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Evidence of Interaction Between PARD6A and IRS4

The interaction score between PARD6A and IRS4 is 19.70.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in PARD6A and IRS4:
Domains in PARD6ADomains in IRS4
IPR001478 PDZ/DHR/GLGF domain
IPR000270 Octicosapeptide/Phox/Bem1p
IPR001849 Pleckstrin-like
IPR002404 Insulin receptor substrate-1, PTB
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in PARD6A and IRS4 are listed below.

Domain 1Domain 2Chi Square
IPR000270 Octicosapeptide/Phox/Bem1p IPR001849 Pleckstrin-like 9.43221
IPR001478 PDZ/DHR/GLGF domain IPR001849 Pleckstrin-like 2.85635
IPR000270 Octicosapeptide/Phox/Bem1p IPR011993 PH_type. 2.22719
IPR001478 PDZ/DHR/GLGF domain IPR011993 PH_type. 0.00703679

The background colour of the table refers to:

  • Blue Domain is only present in PARD6A
  • Yellow Domain is only present in IRS4
  • Green Domain is present in both PARD6A and IRS4

 0.165
Post-translational Modifications

Protein: PARD6A

PTMResidueReference
Phosphorylation 278 PubMed, HPRD

Protein: IRS4

PTMResidueReference
Phosphorylation 700 PubMed, HPRD
Phosphorylation 717 PubMed, HPRD
Phosphorylation 743 PubMed, HPRD
Phosphorylation 779 PubMed, HPRD
Localisation

Protein: PARD6A

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: IRS4

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PARD6A and IRS4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PARD6A andIRS4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PARD6A has 1139 interactors and IRS4 has 1088 interactors of which there are 734 common interactors.

Common InteractorName of Common InteractorScore for PARD6A-Interactor (?)Score for IRS4-Interactor (?)
PRKCG PRKCG, PKCG: Protein kinase C gamma type 22.50 0.123
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 22.50 0.109
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 12.60 0.028
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 12.60 0.109
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 12.60 0.123
PRKCB1 N/A 3.81 0.028
ROCK1 ROCK1: Rho-associated protein kinase 1 0.165 0.152
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.165 0.165
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.165 0.251
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.165 0.055
MAP2K5 N/A 0.165 0.165
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.165 0.152
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.165 0.165
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.165 0.109
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.165 0.191
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.165 0.191
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.165 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.165
IRS2 IRS2: Insulin receptor substrate 2 0.165 0.055
CDKL5 N/A 0.165 0.123
IRS1 IRS1: Insulin receptor substrate 1 0.165 0.062
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.165 0.109
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.165 0.109
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.165 0.123
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.165
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.165 0.028
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.165 0.123
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.165 0.123
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.165 0.123
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.165 0.109
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.165 0.123
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.165 0.109
STK16 N/A 0.165 0.152
DAPK2 DAPK2: Death-associated protein kinase 2 0.165 0.152
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.165 0.123
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.165
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.165 0.123
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.165 0.109
NOS1 NOS1: Nitric-oxide synthase, brain 0.165 0.060
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.165 0.123
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.165 0.109
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.165 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.165 0.165
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.165 0.165
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.165 0.152
YWHAG YWHAG: 14-3-3 protein gamma 0.165 0.083
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.165 0.123
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.165 0.109
FLNA FLNA, FLN, FLN1: Filamin-A 0.165 0.049
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.165 0.123
MAPKAPK5 N/A 0.165 0.165
PRKAA1 N/A 0.165 0.123
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.165
LIMK2 LIMK2: LIM domain kinase 2 0.165 0.123
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.165 0.123
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.165 0.123
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.165
YWHAQ YWHAQ: 14-3-3 protein theta 0.165 0.055
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.165 0.123
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.165 0.191
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.148 0.123
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.148 0.123
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.148 0.123
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.148 0.152
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.148 0.062
CDK7 CDK7, MO15: Cell division protein kinase 7 0.148 0.123
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.148 0.123
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.148 0.109
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.148 0.123
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.148 0.123
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.148 0.109
ACTN4 ACTN4: Alpha-actinin-4 0.148 0.083
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.083
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.148 0.165
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.148 0.152
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.148 0.165
STK10 STK10: Uncharacterized protein STK10 0.148 0.109
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.148 0.123
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.148 0.123
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.148 0.123
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.148 0.165
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.148 0.109
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.148 0.152
ACTN1 ACTN1: Alpha-actinin-1 0.148 0.049
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.148 0.109
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.148 0.109
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.148 0.152
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.148 0.109
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.148 0.251
WEE1 WEE1: Wee1-like protein kinase 0.148 0.123
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.148 0.123
MYO18A 0.148 0.028
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.148 0.152
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.148 0.165
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.148 0.165
DYRK3 N/A 0.148 0.109
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.148 0.109
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.148 0.062
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.148 0.165
VAV1 VAV1, VAV: Proto-oncogene vav 0.148 0.123
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.148 0.165
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.148 0.077
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.148 0.191
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.148 0.083
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.148 0.152
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.148 0.123
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.148 0.123
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.148 0.152
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.148 0.123
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.148 0.165
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.148 0.109
YWHAE YWHAE: 14-3-3 protein epsilon 0.148 0.062
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.148 0.165
RPS6KB1 N/A 0.148 0.123
MYO3A MYO3A: Myosin IIIA 0.148 0.191
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.148 0.049
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.148 0.109
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.148 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.165
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.148 0.109
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.148 0.096
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.148 0.123
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.148 0.123
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.165
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.148 0.098
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.148 0.109
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.148 0.152
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.148 0.152
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.148 0.123
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.148 0.123
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.165
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.148 0.152
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.148 0.083
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.148 0.165
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.148 0.096
CDK6 CDK6: Cell division protein kinase 6 0.148 0.109
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.148 0.123
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.148 0.062
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.148 0.109
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.148 0.028
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.148 0.098
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.148 0.191
DOK1 DOK1: Docking protein 1 0.148 0.062
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.148 0.152
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.148 0.165
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.148 0.109
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.148 0.165
CDK4 CDK4: Cell division protein kinase 4 0.148 0.152
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.083
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.165
CDK5 CDK5: Cell division protein kinase 5 0.148 0.109
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.148 0.109
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.148 0.055
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.148 0.152
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.148 0.152
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.148 0.123
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.148 0.191
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.148 0.152
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.148 0.123
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.148 0.109
RAB5B RAB5B: Ras-related protein Rab-5B 0.148 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.148 0.165
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.148 0.034
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.148 0.152
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.148 0.077
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.148 0.123
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.148 0.152
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.148 0.123
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.148 0.191
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.148 0.152
GMIP GMIP: GEM-interacting protein 0.148 0.055
LCP1 LCP1, PLS2: Plastin-2 0.148 0.062
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.148 0.109
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.148 0.055
CDK2 CDK2: Cell division protein kinase 2 0.148 0.152
CDC2 CDC2: Cell division control protein 2 homolog 0.148 0.165
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.148 0.109
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.148 0.123
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.109 0.049
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.032
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.109 0.049
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.109 0.049
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.109 0.0453
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.109 0.126
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.109 0.072
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.109 0.075
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.109 0.049
SCTR SCTR: Secretin receptor precursor 0.098 0.074
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.098 0.049
CALCRL CALCRL, CGRPR: Calcitonin gene-related peptide type 1 receptor precursor 0.098 0.030
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.098 0.109
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.098 0.0453
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.098 0.072
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.098 0.037
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.098 0.166
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.098 0.072
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.098 0.037
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.098 0.100
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.098 0.109
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.098 0.032
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.098 0.030
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.098 0.109
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.098 0.109
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.098 0.057
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.098 0.037
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.098 0.081
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.049
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.098 0.0453
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.098 0.049
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.083 0.165
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.083 0.123
BMX N/A 0.083 0.191
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.083 0.083
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.083 0.0425
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.083 0.109
NF2 NF2, SCH: Merlin 0.083 0.165
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.083 0.191
GAB1 GAB1: GRB2-associated-binding protein 1 0.083 0.096
CNN2 CNN2: Calponin-2 0.083 0.083
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.083 0.077
CNN3 CNN3: Calponin-3 0.083 0.049
LNK SH2B3, LNK: SH2B adapter protein 3 0.083 0.165
WWC2 WW and C2 domain containing 2 0.083 0.055
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.083 0.123
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.083 0.062
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.083 0.028
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.083 0.123
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.028
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.083 0.055
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.052
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.083 0.123
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.083 0.083
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.083 0.165
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.083 0.026
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.083 0.039
GAS2 GAS2: Growth arrest-specific protein 2 0.083 0.034
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.083 0.165
GRLF1 N/A 0.083 0.152
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.083 0.251
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.083 0.123
PPEF1 N/A 0.083 0.028
WWC1 WWC1, KIAA0869: WW domain-containing protein 1 0.083 0.062
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.083 0.039
SPTAN1 N/A 0.083 0.123
VASP VASP: Vasodilator-stimulated phosphoprotein 0.083 0.055
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.083 0.039
MCF2 MCF2, DBL: Proto-oncogene DBL 0.083 0.096
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.083 0.062
GAB2 N/A 0.083 0.055
MAPK15 N/A 0.083 0.165
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.083 0.109
PSCD2 N/A 0.083 0.083
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.083 0.152
S100A16 S100A16, AAG13: Protein S100-A16 0.083 0.028
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.075 0.152
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.075 0.055
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.075 0.062
HCK N/A 0.075 0.109
RRAS RRAS: Ras-related protein R-Ras precursor 0.075 0.109
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.075 0.152
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.075 0.123
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.075 0.109
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.075 0.152
STAT3 0.075 0.165
CSK CSK: Tyrosine-protein kinase CSK 0.075 0.123
NRAS NRAS, HRAS1: GTPase NRas precursor 0.075 0.109
ATM ATM: Serine-protein kinase ATM 0.075 0.123
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.075 0.123
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.075 0.028
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.075 0.123
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.075 0.055
VIL2 N/A 0.075 0.123
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.075 0.165
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.075 0.123
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.075 0.123
CXorf9 N/A 0.075 0.152
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.075 0.052
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.075 0.062
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.075 0.062
CRKL CRKL: Crk-like protein 0.075 0.123
RDX RDX: Radixin 0.075 0.123
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.075 0.083
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.075 0.062
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.075 0.096
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.075 0.098
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.075 0.123
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.075 0.055
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.075 0.098
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.075 0.123
PLD1 PLD1: Phospholipase D1 0.075 0.077
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.075 0.109
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.075 0.191
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.075 0.109
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.075 0.123
LYN LYN: Tyrosine-protein kinase Lyn 0.075 0.123
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.075 0.109
RAB11FIP5 RAB11FIP5, GAF1, KIAA0857, RIP11: Rab11 family-interacting protein 5 0.075 0.077
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.075 0.123
PARVA PARVA, MXRA2: Alpha-parvin 0.075 0.060
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.075 0.123
PSCD4 PSCD4, CYT4: Cytohesin-4 0.075 0.055
RRAD RRAD, RAD: GTP-binding protein RAD 0.075 0.191
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.075 0.165
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.075 0.034
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.075 0.123
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.075 0.049
RAD50 RAD50: DNA repair protein RAD50 0.075 0.028
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.075 0.165
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.075 0.055
STAT6 STAT6: Signal transducer and activator of transcription 6 0.075 0.123
SYK SYK: Tyrosine-protein kinase SYK 0.075 0.109
ARHGEF7 N/A 0.075 0.083
RASA3 RASA3: Ras GTPase-activating protein 3 0.075 0.152
PSD TYL: TYL protein 0.075 0.055
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.075 0.034
EEF2 EEF2, EF2: Elongation factor 2 0.075 0.123
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.075 0.039
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.165
APS SH2B2, APS: SH2B adapter protein 2 0.075 0.152
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.075 0.165
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.075 0.191
MSN MSN: Moesin 0.075 0.109
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.075 0.055
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.075 0.062
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.075 0.109
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.075 0.123
DAB1 DAB1: Disabled homolog 1 0.075 0.048
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.075 0.109
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.075 0.251
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.075 0.165
JAK1 0.075 0.123
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.165
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.075 0.123
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.075 0.039
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.075 0.083
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.075 0.062
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.075 0.028
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.123
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.075 0.165
DAB2 DAB2, DOC2: Disabled homolog 2 0.075 0.034
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.075 0.055
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.075 0.123
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.075 0.123
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.075 0.055
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.075 0.165
MYL3 MYL3: Myosin light polypeptide 3 0.075 0.026
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.075 0.165
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.075 0.123
EEF2K EEF2K: Elongation factor 2 kinase 0.075 0.165
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.075 0.152
PLD2 PLD2: Phospholipase D2 0.075 0.062
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.075 0.152
ELMO1 N/A 0.075 0.083
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.075 0.034
RYR2 RYR2: Ryanodine receptor 2 0.0688 0.031
KCNB1 KCNB1: Potassium voltage-gated channel subfamily B member 1 0.062 0.025
KCNA2 KCNA2: Potassium voltage-gated channel subfamily A member 2 0.062 0.039
GRIN2A GRIN2A, NMDAR2A: Glutamate [NMDA] receptor subunit epsilon-1 precursor 0.062 0.039
SI SI: Sucrase-isomaltase, intestinal [Contains: Sucrase 0.062 0.031
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.062 0.105
KCNQ2 KCNQ2: Potassium voltage-gated channel subfamily KQT member 2 0.062 0.034
GRIN2B GRIN2B, NMDAR2B: Glutamate [NMDA] receptor subunit epsilon-2 precursor 0.062 0.063
RYR1 0.062 0.039
KCNH2 KCNH2, ERG, ERG1, HERG, HERG1: Potassium voltage-gated channel subfamily H membe 0.062 0.034
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.062 0.051
DLG2 DLG2: Disks large homolog 2 0.062 0.051
GRIN2C GRIN2C, NMDAR2C: Glutamate [NMDA] receptor subunit epsilon-3 precursor 0.062 0.031
CDC42 CDC42: Cell division control protein 42 homolog precursor 0.056 0.0416
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.056 0.056
RHOG RHOG, ARHG: Rho-related GTP-binding protein RhoG precursor 0.056 0.0416
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.056 0.056
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.052 0.039
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.052 0.028
RGS16 RGS16, RGSR: Regulator of G-protein signaling 16 0.052 0.026
AXIN1 0.052 0.028
DES DES: Desmin 0.052 0.026
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.052 0.028
PKP4 PKP4: Plakophilin-4 0.052 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.052 0.028
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.051 0.038
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
MAPK7 MAPK7, ERK4, ERK5, PRKM7: Mitogen-activated protein kinase 7 0.051 0.051
MAPK11 MAPK11, PRKM11, SAPK2: Mitogen-activated protein kinase 11 0.051 0.051
GSK3B GSK3B: Glycogen synthase kinase-3 beta 0.051 0.051
MAP4K4 N/A 0.051 0.051
MARK1 MARK1, KIAA1477, MARK: Serine/threonine-protein kinase MARK1 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.051 0.059
CHUK CHUK, IKKA, TCF16: Inhibitor of nuclear factor kappa-B kinase subunit alpha 0.051 0.051
PRKCD PRKCD: Protein kinase C delta type 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
MARK2 N/A 0.051 0.051
RAC2 RAC2: Ras-related C3 botulinum toxin substrate 2 precursor 0.050 0.037
RAB21 RAB21, KIAA0118: Ras-related protein Rab-21 0.050 0.056
RAB11B RAB11B, YPT3: Ras-related protein Rab-11B 0.050 0.051
RAB27B RAB27B: Ras-related protein Rab-27B 0.050 0.0416
RAB32 RAB32: Ras-related protein Rab-32 0.050 0.037
RAB11A RAB11A, RAB11: Ras-related protein Rab-11A 0.050 0.037
RHOC RHOC, ARH9, ARHC: Rho-related GTP-binding protein RhoC precursor 0.050 0.056
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.049 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.049 0.100
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.049 0.081
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.049 0.081
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.049 0.100
DLK1 DLK1, DLK: Delta-like protein precursor 0.049 0.049
EGF EGF: Pro-epidermal growth factor precursor 0.049 0.100
UMOD UMOD: Uromodulin precursor 0.049 0.037
RAB4A N/A 0.049 0.109
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.049 0.072
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.049 0.032
PLEK PLEK, P47: Pleckstrin 0.049 0.037
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.049 0.072
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.109
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.049 0.0453
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.109
MET MET: Hepatocyte growth factor receptor precursor 0.049 0.100
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.049 0.109
SORL1 SORL1: Sortilin-related receptor precursor 0.049 0.072
SYTL4 Endocrine transmitter regulatory protein 0.049 0.049
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.049 0.0453
FADD FADD, MORT1: Protein FADD 0.049 0.030
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.049 0.109
ARVCF ARVCF: Armadillo repeat protein deleted in velo-cardio-facial syndrome 0.047 0.032
TLN2 TLN2: Uncharacterized protein TLN2 0.047 0.152
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.047 0.123
TLN1 TLN1: Uncharacterized protein TLN1 0.047 0.123
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.046 0.0338
TLK2 TLK2: Serine/threonine-protein kinase tousled-like 2 0.046 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.046 0.051
IKBKE IKBKE, IKKE, IKKI, KIAA0151: Inhibitor of nuclear factor kappa-B kinase subunit 0.046 0.051
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.046 0.0253
SRPK1 SRPK1: Serine/threonine-protein kinase SRPK1 0.046 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.051
NUAK1 NUAK1, ARK5, KIAA0537: NUAK family SNF1-like kinase 1 0.046 0.0338
APP APP, A4, AD1: Amyloid beta A4 protein precursor 0.044 0.109
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.044 0.081
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.044 0.100
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.044 0.072
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.044 0.126
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.044 0.072
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.044 0.100
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.044 0.109
CREBBP CREBBP, CBP: CREB-binding protein 0.044 0.037
LDLR LDLR: Low-density lipoprotein receptor precursor 0.044 0.037
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.044 0.100
LIG1 LIG1: DNA ligase 1 0.044 0.037
TMPRSS9 N/A 0.044 0.049
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.044 0.032
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.044 0.081
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.044 0.0263
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.044 0.081
STAT4 STAT4: Signal transducer and activator of transcription 4 0.044 0.081
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.044 0.081
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.044 0.081
JAG2 JAG2: Jagged-2 precursor 0.044 0.049
MYH9 MYH9: Myosin-9 0.044 0.032
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.044 0.109
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.044 0.109
NOTCH4 N/A 0.044 0.0453
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.109
LIG4 LIG4: DNA ligase 4 0.044 0.037
KIT KIT: Mast/stem cell growth factor receptor precursor 0.044 0.072
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.044 0.081
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.044 0.032
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.044 0.037
ITGB7 ITGB7: Integrin beta-7 precursor 0.044 0.081
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.044 0.072
INSR INSR: Insulin receptor precursor 0.044 0.072
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.044 0.072
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.044 0.065
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.044 0.072
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.044 0.072
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.044 0.081
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.044 0.072
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.044 0.032
ATRN N/A 0.044 0.109
SOS1 SOS1: Son of sevenless homolog 1 0.044 0.081
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.044 0.065
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.044 0.081
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.044 0.072
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.044 0.100
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.044 0.081
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.044 0.109
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.044 0.081
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.044 0.032
F10 F10: Coagulation factor X precursor 0.044 0.032
SPINT2 SPINT2, HAI2, KOP: Kunitz-type protease inhibitor 2 precursor 0.04 0.029
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.04 0.109
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.04 0.126
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.04 0.072
RAB8A RAB8A: RAB8A protein 0.040 0.029
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.036 0.100
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.036 0.100
GNA13 GNA13: Guanine nucleotide-binding protein alpha-13 subunit 0.036 0.037
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.036 0.109
APLP2 APLP2, APPL2: Amyloid-like protein 2 precursor 0.036 0.072
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 0.036 0.0263
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.036 0.081
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.036 0.037
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.036 0.100
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.036 0.0263
ABCG8 ABCG8: ATP-binding cassette sub-family G member 8 0.034 0.028
CENTA1 CENTA1: Centaurin-alpha 1 0.034 0.062
CFI CFI, IF: Complement factor I precursor 0.034 0.025
CFTR CFTR: Cystic fibrosis transmembrane conductance regulator ATP-binding cassette s 0.034 0.026
ABCA4 ABCA4, ABCR: Retinal-specific ATP-binding cassette transporter 0.034 0.026
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.030 0.0688
ABCB1 ABCB1, MDR1, PGY1: Multidrug resistance protein 1 0.030 0.026
ABCB9 ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor 0.030 0.028
F7 F7: Coagulation factor VII precursor 0.030 0.034
BMP1 N/A 0.030 0.034
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.030 0.045
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.030 0.025
ALK ALK: ALK tyrosine kinase receptor precursor 0.030 0.0794
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.030 0.051
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.030 0.031
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.028 0.165
MATK 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.028 0.026
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.028 0.026
LNX1 N/A 0.028 0.028
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.028 0.109
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
PDE4A N/A 0.028 0.026
CASP6 CASP6, MCH2: Caspase-6 precursor 0.028 0.028
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.028 0.026
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.028 0.165
CIITA CIITA, MHC2TA: MHC class II transactivator 0.028 0.026
CACNB2 N/A 0.028 0.028
WRNIP1 WRNIP1, WHIP: ATPase WRNIP1 0.028 0.028
API5 N/A 0.028 0.026
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.028 0.026
SLC9A3R2 SLC9A3R2: SLC9A3R2 protein (Fragment) 0.028 0.028
SNCB SNCB: Beta-synuclein 0.028 0.034
CDC42 N/A 0.028 0.028
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.028 0.123
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
MAP2K5 N/A 0.028 0.026
HD HD, IT15: Huntingtin 0.028 0.048
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.028 0.165
SH2D3A SH2D3A, NSP1, UNQ175/PRO201: SH2 domain-containing protein 3A 0.028 0.028
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.028 0.123
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.028 0.026
AFAP AFAP1, AFAP: Actin filament-associated protein 1 0.028 0.026
DFFA DFFA, DFF1, H13, DFF45: DNA fragmentation factor subunit alpha 0.028 0.026
COBL N/A 0.028 0.055
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.028 0.028
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.028 0.039
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.028 0.109
CTTN CTTN, EMS1: Src substrate cortactin 0.028 0.123
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.028 0.032
STAP2 Uncharacterized protein ENSP00000317912 0.028 0.028
USP21 USP21, USP23: Ubiquitin carboxyl-terminal hydrolase 21 0.028 0.032
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.028 0.028
LMO7 LMO7, FBX20, FBXO20, KIAA0858: LIM domain only protein 7 0.028 0.026
CASP14 CASP14: Caspase-14 precursor 0.028 0.028
PDE5A PDE5A, PDE5: cGMP-specific 3',5'-cyclic phosphodiesterase 0.028 0.028
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.028 0.026
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.028
C9orf88 N/A 0.028 0.028
NCF4 N/A 0.028 0.028
PTPN7 N/A 0.028 0.028
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.028 0.109
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.028 0.109
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.028
IPO7 IPO7: Uncharacterized protein IPO7 0.028 0.077
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.028 0.083
IREB2 IREB2: Iron-responsive element-binding protein 2 0.028 0.026
C13orf1 N/A 0.028 0.032
FASN FASN, FAS: Fatty acid synthase 0.028 0.028
ABLIM1 ABLIM1, RP11-317F20.1-001: Actin binding LIM protein 1 0.028 0.028
PHLDB2 N/A 0.028 0.028
AHSA2 AHSA2, DKFZp564C236, hCG_15158: Putative uncharacterized protein DKFZp564C236 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NAT1 NAT1, AAC1: Arylamine N-acetyltransferase 1 0.028 0.032
AMPH AMPH, AMPH1: Amphiphysin 0.028 0.165
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.028 0.026
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.028 0.191
SIVA SIVA1, SIVA: Apoptosis regulatory protein Siva 0.028 0.028
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.028 0.039
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
RHOD RHOD, ARHD: Rho-related GTP-binding protein RhoD precursor 0.027 0.027
MAP2K7 MAP2K7, JNKK2, MEK7, MKK7, PRKMK7: Dual specificity mitogen-activated protein ki 0.027 0.0308
RERG RERG: Ras-related and estrogen-regulated growth inhibitor 0.027 0.027
CDC2L2 N/A 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
PTPN13 N/A 0.027 0.027
HUNK HUNK, MAKV: Hormonally up-regulated neu tumor-associated kinase 0.027 0.0308
MAP3K2 MAP3K2, MAPKKK2, MEKK2: Mitogen-activated protein kinase kinase kinase 2 0.027 0.0308
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
PRKG2 PRKG2, PRKGR2: cGMP-dependent protein kinase 2 0.027 0.0308
STAC STAC: SH3 and cysteine-rich domain-containing protein 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
SHANK1 SHANK1: SH3 and multiple ankyrin repeat domains protein 1 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
KALRN DUET, TRAD: Serine/threonine-protein kinase Duet 0.027 0.041
GIT2 N/A 0.025 0.083
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.025 0.026
TSC2 TSC2, TSC4: Tuberin 0.025 0.028
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.025 0.031
G3BP2 G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2 0.025 0.028
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.025 0.123
ACTG1 ACTB: Actin, cytoplasmic 1 0.025 0.062
APC N/A 0.025 0.026
SH3PX3 SH3PX3, DKFZp666B159, hCG_1731072: SH3 and PX domain-containing protein 3. 0.025 0.028
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.028
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.028
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.028
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.025 0.123
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.028
SAPS3 N/A 0.025 0.032
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.025 0.191
CAMK2A N/A 0.025 0.028
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.025 0.026
CD2AP CD2AP: CD2-associated protein 0.025 0.109
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.025 0.026
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.025 0.028
CAMKK1 N/A 0.025 0.028
SORBS3 SORBS3, SCAM1: Vinexin 0.025 0.123
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.025 0.191
TTN N/A 0.025 0.096
EPN2 N/A 0.025 0.028
TK1 TK1: Thymidine kinase, cytosolic 0.025 0.026
GPI GPI: Glucose-6-phosphate isomerase 0.025 0.026
CA3 CA3: Carbonic anhydrase 3 0.025 0.032
CRMP1 CRMP1, DPYSL1: Dihydropyrimidinase-related protein 1 0.025 0.062
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.028
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.025 0.026
BCR N/A 0.025 0.028
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.025 0.026
SH2D4A SH2D4A, SH2A: SH2 domain-containing protein 4A 0.025 0.032
ADK ADK: Adenosine kinase 0.025 0.028
KIAA0690 N/A 0.025 0.026
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.025 0.165
XPO1 XPO1, CRM1: Exportin-1 0.025 0.062
WASPIP N/A 0.025 0.062
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.025 0.039
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.025 0.123
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.028
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.028
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.028
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.028
DCTN1 DCTN1: Dynactin subunit 1 0.025 0.028
SNX3 N/A 0.025 0.052
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.025 0.165
PI4KII PI4K2A: Phosphatidylinositol 4-kinase type 2-alpha 0.025 0.026
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.025 0.026
MDN1 MDN1, KIAA0301: Midasin 0.025 0.062
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.025 0.026
SPAST SPAST, KIAA1083, SPG4: Spastin 0.025 0.028
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.028
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.025 0.083
USP16 USP16: Ubiquitin carboxyl-terminal hydrolase 16 0.025 0.028
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.025 0.026
LMO6 LMO6: LIM domain only protein 6 0.025 0.028
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.028
PRDX1 PRDX1, PAGA, PAGB, TDPX2: Peroxiredoxin-1 0.025 0.026
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.025 0.028
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.028
SENP6 SENP6, KIAA0797, FKSG6, SSP1, SUSP1: Sentrin-specific protease 6 0.025 0.026
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.025 0.191
RIN1 RIN1: Ras and Rab interactor 1 0.025 0.152
MAP2K3 N/A 0.025 0.028
BCOR N/A 0.025 0.028
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.025 0.165
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.025 0.026
DPYSL3 DPYSL3, CRMP4, DRP3, ULIP: Dihydropyrimidinase-related protein 3 0.025 0.062
PDE4B PDE4B, DPDE4: cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0.025 0.028
GMFB GMFB: Glia maturation factor beta 0.025 0.026
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.025 0.165
SPAG1 SPAG1: Sperm-associated antigen 1 0.025 0.032
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.025 0.032
CCT8 CCT8: Uncharacterized protein CCT8 0.025 0.026
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.025 0.026
GRK6 N/A 0.025 0.028
PMP2 PMP2: Myelin P2 protein 0.025 0.109
PPIG PPIG: Peptidyl-prolyl cis-trans isomerase G 0.025 0.026
GAPD GAPDH, GAPD, CDABP0047, OK/SW-cl.12: Glyceraldehyde-3-phosphate dehydrogenase 0.025 0.026
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.025 0.062
KLC2 KLC2: Kinesin light chain 2 0.025 0.034
MARK1 N/A 0.025 0.026
DPYSL2 DPYSL2, CRMP2: Dihydropyrimidinase-related protein 2 0.025 0.055
NIPBL N/A 0.025 0.028
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.028
RAC1 N/A 0.025 0.028
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.025 0.026
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.025 0.032
EEF1A2 EEF1A2, EEF1AL, STN: Elongation factor 1-alpha 2 0.025 0.026
MTAP MTAP, MSAP: S-methyl-5-thioadenosine phosphorylase 0.025 0.0425
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.165
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.025 0.032
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.165
DBNL N/A 0.025 0.028
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.028
CFL2 CFL2: Cofilin-2 0.025 0.028
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.025 0.026
NCK2 NCK2: Cytoplasmic protein NCK2 0.025 0.109
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.028
RSN CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1 0.025 0.028
SVIL SVIL: Supervillin 0.025 0.028
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.028
GSN GSN: Gelsolin precursor 0.025 0.028
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.025 0.026
SCRIB N/A 0.025 0.028
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.025 0.098
NCOA5 NCOA5, KIAA1637: Nuclear receptor coactivator 5 0.025 0.028
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 0.025 0.028
VIL1 VIL1, VIL: Villin-1 0.025 0.032
FNBP1 N/A 0.025 0.123
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 0.028
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.025 0.062
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.025 0.123
CASP7 N/A 0.025 0.028
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.025 0.055
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.025 0.026
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.028
PDE1B PDE1B, PDE1B1, PDES1B: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phos 0.025 0.026
STAM2 STAM2: Signal transducing adapter molecule 2 0.025 0.152
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.025 0.028
0.299
Total Score 19.70