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Evidence of Interaction Between CBL and TXK

The interaction score between CBL and TXK is 52.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CBL and TXK = -0.03

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismCBL OrthologueTXK OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q9VSK2 0.118 P08630 0.057

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in CBL and TXK:
Domains in CBLDomains in TXK
IPR001841 Zn-finger, RING
IPR000449 Ubiquitin-associated domain
IPR000980 SH2 motif
IPR000217 Tubulin
IPR003153 Adaptor protein Cbl, N-terminal
IPR011992 EF-Hand_type.
IPR013090 Phospholip_A2_AS.
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001452 SH3
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in CBL and TXK are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR000980 SH2 motif IPR001452 SH3 59.5667
IPR000980 SH2 motif IPR000980 SH2 motif 36.445
IPR003153 Adaptor protein Cbl, N-terminal IPR000980 SH2 motif 26.7596
IPR003153 Adaptor protein Cbl, N-terminal IPR001452 SH3 20.2778
IPR001841 Zn-finger, RING IPR001452 SH3 18.8486
IPR001841 Zn-finger, RING IPR008266 Tyrosine protein kinase, active site 16.2425
IPR001841 Zn-finger, RING IPR011009 Protein kinase-like 15.6712
IPR011992 EF-Hand_type. IPR000719 Protein kinase 15.5567
IPR001841 Zn-finger, RING IPR001245 Tyrosine protein kinase 15.1425
IPR001841 Zn-finger, RING IPR000719 Protein kinase 14.0542
IPR003153 Adaptor protein Cbl, N-terminal IPR008266 Tyrosine protein kinase, active site 13.6309
IPR011992 EF-Hand_type. IPR001452 SH3 11.7553
IPR001841 Zn-finger, RING IPR000980 SH2 motif 9.93803
IPR011992 EF-Hand_type. IPR011009 Protein kinase-like 9.34155
IPR003153 Adaptor protein Cbl, N-terminal IPR001245 Tyrosine protein kinase 9.19853
IPR011992 EF-Hand_type. IPR001245 Tyrosine protein kinase 6.38624
IPR011992 EF-Hand_type. IPR000980 SH2 motif 5.54712
IPR003153 Adaptor protein Cbl, N-terminal IPR000719 Protein kinase 3.06419
IPR003153 Adaptor protein Cbl, N-terminal IPR011009 Protein kinase-like 3.04324
IPR011992 EF-Hand_type. IPR008266 Tyrosine protein kinase, active site 1.24952
IPR000449 Ubiquitin-associated domain IPR000980 SH2 motif 0.609113
IPR000217 Tubulin IPR011009 Protein kinase-like 0.524874
IPR000449 Ubiquitin-associated domain IPR011009 Protein kinase-like 0.41941
IPR000449 Ubiquitin-associated domain IPR001245 Tyrosine protein kinase 0.348773
IPR000449 Ubiquitin-associated domain IPR001452 SH3 0.223539
IPR000217 Tubulin IPR001452 SH3 0.17131
IPR000217 Tubulin IPR008266 Tyrosine protein kinase, active site 0.0503676
IPR000217 Tubulin IPR000980 SH2 motif 0.0425012
IPR000217 Tubulin IPR000719 Protein kinase 0.0254403
IPR000449 Ubiquitin-associated domain IPR008266 Tyrosine protein kinase, active site 0.00515077
IPR000449 Ubiquitin-associated domain IPR000719 Protein kinase 0.00138935
IPR000217 Tubulin IPR001245 Tyrosine protein kinase 0.00033966

The background colour of the table refers to:

  • Blue Domain is only present in CBL
  • Yellow Domain is only present in TXK
  • Green Domain is present in both CBL and TXK

 0.980
Post-translational Modifications

Protein: CBL

PTMResidueReference
Phosphorylation 371 PubMed, HPRD
Phosphorylation 619 PubMed, HPRD
Phosphorylation 623 PubMed, HPRD
Phosphorylation 639 PubMed, HPRD
Phosphorylation 642 PubMed, HPRD
Phosphorylation 667 PubMed, HPRD
Phosphorylation 669 PubMed, HPRD
Phosphorylation 674 PubMed, HPRD
Phosphorylation 675 PubMed, HPRD
Phosphorylation 700 PubMed, HPRD
Phosphorylation 731 PubMed, HPRD
Phosphorylation 774 PubMed, HPRD
Phosphoserine 669 HPRD
Phosphotyrosine 371 PubMed, HPRD
Phosphotyrosine 674 HPRD
Phosphotyrosine 700 HPRD
Phosphotyrosine 774 HPRD

Protein: TXK

PTMResidueReference
Phosphorylation 91 PubMed, HPRD
Phosphorylation 420 PubMed, HPRD
Localisation

Protein: CBL

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: TXK

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between CBL and TXK that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CBL andTXK. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CBL has 1376 interactors and TXK has 1477 interactors of which there are 923 common interactors.

Common InteractorName of Common InteractorScore for CBL-Interactor (?)Score for TXK-Interactor (?)
ZAP70 ZAP70: Uncharacterized protein ZAP70 277.00 12.80
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 214.00 0.520
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 173.00 0.808
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 137.00 0.644
SORBS3 SORBS3, SCAM1: Vinexin 43.20 0.098
NCK2 NCK2: Cytoplasmic protein NCK2 30.80 1.78
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 8.34 1.17
SHC3 SHC3, NSHC, SHCC: SHC-transforming protein 3 5.94 0.156
YWHAB YWHAB: 14-3-3 protein beta/alpha 4.41 0.029
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 2.47 0.038
GRAP GRAP: GRB2-related adapter protein 2.13 0.402
SHC2 N/A 1.29 0.0258
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.20 1.20
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 1.13 0.859
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 1.01 0.770
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 1.30
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 1.30
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.902 0.859
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.878 1.17
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.878 1.17
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.878 1.30
SYK SYK: Tyrosine-protein kinase SYK 0.808 0.874
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.731 0.859
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.731 4.07
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.655 1.07
LYN LYN: Tyrosine-protein kinase Lyn 0.655 1.20
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.655 0.770
CSK CSK: Tyrosine-protein kinase CSK 0.655 1.78
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.655 1.35
HCK N/A 0.655 0.975
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.655 1.50
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.644 0.859
BMX N/A 0.644 0.859
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.617 0.617
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.617 0.617
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.617 0.617
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.617 0.617
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.577 0.874
JAK1 0.577 6.03
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.577 0.694
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.577 0.770
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.577 0.975
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.553 0.553
FLT4 VEGFR3 long form 0.553 0.553
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.540 0.980
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.540 0.980
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.540 0.980
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.484 0.484
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.484 0.878
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.484 0.878
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.484 0.878
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.484 0.878
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.445 0.520
ALK ALK: ALK tyrosine kinase receptor precursor 0.445 0.361
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.445 0.520
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.445 0.808
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.445 0.581
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.403 0.581
MET MET: Hepatocyte growth factor receptor precursor 0.403 0.581
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.361 0.644
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.361 0.577
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.361 0.577
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.361 0.520
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.320 0.644
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.318 0.731
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.318 0.577
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.318 0.520
INSR INSR: Insulin receptor precursor 0.318 0.577
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.318 0.520
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.318 0.655
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.318 0.655
KIT KIT: Mast/stem cell growth factor receptor precursor 0.318 0.644
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.286 0.520
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.286 0.581
PRKAA1 N/A 0.251 0.251
TNK1 TNK1: Non-receptor tyrosine-protein kinase TNK1 0.237 0.265
DYRK3 N/A 0.225 0.088
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.217 0.265
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.191 0.152
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.191 0.123
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.191 0.109
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.171 0.110
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.171 0.097
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.165
MAPK15 N/A 0.165 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.165 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.165
MAPKAPK5 N/A 0.165 0.165
PPEF1 N/A 0.165 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.165 0.165
NF2 NF2, SCH: Merlin 0.165 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.165 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.165
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.152 0.049
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.152 0.307
PLEK PLEK, P47: Pleckstrin 0.152 0.166
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.152 0.081
STAT2 STAT2: Signal transducer and activator of transcription 2 0.152 0.902
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.152 0.251
ROCK1 ROCK1: Rho-associated protein kinase 1 0.152 0.191
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.152 0.072
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.152 0.152
STK16 N/A 0.152 0.123
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.152 0.191
IRS1 IRS1: Insulin receptor substrate 1 0.152 0.109
SCML2 SCML2: Sex comb on midleg-like protein 2 0.152 0.065
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.152 0.191
STAM2 STAM2: Signal transducing adapter molecule 2 0.148 0.097
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.148 0.098
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.148 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.148
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.148 0.098
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.148 0.109
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.148 0.148
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.148 0.098
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.980
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.148 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.148
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.148
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.148 0.148
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.148 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.148
ELMO1 N/A 0.148 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.148 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.148 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.148 0.148
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.148 0.165
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.148 0.148
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.148 0.148
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.148 0.148
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.148 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.148 0.165
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.148 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.148 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.148 0.148
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.148 0.098
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.148 0.148
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.145 0.156
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.143 1.36
FYN N/A 0.143 1.36
FGFR2 N/A 0.140 0.217
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.140 0.069
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.136 0.202
SOS1 SOS1: Son of sevenless homolog 1 0.136 0.181
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.136 0.073
CDK7 CDK7, MO15: Cell division protein kinase 7 0.136 0.110
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.136 0.171
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.136 0.088
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.136 0.225
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.136 0.152
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.136 0.136
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.136 0.097
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.136 0.110
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.136 0.088
TTN N/A 0.136 0.097
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.136 0.109
WEE1 WEE1: Wee1-like protein kinase 0.136 0.097
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.136 0.136
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.129 0.200
GRLF1 N/A 0.127 0.109
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.126 0.217
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.123 0.123
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.123 0.191
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.123 0.123
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.123 0.0727
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.123 0.123
DAPK2 DAPK2: Death-associated protein kinase 2 0.123 0.109
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.123 0.307
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.123 0.109
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.123 0.123
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.123 0.581
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.123 0.416
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 0.116 0.296
INSRR INSRR, IRR: Insulin receptor-related protein precursor 0.116 0.128
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.110 0.225
CDK2 CDK2: Cell division protein kinase 2 0.110 0.110
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.110 0.110
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.110 0.136
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.110 0.136
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.110 0.225
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.110 0.136
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.110 0.097
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.110 0.088
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.110 0.136
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.110 0.063
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.110 0.171
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.110 0.088
CDK4 CDK4: Cell division protein kinase 4 0.110 0.097
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.110 0.251
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.110 0.136
CXorf9 N/A 0.110 0.275
CDK6 CDK6: Cell division protein kinase 6 0.110 0.110
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.110 0.088
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.110 0.148
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.110 0.461
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.110 0.058
ATM ATM: Serine-protein kinase ATM 0.110 1.62
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.110 0.152
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.110 0.109
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.110 0.110
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.110 0.275
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.110 0.110
FNBP1 N/A 0.110 0.275
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.110 0.110
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.110 0.225
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.110 0.098
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.110 0.110
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.110 0.136
STK10 STK10: Uncharacterized protein STK10 0.110 0.763
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.110 0.372
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.110 0.136
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.110 0.090
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.110 0.763
DOK1 DOK1: Docking protein 1 0.110 0.136
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.110 0.097
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.110 0.225
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.110 0.136
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.110 0.100
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.110 0.171
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.110 0.088
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.110 0.372
STAT4 STAT4: Signal transducer and activator of transcription 4 0.110 10.70
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.110 0.225
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.109 0.028
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
CASP9 CASP9, MCH6: Caspase-9 precursor 0.109 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.109 0.083
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
MAP2K5 N/A 0.109 0.165
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.109 0.028
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 1.30
PSCD2 N/A 0.109 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.109 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.109 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 1.30
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 1.30
CNN2 CNN2: Calponin-2 0.109 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.165
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.109 0.081
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.109 0.152
GAB1 GAB1: GRB2-associated-binding protein 1 0.109 0.123
IRS2 IRS2: Insulin receptor substrate 2 0.109 0.109
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.109 0.251
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.109 0.052
GAB2 N/A 0.109 0.098
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.109 0.123
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.098
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.109 0.065
TP73 TP73, P73: Tumor protein p73 0.109 0.072
CDKL5 N/A 0.109 0.109
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.109 0.416
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.109 0.123
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.109 5.04
ETS2 ETS2: Protein C-ets-2 0.109 0.072
AMHR2 AMHR2, AMHR: Anti-Muellerian hormone type-2 receptor precursor 0.105 0.143
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.100 0.109
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.100 0.859
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.098 0.0727
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.098 0.191
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.098 0.148
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.098 0.165
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.098 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.098 0.165
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.098 0.025
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.098 1.17
ARHGEF7 N/A 0.098 0.148
ACTN4 ACTN4: Alpha-actinin-4 0.098 0.148
STAT3 0.098 1.30
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 0.148
USP16 USP16: Ubiquitin carboxyl-terminal hydrolase 16 0.098 0.025
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.098 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.098 0.148
MYO18A 0.098 0.025
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.098 0.148
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.097 0.097
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.097 0.065
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.097 0.097
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.097 0.064
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.097 0.148
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.097 0.026
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.097 1.62
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.097 0.136
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.097 0.110
DAB1 DAB1: Disabled homolog 1 0.097 0.097
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.097 0.081
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.097 0.065
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.097 0.110
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.097 0.097
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.097 0.097
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.099
RPS6KB1 N/A 0.097 0.275
CDK5 CDK5: Cell division protein kinase 5 0.097 0.097
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.097 0.098
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.097 0.416
MYO3A MYO3A: Myosin IIIA 0.097 0.097
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.097 0.098
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.097 9.65
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.097 0.275
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.110
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.097 0.275
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.097 0.225
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.097 0.307
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.097 0.097
RIN1 RIN1: Ras and Rab interactor 1 0.097 0.975
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.097 0.110
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.097 0.088
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.097 0.110
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.097 0.110
ROR2 ROR2, NTRKR2: Tyrosine-protein kinase transmembrane receptor ROR2 precursor 0.094 0.115
MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 0.094 0.128
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.0924 0.162
STYK1 STYK1, NOK: Tyrosine protein-kinase STYK1 0.0924 0.200
RET urf-ret: Urf-ret protein 0.0924 0.143
TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 0.0924 0.129
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.090 0.110
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.090 0.026
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.090 0.152
PSCD4 PSCD4, CYT4: Cytohesin-4 0.090 0.225
CD2AP CD2AP: CD2-associated protein 0.090 0.152
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.090 0.781
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.090 0.098
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.090 0.225
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.090 0.171
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.090 0.097
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.088 0.097
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.088 0.058
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.088 0.109
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.088 0.225
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.088 0.088
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.088 0.225
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.088 0.113
HES6 HES6: Transcription cofactor HES-6 0.083 0.049
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.083 0.083
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.04
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.04
MCF2 MCF2, DBL: Proto-oncogene DBL 0.081 0.109
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.081 0.210
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.975
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.081 0.123
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.109
LIMK2 LIMK2: LIM domain kinase 2 0.081 0.109
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.081 4.07
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.081 1.98
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.081 0.210
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.081 0.032
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.081 0.416
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.077 0.026
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.075 0.025
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.075 0.115
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.073 0.029
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.073 0.225
THOC1 THOC1, HPR1: THO complex subunit 1 0.073 0.114
RASA3 RASA3: Ras GTPase-activating protein 3 0.073 0.461
WASPIP N/A 0.073 0.515
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.073 0.307
LCP1 LCP1, PLS2: Plastin-2 0.073 0.225
STAT6 STAT6: Signal transducer and activator of transcription 6 0.073 1.78
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.073 0.136
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.073 0.461
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.073 0.171
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.073 0.029
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.073 0.275
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.073 0.109
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.073 0.171
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.073 0.110
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.073 0.088
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.073 0.0425
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.073 0.029
VAV1 VAV1, VAV: Proto-oncogene vav 0.073 2.17
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.073 0.110
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.073 0.136
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.073 2.94
PLD1 PLD1: Phospholipase D1 0.073 0.097
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.073 0.029
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.073 0.136
APS SH2B2, APS: SH2B adapter protein 2 0.073 0.770
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 4.07
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.072 0.109
SPTAN1 N/A 0.072 0.109
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.072 0.109
FLNA FLNA, FLN, FLN1: Filamin-A 0.072 0.0425
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.072 1.98
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.109
VASP VASP: Vasodilator-stimulated phosphoprotein 0.072 0.152
RYR1 0.071 0.045
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.071 0.041
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.069 0.041
LIG4 LIG4: DNA ligase 4 0.069 0.027
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.069 0.041
BRPF1 BRPF1, BR140: Peregrin 0.069 0.038
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.0688 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.0688 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.0688 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.0688 0.109
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.0688 0.0688
KIR3DL1 N/A 0.0688 0.109
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.0688 0.0688
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.0688 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.0688 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.0688 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.0688 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.0688 0.109
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.0688 0.109
LAT LAT: Linker for activation of T-cells family member 1 0.0688 0.109
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.0688 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.0688 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.0688 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.0688 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.0688 0.109
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.0688 0.049
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.0688 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.0688 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.0688 0.109
FN1 N/A 0.0688 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.0688 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.0688 0.109
CTTN CTTN, EMS1: Src substrate cortactin 0.065 0.110
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.065 0.056
COBL N/A 0.065 0.098
CNN3 CNN3: Calponin-3 0.065 0.110
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.064 0.099
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.064 4.07
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.064 0.136
ACTN1 ACTN1: Alpha-actinin-1 0.064 0.097
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.064 0.097
PLD2 PLD2: Phospholipase D2 0.064 0.097
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.064 0.136
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.064 0.088
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.064 0.136
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.064 0.088
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.064 0.109
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.064 0.038
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.064 1.35
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.064 0.097
CRKL CRKL: Crk-like protein 0.064 1.35
VIL2 N/A 0.064 0.136
RDX RDX: Radixin 0.064 0.088
TLN1 TLN1: Uncharacterized protein TLN1 0.064 0.110
TLN2 TLN2: Uncharacterized protein TLN2 0.064 0.099
MSN MSN: Moesin 0.064 0.275
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.064 0.110
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.064 0.372
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.064 0.097
RPS10 RPS10: 40S ribosomal protein S10 0.064 0.029
CCR5 CCR5: CCR5 receptor (Fragment) 0.063 0.202
LILRB1 N/A 0.063 0.081
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.063 0.072
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.063 0.072
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.063 0.065
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.063 0.126
PRLR PRLR: Prolactin receptor precursor 0.063 0.072
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.063 0.065
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.063 0.100
ANXA9 ANXA9, ANX31: Annexin A9 0.063 0.030
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.063 0.065
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.063 0.274
NFATC1 N/A 0.062 0.074
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.062 0.027
IRF3 IRF3: Interferon regulatory factor 3 0.062 0.091
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.062 0.036
MDM4 MDM4, MDMX: Mdm4 protein 0.062 0.037
CNTN1 CNTN1: Contactin-1 precursor 0.062 0.098
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.062 0.098
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.062 0.098
KCNQ2 KCNQ2: Potassium voltage-gated channel subfamily KQT member 2 0.062 0.030
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.062 0.098
BSG N/A 0.062 0.098
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.062 0.062
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.062 0.098
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.062 0.098
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.062 0.044
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.062 0.098
CNTN4 CNTN4: Contactin-4 precursor 0.062 0.098
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.062 0.098
KCNH2 KCNH2, ERG, ERG1, HERG, HERG1: Potassium voltage-gated channel subfamily H membe 0.062 0.034
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.058 0.097
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.058 0.097
PSD TYL: TYL protein 0.058 0.110
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.058 0.088
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.058 0.225
NEO1 NEO1, NGN: Neogenin precursor 0.057 0.064
DCC DCC: Netrin receptor DCC precursor 0.057 0.064
GLRA1 N/A 0.057 0.033
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.057 0.064
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.056 0.056
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.056 0.056
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.056 0.032
TP53 TP53, P53: Cellular tumor antigen p53 0.056 0.027
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.056 0.026
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.056 0.027
AIP AIP, XAP2: AH receptor-interacting protein 0.056 0.029
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.056 0.051
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.056 0.033
HES1 HES1, HL, HRY: Transcription factor HES-1 0.056 0.026
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.056 0.029
ETS1 ETS1, EWSR2: Protein C-ets-1 0.056 0.066
ZNF335 ZNF335: Zinc finger protein 335 0.056 0.0446
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.056 0.0446
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.055 0.032
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.055 0.0425
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.053 0.030
FBXO4 FBXO4, FBX4: F-box only protein 4 0.052 0.028
PTPRA N/A 0.051 0.051
MAPK7 MAPK7, ERK4, ERK5, PRKM7: Mitogen-activated protein kinase 7 0.051 0.051
IGHD N/A 0.051 0.051
NULL Ig lambda chain V-II region NEI 0.051 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-68 alpha chain precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
IFNAR2 IFNAR2, IFNABR, IFNARB: Interferon-alpha/beta receptor beta chain precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
HLA-DRA HLA-DRA, HLA-DRA1: HLA class II histocompatibility antigen, DR alpha chain precu 0.051 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-27 alpha chain precursor 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
IGHA2 IGHA2: Ig alpha-2 chain C region 0.051 0.051
NULL Ig heavy chain V-III region WEA 0.051 0.051
HLA-DRB2 HLA class II histocompatibility antigen, DW2.2/DR2.2 beta chain (Fragment) 0.051 0.051
HLA-DQB1 HLA-DQB1: HLA class II histocompatibility antigen, DQB1*0602 beta chain precurso 0.051 0.051
PRKCD PRKCD: Protein kinase C delta type 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
NCAM1 N/A 0.051 0.051
GSK3B GSK3B: Glycogen synthase kinase-3 beta 0.051 0.051
MAP4K4 N/A 0.051 0.051
IGHG1 N/A 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
TRB@ TCRB: T-cell receptor beta chain V region CTL-L17 precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.617
C9orf88 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
UBAP2L N/A 0.051 0.051
IGHE IGHE: Ig epsilon chain C region 0.051 0.051
NULL TCRA: T-cell receptor alpha chain V region CTL-L17 precursor 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
GRB10 N/A 0.051 0.617
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
HLA-A N/A 0.051 0.051
MAPK11 MAPK11, PRKM11, SAPK2: Mitogen-activated protein kinase 11 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
RAPH1 N/A 0.051 0.051
CDC42EP1 CDC42EP1, BORG5, CEP1, MSE55: Cdc42 effector protein 1 0.051 0.051
MARK1 MARK1, KIAA1477, MARK: Serine/threonine-protein kinase MARK1 0.051 0.051
IGHG3 N/A 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
CHUK CHUK, IKKA, TCF16: Inhibitor of nuclear factor kappa-B kinase subunit alpha 0.051 0.051
IGHM N/A 0.051 0.051
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
IGHA1 N/A 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
FCGR2A FCGR2A, CD32, FCG2, FCGR2A1, IGFR2: Low affinity immunoglobulin gamma Fc region 0.051 0.051
MARK2 N/A 0.051 0.051
NULL Ig kappa chain V-I region CAR 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
GPA33 GPA33: Cell surface A33 antigen precursor 0.051 0.126
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.051 0.072
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.051 0.045
IL9R IL9R: Interleukin-9 receptor precursor 0.051 0.081
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.051 0.202
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.051 0.561
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.051 0.274
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.051 0.202
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.051 0.072
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.051 0.065
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.051 0.100
GHR GHR: Growth hormone receptor precursor 0.051 0.072
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.051 0.072
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.051 0.072
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.051 0.032
SORL1 SORL1: Sortilin-related receptor precursor 0.051 0.202
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.051 0.072
PVR PVR, PVS: Poliovirus receptor precursor 0.051 0.065
ITGB4 N/A 0.051 0.072
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.051 0.072
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.051 0.072
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.051 0.202
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.051 0.202
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.051 0.072
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.051 0.202
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.051 0.072
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.051 0.045
EPOR EPOR: Erythropoietin receptor precursor 0.051 0.072
EGF EGF: Pro-epidermal growth factor precursor 0.051 0.072
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.051 0.100
CSPG2 N/A 0.051 0.045
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.051 0.166
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.051 0.072
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.051 0.041
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.051 0.202
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.051 0.274
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.051 0.274
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.051 0.081
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.051 0.037
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.051 0.065
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.051 0.202
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.051 0.081
GABRR1 N/A 0.051 0.032
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.051 0.274
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.051 0.100
F3 F3: Tissue factor precursor 0.051 0.072
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.051 0.069
FLII FLII, FLIL: Protein flightless-1 homolog 0.051 0.043
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.050
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.165
CASP6 CASP6, MCH2: Caspase-6 precursor 0.049 0.028
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.049 0.028
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.049 0.028
AXIN1 0.049 0.028
CASP14 CASP14: Caspase-14 precursor 0.049 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.049 0.083
YWHAG YWHAG: 14-3-3 protein gamma 0.049 0.028
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.165
MLL MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX 0.049 0.027
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.049 0.051
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.049 0.055
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.038
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.047 0.044
GIT2 N/A 0.047 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.047 0.098
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.046 0.046
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.046
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.046 0.046
LMO7 N/A 0.046 0.051
SRPK1 SRPK1: Serine/threonine-protein kinase SRPK1 0.046 0.046
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.046 0.046
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.046 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.046 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
TLK2 TLK2: Serine/threonine-protein kinase tousled-like 2 0.046 0.051
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.046
IKBKE IKBKE, IKKE, IKKI, KIAA0151: Inhibitor of nuclear factor kappa-B kinase subunit 0.046 0.046
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.553
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.046 0.046
DLG2 DLG2: Disks large homolog 2 0.046 0.037
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.046 0.148
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.046 0.113
SLC9A7 SLC9A7, NHE7: Sodium/hydrogen exchanger 7 0.046 0.029
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.046 0.114
SLC9A3 SLC9A3, NHE3: Sodium/hydrogen exchanger 3 0.046 0.029
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.046 0.037
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.046 0.113
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.046 0.073
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.0453 0.096
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.045 0.166
FADD FADD, MORT1: Protein FADD 0.045 0.0453
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.045 0.051
CRLF3 N/A 0.045 0.202
SLC9A1 SLC9A1, APNH1, NHE1: Sodium/hydrogen exchanger 1 0.045 0.057
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.045 0.065
ANXA2 ANXA2, ANX2, ANX2L4, CAL1H, LPC2D: Annexin A2 0.045 0.0263
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.045 0.041
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.045 0.081
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.045 0.063
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.045 0.100
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.045 0.051
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.045 0.065
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.045 0.045
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.045 0.072
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.045 0.274
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.045 0.561
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.045 0.081
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.045 0.072
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.045 0.041
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.045 0.065
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.045 0.030
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.045 0.065
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.045 0.045
CD7 CD7: T-cell antigen CD7 precursor 0.045 1.19
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.045 0.072
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.045 0.100
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.045 0.072
RYR2 RYR2: Ryanodine receptor 2 0.045 0.045
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.045 0.072
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.045 0.0727
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.044 0.028
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.044 0.165
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.044 0.165
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.075
RSN CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1 0.044 0.025
LMO6 LMO6: LIM domain only protein 6 0.044 0.025
SPAST SPAST, KIAA1083, SPG4: Spastin 0.044 0.025
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.044 0.025
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.044 0.025
DCTN1 DCTN1: Dynactin subunit 1 0.044 0.025
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.044 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.025
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.042 0.0338
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.041 0.081
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.051
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.041 0.045
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.041 0.065
LPXN LPXN, LDLP: Leupaxin 0.041 0.052
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.041 0.086
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.041 0.088
VRK3 N/A 0.041 0.0308
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.041 0.029
ADCY3 ADCY3, KIAA0511: Adenylate cyclase type 3 0.041 0.029
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.041 0.065
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.041 0.148
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.041 0.064
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.041 0.037
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.041
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.041 0.166
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.041 0.041
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.041 0.037
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.041 0.064
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.041 0.064
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.041 0.064
MCOLN1 MCOLN1, ML4, MSTP080: Mucolipin-1 0.041 0.057
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.041 0.058
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.041 0.037
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.041 0.041
KCNA2 KCNA2: Potassium voltage-gated channel subfamily A member 2 0.041 0.039
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.04 0.052
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.039 0.037
CDC42EP3 CDC42EP3, BORG2, CEP3: Cdc42 effector protein 3 0.038 0.047
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.038 0.047
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.038 0.0955
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.037 0.037
RAB32 RAB32: Ras-related protein Rab-32 0.037 0.0296
FUBP1 N/A 0.037 0.155
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.037 0.026
S100A3 S100A3, S100E: Protein S100-A3 0.037 0.109
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.037 0.070
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.109
PTPRZ1 N/A 0.037 0.058
TNC TNC, HXB: Tenascin precursor 0.037 0.058
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.037 0.041
GLRB GLRB: Glycine receptor subunit beta precursor 0.037 0.026
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.037 0.073
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.036 0.148
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.036 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.036 0.165
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.035 0.029
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.035 0.109
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.035 0.066
CCNB1 Cyclin B1 0.035 0.026
CCNH CCNH: Cyclin-H 0.035 0.041
TSHR N/A 0.035 0.029
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.034 0.053
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.034 0.0338
TNN TNN: Tenascin-N precursor 0.034 0.053
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.0338 0.047
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.030
CNN1 CNN1: Calponin-1 0.0338 0.0338
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.034 0.049
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.034 0.049
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.034 0.049
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.034 0.049
MAL2 MAL2: Protein MAL2 0.034 0.034
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.034 0.049
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.034 0.109
DNASE1 DNASE1, DNL1, DRNI: Deoxyribonuclease-1 precursor 0.034 0.034
HDLBP HDLBP, HBP, VGL: Vigilin 0.033 0.044
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.033 0.049
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.033 0.029
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.033 0.038
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.033 0.086
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.033 0.069
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.033 0.069
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.033 0.029
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.033 0.136
GMIP GMIP: GEM-interacting protein 0.033 0.251
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.033 0.026
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.033 0.026
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.026
LIMS1 N/A 0.032 0.026
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.109
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.109
F5 F5: Coagulation factor V precursor 0.031 0.045
NUAK1 NUAK1, ARK5, KIAA0537: NUAK family SNF1-like kinase 1 0.030 0.0273
GGA3 GGA3, KIAA0154: ADP-ribosylation factor-binding protein GGA3 0.030 0.044
ATRN N/A 0.030 0.044
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.030 0.044
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.030 0.044
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.030 0.044
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.030 0.152
PHB2 PHB2, BAP, REA: Prohibitin-2 0.030 0.062
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.030 0.055
MVP MVP, LRP: Major vault protein 0.030 0.0425
S100B S100B: Protein S100-B 0.029 0.109
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.029 0.104
ACTG1 ACTB: Actin, cytoplasmic 1 0.029 0.029
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.029 0.461
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.029 0.038
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.029 0.055
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.029 0.029
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.029 0.049
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.225
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.029 0.029
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.029 0.055
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.029 0.136
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
ROS1 ROS1: Proto-oncogene tyrosine-protein kinase ROS precursor 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
NULL N/A 0.0288 0.0288
MUSK MUSK: MUSK protein 0.0288 0.0288
NULL Tyrosine kinase 0.0288 0.0288
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
NTRK3 NTRK3, TRKC: NT-3 growth factor receptor precursor 0.0288 0.0288
NTRK3 N/A 0.0288 0.0288
TTN TTN: Uncharacterized protein TTN (Fragment) 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
TESK2 TESK2: Dual specificity testis-specific protein kinase 2 0.0288 0.0288
DDR2 DDR2, NTRKR3, TKT, TYRO10: Discoidin domain-containing receptor 2 precursor 0.0288 0.0288
NULL N/A 0.0288 0.0288
AATK apoptosis-associated tyrosine kinase 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
PHLDB2 N/A 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
BID BID: BH3-interacting domain death agonist 0.028 0.049
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.109
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
HPN HPN, TMPRSS1: Serine protease hepsin 0.028 0.029
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.028 0.090
PRKY PRKY: Serine/threonine-protein kinase PRKY 0.028 0.029
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.027 0.029
EXOC2 N/A 0.027 0.046
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.027 0.372
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.027 0.055
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.027 0.029
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
FAM43A N/A 0.027 0.027
CDC2L2 N/A 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
OSBPL9 N/A 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
MID2 N/A 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
SHANK1 SHANK1: SH3 and multiple ankyrin repeat domains protein 1 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
FANK1 FANK1, HSD13, UNQ6504/PRO21382: Fibronectin type 3 and ankyrin repeat domains pr 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
CASKIN1 N/A 0.027 0.027
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
PPP1R9A PPP1R9A, KIAA1222: Neurabin-1 0.027 0.027
DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 0.027 0.027
UBL7 UBL7, BMSCUBP, SB132: Ubiquitin-like protein 7 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0263 0.034
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.0263 0.098
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.0263 0.098
MT3 MT3: Metallothionein-3 0.026 0.033
PMP2 PMP2: Myelin P2 protein 0.026 0.055
FES N/A 0.0258 0.0258
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.026 0.026
KIF23 N/A 0.026 0.032
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.026 0.037
TRRAP N/A 0.026 0.026
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.026 0.036
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.025 0.081
RAP1GA1 N/A 0.025 0.029
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.025 0.037
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.025 0.032
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.025 0.072
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.025 0.029
KCNJ3 KCNJ3, GIRK1: G protein-activated inward rectifier potassium channel 1 0.025 0.0263
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.148
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.025 0.044
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.148
PRKCB1 N/A 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.098
BCOR N/A 0.025 0.028
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
CREB1 CREB1: cAMP response element-binding protein 0.025 0.049
CAMK2A N/A 0.025 0.025
NIPBL N/A 0.025 0.025
CAMKK1 N/A 0.025 0.028
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.025 0.044
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
MAP2K3 N/A 0.025 0.025
CCNT2 CCNT2: Cyclin-T2 0.025 0.044
GRK6 N/A 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
0.228
Total Score 52.50