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Evidence of Interaction Between PPP1R8 and RAF1

The interaction score between PPP1R8 and RAF1 is 4.77.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PPP1R8 and RAF1 = 0.68

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismPPP1R8 OrthologueRAF1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm O61817 1 Q07292 0.234
fly Q9V7W9 1 P11346 0.113

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in PPP1R8 and RAF1:
Domains in PPP1R8Domains in RAF1
IPR000253 Forkhead-associated (FHA)
IPR000719 Protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR002219 Protein kinase C, phorbol ester/diacylglycerol binding
IPR003116 Raf-like Ras-binding

The Chi square scores for co-occurrence of domains that are present in PPP1R8 and RAF1 are listed below.

Domain 1Domain 2Chi Square
IPR000253 Forkhead-associated (FHA) IPR000719 Protein kinase 0.131582
IPR000253 Forkhead-associated (FHA) IPR008271 Serine/threonine protein kinase, active site 0.000657715

The background colour of the table refers to:

  • Blue Domain is only present in PPP1R8
  • Yellow Domain is only present in RAF1
  • Green Domain is present in both PPP1R8 and RAF1

 0.014
Post-translational Modifications

Protein: PPP1R8

PTMResidueReference
Phosphorylation 161 PubMed, HPRD
Phosphorylation 178 PubMed, HPRD
Phosphorylation 199 PubMed, HPRD
Phosphorylation 204 PubMed, HPRD
Phosphorylation 264 PubMed, HPRD
Phosphorylation 335 PubMed, HPRD
Phosphotyrosine 264 PubMed, HPRD

Protein: RAF1

PTMResidueReference
Dephosphorylation 340 PubMed, HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 43 PubMed, HPRD
Phosphorylation 233 PubMed, HPRD
Phosphorylation 259 PubMed, HPRD
Phosphorylation 268 PubMed, HPRD
Phosphorylation 269 PubMed, HPRD
Phosphorylation 289 PubMed, HPRD
Phosphorylation 296 PubMed, HPRD
Phosphorylation 301 PubMed, HPRD
Phosphorylation 338 PubMed, HPRD
Phosphorylation 339 PubMed, HPRD
Phosphorylation 340 PubMed, HPRD
Phosphorylation 341 PubMed, HPRD
Phosphorylation 491 PubMed, HPRD
Phosphorylation 494 PubMed, HPRD
Phosphorylation 499 PubMed, HPRD
Phosphorylation 621 PubMed, HPRD
Phosphorylation 642 PubMed, HPRD
Phosphoserine 43 HPRD
Phosphoserine 259 PubMed, HPRD
Phosphoserine 338 PubMed, HPRD
Phosphoserine 499 PubMed, HPRD
Phosphoserine 621 HPRD
Phosphothreonine 268 PubMed, HPRD
Localisation

Protein: PPP1R8

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: RAF1

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PPP1R8 and RAF1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PPP1R8 andRAF1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PPP1R8 has 977 interactors and RAF1 has 1538 interactors of which there are 667 common interactors.

Common InteractorName of Common InteractorScore for PPP1R8-Interactor (?)Score for RAF1-Interactor (?)
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 1.50 0.426
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.822 0.233
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.763 0.188
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.583 0.0554
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.515 0.763
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.515 0.260
NBN NBN, NBS, NBS1, P95: Nibrin 0.430 0.0446
ELF1 ELF1: ETS-related transcription factor Elf-1 0.430 0.074
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.416 0.155
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.385 0.040
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.385 0.040
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.385 0.129
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.385 0.233
KIAA1012 KIAA1012: Protein TRS85 homolog 0.385 0.233
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.385 0.040
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.372 0.188
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.308 0.0446
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.308 0.0446
PTMA N/A 0.308 0.0446
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.276 0.066
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.276 0.040
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.276 0.040
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.276 0.066
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.276 0.227
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.276 0.040
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.276 0.040
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.276 0.040
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.276 0.129
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.276 0.040
NUP153 N/A 0.276 0.040
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.276 0.040
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.276 0.040
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.276 0.040
ATM ATM: Serine-protein kinase ATM 0.275 0.139
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.269 0.0446
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.241 0.763
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.241 0.372
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.241 0.461
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.241 0.304
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.233 0.372
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.233 0.188
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.233 0.032
XPO1 XPO1, CRM1: Exportin-1 0.227 0.078
CDC23 CDC23: Cell division cycle protein 23 homolog 0.227 0.188
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.227 0.188
XRCC1 XRCC1: DNA-repair protein XRCC1 0.210 0.036
H1FX H1FX: Histone H1x 0.210 0.153
IRF3 IRF3: Interferon regulatory factor 3 0.210 0.036
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.188 0.067
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.188 0.038
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.188 0.188
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.188 0.032
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.188 0.063
COPE COPE: Coatomer subunit epsilon 0.188 0.188
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.188 0.0818
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.188 0.067
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.185 0.129
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.171 0.114
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.163 0.036
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.163 0.416
FUBP1 N/A 0.157 0.087
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.156 0.032
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.152 0.087
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.152 0.077
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.146 0.461
RPS6KB1 N/A 0.146 0.372
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.146 0.372
STK10 STK10: Uncharacterized protein STK10 0.146 0.461
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.146 0.461
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.146 0.763
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.144 0.0446
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.144 0.0446
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.144 0.036
IFI16 N/A 0.144 0.0446
MATR3 MATR3, KIAA0723: Matrin-3 0.144 0.036
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.144 0.274
TOP2B N/A 0.144 0.0446
DDX21 DDX21: Nucleolar RNA helicase 2 0.144 0.036
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.144 0.340
SET SET: Protein SET 0.144 0.036
GNB2L1 Lung cancer oncogene 7 0.144 0.0446
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.144 0.0446
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.144 0.087
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.144 0.260
ABCF1 N/A 0.144 0.070
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.141 0.078
HNRPK N/A 0.141 0.129
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.141 0.078
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.139 0.275
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.139 0.046
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.139 0.114
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.139 0.114
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.139 0.067
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.137 0.063
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.137 0.385
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.137 0.188
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.137 0.188
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.030
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.030
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.136 0.056
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.132 0.307
ROCK1 ROCK1: Rho-associated protein kinase 1 0.132 0.416
CBX3 CBX3: Chromobox protein homolog 3 0.129 0.040
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.129 0.032
MCM3 MCM3: DNA replication licensing factor MCM3 0.129 0.090
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.129 0.066
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.129 0.040
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.129 0.032
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.129 0.040
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.129 0.040
HDAC3 HDAC3: Histone deacetylase 3 0.129 0.040
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.129 0.040
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.129 0.111
TIAL1 TIAL1: Nucleolysin TIAR 0.129 0.040
YY1 YY1: Transcriptional repressor protein YY1 0.129 0.066
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.129 0.040
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.032
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.129 0.066
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.129 0.040
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.129 0.040
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.129 0.040
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.129 0.040
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.129 0.040
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.129 0.032
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.129 0.066
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.129 0.040
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.040
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.129 0.040
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.129 0.227
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.129 0.040
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.129 0.304
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.129 0.040
SP3 SP3: Transcription factor Sp3 0.129 0.066
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.129 0.040
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.129 0.032
KLHDC4 N/A 0.129 0.046
SSB SSB: Lupus La protein 0.129 0.040
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.129 0.066
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.129 0.032
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.129 0.137
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.129 0.063
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.129 0.233
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.124 0.155
HD HD, IT15: Huntingtin 0.124 0.070
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.118 23.50
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.118 0.372
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.118 0.225
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.118 0.372
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.118 0.372
CDK4 CDK4: Cell division protein kinase 4 0.118 0.275
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.118 0.181
CDK2 CDK2: Cell division protein kinase 2 0.118 0.275
AIP AIP, XAP2: AH receptor-interacting protein 0.114 0.139
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.114 0.038
FKBP4 FKBP4: FK506-binding protein 4 0.114 0.086
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.051
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.114 0.041
SYMPK SYMPK, SPK: Symplekin 0.114 0.038
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.114 0.114
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.114 0.114
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.112 501.00
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.111 0.146
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0971 0.251
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0971 0.416
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.0971 0.275
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0971 0.307
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0971 0.251
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.0971 0.251
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.096 0.027
ERF ERF: ETS domain-containing transcription factor ERF 0.096 0.057
IPO7 IPO7: Uncharacterized protein IPO7 0.091 0.0425
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.091 0.052
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.087 0.036
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.087 0.036
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.087 0.074
KIAA0853 N/A 0.087 0.036
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.087 0.087
DNMT1 DNMT1, AIM, DNMT: DNA 0.087 0.027
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.0446
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.087 0.027
SP100 N/A 0.087 0.036
NCOA3 N/A 0.087 0.036
API5 N/A 0.087 0.052
TCOF1 N/A 0.087 0.036
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.087 0.036
PLEK PLEK, P47: Pleckstrin 0.087 0.340
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.087 0.027
RBM14 RBM14, SIP: RNA-binding protein 14 0.087 0.0446
WDR1 N/A 0.087 0.0446
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.087 0.070
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.087 0.036
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.087 0.052
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.087 0.0446
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.087 0.027
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.087 0.0446
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.087 0.372
CDK7 CDK7, MO15: Cell division protein kinase 7 0.087 0.225
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.087 0.372
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.087 0.275
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.087 0.372
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.087 0.275
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.086 0.054
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.0818 0.038
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.0818 0.114
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.0818 0.038
EIF3S6IP N/A 0.081 0.038
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.080 0.251
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.078 0.063
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.078 0.139
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.078 0.111
NOL1 N/A 0.078 0.032
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.078 0.040
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.078 0.040
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.078 0.078
SNRPC SNRPC: U1 small nuclear ribonucleoprotein C 0.078 0.032
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.078 0.032
SEC31L1 N/A 0.078 0.032
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.078 0.032
EP300 N/A 0.078 0.066
DIAPH1 Diaphanous 1 0.078 0.129
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.078 0.040
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.078 0.032
PHF10 N/A 0.078 0.040
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.078 0.763
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.078 0.078
FNBP1 N/A 0.078 0.233
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.078 0.032
POLA2 POLA2: DNA polymerase subunit alpha B 0.078 0.032
SAPS3 N/A 0.078 0.063
CXorf9 N/A 0.078 0.233
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.078 0.063
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.078 0.032
WBSCR20A N/A 0.078 0.032
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.078 0.040
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 0.040
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.078 0.040
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.078 0.063
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.233
COPA COPA: Coatomer subunit alpha 0.078 0.063
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.078 0.227
CUL5 CUL5, VACM1: Cullin-5 0.078 0.032
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.078 0.040
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.078 0.111
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.078 0.032
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.078 0.032
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.078 0.040
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.078 0.040
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.078 0.040
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.078 0.040
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.078 0.040
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.129
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.078 0.040
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.077 0.032
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.076 0.067
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.044
NIPBL N/A 0.075 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.075 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.075 0.148
ELMO1 N/A 0.075 0.148
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.074 0.127
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.071 0.171
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.071 0.275
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.071 0.225
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.071 0.275
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.071 0.136
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.071 0.171
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.071 0.372
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.070 0.0425
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.070 0.075
ARFGAP1 N/A 0.070 0.124
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.070 0.074
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.070 0.036
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.070 0.340
TGIF2 TGIF2: Homeobox protein TGIF2 0.070 0.036
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.070 0.260
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.070 0.027
RBM6 RBM6, DEF3: RNA-binding protein 6 0.070 0.027
CHUK N/A 0.070 0.052
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.070 0.0446
RB1 RB1: Retinoblastoma-associated protein 0.070 0.091
KIAA0690 N/A 0.069 0.038
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.069 0.033
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.067 0.038
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.067 0.086
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.067 0.171
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.067 0.225
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.066 367.00
RPL8 RPL8: 60S ribosomal protein L8 0.066 0.078
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.066 0.461
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.066 0.078
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.066 0.078
FRG1 FRG1: Protein FRG1 0.066 0.078
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.066 0.188
QARS QARS: Glutaminyl-tRNA synthetase 0.066 0.129
LDHB LDHB: L-lactate dehydrogenase B chain 0.066 0.046
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.066 0.063
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.066 0.233
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.066 0.078
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.066 0.276
UBE4A N/A 0.066 0.129
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.066 0.372
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.066 0.078
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.066 0.129
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.066 0.046
CSK CSK: Tyrosine-protein kinase CSK 0.066 0.461
USP47 USP47: Ubiquitin carboxyl-terminal hydrolase 47 0.066 0.063
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.066 0.063
PPARBP N/A 0.066 0.063
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.066 0.129
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.066 0.078
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.066 0.763
RPS10 RPS10: 40S ribosomal protein S10 0.066 0.233
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.066 0.129
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.066 0.063
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.066 0.372
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.066 0.372
MDN1 MDN1, KIAA0301: Midasin 0.063 0.046
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.503
TP53 TP53, P53: Cellular tumor antigen p53 0.063 0.032
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.063 0.054
JUND JUND: Transcription factor jun-D 0.063 0.112
SOS1 SOS1: Son of sevenless homolog 1 0.063 0.181
GSK3B N/A 0.063 0.078
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.063 0.067
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.063 0.066
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.063
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.063 0.114
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.063 0.040
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.063 0.046
SRF SRF: Serum response factor 0.063 0.032
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.063 0.763
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.063 0.137
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.063 0.032
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.040
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.063 0.032
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.063 0.067
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.063 0.188
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.063 0.066
NPM1 NPM1, NPM: Nucleophosmin 0.063 0.067
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.063 0.040
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.063 0.137
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.372
STK16 N/A 0.060 0.251
PRKAA1 N/A 0.060 0.152
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.060 0.191
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.060 0.126
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.057 0.096
ETV1 ETV1, ER81: ETS translocation variant 1 0.056 0.033
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.054 0.171
CDK6 CDK6: Cell division protein kinase 6 0.054 0.171
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.054 0.136
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.054 0.171
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.054 0.171
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.054 0.038
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.0727
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.053 0.030
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.0525 0.078
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.052 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.052 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.052 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.052 0.165
MAPK15 N/A 0.052 0.165
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.052 0.070
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.052 0.027
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.0425
GTF3C1 N/A 0.052 0.027
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.052 0.027
AFF1 N/A 0.052 0.027
MEF2A N/A 0.052 0.027
ZNF267 ZNF267: Zinc finger protein 267 0.052 0.036
TRRAP N/A 0.052 0.0425
NFATC1 N/A 0.052 0.091
MYB MYB: Myb proto-oncogene protein 0.052 0.075
MARK2 N/A 0.052 0.070
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.070
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.052 0.155
UBAP2 N/A 0.052 0.052
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.052 0.0425
ID2 ID2: DNA-binding protein inhibitor ID-2 0.052 0.027
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.052 0.070
ESPL1 N/A 0.052 0.0425
MTF1 MTF1: Metal regulatory transcription factor 1 0.052 0.032
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.052 0.075
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.051 0.086
PKP4 PKP4: Plakophilin-4 0.049 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.049 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.049 0.028
NASP NASP: Nuclear autoantigenic sperm protein 0.049 0.083
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.029
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.048 0.152
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.048 0.109
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.048 0.275
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.047 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.148
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.047 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.047 0.148
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.047 0.148
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.047 0.098
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.047 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.047 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.047 0.148
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.047 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.047 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.047 0.148
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.047 0.148
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.047 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.047 0.098
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.047 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.047 0.148
CDC2 CDC2: Cell division control protein 2 homolog 0.047 0.148
MYH9 MYH9: Myosin-9 0.046 0.040
CCNB1 Cyclin B1 0.046 0.067
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.046 0.054
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.046 0.078
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.046 0.054
BRPF1 BRPF1, BR140: Peregrin 0.046 0.046
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.046 0.275
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.046 0.032
DOK1 DOK1: Docking protein 1 0.046 0.372
CDC20 CDC20: Cell division cycle protein 20 homolog 0.046 0.067
CDKN1B CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B 0.046 0.111
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.046 0.046
CCNH CCNH: Cyclin-H 0.046 0.067
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.046 0.032
CREBBP CREBBP, CBP: CREB-binding protein 0.046 0.040
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.046 0.111
CORO1C CORO1C, CRNN4: Coronin-1C 0.046 0.032
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.046 0.067
JUNB JUNB: Transcription factor jun-B 0.046 0.112
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.046 0.067
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.046 0.038
RBM7 0.046 0.032
YWHAQ YWHAQ: 14-3-3 protein theta 0.0446 0.307
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.0446 0.155
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.0446 0.852
SRPR SRPR: Uncharacterized protein SRPR 0.0446 0.070
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.044 0.033
SPAG1 SPAG1: Sperm-associated antigen 1 0.044 0.049
KLC2 KLC2: Kinesin light chain 2 0.044 0.044
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.044 0.025
TSC2 TSC2, TSC4: Tuberin 0.044 0.075
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.044 0.111
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.043 0.171
CDK5 CDK5: Cell division protein kinase 5 0.043 0.136
RGS14 N/A 0.0425 0.036
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.052
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.0425 0.246
STAT2 STAT2: Signal transducer and activator of transcription 2 0.0425 0.166
BACH1 BACH1: Transcription regulator protein BACH1 0.0425 0.125
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.075
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0425 0.127
SMARCC2 N/A 0.0425 0.027
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.0425 0.096
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.0425 0.515
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.0425 0.251
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.041 0.225
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.04 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.04 0.165
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.04 0.148
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.04 0.028
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.040 0.139
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.040 0.129
STAT6 STAT6: Signal transducer and activator of transcription 6 0.040 0.763
JAK1 0.040 0.372
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.040 0.046
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.040 0.461
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.040 0.063
CCT8 CCT8: Uncharacterized protein CCT8 0.040 0.046
EEF2 EEF2, EF2: Elongation factor 2 0.040 0.372
PPIG PPIG: Peptidyl-prolyl cis-trans isomerase G 0.040 0.046
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.040 0.046
CRKL CRKL: Crk-like protein 0.040 0.372
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.040 0.046
SEC24B SEC24B: Protein transport protein Sec24B 0.040 0.233
TPT1 TPT1: Translationally-controlled tumor protein 0.040 0.078
PTPN11 N/A 0.040 0.046
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.040 0.461
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.040 0.063
CARS CARS: Cysteinyl-tRNA synthetase, cytoplasmic 0.040 0.063
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.040 0.063
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.040 0.063
LCP1 LCP1, PLS2: Plastin-2 0.040 0.129
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.040 0.763
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.040 0.372
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.040 0.461
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.040 0.372
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.040 0.129
LPXN LPXN, LDLP: Leupaxin 0.040 0.188
ACTG1 ACTB: Actin, cytoplasmic 1 0.040 0.129
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.040 0.275
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.040 0.275
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.040 0.078
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.040 0.078
THOC1 THOC1, HPR1: THO complex subunit 1 0.040 0.139
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.040 0.078
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.040 0.385
VAV1 VAV1, VAV: Proto-oncogene vav 0.040 0.461
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.040 0.063
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.040 0.461
MSN MSN: Moesin 0.040 0.763
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.040 0.139
WASPIP N/A 0.040 0.385
HSP90AA1 Hsp89-alpha-delta-N 0.040 0.139
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.040 0.139
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.040 0.046
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.040 0.763
CD2AP CD2AP: CD2-associated protein 0.040 0.188
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.040 0.233
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.039 0.123
MDM4 MDM4, MDMX: Mdm4 protein 0.039 0.037
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.039 0.123
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.039 0.072
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.039 0.110
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.114
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.038 0.086
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.038 0.046
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.038 0.086
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.038 0.063
RELA RELA, NFKB3: Transcription factor p65 0.038 0.111
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.029
WEE1 WEE1: Wee1-like protein kinase 0.038 0.086
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.037 0.048
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.037 0.136
HELZ HELZ, KIAA0054: Probable helicase with zinc finger domain 0.036 0.061
PHB2 PHB2, BAP, REA: Prohibitin-2 0.036 0.052
DNM2 N/A 0.036 0.087
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.036 0.260
LIMS1 N/A 0.036 0.260
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.036 0.210
MPG N/A 0.036 0.070
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.036 0.0425
IFI35 N/A 0.036 0.070
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.036 0.070
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.036 0.0425
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.035 0.110
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.035 82.20
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.035 0.097
CDKL5 N/A 0.035 0.109
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.034 0.109
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.033 0.097
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.033 0.171
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.033 0.056
VIM VIM: Vimentin 0.032 0.075
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.032 0.046
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.127
GAB2 N/A 0.032 0.307
NUP214 N/A 0.032 0.036
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.032 0.036
LYN LYN: Tyrosine-protein kinase Lyn 0.032 0.461
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.032 0.038
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.063
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.032 0.038
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.032 0.275
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.032 0.233
SYK SYK: Tyrosine-protein kinase SYK 0.032 0.461
PREP PREP, PEP: Prolyl endopeptidase 0.032 0.063
FLII FLII, FLIL: Protein flightless-1 homolog 0.032 0.078
CTPS CTPS: CTP synthase 1 0.032 0.139
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.032 0.038
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.032 0.038
TBCE TBCE: Tubulin-specific chaperone E 0.032 0.046
NRAS NRAS, HRAS1: GTPase NRas precursor 0.032 132.00
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.032 0.188
CASP3 CASP3, CPP32: Caspase-3 precursor 0.032 0.046
MAD1L1 MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1 0.032 0.063
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.032 0.063
HSPD1 0.032 0.038
PSCD4 PSCD4, CYT4: Cytohesin-4 0.032 0.461
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.032 221.00
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.233
CSE1L CSE1L, CAS, XPO2: Exportin-2 0.032 0.046
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.031 0.099
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.031 0.099
MYO3A MYO3A: Myosin IIIA 0.031 0.099
DYRK3 N/A 0.0308 0.097
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.0308 0.097
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.0308 0.110
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.0308 0.073
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.0308 0.110
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.0308 0.097
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.030 0.070
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.029 0.086
ZFP36 ZFP36, G0S24, RNF162A, TIS11A, TTP: Tristetraproline 0.029 0.032
STAT4 STAT4: Signal transducer and activator of transcription 4 0.029 0.090
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.029 0.181
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.029 0.032
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.029 0.032
SNRK SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase 0.029 0.029
JUN JUN: Transcription factor AP-1 0.029 0.054
BID BID: BH3-interacting domain death agonist 0.028 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.028 0.049
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.083
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.049
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.109
PPEF1 N/A 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.083
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
RAB4A N/A 0.028 0.109
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
PHLDB2 N/A 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.083
MAPKAPK5 N/A 0.028 0.083
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.028 0.049
NF2 NF2, SCH: Merlin 0.028 0.165
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.028 0.097
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.028 0.088
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.028 0.088
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.028 0.110
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.027 0.098
MVP MVP, LRP: Major vault protein 0.027 0.070
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.027 0.155
CASP8 N/A 0.027 0.070
CIITA CIITA, MHC2TA: MHC class II transactivator 0.027 0.127
DAPP1 N/A 0.027 0.070
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.027 0.251
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.027 0.080
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.027 0.515
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.027 0.260
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.027 0.032
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.026 0.155
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.032
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.077
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.026 0.077
IRS2 IRS2: Insulin receptor substrate 2 0.026 0.251
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.026 0.037
SAMD9 SAMD9, C7orf5, DRIF1, KIAA2004, OEF1: Sterile alpha motif domain-containing prot 0.0255 0.0255
GRK6 N/A 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.075
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.148
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.148
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.098
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.044
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.075
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.036
RBL1 RBL1: Retinoblastoma-like protein 1 0.025 0.044
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.075
CCNT2 CCNT2: Cyclin-T2 0.025 0.044
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
GIT2 N/A 0.025 0.075
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.148
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.044
CREB1 CREB1: cAMP response element-binding protein 0.025 0.098
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.025 0.044
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
MAP2K3 N/A 0.025 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.025 0.044
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.148
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
PRKCB1 N/A 0.025 0.025
CAMK2A N/A 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.025 0.098
BCOR N/A 0.025 0.025
CAMKK1 N/A 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.148
0.299
Total Score 4.77