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Evidence of Interaction Between PPP1R8 and CSK

The interaction score between PPP1R8 and CSK is 6.01.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PPP1R8 and CSK = 0.73

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismPPP1R8 OrthologueCSK OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm O61817 1 Q9BL77 1
fly Q9V7W9 1 Q9VGK8 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in PPP1R8 and CSK:
Domains in PPP1R8Domains in CSK
IPR000253 Forkhead-associated (FHA)
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001452 SH3
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in PPP1R8 and CSK are listed below.

Domain 1Domain 2Chi Square
IPR000253 Forkhead-associated (FHA) IPR000719 Protein kinase 0.131582

The background colour of the table refers to:

  • Blue Domain is only present in PPP1R8
  • Yellow Domain is only present in CSK
  • Green Domain is present in both PPP1R8 and CSK

 0.014
Post-translational Modifications

Protein: PPP1R8

PTMResidueReference
Phosphorylation 161 PubMed, HPRD
Phosphorylation 178 PubMed, HPRD
Phosphorylation 199 PubMed, HPRD
Phosphorylation 204 PubMed, HPRD
Phosphorylation 264 PubMed, HPRD
Phosphorylation 335 PubMed, HPRD
Phosphotyrosine 264 PubMed, HPRD

Protein: CSK

PTMResidueReference
Phosphorylation 184 PubMed, HPRD
Phosphorylation 304 PubMed, HPRD
Phosphorylation 364 PubMed, HPRD
Phosphotyrosine 184 HPRD
Phosphotyrosine 304 PubMed, HPRD
Localisation

Protein: PPP1R8

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: CSK

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PPP1R8 and CSK that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PPP1R8 andCSK. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PPP1R8 has 977 interactors and CSK has 1875 interactors of which there are 685 common interactors.

Common InteractorName of Common InteractorScore for PPP1R8-Interactor (?)Score for CSK-Interactor (?)
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 1.50 0.964
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.822 0.129
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.763 0.385
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.583 0.093
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.515 0.763
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.515 1.81
NBN NBN, NBS, NBS1, P95: Nibrin 0.430 0.157
ELF1 ELF1: ETS-related transcription factor Elf-1 0.430 0.157
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.416 0.210
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.385 0.066
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.385 0.066
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.385 0.129
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.385 0.763
KIAA1012 KIAA1012: Protein TRS85 homolog 0.385 0.276
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.385 0.040
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.372 0.461
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.308 0.074
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.308 0.074
PTMA N/A 0.308 0.074
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.276 0.141
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.276 0.066
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.276 0.066
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.276 0.066
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.276 1.07
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.276 0.141
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.276 0.066
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.276 0.137
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.276 0.129
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.276 0.066
NUP153 N/A 0.276 0.040
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.276 0.066
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.276 0.040
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.276 0.066
ATM ATM: Serine-protein kinase ATM 0.275 0.372
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.269 0.074
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.241 0.763
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.241 0.461
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.241 0.763
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.241 0.503
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.233 0.461
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.233 0.129
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.233 0.040
XPO1 XPO1, CRM1: Exportin-1 0.227 0.078
CDC23 CDC23: Cell division cycle protein 23 homolog 0.227 0.063
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.227 0.078
XRCC1 XRCC1: DNA-repair protein XRCC1 0.210 0.027
H1FX H1FX: Histone H1x 0.210 0.124
IRF3 IRF3: Interferon regulatory factor 3 0.210 0.253
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.210 0.027
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.188 0.111
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.188 0.029
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.188 0.063
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.188 0.246
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.188 0.129
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.188 0.032
COPE COPE: Coatomer subunit epsilon 0.188 0.063
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.188 0.0818
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.188 0.111
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.185 0.078
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.171 0.136
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.163 0.0446
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.163 0.852
FUBP1 N/A 0.157 0.430
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.156 0.066
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.152 0.087
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.152 0.152
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.146 0.763
RPS6KB1 N/A 0.146 0.461
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.146 0.372
STK10 STK10: Uncharacterized protein STK10 0.146 0.763
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.146 0.461
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.146 0.763
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.144 0.0446
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.144 0.036
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.144 0.074
IFI16 N/A 0.144 0.157
MATR3 MATR3, KIAA0723: Matrin-3 0.144 0.0446
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.144 0.561
TOP2B N/A 0.144 0.0446
DDX21 DDX21: Nucleolar RNA helicase 2 0.144 0.074
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.144 0.340
SET SET: Protein SET 0.144 0.0446
GNB2L1 Lung cancer oncogene 7 0.144 0.074
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.144 0.074
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.144 0.087
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.144 0.087
ABCF1 N/A 0.144 0.087
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.141 0.129
HNRPK N/A 0.141 0.129
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.141 0.129
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.139 0.372
ETS1 ETS1, EWSR2: Protein C-ets-1 0.139 0.032
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.139 0.063
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.139 0.046
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.139 0.046
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.139 0.033
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.137 0.038
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.137 1.62
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.137 0.063
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.137 0.046
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.030
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.030
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.136 0.110
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.132 1.81
ROCK1 ROCK1: Rho-associated protein kinase 1 0.132 0.515
CBX3 CBX3: Chromobox protein homolog 3 0.129 0.040
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.129 0.032
MCM3 MCM3: DNA replication licensing factor MCM3 0.129 0.090
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.129 0.040
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.129 0.040
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.129 0.040
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.129 0.066
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.129 0.066
HDAC3 HDAC3: Histone deacetylase 3 0.129 0.040
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.129 0.032
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.129 0.484
TIAL1 TIAL1: Nucleolysin TIAR 0.129 0.066
YY1 YY1: Transcriptional repressor protein YY1 0.129 0.066
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.129 0.066
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.032
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.129 0.503
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.129 0.066
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.129 0.066
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.129 0.141
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.129 0.066
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.129 0.040
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.129 0.040
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.129 0.066
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.129 0.040
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.040
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.129 0.040
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.129 0.137
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.129 0.040
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.129 0.137
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.129 0.066
SP3 SP3: Transcription factor Sp3 0.129 0.040
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.129 0.066
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.129 0.040
KLHDC4 N/A 0.129 0.129
SSB SSB: Lupus La protein 0.129 0.040
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.129 0.227
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.129 0.040
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.129 0.040
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.129 0.129
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.129 0.461
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.124 0.052
HD HD, IT15: Huntingtin 0.124 0.260
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.118 0.372
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.118 0.372
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.118 0.225
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.118 0.275
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.118 0.763
CDK4 CDK4: Cell division protein kinase 4 0.118 0.275
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.118 2.73
CDK2 CDK2: Cell division protein kinase 2 0.118 0.275
AIP AIP, XAP2: AH receptor-interacting protein 0.114 0.078
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.114 0.038
FKBP4 FKBP4: FK506-binding protein 4 0.114 0.029
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.114 0.032
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.067
SYMPK SYMPK, SPK: Symplekin 0.114 0.046
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.114 0.029
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.114 0.038
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.112 0.461
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.111 0.063
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0971 0.307
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0971 0.307
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.0971 0.225
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0971 0.307
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0971 0.416
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.0971 0.416
ERF ERF: ETS domain-containing transcription factor ERF 0.096 0.057
IPO7 IPO7: Uncharacterized protein IPO7 0.091 0.0425
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.091 0.052
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.087 0.0446
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.087 0.027
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.087 0.074
KIAA0853 N/A 0.087 0.0446
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.087 0.087
DNMT1 DNMT1, AIM, DNMT: DNA 0.087 0.0446
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.0446
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.087 0.0446
SP100 N/A 0.087 0.074
NCOA3 N/A 0.087 0.157
API5 N/A 0.087 0.052
TCOF1 N/A 0.087 0.0446
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.087 0.0446
PLEK PLEK, P47: Pleckstrin 0.087 1.19
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.087 0.027
RBM14 RBM14, SIP: RNA-binding protein 14 0.087 0.0446
WDR1 N/A 0.087 0.0446
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.087 0.070
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.087 0.036
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.087 0.132
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.087 0.0446
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.087 0.027
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.087 0.074
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.087 0.461
CDK7 CDK7, MO15: Cell division protein kinase 7 0.087 0.275
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.087 0.275
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.087 0.225
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.087 0.372
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.087 0.225
LIG4 LIG4: DNA ligase 4 0.086 0.033
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.0818 0.038
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.0818 0.038
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.0818 0.038
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.080 0.251
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.078 0.063
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.078 0.275
LIG1 LIG1: DNA ligase 1 0.078 0.090
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.078 0.040
NOL1 N/A 0.078 0.040
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.078 0.040
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.078 0.032
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.078 0.040
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.078 0.032
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.078 0.040
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.078 0.146
SNRPC SNRPC: U1 small nuclear ribonucleoprotein C 0.078 0.032
CUL4B N/A 0.078 0.032
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.078 0.032
DDX51 DDX51: ATP-dependent RNA helicase DDX51 0.078 0.040
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.078 0.040
EP300 N/A 0.078 0.040
DIAPH1 Diaphanous 1 0.078 0.129
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.078 0.141
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.078 0.066
PHF10 N/A 0.078 0.032
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 0.078 0.032
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.078 0.763
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.078 0.129
FNBP1 N/A 0.078 1.62
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.078 0.040
POLA2 POLA2: DNA polymerase subunit alpha B 0.078 0.032
SAPS3 N/A 0.078 0.063
CXorf9 N/A 0.078 1.62
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.078 0.078
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.078 0.040
WBSCR20A N/A 0.078 0.066
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.078 0.040
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.078 0.032
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 0.040
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.078 0.032
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.078 0.032
UBA2 SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2 0.078 0.040
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.078 0.066
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.078 0.078
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.461
COPA COPA: Coatomer subunit alpha 0.078 0.063
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.078 0.246
CUL5 CUL5, VACM1: Cullin-5 0.078 0.032
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.078 0.032
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.078 0.137
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.078 0.040
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.078 0.032
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.078 0.040
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.078 0.040
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.078 0.227
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.078 0.040
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.078 0.040
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.078
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.078 0.040
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.077 0.032
ETS2 ETS2: Protein C-ets-2 0.077 0.100
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.076 0.040
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.044
NIPBL N/A 0.075 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.075 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.075 0.148
ELMO1 N/A 0.075 0.148
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.074 0.070
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.071 0.136
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.071 0.372
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.071 0.171
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.071 0.225
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.071 0.171
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.071 0.136
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.071 0.275
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.070 0.052
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.070 0.075
ARFGAP1 N/A 0.070 0.0446
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.070 0.074
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.070 0.074
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.070 3.05
TGIF2 TGIF2: Homeobox protein TGIF2 0.070 0.074
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.070 0.515
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.070 0.036
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.070 0.027
RBM6 RBM6, DEF3: RNA-binding protein 6 0.070 0.0446
CHUK N/A 0.070 0.070
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.070 0.0446
RB1 RB1: Retinoblastoma-associated protein 0.070 0.036
KIAA0690 N/A 0.069 0.029
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.069 0.041
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.067 0.029
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.067 0.029
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.067 0.171
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.067 0.275
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.066 0.129
RPL8 RPL8: 60S ribosomal protein L8 0.066 0.129
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.066 0.188
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.066 0.129
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.066 0.129
FRG1 FRG1: Protein FRG1 0.066 0.129
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.066 0.233
QARS QARS: Glutaminyl-tRNA synthetase 0.066 0.276
LDHB LDHB: L-lactate dehydrogenase B chain 0.066 0.063
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.066 0.129
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.066 0.385
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.066 0.276
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.066 0.276
UBE4A N/A 0.066 0.078
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.066 0.275
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.066 0.276
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.066 0.385
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.066 0.139
USP47 USP47: Ubiquitin carboxyl-terminal hydrolase 47 0.066 0.078
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.066 0.129
PPARBP N/A 0.066 0.129
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.066 0.276
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.066 0.129
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.066 12.80
RPS10 RPS10: 40S ribosomal protein S10 0.066 0.129
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.066 0.276
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.066 0.063
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.066 0.233
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.066 0.233
MDN1 MDN1, KIAA0301: Midasin 0.063 0.063
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 0.063 0.040
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 2.20
TP53 TP53, P53: Cellular tumor antigen p53 0.063 0.112
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.063 0.113
JUND JUND: Transcription factor jun-D 0.063 0.040
SOS1 SOS1: Son of sevenless homolog 1 0.063 0.246
GSK3B N/A 0.063 0.063
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.063 0.246
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.063 0.040
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.078
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.063 0.225
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.063 0.066
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.063 0.046
SRF SRF: Serum response factor 0.063 0.032
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.063 0.461
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.063 0.032
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.063 0.040
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.063 0.137
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.063 0.032
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.111
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.063 0.032
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.063 0.067
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.063 0.372
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.063 0.032
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.063 0.040
NPM1 NPM1, NPM: Nucleophosmin 0.063 0.111
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.063 0.032
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.063 0.032
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.063 0.032
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.038
STK16 N/A 0.060 0.251
PRKAA1 N/A 0.060 0.191
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.060 0.251
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.060 0.100
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.057 0.127
ETV1 ETV1, ER81: ETS translocation variant 1 0.056 0.033
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.054 0.136
CDK6 CDK6: Cell division protein kinase 6 0.054 0.136
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.054 0.171
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.054 0.275
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.054 0.136
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.054 0.029
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.054
C11orf58 SMAP, C11orf58: Small acidic protein 0.053 0.025
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.052 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.052 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.052 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.052 0.165
MAPK15 N/A 0.052 0.165
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.052 0.087
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.052 0.036
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.070
GTF3C1 N/A 0.052 0.027
CENPA CENPA: Histone H3-like centromeric protein A 0.052 0.166
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.052 0.027
MEF2A N/A 0.052 0.027
ZNF267 ZNF267: Zinc finger protein 267 0.052 0.036
KIF22 KIF22, KID, KNSL4: Kinesin-like protein KIF22 0.052 0.075
TRRAP N/A 0.052 0.070
NFATC1 N/A 0.052 0.125
MYB MYB: Myb proto-oncogene protein 0.052 0.046
MARK2 N/A 0.052 0.070
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.052
SREBF2 N/A 0.052 0.0446
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.052 0.070
UBAP2 N/A 0.052 0.052
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.052 0.052
ID2 ID2: DNA-binding protein inhibitor ID-2 0.052 0.036
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.052 0.052
ESPL1 N/A 0.052 0.0425
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.052 0.091
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.051 0.029
PKP4 PKP4: Plakophilin-4 0.049 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.049 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.049 0.028
NASP NASP: Nuclear autoantigenic sperm protein 0.049 0.028
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.029
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.048 0.152
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.048 0.123
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.048 0.171
EIF3S7 EIF3S7: Eukaryotic translation initiation factor 3 subunit 7 0.0479 0.0479
SRRM1 SRRM1, SRM160: Serine/arginine repetitive matrix protein 1 0.0479 0.0479
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.047 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.148
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.047 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.047 0.148
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.047 0.148
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.047 0.098
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.047 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.047 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.047 0.148
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.047 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.047 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.047 0.148
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.047 0.148
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.047 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.047 0.098
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.047 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.047 0.148
CDC2 CDC2: Cell division control protein 2 homolog 0.047 0.148
CCNB1 Cyclin B1 0.046 0.051
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.046 0.090
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.046 0.063
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.046 0.113
BRPF1 BRPF1, BR140: Peregrin 0.046 0.046
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.046 0.275
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.046 0.032
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 0.046 0.0818
DOK1 DOK1: Docking protein 1 0.046 0.372
CDC20 CDC20: Cell division cycle protein 20 homolog 0.046 0.067
CDKN1B CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B 0.046 0.0818
H2AFX H2AFX, H2AX: Histone H2A.x 0.046 0.148
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.046 0.046
CCNH CCNH: Cyclin-H 0.046 0.067
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.046 0.032
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.046 0.066
MTA1 MTA1: Metastasis-associated protein MTA1 0.046 0.040
CREBBP CREBBP, CBP: CREB-binding protein 0.046 0.032
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.046 0.032
JUNB JUNB: Transcription factor jun-B 0.046 0.040
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.046 0.046
YWHAQ YWHAQ: 14-3-3 protein theta 0.0446 0.0425
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.0446 0.155
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.0446 0.087
SRPR SRPR: Uncharacterized protein SRPR 0.0446 0.087
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.044 0.033
KLC2 KLC2: Kinesin light chain 2 0.044 0.028
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.044 0.025
TSC2 TSC2, TSC4: Tuberin 0.044 0.075
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.044 0.040
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.043 0.171
CDK5 CDK5: Cell division protein kinase 5 0.043 0.136
HIVEP1 N/A 0.0425 0.027
RGS14 N/A 0.0425 0.036
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.0425
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.0425 0.181
STAT2 STAT2: Signal transducer and activator of transcription 2 0.0425 1.81
BACH1 BACH1: Transcription regulator protein BACH1 0.0425 0.036
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.166
KIF23 N/A 0.0425 0.057
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0425 0.191
SMARCC2 N/A 0.0425 0.027
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.0425 0.032
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.0425 0.416
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.0425 0.307
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.0425 0.027
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.041 0.136
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.041 0.069
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.04 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.04 0.165
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.04 0.148
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.04 0.028
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.040 0.275
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.040 0.129
STAT6 STAT6: Signal transducer and activator of transcription 6 0.040 12.80
JAK1 0.040 3.64
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.040 0.078
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.040 2.17
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.040 0.078
CCT8 CCT8: Uncharacterized protein CCT8 0.040 0.078
EEF2 EEF2, EF2: Elongation factor 2 0.040 0.129
PPIG PPIG: Peptidyl-prolyl cis-trans isomerase G 0.040 0.078
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.040 0.063
CRKL CRKL: Crk-like protein 0.040 2.94
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.040 0.063
SEC24B SEC24B: Protein transport protein Sec24B 0.040 0.146
TPT1 TPT1: Translationally-controlled tumor protein 0.040 0.078
PTPN11 N/A 0.040 0.046
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.040 0.461
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.040 0.063
CARS CARS: Cysteinyl-tRNA synthetase, cytoplasmic 0.040 0.129
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.040 0.188
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.040 0.063
LCP1 LCP1, PLS2: Plastin-2 0.040 1.62
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.040 0.078
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.040 0.078
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.040 6.03
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.040 0.233
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.040 0.385
LPXN LPXN, LDLP: Leupaxin 0.040 0.276
ACTG1 ACTB: Actin, cytoplasmic 1 0.040 0.078
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.040 0.063
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.040 0.063
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.040 0.078
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.040 0.461
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.040 0.063
THOC1 THOC1, HPR1: THO complex subunit 1 0.040 0.139
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.040 0.063
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.040 1.62
VAV1 VAV1, VAV: Proto-oncogene vav 0.040 12.80
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.040 0.078
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.040 6.03
MSN MSN: Moesin 0.040 0.461
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.040 0.188
WASPIP N/A 0.040 1.62
HSP90AA1 Hsp89-alpha-delta-N 0.040 0.114
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.040 0.188
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.040 0.063
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.040 1.62
CD2AP CD2AP: CD2-associated protein 0.040 0.461
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.040 0.763
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.039 0.123
MDM4 MDM4, MDMX: Mdm4 protein 0.039 0.0453
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.039 0.123
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.039 0.644
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.039 0.171
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.275
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.038 0.171
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.038 0.038
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.038 0.246
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.038 0.181
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.038 0.275
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.038 0.063
RELA RELA, NFKB3: Transcription factor p65 0.038 0.032
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.029
ZNF335 ZNF335: Zinc finger protein 335 0.038 0.032
WEE1 WEE1: Wee1-like protein kinase 0.038 0.225
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.037 0.026
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.037 0.136
PHB2 PHB2, BAP, REA: Prohibitin-2 0.036 0.260
DNM2 N/A 0.036 0.087
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.036 0.515
LIMS1 N/A 0.036 0.070
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.036 0.260
MPG N/A 0.036 0.070
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.036 0.155
IFI35 N/A 0.036 0.144
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.036 0.070
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.036 0.052
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.035 0.110
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.035 0.110
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.035 0.097
CDKL5 N/A 0.035 0.098
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.034 0.123
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.033 0.110
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.033 0.136
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.307
GAB2 N/A 0.032 0.191
LYN LYN: Tyrosine-protein kinase Lyn 0.032 6.03
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.032 0.038
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.063
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.032 0.046
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.032 0.372
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.032 0.763
SYK SYK: Tyrosine-protein kinase SYK 0.032 6.03
PREP PREP, PEP: Prolyl endopeptidase 0.032 0.063
FLII FLII, FLIL: Protein flightless-1 homolog 0.032 0.146
CTPS CTPS: CTP synthase 1 0.032 0.139
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.032 0.078
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.032 0.038
TBCE TBCE: Tubulin-specific chaperone E 0.032 0.046
NRAS NRAS, HRAS1: GTPase NRas precursor 0.032 0.063
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.032 0.372
CASP3 CASP3, CPP32: Caspase-3 precursor 0.032 0.046
MAD1L1 MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1 0.032 0.129
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.032 1.62
HSPD1 0.032 0.046
PSCD4 PSCD4, CYT4: Cytohesin-4 0.032 0.461
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.032 0.078
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.461
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.031 0.099
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.031 0.099
MYO3A MYO3A: Myosin IIIA 0.031 0.088
DYRK3 N/A 0.0308 0.088
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.0308 0.097
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.0308 0.110
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.0308 0.655
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.0308 0.110
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.0308 0.097
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.030 0.070
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.029 0.029
STAT4 STAT4: Signal transducer and activator of transcription 4 0.029 1.33
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.029 0.181
SNRK SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase 0.029 0.038
BID BID: BH3-interacting domain death agonist 0.028 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.165
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.028 0.04
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.165
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.109
PPEF1 N/A 0.028 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.165
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.083
PHLDB2 N/A 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.165
MAPKAPK5 N/A 0.028 0.165
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.028 0.04
NF2 NF2, SCH: Merlin 0.028 0.165
HES6 HES6: Transcription cofactor HES-6 0.028 0.049
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.028 0.110
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.028 0.099
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.028 0.097
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.028 0.097
PIK3C2B PIK3C2B: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta pol 0.028 0.044
LSM14A N/A 0.027 0.027
LOC653105 PNRC2, HSPC208: Proline-rich nuclear receptor coactivator 2 0.027 0.027
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.027 0.775
MVP MVP, LRP: Major vault protein 0.027 0.070
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.027 0.070
CASP8 N/A 0.027 0.087
CIITA CIITA, MHC2TA: MHC class II transactivator 0.027 0.087
DAPP1 N/A 0.027 0.087
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.027 4.07
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.027 0.032
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.027 4.07
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.027 0.260
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.027 0.0425
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.026 0.155
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 1.50
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.026 0.152
IRS2 IRS2: Insulin receptor substrate 2 0.026 0.152
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.026 0.037
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.026 0.026
SAMD9 SAMD9, C7orf5, DRIF1, KIAA2004, OEF1: Sterile alpha motif domain-containing prot 0.0255 0.083
GRK6 N/A 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.148
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.148
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.148
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.098
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.098
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.148
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.098
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.098
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.148
CCNT2 CCNT2: Cyclin-T2 0.025 0.044
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
GIT2 N/A 0.025 0.025
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.098
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
CREB1 CREB1: cAMP response element-binding protein 0.025 0.044
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.025 0.044
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
MAP2K3 N/A 0.025 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.025 0.044
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.148
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
PRKCB1 N/A 0.025 0.025
CAMK2A N/A 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.025 0.878
BCOR N/A 0.025 0.025
CAMKK1 N/A 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.148
DCLRE1C N/A 0.025 0.025
SFRS2IP SFRS2IP, CASP11, SIP1: SFRS2-interacting protein 0.025 0.025
0.228
Total Score 6.01