = 0.09

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology N/A N/A
Domains Domains present in KIT and GAB1:
Domains in KITDomains in GAB1
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.
IPR001849 Pleckstrin-like
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in KIT and GAB1 are listed below.

Domain 1Domain 2Chi Square
IPR001245 Tyrosine protein kinase IPR001849 Pleckstrin-like 125.014
IPR008266 Tyrosine protein kinase, active site IPR001849 Pleckstrin-like 119.16
IPR001245 Tyrosine protein kinase IPR011993 PH_type. 88.2896
IPR008266 Tyrosine protein kinase, active site IPR011993 PH_type. 85.0032
IPR000719 Protein kinase IPR001849 Pleckstrin-like 66.4046
IPR011009 Protein kinase-like IPR001849 Pleckstrin-like 42.4143
IPR000719 Protein kinase IPR011993 PH_type. 37.108
IPR011009 Protein kinase-like IPR011993 PH_type. 21.3114
IPR001824 Receptor tyrosine kinase, class III IPR001849 Pleckstrin-like 8.8433
IPR009134 Vascular endothelial growth factor receptor, VEGFR IPR001849 Pleckstrin-like 8.67287
IPR007110 Immunoglobulin-like IPR001849 Pleckstrin-like 4.03606
IPR009134 Vascular endothelial growth factor receptor, VEGFR IPR011993 PH_type. 3.65681
IPR001824 Receptor tyrosine kinase, class III IPR011993 PH_type. 3.54397
IPR003599 Immunoglobulin subtype IPR011993 PH_type. 2.87015
IPR007110 Immunoglobulin-like IPR011993 PH_type. 1.73192
IPR003599 Immunoglobulin subtype IPR001849 Pleckstrin-like 1.64574
IPR013151 Immunoglobulin. IPR011993 PH_type. 0.399518
IPR013151 Immunoglobulin. IPR001849 Pleckstrin-like 0.0636896
IPR003598 Immunoglobulin C-2 type IPR011993 PH_type. 0.0205778
IPR003598 Immunoglobulin C-2 type IPR001849 Pleckstrin-like 0.00269084

The background colour of the table refers to:

  • Blue Domain is only present in KIT
  • Yellow Domain is only present in GAB1
  • Green Domain is present in both KIT and GAB1

 0.109
Post-translational Modifications

Protein: KIT

PTMResidueReference
Dephosphorylation 570 PubMed, HPRD
N-linked 130 PubMed, HPRD
Phosphorylation 545 PubMed, HPRD
Phosphorylation 547 PubMed, HPRD
Phosphorylation 553 PubMed, HPRD
Phosphorylation 568 PubMed, HPRD
Phosphorylation 570 PubMed, HPRD
Phosphorylation 703 PubMed, HPRD
Phosphorylation 721 PubMed, HPRD
Phosphorylation 730 PubMed, HPRD
Phosphorylation 741 PubMed, HPRD
Phosphorylation 746 PubMed, HPRD
Phosphorylation 747 PubMed, HPRD
Phosphorylation 821 PubMed, HPRD
Phosphorylation 900 PubMed, HPRD
Phosphorylation 936 PubMed, HPRD
Phosphorylation 959 PubMed, HPRD

Protein: GAB1

PTMResidueReference
Dephosphorylation 657 PubMed, HPRD
Dephosphorylation 689 PubMed, HPRD
Phosphorylation 242 PubMed, HPRD
Phosphorylation 259 PubMed, HPRD
Phosphorylation 266 PubMed, HPRD
Phosphorylation 285 PubMed, HPRD
Phosphorylation 307 PubMed, HPRD
Phosphorylation 312 PubMed, HPRD
Phosphorylation 373 PubMed, HPRD
Phosphorylation 381 PubMed, HPRD
Phosphorylation 406 PubMed, HPRD
Phosphorylation 447 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 472 PubMed, HPRD
Phosphorylation 476 PubMed, HPRD
Phosphorylation 581 PubMed, HPRD
Phosphorylation 597 PubMed, HPRD
Phosphorylation 619 PubMed, HPRD
Phosphorylation 657 PubMed, HPRD
Phosphorylation 689 PubMed, HPRD
Phosphoserine 266 HPRD
Phosphotyrosine 259 HPRD
Localisation

Protein: KIT

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD

Protein: GAB1

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between KIT and GAB1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between KIT andGAB1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , KIT has 1344 interactors and GAB1 has 1413 interactors of which there are 656 common interactors.

Common InteractorName of Common InteractorScore for KIT-Interactor (?)Score for GAB1-Interactor (?)
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 487.00 0.123
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 422.00 0.165
CRKL CRKL: Crk-like protein 388.00 0.152
NCK2 NCK2: Cytoplasmic protein NCK2 315.00 0.109
STAT5B STAT5B: Signal transducer and activator of transcription 5B 214.00 0.152
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 127.00 0.100
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 112.00 0.072
SHC3 SHC3, NSHC, SHCC: SHC-transforming protein 3 69.80 0.0308
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 46.80 0.072
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 46.80 0.081
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 43.20 0.152
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 35.00 0.096
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 8.99 0.0263
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 2.08 0.114
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.165
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.980 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.165
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.902 0.152
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.902 0.152
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.902 0.123
SYK SYK: Tyrosine-protein kinase SYK 0.902 0.123
STAT3 0.878 0.165
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.878 0.165
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.808 0.123
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.808 0.191
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.808 0.152
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.808 0.191
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.731 0.123
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.191
JAK1 0.731 0.109
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.731 0.251
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.731 0.123
RIN1 RIN1: Ras and Rab interactor 1 0.655 0.152
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.655 0.109
CSK CSK: Tyrosine-protein kinase CSK 0.655 0.123
VAV1 VAV1, VAV: Proto-oncogene vav 0.655 0.123
BMX N/A 0.654 0.152
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.644 0.123
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.644 0.109
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.644 0.098
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.644 0.123
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.644 0.152
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.644 0.152
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.617 0.051
GRB10 N/A 0.617 0.051
CRK CRK: Proto-oncogene C-crk 0.617 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.617 0.051
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.581 0.109
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.577 0.109
STAT6 STAT6: Signal transducer and activator of transcription 6 0.577 0.123
LYN LYN: Tyrosine-protein kinase Lyn 0.577 0.123
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.577 0.152
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.577 0.109
APS SH2B2, APS: SH2B adapter protein 2 0.577 0.191
HCK N/A 0.577 0.152
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.577 0.123
VAV2 VAV2: Uncharacterized protein VAV2 0.553 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.553 0.051
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.520 0.191
STAT2 STAT2: Signal transducer and activator of transcription 2 0.497 0.152
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.484 0.165
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.403 0.109
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.361 0.123
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.355 0.109
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.318 0.109
STAT4 STAT4: Signal transducer and activator of transcription 4 0.318 0.123
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.307 0.166
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.275 0.100
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.027
SOCS5 SOCS5, CIS6, CISH5, CISH6, KIAA0671: Suppressor of cytokine signaling 5 0.251 0.0308
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.217 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.217 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.217 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.217 0.027
IPO7 IPO7: Uncharacterized protein IPO7 0.202 0.096
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.191 0.126
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.081
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.181 0.152
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.181 0.123
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.171 0.072
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.171 0.100
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.166 0.060
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.049
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
FN1 N/A 0.165 0.109
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.049
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.165 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.165 0.049
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.049
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.049
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.049
KIR3DL1 N/A 0.165 0.049
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.109
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.152 0.100
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.152 0.109
ITGAE ITGAE: Integrin alpha-E precursor 0.152 0.0453
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.152 0.100
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.152 0.081
EPOR EPOR: Erythropoietin receptor precursor 0.152 0.126
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.152 0.081
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.152 0.037
PTPRZ1 N/A 0.152 0.081
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.152 0.032
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.148 0.123
ATRN N/A 0.148 0.109
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.148 0.049
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.148 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.148 0.109
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.148 0.049
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.148 0.049
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.148 0.109
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.109
BSG N/A 0.148 0.049
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.148 0.109
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.109
SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 0.143 0.0308
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.136 0.166
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.136 0.057
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.127 0.100
GAB2 N/A 0.126 0.026
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.123 0.037
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.123 0.100
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.123 0.032
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.123 0.081
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.123 0.100
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.123 0.0453
SELE SELE, ELAM1: E-selectin precursor 0.123 0.032
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.123 0.0453
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.123 0.032
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.123 0.081
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.123 0.037
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.032
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.123 0.037
SORL1 SORL1: Sortilin-related receptor precursor 0.123 0.081
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.123 0.126
F10 F10: Coagulation factor X precursor 0.123 0.037
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.113 0.191
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.113 0.096
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.113 0.191
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.110 0.081
DCC DCC: Netrin receptor DCC precursor 0.110 0.126
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.110 0.065
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.110 0.072
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.110 0.072
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.110 0.081
INSR INSR: Insulin receptor precursor 0.110 0.081
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.110 0.126
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.110 0.081
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.037
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.028
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
NF2 NF2, SCH: Merlin 0.109 0.083
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.109 0.083
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.165
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.028
PPEF1 N/A 0.109 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.109 0.028
PSCD2 N/A 0.109 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.165
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.109 0.028
CNN2 CNN2: Calponin-2 0.109 0.083
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.109 0.028
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.126
THBD THBD, THRM: Thrombomodulin precursor 0.109 0.037
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.109 0.0453
EGF EGF: Pro-epidermal growth factor precursor 0.109 0.081
IL9R IL9R: Interleukin-9 receptor precursor 0.109 0.166
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.100
GHR GHR: Growth hormone receptor precursor 0.109 0.072
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.109 0.032
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.0453
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.109 0.0453
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.037
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.109 0.0453
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.109 0.037
ITGB4 N/A 0.109 0.065
CRLF3 N/A 0.109 0.081
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.030
PRLR PRLR: Prolactin receptor precursor 0.109 0.126
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.100 0.034
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.100 0.026
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.100 0.152
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.098 0.057
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.098 0.029
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.098 0.166
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.098 0.126
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.029
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.098 0.0453
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.098 0.081
ELMO1 N/A 0.098 0.028
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.098 0.028
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.098 0.083
CDC25A CDC25A: M-phase inducer phosphatase 1 0.098 0.028
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.098 0.165
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.098 0.028
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.098 0.083
ARHGEF7 N/A 0.098 0.028
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 0.083
SNX3 N/A 0.098 0.052
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.098 0.083
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.098 0.0688
EEF2K EEF2K: Elongation factor 2 kinase 0.098 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.098 0.083
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.098 0.052
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.098 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.098 0.165
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.165
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.083
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.098 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.098 0.165
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.098 0.034
BMP1 N/A 0.098 0.034
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.098 0.0688
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.098 0.165
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.098 0.083
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.098 0.165
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.098 0.052
CDC25C CDC25C: M-phase inducer phosphatase 3 0.098 0.028
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.098 0.083
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.098 0.165
MEP1B MEP1B: Meprin A subunit beta precursor 0.097 0.075
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.097 0.065
ITGB7 ITGB7: Integrin beta-7 precursor 0.097 0.081
NEO1 NEO1, NGN: Neogenin precursor 0.097 0.081
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.097 0.081
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.097 0.191
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.097 0.081
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.097 0.072
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.097 0.126
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.097 0.100
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.097 0.100
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.097 0.100
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.097 0.100
MEP1A MEP1A: Meprin A subunit alpha precursor 0.097 0.037
TNC TNC, HXB: Tenascin precursor 0.097 0.072
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.096 0.152
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.096 0.0453
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.096 0.152
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.094 0.048
SOS1 SOS1: Son of sevenless homolog 1 0.094 0.123
CDK6 CDK6: Cell division protein kinase 6 0.091 0.152
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.091 0.096
RDX RDX: Radixin 0.090 0.077
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.090 0.152
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.090 0.191
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.090 0.123
CD2AP CD2AP: CD2-associated protein 0.090 0.123
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.090 0.049
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.090 0.152
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.090 0.063
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.090 0.062
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.090 0.062
DOK1 DOK1: Docking protein 1 0.090 0.096
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.090 0.127
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.090 0.191
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.090 0.026
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.088 0.166
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.088 0.081
F7 F7: Coagulation factor VII precursor 0.087 0.034
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.086 0.123
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.086 0.152
LAT LAT: Linker for activation of T-cells family member 1 0.083 0.049
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.049
DLK1 DLK1, DLK: Delta-like protein precursor 0.083 0.049
PCDHA2 PCDHA2: Protocadherin alpha 2 precursor 0.083 0.049
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.083 0.049
CDH6 CDH6: Cadherin-6 precursor 0.083 0.049
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.109
ATP2A3 ATP2A3: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 0.083 0.109
MUCDHL MUPCDH, MUCDHL, UNQ2781/PRO7168: Mucin and cadherin-like protein precursor 0.083 0.049
XPO1 XPO1, CRM1: Exportin-1 0.0818 0.077
ROCK1 ROCK1: Rho-associated protein kinase 1 0.081 0.191
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.081 0.032
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.105
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.081 0.152
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.081 0.152
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.081 0.123
GRLF1 N/A 0.081 0.191
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.081 0.109
IRS1 IRS1: Insulin receptor substrate 1 0.081 0.077
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.081 0.055
SPTAN1 N/A 0.081 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.081 0.032
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.077
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.081 0.123
SNCB SNCB: Beta-synuclein 0.081 0.039
CNN3 CNN3: Calponin-3 0.081 0.055
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.080 0.031
ATP2B1 N/A 0.077 0.0453
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.077 0.081
FADD FADD, MORT1: Protein FADD 0.077 0.030
DSG2 DSG2: Desmoglein-2 precursor 0.077 0.032
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.075 0.026
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.075 0.152
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.075 0.039
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.075 0.109
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.165
JAG2 JAG2: Jagged-2 precursor 0.075 0.049
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.075 0.049
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.075 0.049
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.073 0.096
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.073 0.062
DLG2 DLG2: Disks large homolog 2 0.073 0.063
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.073 0.026
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.073 0.026
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.073 0.123
PSD TYL: TYL protein 0.073 0.026
MSN MSN: Moesin 0.073 0.062
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.073 0.123
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.073 0.152
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.073 0.123
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.073 0.062
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.073 0.039
FNBP1 N/A 0.073 0.123
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.073 0.077
PLD2 PLD2: Phospholipase D2 0.073 0.080
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.073 0.034
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.073 0.109
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.073 0.062
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.073 0.096
TLN1 TLN1: Uncharacterized protein TLN1 0.073 0.127
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.073 0.096
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.073 0.123
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.072 0.123
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.096
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.096
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.072 0.152
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.072 0.051
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.051
CSPG2 N/A 0.072 0.031
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.109
VASP VASP: Vasodilator-stimulated phosphoprotein 0.072 0.062
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.072 0.191
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.069 0.123
NSBP1 NSBP1: Nucleosome-binding protein 1 0.0688 0.028
CETN1 CETN1, CEN1, CETN: Centrin-1 0.0688 0.028
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.067 0.123
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.067 0.026
HSP90AA1 Hsp89-alpha-delta-N 0.067 0.026
CDK4 CDK4: Cell division protein kinase 4 0.067 0.123
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.067 0.062
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.067 0.191
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.067 0.152
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.067 0.039
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.065 0.191
DAB1 DAB1: Disabled homolog 1 0.064 0.039
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.064 0.062
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.064 0.051
ALK ALK: ALK tyrosine kinase receptor precursor 0.064 0.063
TTN N/A 0.064 0.055
STAM2 STAM2: Signal transducing adapter molecule 2 0.064 0.191
LCP1 LCP1, PLS2: Plastin-2 0.064 0.062
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.064 0.077
SORBS3 SORBS3, SCAM1: Vinexin 0.064 0.191
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.064 0.062
PSCD4 PSCD4, CYT4: Cytohesin-4 0.064 0.026
CXorf9 N/A 0.064 0.123
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.064 0.026
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.064 0.109
VIL2 N/A 0.064 0.055
GMIP GMIP: GEM-interacting protein 0.064 0.077
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.064 0.045
RASA3 RASA3: Ras GTPase-activating protein 3 0.064 0.123
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.064 0.026
DAB2 DAB2, DOC2: Disabled homolog 2 0.064 0.034
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.064 0.055
ACTN1 ACTN1: Alpha-actinin-1 0.064 0.055
TLN2 TLN2: Uncharacterized protein TLN2 0.064 0.062
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.064 0.051
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.064 0.062
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.063 0.034
RYR2 RYR2: Ryanodine receptor 2 0.063 0.031
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.063 0.077
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.062 0.075
CDH5 CDH5: Cadherin-5 precursor 0.062 0.032
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.062 0.057
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.062 0.0453
MT3 MT3: Metallothionein-3 0.062 0.123
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.062 0.028
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.062 0.052
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.058 0.123
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.058 0.077
PLD1 PLD1: Phospholipase D1 0.058 0.060
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.058 0.191
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.057 0.039
PROC PROC: Vitamin K-dependent protein C precursor 0.057 0.025
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.057 0.026
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.057 0.026
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.057 0.152
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.056 0.048
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.056 0.032
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.056 0.0453
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.056 0.100
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.056 0.037
NOTCH4 N/A 0.056 0.0453
CDH17 CDH17: Cadherin-17 precursor 0.055 0.037
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.055 0.0263
CDH2 CDH2, CDHN, NCAD: Cadherin-2 precursor 0.055 0.0453
RHO RHO, OPN2: Rhodopsin 0.055 0.037
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.055 0.037
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.055 0.037
CD44 N/A 0.055 0.037
CDH13 CDH13, CDHH: Cadherin-13 precursor 0.055 0.0453
UMOD UMOD: Uromodulin precursor 0.055 0.032
AREG AREG, SDGF: Amphiregulin precursor 0.055 0.032
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 0.055 0.037
BZRAP1 BZRAP1, KIAA0612, RBP1: Peripheral-type benzodiazepine receptor-associated prote 0.053 0.0308
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.052 0.030
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
ITGB1 ITGB1, FNRB, MDF2, MSK12: Integrin beta-1 precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
MARK1 MARK1, KIAA1477, MARK: Serine/threonine-protein kinase MARK1 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
MARK2 N/A 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
PLEK PLEK, P47: Pleckstrin 0.051 0.026
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.051 0.055
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.025
ETS2 ETS2: Protein C-ets-2 0.0513 0.048
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.051 0.109
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.051 0.152
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.051 0.191
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.051 0.026
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.051 0.039
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.051 0.251
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.051 0.152
MDN1 MDN1, KIAA0301: Midasin 0.051 0.055
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.051 0.109
SYMPK SYMPK, SPK: Symplekin 0.051 0.026
CTPS CTPS: CTP synthase 1 0.051 0.026
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.051 0.077
DSG3 DSG3: Desmoglein-3 precursor 0.049 0.032
DSC2 DSC2, DSC3: Desmocollin-2 precursor 0.049 0.032
PCDH7 PCDH7, BHPCDH: Protocadherin-7 precursor 0.049 0.057
MAPK15 N/A 0.049 0.165
MAP2K5 N/A 0.049 0.165
TSC2 TSC2, TSC4: Tuberin 0.049 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.049 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.049 0.052
PLAT PLAT: Tissue-type plasminogen activator precursor 0.049 0.034
MYO18A 0.049 0.028
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.049 0.029
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.049 0.032
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.049 0.072
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.081
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.049 0.037
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.047 0.049
F9 F9: Coagulation factor IX precursor 0.0462 0.039
FLT4 VEGFR3 long form 0.046 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.051
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.046 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.051
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.046 0.039
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.046 0.039
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.046 0.030
HD HD, IT15: Huntingtin 0.0453 0.048
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0453 0.039
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0453 0.123
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0453 0.123
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0453 0.123
COBL N/A 0.0453 0.062
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.0453 0.032
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.0453 0.152
WEE1 WEE1: Wee1-like protein kinase 0.0453 0.152
TP73 TP73, P73: Tumor protein p73 0.045 0.062
LDLR LDLR: Low-density lipoprotein receptor precursor 0.044 0.037
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.044 0.072
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.044 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.044 0.165
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.044 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.044 0.165
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.028
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.083
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.044 0.165
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.044 0.165
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.044 0.028
NIPBL N/A 0.044 0.028
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.044 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.044 0.165
SEC24B SEC24B: Protein transport protein Sec24B 0.041 0.026
WWC2 WW and C2 domain containing 2 0.041 0.062
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.041 0.152
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.041 0.109
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.041 0.063
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.041 0.152
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.041 0.191
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.041 0.109
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.041 0.077
CDK2 CDK2: Cell division protein kinase 2 0.041 0.123
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.041 0.109
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.041 0.152
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.041 0.191
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.041 0.123
CDK5 CDK5: Cell division protein kinase 5 0.041 0.123
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.041 0.123
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.041 0.045
RPS6KB1 N/A 0.041 0.152
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.041 0.152
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.041 0.039
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.048
MYH9 MYH9: Myosin-9 0.041 0.055
COTL1 COTL1, CLP: Coactosin-like protein 0.04 0.028
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.04 0.028
DSP DSP: Desmoplakin 0.04 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.04 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.04 0.028
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.039 0.026
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 0.038 0.046
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.152
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.037 0.109
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.037 0.039
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.037 0.123
RAB11FIP5 RAB11FIP5, GAF1, KIAA0857, RIP11: Rab11 family-interacting protein 5 0.037 0.062
CFL2 CFL2: Cofilin-2 0.036 0.028
SVIL SVIL: Supervillin 0.036 0.028
GSN GSN: Gelsolin precursor 0.036 0.028
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.035 0.126
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.035 0.0453
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.035 0.057
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.035 0.037
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.035 0.032
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.035 0.026
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.035 0.026
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.035 0.026
SYTL4 Endocrine transmitter regulatory protein 0.034 0.083
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.034
BID BID: BH3-interacting domain death agonist 0.034 0.028
GMFB GMFB: Glia maturation factor beta 0.033 0.026
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.033 0.152
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.033 0.152
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.033 0.123
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.033 0.123
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.033 0.152
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.033 0.123
STK10 STK10: Uncharacterized protein STK10 0.033 0.123
DYRK3 N/A 0.033 0.109
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.033 0.123
KIAA0690 N/A 0.033 0.032
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.033 0.055
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.033 0.152
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.033 0.123
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.033 0.109
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.033 0.152
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.033 0.191
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.033 0.123
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.033 0.031
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.033 0.152
CFI CFI, IF: Complement factor I precursor 0.032 0.031
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.032 0.039
CFB CFB, BF, BFD: Complement factor B precursor 0.032 0.025
PRKAA1 N/A 0.032 0.109
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.032 0.109
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.152
GAS2 GAS2: Growth arrest-specific protein 2 0.032 0.048
FLNA FLNA, FLN, FLN1: Filamin-A 0.032 0.062
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.032 0.034
STK16 N/A 0.032 0.123
CDKL5 N/A 0.032 0.152
C8A C8A: Complement component C8 alpha chain precursor 0.032 0.025
MUC2 MUC2, SMUC: Mucin-2 precursor 0.032 0.031
XRCC1 XRCC1: DNA-repair protein XRCC1 0.031 0.026
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.0308 0.057
TNN TNN: Tenascin-N precursor 0.030 0.0782
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.030 0.028
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.030 0.165
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.030 0.083
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.030 0.028
CCNT2 CCNT2: Cyclin-T2 0.030 0.028
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.030 0.028
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.030 0.028
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.030 0.165
CREB1 CREB1: cAMP response element-binding protein 0.030 0.028
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.030 0.045
C2 C2: Complement C2 precursor 0.029 0.025
C6 C6: Complement component C6 precursor 0.029 0.025
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.029 0.109
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.029 0.123
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.029 0.152
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.029 0.025
ATM ATM: Serine-protein kinase ATM 0.029 0.123
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.029 0.251
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.029 0.152
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.029 0.191
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.029 0.152
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.029 0.026
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.123
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.029 0.123
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.029 0.055
WASPIP N/A 0.029 0.062
CDK7 CDK7, MO15: Cell division protein kinase 7 0.029 0.109
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.109
MYO3A MYO3A: Myosin IIIA 0.029 0.123
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.109
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.029 0.062
DLG1 N/A 0.029 0.032
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
DRD2 DRD2: D(2) dopamine receptor 0.028 0.049
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.028 0.026
CHC1 RCC1: RCC1-I (Fragment) 0.028 0.031
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.028 0.026
PMP2 PMP2: Myelin P2 protein 0.027 0.123
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.027 0.098
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.0263 0.051
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.0263 0.045
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.0263 0.041
FABP1 FABP1, FABPL: Fatty acid-binding protein, liver 0.0263 0.123
C8B C8B: Complement component C8 beta chain precursor 0.026 0.025
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.026 0.031
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.026 0.191
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.026 0.191
PARVA PARVA, MXRA2: Alpha-parvin 0.026 0.048
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.026 0.152
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.026 0.027
SPINT2 SPINT2, HAI2, KOP: Kunitz-type protease inhibitor 2 precursor 0.026 0.032
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.026 0.191
ERF ERF: ETS domain-containing transcription factor ERF 0.025 0.032
SALF GTF2A1L, ALF, GTF2A1LF: TFIIA-alpha and beta-like factor 0.025 0.026
SCML2 SCML2: Sex comb on midleg-like protein 2 0.025 0.055
ETV1 ETV1, ER81: ETS translocation variant 1 0.025 0.026
MDM4 MDM4, MDMX: Mdm4 protein 0.025 0.032
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.152
APP APP, A4, AD1: Amyloid beta A4 protein precursor 0.025 0.109
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.025 0.109
TMPRSS9 N/A 0.025 0.049
0.572
Total Score 18.60