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Evidence of Interaction Between PPP1R8 and BRAF

The interaction score between PPP1R8 and BRAF is 7.94.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PPP1R8 and BRAF = 0.45

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 4.62E-3
Orthology
OrganismPPP1R8 OrthologueBRAF OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm O61817 1 Q07292 1
fly Q9V7W9 1 P11346 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in PPP1R8 and BRAF:
Domains in PPP1R8Domains in BRAF
IPR000253 Forkhead-associated (FHA)
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR002219 Protein kinase C, phorbol ester/diacylglycerol binding
IPR003116 Raf-like Ras-binding

The Chi square scores for co-occurrence of domains that are present in PPP1R8 and BRAF are listed below.

Domain 1Domain 2Chi Square
IPR000253 Forkhead-associated (FHA) IPR000719 Protein kinase 0.131582
IPR000253 Forkhead-associated (FHA) IPR002290 Serine/threonine protein kinase 0.0090931
IPR000253 Forkhead-associated (FHA) IPR008271 Serine/threonine protein kinase, active site 0.000657715

The background colour of the table refers to:

  • Blue Domain is only present in PPP1R8
  • Yellow Domain is only present in BRAF
  • Green Domain is present in both PPP1R8 and BRAF

 0.040
Post-translational Modifications

Protein: PPP1R8

PTMResidueReference
Phosphorylation 161 PubMed, HPRD
Phosphorylation 178 PubMed, HPRD
Phosphorylation 199 PubMed, HPRD
Phosphorylation 204 PubMed, HPRD
Phosphorylation 264 PubMed, HPRD
Phosphorylation 335 PubMed, HPRD
Phosphotyrosine 264 PubMed, HPRD

Protein: BRAF

PTMResidueReference
Phosphorylation 365 PubMed, HPRD
Phosphorylation 401 PubMed, HPRD
Phosphorylation 429 PubMed, HPRD
Phosphorylation 430 PubMed, HPRD
Phosphorylation 440 PubMed, HPRD
Phosphorylation 446 PubMed, HPRD
Phosphorylation 599 PubMed, HPRD
Phosphorylation 602 PubMed, HPRD
Phosphorylation 729 PubMed, HPRD
Phosphoserine 729 HPRD
Phosphothreonine 373 PubMed, HPRD
Phosphothreonine 401 HPRD
Localisation

Protein: PPP1R8

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: BRAF

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PPP1R8 and BRAF that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PPP1R8 andBRAF. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PPP1R8 has 977 interactors and BRAF has 1513 interactors of which there are 536 common interactors.

Common InteractorName of Common InteractorScore for PPP1R8-Interactor (?)Score for BRAF-Interactor (?)
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 1.50 0.046
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.822 0.139
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.763 0.086
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.583 0.045
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.515 0.225
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.515 0.096
NBN NBN, NBS, NBS1, P95: Nibrin 0.430 0.061
ELF1 ELF1: ETS-related transcription factor Elf-1 0.430 0.075
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.416 0.096
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.385 0.029
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.385 0.225
KIAA1012 KIAA1012: Protein TRS85 homolog 0.385 0.114
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.372 0.114
PTMA N/A 0.308 0.074
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.276 0.148
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.276 0.038
ATM ATM: Serine-protein kinase ATM 0.275 0.069
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.269 0.027
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.241 0.225
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.241 0.275
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.241 0.275
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.241 0.148
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.233 0.171
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.233 0.114
XPO1 XPO1, CRM1: Exportin-1 0.227 0.038
CDC23 CDC23: Cell division cycle protein 23 homolog 0.227 0.086
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.227 0.139
XRCC1 XRCC1: DNA-repair protein XRCC1 0.210 0.027
H1FX H1FX: Histone H1x 0.210 0.075
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.188 0.051
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.188 0.029
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.188 0.056
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.188 0.051
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.188 0.038
COPE COPE: Coatomer subunit epsilon 0.188 0.188
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.188 0.0818
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.188 0.051
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.185 0.046
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.171 0.086
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.163 0.027
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.163 0.191
FUBP1 N/A 0.157 0.0425
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.152 0.109
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.152 0.096
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.146 0.225
RPS6KB1 N/A 0.146 0.171
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.146 0.136
STK10 STK10: Uncharacterized protein STK10 0.146 0.225
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.146 0.275
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.146 0.275
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.144 0.027
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.144 0.166
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.144 0.166
GNB2L1 Lung cancer oncogene 7 0.144 0.027
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.144 0.027
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.144 0.0425
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.144 0.127
ABCF1 N/A 0.144 0.0425
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.141 0.046
HNRPK N/A 0.141 0.046
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.141 0.038
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.139 0.275
ETS1 ETS1, EWSR2: Protein C-ets-1 0.139 0.067
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.139 0.046
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.139 0.139
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.139 0.069
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.139 0.067
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.137 0.046
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.137 0.225
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.137 0.114
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.137 0.114
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.136 0.110
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.132 0.191
ROCK1 ROCK1: Rho-associated protein kinase 1 0.132 0.152
MCM3 MCM3: DNA replication licensing factor MCM3 0.129 0.054
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.129 0.067
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.129 0.067
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.129 0.148
KLHDC4 N/A 0.129 0.046
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.129 0.090
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.129 0.051
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.129 0.046
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.129 0.139
ERG ERG: Transcriptional regulator ERG 0.127 0.037
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.124 0.127
HD HD, IT15: Huntingtin 0.124 0.0425
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.118 50.90
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.118 0.275
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.118 0.136
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.118 0.171
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.118 0.225
CDK4 CDK4: Cell division protein kinase 4 0.118 0.225
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.118 0.113
CDK2 CDK2: Cell division protein kinase 2 0.118 0.171
AIP AIP, XAP2: AH receptor-interacting protein 0.114 0.139
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.114 0.038
FKBP4 FKBP4: FK506-binding protein 4 0.114 0.139
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.041
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.114 0.033
SYMPK SYMPK, SPK: Symplekin 0.114 0.038
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.114 0.086
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.114 0.139
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.112 370.00
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.111 0.071
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0971 0.191
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0971 0.191
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.0971 0.225
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0971 0.152
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0971 0.152
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.0971 0.251
ERF ERF: ETS domain-containing transcription factor ERF 0.096 0.057
IPO7 IPO7: Uncharacterized protein IPO7 0.091 0.032
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.091 0.0425
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.087 0.027
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.087 0.052
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.036
API5 N/A 0.087 0.032
PLEK PLEK, P47: Pleckstrin 0.087 0.166
WDR1 N/A 0.087 0.027
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.087 0.032
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.087 0.070
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.087 0.136
CDK7 CDK7, MO15: Cell division protein kinase 7 0.087 0.136
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.087 0.171
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.087 0.171
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.087 0.372
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.087 0.372
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.086 0.0818
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.049
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.0818 0.029
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.0818 0.086
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.080 0.109
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.078 0.029
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.078 0.086
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.078 0.067
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.078 0.032
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.078 0.046
DIAPH1 Diaphanous 1 0.078 0.038
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.078 0.032
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.078 0.171
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.078 0.063
FNBP1 N/A 0.078 0.225
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.078 0.032
SAPS3 N/A 0.078 0.046
CXorf9 N/A 0.078 0.225
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 0.032
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.078 0.029
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.139
COPA COPA: Coatomer subunit alpha 0.078 0.038
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.078 0.113
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.078 0.067
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.078 0.032
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.038
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.077 0.032
ETS2 ETS2: Protein C-ets-2 0.077 0.057
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.076 0.051
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.044
NIPBL N/A 0.075 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.075 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.075 0.148
ELMO1 N/A 0.075 0.148
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.074 0.096
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.071 0.110
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.071 0.136
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.071 0.110
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.071 0.110
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.071 0.110
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.071 0.110
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.071 0.461
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.070 0.032
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.070 0.0453
ARFGAP1 N/A 0.070 0.091
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.070 0.057
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.070 0.126
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.070 0.096
CHUK N/A 0.070 0.032
RB1 RB1: Retinoblastoma-associated protein 0.070 0.075
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.069 0.029
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.067 0.029
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.067 0.385
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.067 0.097
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.066 0.225
RPL8 RPL8: 60S ribosomal protein L8 0.066 0.046
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.066 0.372
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.066 0.038
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.066 0.038
FRG1 FRG1: Protein FRG1 0.066 0.038
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.066 0.114
QARS QARS: Glutaminyl-tRNA synthetase 0.066 0.063
LDHB LDHB: L-lactate dehydrogenase B chain 0.066 0.046
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.066 0.038
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.066 0.139
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.066 0.038
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.066 0.038
UBE4A N/A 0.066 0.038
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.066 0.225
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.066 0.038
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.066 0.046
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.066 0.038
CSK CSK: Tyrosine-protein kinase CSK 0.066 0.275
USP47 USP47: Ubiquitin carboxyl-terminal hydrolase 47 0.066 0.038
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.066 0.038
PPARBP N/A 0.066 0.038
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.066 0.046
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.066 0.038
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.066 0.275
RPS10 RPS10: 40S ribosomal protein S10 0.066 0.139
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.066 0.046
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.066 0.038
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.066 0.225
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.066 0.225
MDN1 MDN1, KIAA0301: Midasin 0.063 0.029
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.113
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.063 0.067
JUND JUND: Transcription factor jun-D 0.063 0.067
SOS1 SOS1: Son of sevenless homolog 1 0.063 0.090
GSK3B N/A 0.063 0.038
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.063 0.0818
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.063
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.063 0.069
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.063 0.046
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.063 0.171
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.063 0.113
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.067
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.063 0.041
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.063 0.114
NPM1 NPM1, NPM: Nucleophosmin 0.063 0.051
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.063 0.051
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.171
STK16 N/A 0.060 0.251
PRKAA1 N/A 0.060 0.109
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.060 0.191
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.060 0.100
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.057 0.155
ETV1 ETV1, ER81: ETS translocation variant 1 0.056 0.029
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.054 0.171
CDK6 CDK6: Cell division protein kinase 6 0.054 0.171
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.054 0.171
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.054 0.171
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.054 0.171
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.052 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.052 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.052 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.052 0.165
MAPK15 N/A 0.052 0.165
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.052 0.032
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.0425
GTF3C1 N/A 0.052 0.027
KIF22 KIF22, KID, KNSL4: Kinesin-like protein KIF22 0.052 0.027
TRRAP N/A 0.052 0.032
NFATC1 N/A 0.052 0.057
MYB MYB: Myb proto-oncogene protein 0.052 0.0453
MARK2 N/A 0.052 0.032
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.070
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.052 0.096
UBAP2 N/A 0.052 0.032
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.052 0.0425
EMD EMD, EDMD, STA: Emerin 0.052 0.036
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.052 0.032
ESPL1 N/A 0.052 0.026
MKI67 MKI67: Antigen KI-67 0.052 0.037
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.052 0.075
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.051 0.139
PKP4 PKP4: Plakophilin-4 0.049 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.049 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.049 0.028
NASP NASP: Nuclear autoantigenic sperm protein 0.049 0.083
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.033
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.048 0.123
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.048 0.109
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.048 0.136
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.047 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.148
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.047 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.047 0.148
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.047 0.148
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.047 0.098
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.047 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.047 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.047 0.148
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.047 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.047 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.047 0.148
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.047 0.148
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.047 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.047 0.098
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.047 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.047 0.148
CDC2 CDC2: Cell division control protein 2 homolog 0.047 0.148
CCNB1 Cyclin B1 0.046 0.090
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.046 0.067
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.046 0.038
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.046 0.051
BRPF1 BRPF1, BR140: Peregrin 0.046 0.029
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.046 0.225
DOK1 DOK1: Docking protein 1 0.046 0.275
CDC20 CDC20: Cell division cycle protein 20 homolog 0.046 0.041
CDKN1B CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B 0.046 0.041
CCNH CCNH: Cyclin-H 0.046 0.090
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.046 0.041
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.046 0.051
MAFG MAFG: Transcription factor MafG 0.046 0.054
JUNB JUNB: Transcription factor jun-B 0.046 0.051
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.046 0.041
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.046 0.038
YWHAQ YWHAQ: 14-3-3 protein theta 0.0446 0.307
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.0446 0.127
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.0446 0.307
SRPR SRPR: Uncharacterized protein SRPR 0.0446 0.0425
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.044 0.033
ELK1 ELK1: ETS domain-containing protein Elk-1 0.044 0.033
SPAG1 SPAG1: Sperm-associated antigen 1 0.044 0.044
KLC2 KLC2: Kinesin light chain 2 0.044 0.086
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.044 0.025
TSC2 TSC2, TSC4: Tuberin 0.044 0.075
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.044 0.067
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.043 0.110
CDK5 CDK5: Cell division protein kinase 5 0.043 0.275
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.032
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.0425 0.113
STAT2 STAT2: Signal transducer and activator of transcription 2 0.0425 0.126
BACH1 BACH1: Transcription regulator protein BACH1 0.0425 0.0453
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.037
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0425 0.077
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.0425 0.062
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.0425 0.191
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.0425 0.191
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.041 0.136
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.041 0.054
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.04 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.04 0.165
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.04 0.148
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.04 0.028
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.040 0.086
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.040 0.038
STAT6 STAT6: Signal transducer and activator of transcription 6 0.040 0.225
JAK1 0.040 0.225
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.040 0.029
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.040 0.171
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.040 0.038
CCT8 CCT8: Uncharacterized protein CCT8 0.040 0.029
EEF2 EEF2, EF2: Elongation factor 2 0.040 0.275
PPIG PPIG: Peptidyl-prolyl cis-trans isomerase G 0.040 0.038
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.040 0.038
CRKL CRKL: Crk-like protein 0.040 0.225
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.040 0.038
SEC24B SEC24B: Protein transport protein Sec24B 0.040 0.114
TPT1 TPT1: Translationally-controlled tumor protein 0.040 0.038
PTPN11 N/A 0.040 0.046
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.040 0.225
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.040 0.087
CARS CARS: Cysteinyl-tRNA synthetase, cytoplasmic 0.040 0.046
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.040 0.029
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.040 0.038
LCP1 LCP1, PLS2: Plastin-2 0.040 0.114
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.040 0.225
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.040 0.225
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.040 0.225
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.040 0.225
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.040 0.046
LPXN LPXN, LDLP: Leupaxin 0.040 0.114
ACTG1 ACTB: Actin, cytoplasmic 1 0.040 0.046
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.040 0.225
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.040 0.171
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.040 0.029
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.040 0.225
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.040 0.029
THOC1 THOC1, HPR1: THO complex subunit 1 0.040 0.086
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.040 0.029
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.040 0.225
VAV1 VAV1, VAV: Proto-oncogene vav 0.040 0.225
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.040 0.063
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.040 0.171
MSN MSN: Moesin 0.040 0.225
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.040 0.086
WASPIP N/A 0.040 0.114
HSP90AA1 Hsp89-alpha-delta-N 0.040 0.086
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.040 0.114
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.040 0.038
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.040 0.225
CD2AP CD2AP: CD2-associated protein 0.040 0.171
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.040 0.225
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.039 0.152
MDM4 MDM4, MDMX: Mdm4 protein 0.039 0.032
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.039 0.109
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.039 0.081
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.039 0.136
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.086
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.038 0.069
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.038 0.038
DYNC1I2 N/A 0.038 0.029
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.038 0.114
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.038 0.029
RELA RELA, NFKB3: Transcription factor p65 0.038 0.067
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.038
WEE1 WEE1: Wee1-like protein kinase 0.038 0.056
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.037 0.039
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.037 0.110
PHB2 PHB2, BAP, REA: Prohibitin-2 0.036 0.070
DNM2 N/A 0.036 0.052
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.036 0.251
LIMS1 N/A 0.036 0.096
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.036 0.127
MPG N/A 0.036 0.070
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.036 0.070
IFI35 N/A 0.036 0.052
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.036 0.032
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.036 0.0425
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.035 0.275
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.035 108.00
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.035 0.110
CDKL5 N/A 0.035 0.109
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.034 0.152
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.033 0.171
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.033 0.136
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.033 0.069
VIM VIM: Vimentin 0.032 0.0453
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.032 0.030
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.077
GAB2 N/A 0.032 0.191
LYN LYN: Tyrosine-protein kinase Lyn 0.032 0.225
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.032 0.029
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.046
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.032 0.038
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.032 0.171
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.032 0.461
SYK SYK: Tyrosine-protein kinase SYK 0.032 0.225
PREP PREP, PEP: Prolyl endopeptidase 0.032 0.038
FLII FLII, FLIL: Protein flightless-1 homolog 0.032 0.046
CTPS CTPS: CTP synthase 1 0.032 0.086
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.032 0.038
TBCE TBCE: Tubulin-specific chaperone E 0.032 0.046
NRAS NRAS, HRAS1: GTPase NRas precursor 0.032 82.20
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.032 0.086
CASP3 CASP3, CPP32: Caspase-3 precursor 0.032 0.038
MAD1L1 MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1 0.032 0.038
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.032 0.114
HSPD1 0.032 0.029
PSCD4 PSCD4, CYT4: Cytohesin-4 0.032 0.171
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.032 0.275
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.225
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.031 0.110
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.031 0.088
MYO3A MYO3A: Myosin IIIA 0.031 0.097
DYRK3 N/A 0.0308 0.088
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.0308 0.097
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.0308 0.088
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.0308 0.064
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.0308 0.136
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.0308 0.171
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.030 0.042
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.029 0.086
STAT4 STAT4: Signal transducer and activator of transcription 4 0.029 0.073
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.029 0.113
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.029 0.041
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.029 0.041
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.029 0.038
JUN JUN: Transcription factor AP-1 0.029 0.051
BID BID: BH3-interacting domain death agonist 0.028 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.028 0.049
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.083
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.049
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.109
PPEF1 N/A 0.028 0.083
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.083
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
RAB4A N/A 0.028 0.109
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
PHLDB2 N/A 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.083
MAPKAPK5 N/A 0.028 0.083
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.028 0.049
NF2 NF2, SCH: Merlin 0.028 0.165
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.028 0.136
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.028 0.097
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.028 0.110
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.028 0.171
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.027 0.109
MVP MVP, LRP: Major vault protein 0.027 0.0425
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.027 0.155
CASP8 N/A 0.027 0.026
CIITA CIITA, MHC2TA: MHC class II transactivator 0.027 0.077
DAPP1 N/A 0.027 0.026
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.027 0.191
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.027 0.048
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.027 0.191
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.027 0.096
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.027 0.0425
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.026 0.057
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.0425
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.155
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.026 0.152
IRS2 IRS2: Insulin receptor substrate 2 0.026 0.152
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.026 0.0453
GRK6 N/A 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.075
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.148
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.148
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.098
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.044
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.075
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.044
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.044
RBL1 RBL1: Retinoblastoma-like protein 1 0.025 0.044
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.075
CCNT2 CCNT2: Cyclin-T2 0.025 0.098
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
GIT2 N/A 0.025 0.075
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.148
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.044
CREB1 CREB1: cAMP response element-binding protein 0.025 0.098
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.025 0.098
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
MAP2K3 N/A 0.025 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.025 0.098
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.148
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
PRKCB1 N/A 0.025 0.025
CAMK2A N/A 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.025 0.098
BCOR N/A 0.025 0.025
CAMKK1 N/A 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.148
0.299
Total Score 7.94