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Evidence of Interaction Between NAP1L1 and IPI00033904

The interaction score between NAP1L1 and IPI00033904 is 2.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between NAP1L1 and IPI00033904 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismNAP1L1 OrthologueIPI00033904 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00030392 0.164 IPI00025419 0.55
human IPI00030392 0.164 IPI00472119 0.978
human IPI00030392 0.164 IPI00478655 0.411
human IPI00456950 0.59 IPI00025419 0.55
human IPI00456950 0.59 IPI00472119 0.978
human IPI00456950 0.59 IPI00478655 0.411
bakers yeast YKR048C 1 YLR441C 0.944
  • AffinityCaptureMS

Get References From PubMed
bakers yeast YKR048C 1 YML063W 1
worm Q19007 1 P48154 1
fly Q24150 1 Q8IMA9 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.119
Domains No domains were used in calculating likelihood of interaction 4.85E-3
Post-translational Modifications

Protein: NAP1L1

PTMResidueReference
Farnesylation 388 PubMed, HPRD
Phosphorylation 62 PubMed, HPRD

Protein: IPI00033904

PTMResidueReference
Phosphotyrosine 255 HPRD
Localisation

Protein: NAP1L1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: IPI00033904

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between NAP1L1 and IPI00033904 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between NAP1L1 andIPI00033904. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , NAP1L1 has 1065 interactors and IPI00033904 has 217 interactors of which there are 82 common interactors.

Common InteractorName of Common InteractorScore for NAP1L1-Interactor (?)Score for IPI00033904-Interactor (?)
RPS6 RPS6, OK/SW-cl.2: 40S ribosomal protein S6 12.60 0.144
RPL36AL RPL36A, RPL44, MIG6: 60S ribosomal protein L36a 6.52 0.0739
RPL10A RPL10A, NEDD6: 60S ribosomal protein L10a 6.52 0.0739
RPL36AL RPL36AL: 60S ribosomal protein L36a-like 0.614 0.0739
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.385 0.0479
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.308 0.053
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.308 0.053
PTMA N/A 0.308 0.053
GNB2L1 Lung cancer oncogene 7 0.308 0.160
SET SET: Protein SET 0.308 0.025
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.276 0.144
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.276 0.0479
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.276 0.0479
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.276 0.0479
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.276 0.133
NCOA3 N/A 0.144 0.025
IFI16 N/A 0.144 0.025
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.144 0.025
DDX21 DDX21: Nucleolar RNA helicase 2 0.144 0.025
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.144 0.025
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.144 0.025
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.144 0.053
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.141 0.144
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.141 0.0479
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.141 0.144
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.141 0.144
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.141 0.027
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.141 1.12
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.141 0.144
RPL8 RPL8: 60S ribosomal protein L8 0.141 0.0479
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.141 0.144
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.129 0.0479
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.129 0.0479
PPP1R8 N/A 0.129 0.0479
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.129 0.0479
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.129 0.0479
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.129 0.0479
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.129 0.0479
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.129 0.0479
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.129 0.0479
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.129 0.0479
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.087 0.025
ELF1 ELF1: ETS-related transcription factor Elf-1 0.087 0.053
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.087 0.053
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.078 0.0479
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.0479
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.078 5.94
FUBP1 N/A 0.074 0.053
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.070 0.025
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.025
HNRPK N/A 0.066 0.0479
RPS10 RPS10: 40S ribosomal protein S10 0.066 0.144
QARS QARS: Glutaminyl-tRNA synthetase 0.066 0.0479
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.066 0.144
RPL7 RPL7: 60S ribosomal protein L7 0.0479 0.027
RPL18A RPL18A: 60S ribosomal protein L18a 0.0479 0.0479
EIF3S5 N/A 0.0479 0.0479
RPL31 RPL31: 60S ribosomal protein L31 0.0479 0.144
SRRM1 SRRM1, SRM160: Serine/arginine repetitive matrix protein 1 0.0479 0.0479
EIF3S7 EIF3S7: Eukaryotic translation initiation factor 3 subunit 7 0.0479 0.144
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.040 3.59
TPT1 TPT1: Translationally-controlled tumor protein 0.040 0.0479
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.040 1.19
RPS13 RPS13: 40S ribosomal protein S13 0.038 0.144
SLC25A6 SLC25A6, ANT3, CDABP0051: ADP/ATP translocase 3 0.038 0.0479
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.032 0.081
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.028 0.029
LSM14A N/A 0.027 0.027
RPS24 40S ribosomal protein S24. Isoform 2 0.027 0.082
RPL14 RPL14: RPL14 protein 0.027 0.082
DKFZP586L0724 NOL11, L14: Nucleolar protein 11 0.027 0.027
RPL17 RPL17: 60S ribosomal protein L17 0.027 0.082
PSME1 PSME1, IFI5111: Proteasome activator complex subunit 1 0.027 0.027
RPS21 RPS21: 40S ribosomal protein S21 0.027 0.082
MGC9850 N/A 0.027 0.027
RPL15 RPL15, EC45, TCBAP0781: 60S ribosomal protein L15 0.027 0.082
HNRPD N/A 0.027 0.027
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.025 0.026
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.026
C11orf58 SMAP, C11orf58: Small acidic protein 0.025 0.053
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.025
KIAA0157 KIAA0157: Uncharacterized protein KIAA0157 0.025 0.025
2.15E-3
Total Score 2.20