PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between PPP1R8 and SYK

The interaction score between PPP1R8 and SYK is 2.93.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between PPP1R8 and SYK = 0.56

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

6.27E-3

Orthology

Organism	PPP1R8 Orthologue		SYK Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
fly	Q9V7W9	1	Q24145	0.402

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.22E-3

Domains

Domains present in PPP1R8 and SYK:

Domains in PPP1R8

Domains in SYK

IPR000253

Forkhead-associated (FHA)

IPR000719	Protein kinase
IPR001245	Tyrosine protein kinase
IPR008266	Tyrosine protein kinase, active site
IPR000980	SH2 motif
IPR012234	TyrPK_SYK.

The Chi square scores for co-occurrence of domains that are present in PPP1R8 and SYK are listed below.

Domain 1		Domain 2		Chi Square
IPR000253	Forkhead-associated (FHA)	IPR000719	Protein kinase	0.131582

The background colour of the table refers to:

Blue Domain is only present in PPP1R8
Yellow Domain is only present in SYK
Green Domain is present in both PPP1R8 and SYK

0.014

Post-translational Modifications

Protein: PPP1R8

PTM	Residue	Reference
Phosphorylation	161	PubMed, HPRD
Phosphorylation	178	PubMed, HPRD
Phosphorylation	199	PubMed, HPRD
Phosphorylation	204	PubMed, HPRD
Phosphorylation	264	PubMed, HPRD
Phosphorylation	335	PubMed, HPRD
Phosphotyrosine	264	PubMed, HPRD

Protein: SYK

PTM	Residue	Reference
Phosphorylation	131	PubMed, HPRD
Phosphorylation	323	PubMed, HPRD
Phosphorylation	348	PubMed, HPRD
Phosphorylation	352	PubMed, HPRD
Phosphorylation	525	PubMed, HPRD
Phosphorylation	526	PubMed, HPRD
Phosphotyrosine	348	HPRD
Phosphotyrosine	352	HPRD

Localisation

Protein: PPP1R8

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: SYK

Localisation	Reference
Cytoplasm	HPRD

Transitive Score

The common interactors between PPP1R8 and SYK that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PPP1R8 andSYK. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PPP1R8 has 977 interactors and SYK has 1720 interactors of which there are 605 common interactors.

Common Interactor	Name of Common Interactor	Score for PPP1R8-Interactor (?)	Score for SYK-Interactor (?)
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	1.50	0.471
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.822	0.063
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.763	0.188
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.583	0.0554
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.515	0.372
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.515	0.515
NBN	NBN, NBS, NBS1, P95: Nibrin	0.430	0.036
ELF1	ELF1: ETS-related transcription factor Elf-1	0.430	0.074
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.416	0.096
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.385	0.032
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.385	0.040
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.385	0.078
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.385	0.461
KIAA1012	KIAA1012: Protein TRS85 homolog	0.385	0.129
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.385	0.032
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.372	0.852
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.308	0.0446
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.308	0.0446
PTMA	N/A	0.308	0.0446
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.276	0.066
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.276	0.032
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.276	0.032
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.276	0.066
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.276	0.503
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.276	0.040
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.276	0.032
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.276	0.040
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.276	0.078
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.276	0.040
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.276	0.040
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.276	0.032
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.276	0.032
ATM	ATM: Serine-protein kinase ATM	0.275	0.171
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.269	0.074
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.241	0.372
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.241	0.275
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.241	0.763
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.241	0.246
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.233	0.461
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.233	0.046
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.233	0.032
XPO1	XPO1, CRM1: Exportin-1	0.227	0.063
CDC23	CDC23: Cell division cycle protein 23 homolog	0.227	0.038
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.227	0.063
H1FX	H1FX: Histone H1x	0.210	0.125
IRF3	IRF3: Interferon regulatory factor 3	0.210	0.091
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.188	0.067
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.188	0.046
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.188	0.246
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.188	0.046
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.188	0.061
COPE	COPE: Coatomer subunit epsilon	0.188	0.046
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.188	0.090
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.188	0.112
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.185	0.118
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.171	0.171
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.163	0.061
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.163	0.416
FUBP1	N/A	0.157	0.210
VDP	DKFZp451D234: Putative uncharacterized protein DKFZp451D234	0.156	0.032
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.152	0.087
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.152	0.123
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.146	0.372
RPS6KB1	N/A	0.146	0.372
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.146	0.275
STK10	STK10: Uncharacterized protein STK10	0.146	0.372
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.146	0.372
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.146	0.461
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.144	0.036
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.144	0.027
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.144	0.027
IFI16	N/A	0.144	0.074
MATR3	MATR3, KIAA0723: Matrin-3	0.144	0.027
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.144	0.274
TOP2B	N/A	0.144	0.027
DDX21	DDX21: Nucleolar RNA helicase 2	0.144	0.0446
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.144	0.274
SET	SET: Protein SET	0.144	0.027
GNB2L1	Lung cancer oncogene 7	0.144	0.0446
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.144	0.074
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.144	0.070
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.144	0.132
ABCF1	N/A	0.144	0.0425
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.141	0.087
HNRPK	N/A	0.141	0.078
RPS3	RPS3, OK/SW-cl.26: 40S ribosomal protein S3	0.141	0.078
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.139	0.046
ELMO2	ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2	0.139	0.275
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.139	0.029
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.139	0.029
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.139	0.038
UBE2E3	UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3	0.137	0.046
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.137	1.62
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.137	0.046
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.137	0.046
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.137	0.030
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.137	0.030
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.136	0.110
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.132	0.030
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.132	0.416
ROCK1	ROCK1: Rho-associated protein kinase 1	0.132	0.416
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.129	0.040
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.129	0.032
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.129	0.032
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.129	0.040
HDAC3	HDAC3: Histone deacetylase 3	0.129	0.032
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.129	0.090
YY1	YY1: Transcriptional repressor protein YY1	0.129	0.040
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.129	0.032
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.129	0.066
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.129	0.066
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.129	0.032
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.129	0.040
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.129	0.0446
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.129	0.032
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.129	0.040
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.129	0.032
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.129	0.032
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.129	0.032
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.129	0.227
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.129	0.040
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.129	0.124
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.129	0.040
SP3	SP3: Transcription factor Sp3	0.129	0.032
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.129	0.032
KLHDC4	N/A	0.129	0.063
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.129	0.137
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.129	0.032
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.129	0.063
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.129	0.763
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.124	0.0425
HD	HD, IT15: Huntingtin	0.124	0.052
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.118	0.372
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.118	0.275
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.118	0.136
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.118	0.251
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.118	0.275
CDK4	CDK4: Cell division protein kinase 4	0.118	0.171
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.118	1.33
CDK2	CDK2: Cell division protein kinase 2	0.118	0.171
AIP	AIP, XAP2: AH receptor-interacting protein	0.114	0.038
EIF4G3	EIF4G3: Eukaryotic translation initiation factor 4 gamma 3	0.114	0.051
SYMPK	SYMPK, SPK: Symplekin	0.114	0.038
DNAJC7	DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7	0.114	0.029
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.114	0.029
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.112	0.225
PPP2R5A	PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha	0.111	0.063
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.0971	0.191
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.0971	0.307
SGK3	SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3	0.0971	0.416
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.0971	0.251
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.0971	0.307
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.0971	0.852
ERF	ERF: ETS domain-containing transcription factor ERF	0.096	0.075
IPO7	IPO7: Uncharacterized protein IPO7	0.091	0.032
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.091	0.0425
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.087	0.0446
KIAA0853	N/A	0.087	0.027
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.087	0.052
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.087	0.027
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.087	0.027
SP100	N/A	0.087	0.0446
NCOA3	N/A	0.087	0.074
API5	N/A	0.087	0.0425
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.087	0.027
PLEK	PLEK, P47: Pleckstrin	0.087	1.19
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.087	0.027
RBM14	RBM14, SIP: RNA-binding protein 14	0.087	0.036
WDR1	N/A	0.087	0.036
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.087	0.052
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.087	0.027
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.087	0.052
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.087	0.0446
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.087	0.036
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.087	0.372
CDK7	CDK7, MO15: Cell division protein kinase 7	0.087	0.136
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.087	0.372
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.087	0.136
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.087	0.225
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.087	0.171
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.0818	0.029
NAPG	NAPG, SNAPG: Gamma-soluble NSF attachment protein	0.0818	0.038
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.0818	0.029
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.080	0.123
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.078	0.038
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.078	0.225
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.078	0.032
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.078	0.032
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.078	0.087
CUL4B	N/A	0.078	0.032
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.078	0.032
SEC31L1	N/A	0.078	0.032
EP300	N/A	0.078	0.040
DIAPH1	Diaphanous 1	0.078	0.078
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.078	0.040
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.078	0.027
PHF10	N/A	0.078	0.032
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.078	0.461
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.078	0.063
FNBP1	N/A	0.078	0.461
SAPS3	N/A	0.078	0.046
CXorf9	N/A	0.078	0.461
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.078	0.046
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.078	0.032
WBSCR20A	N/A	0.078	0.032
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.078	0.032
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.078	0.040
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.078	0.032
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.078	0.046
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.078	0.372
COPA	COPA: Coatomer subunit alpha	0.078	0.063
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.078	0.340
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.078	0.067
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.078	0.032
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.078	0.032
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.078	0.063
ETS2	ETS2: Protein C-ets-2	0.077	0.166
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.075	0.036
NIPBL	N/A	0.075	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.075	0.025
EEF2K	EEF2K: Elongation factor 2 kinase	0.075	0.165
ELMO1	N/A	0.075	0.148
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.074	0.080
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.071	0.110
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.071	0.225
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.071	0.171
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.071	0.171
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.071	0.110
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.071	0.136
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.071	0.372
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.070	0.032
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.070	0.0453
ARFGAP1	N/A	0.070	0.027
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.070	0.027
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.070	0.027
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.070	1.81
TGIF2	TGIF2: Homeobox protein TGIF2	0.070	0.0446
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.070	0.515
CHUK	N/A	0.070	0.052
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.070	0.0446
RB1	RB1: Retinoblastoma-associated protein	0.070	0.027
KIAA0690	N/A	0.069	0.038
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	0.069	0.041
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.067	0.136
BRAF	BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase	0.067	0.225
RAP1B	RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor	0.066	0.063
RPL8	RPL8: 60S ribosomal protein L8	0.066	0.063
PSMB7	PSMB7: Proteasome subunit beta type-7 precursor	0.066	0.188
ME2	ME2: NAD-dependent malic enzyme, mitochondrial precursor	0.066	0.070
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.066	0.078
FRG1	FRG1: Protein FRG1	0.066	0.078
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.066	0.139
QARS	QARS: Glutaminyl-tRNA synthetase	0.066	0.129
LDHB	LDHB: L-lactate dehydrogenase B chain	0.066	0.038
LAMR1	RPSA, LAMBR, LAMR1: 40S ribosomal protein SA	0.066	0.063
NMT1	NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1	0.066	0.233
EIF2S3	EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3	0.066	0.070
ARHGDIB	ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2	0.066	0.129
UBE4A	N/A	0.066	0.063
ACP1	ACP1: Low molecular weight phosphotyrosine protein phosphatase	0.066	0.225
EIF3S6	EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6	0.066	0.078
PCBP1	PCBP1: Poly(rC)-binding protein 1	0.066	0.233
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.066	0.139
CSK	CSK: Tyrosine-protein kinase CSK	0.066	6.03
USP47	USP47: Ubiquitin carboxyl-terminal hydrolase 47	0.066	0.063
EEF1B2	EEF1B2, EEF1B, EF1B: Elongation factor 1-beta	0.066	0.078
PPARBP	N/A	0.066	0.078
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.066	0.129
RPL3	RPL3, OK/SW-cl.32: 60S ribosomal protein L3	0.066	0.078
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.066	6.03
RPS10	RPS10: 40S ribosomal protein S10	0.066	0.078
ACTR3	ACTR3, ARP3: Actin-related protein 3	0.066	0.129
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.066	0.046
PSMA3	PSMA3, PSC8: Proteasome subunit alpha type-3	0.066	0.139
PSMA5	PSMA5: Proteasome subunit alpha type-5	0.066	0.139
MDN1	MDN1, KIAA0301: Midasin	0.063	0.029
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.063	1.33
TP53	TP53, P53: Cellular tumor antigen p53	0.063	0.067
K-ALPHA-1	TUBA1B: Tubulin alpha-1B chain	0.063	0.100
JUND	JUND: Transcription factor jun-D	0.063	0.066
SOS1	SOS1: Son of sevenless homolog 1	0.063	0.148
GSK3B	N/A	0.063	0.063
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.063	0.166
WDR44	WDR44: WD repeat-containing protein 44	0.063	0.032
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.063	0.032
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.063	0.046
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.063	0.136
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.063	0.066
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.063	0.029
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.063	0.461
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.063	0.185
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.063	0.0818
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.063	0.275
NPM1	NPM1, NPM: Nucleophosmin	0.063	0.051
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.063	0.032
DYNC1LI1	DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1	0.063	0.046
STK16	N/A	0.060	0.152
PRKAA1	N/A	0.060	0.152
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.060	0.191
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.060	0.100
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.057	0.077
ETV1	ETV1, ER81: ETS translocation variant 1	0.056	0.033
PRKCI	PRKCI, DXS1179E: Protein kinase C iota type	0.054	0.136
CDK6	CDK6: Cell division protein kinase 6	0.054	0.136
PSKH1	PSKH1: Serine/threonine-protein kinase H1	0.054	0.152
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.054	0.171
MAP2K4	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k	0.054	0.110
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.054	0.060
SUPT5H	SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5	0.054	0.054
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.052	0.165
C20orf18	N/A	0.052	0.04
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.052	0.165
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.052	0.165
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.052	0.04
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.052	0.165
UHRF1		0.052	0.04
MAPK15	N/A	0.052	0.165
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.052	0.052
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.052	0.070
MEF2A	N/A	0.052	0.036
TRRAP	N/A	0.052	0.032
NFATC1	N/A	0.052	0.074
MYB	MYB: Myb proto-oncogene protein	0.052	0.046
MARK2	N/A	0.052	0.070
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.052	0.070
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.052	0.052
UBAP2	N/A	0.052	0.032
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.052	0.032
ID2	ID2: DNA-binding protein inhibitor ID-2	0.052	0.027
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.052	0.070
ESPL1	N/A	0.052	0.026
MTF1	MTF1: Metal regulatory transcription factor 1	0.052	0.036
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.052	0.057
PKP4	PKP4: Plakophilin-4	0.049	0.028
DNAJC13	DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13	0.049	0.028
SPAG6	SPAG6, PF16: Sperm-associated antigen 6	0.049	0.028
NASP	NASP: Nuclear autoantigenic sperm protein	0.049	0.028
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.049	0.027
ICK	ICK, KIAA0936: Serine/threonine-protein kinase ICK	0.048	0.123
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.048	0.109
SGK	SGK, SGK1: Serine/threonine-protein kinase Sgk1	0.048	0.416
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.047	0.148
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.047	0.036
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.047	0.148
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.047	0.098
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.047	0.165
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.047	0.036
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.047	0.148
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.047	0.098
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.047	0.036
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.047	0.148
RNF20		0.047	0.036
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.047	0.148
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.047	0.148
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.047	0.148
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.047	0.148
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.047	0.148
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.047	0.165
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.047	0.148
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.047	0.098
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.047	0.148
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.047	0.148
CDC2	CDC2: Cell division control protein 2 homolog	0.047	0.165
CCNB1	Cyclin B1	0.046	0.033
TUBA6	TUBA1C, TUBA6: Tubulin alpha-1C chain	0.046	0.081
AGTPBP1	AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein	0.046	0.070
TUBB	TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain	0.046	0.090
BRPF1	BRPF1, BR140: Peregrin	0.046	0.046
PTPN12	PTPN12: Tyrosine-protein phosphatase non-receptor type 12	0.046	0.251
DOK1	DOK1: Docking protein 1	0.046	0.372
CDC20	CDC20: Cell division cycle protein 20 homolog	0.046	0.041
CDKN1B	CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B	0.046	0.057
CCNH	CCNH: Cyclin-H	0.046	0.041
CORO1C	CORO1C, CRNN4: Coronin-1C	0.046	0.066
JUNB	JUNB: Transcription factor jun-B	0.046	0.066
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.046	0.029
YWHAQ	YWHAQ: 14-3-3 protein theta	0.0446	0.032
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.0446	0.096
RHOA	RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor	0.0446	0.144
SRPR	SRPR: Uncharacterized protein SRPR	0.0446	0.087
UBE2A	UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A	0.044	0.025
TSC2	TSC2, TSC4: Tuberin	0.044	0.075
MYCBP2	MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2	0.044	0.112
MAP2K6	MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki	0.043	0.372
CDK5	CDK5: Cell division protein kinase 5	0.043	0.136
POLB	POLB: DNA polymerase beta	0.0425	0.027
RGS14	N/A	0.0425	0.027
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.0425	0.052
DUSP1	DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1	0.0425	0.340
STAT2	STAT2: Signal transducer and activator of transcription 2	0.0425	1.81
BACH1	BACH1: Transcription regulator protein BACH1	0.0425	0.036
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.0425	0.166
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.0425	0.191
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.0425	0.026
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.0425	0.416
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.0425	0.307
DAPK1	DAPK1, DAPK: Death-associated protein kinase 1	0.041	0.251
JUP	JUP, CTNNG, DP3: Junction plakoglobin	0.041	0.062
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.04	0.165
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.04	0.165
CAMK4	CAMK4: Calcium/calmodulin-dependent protein kinase type IV	0.04	0.165
TRIM39	TRIM39, RNF23, TFP: Tripartite motif-containing protein 39	0.04	0.052
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.040	0.171
USP10	USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10	0.040	0.078
STAT6	STAT6: Signal transducer and activator of transcription 6	0.040	6.03
JAK1		0.040	2.94
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.040	0.046
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.040	2.17
GSR	GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor	0.040	0.052
CCT8	CCT8: Uncharacterized protein CCT8	0.040	0.038
EEF2	EEF2, EF2: Elongation factor 2	0.040	0.046
PPIG	PPIG: Peptidyl-prolyl cis-trans isomerase G	0.040	0.063
EPRS	EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes:	0.040	0.038
CRKL	CRKL: Crk-like protein	0.040	1.78
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.040	0.029
SEC24B	SEC24B: Protein transport protein Sec24B	0.040	0.087
TPT1	TPT1: Translationally-controlled tumor protein	0.040	0.063
PTPN11	N/A	0.040	0.038
ARHGEF6	ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6	0.040	0.372
TXNL1	TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1	0.040	0.038
CARS	CARS: Cysteinyl-tRNA synthetase, cytoplasmic	0.040	0.046
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.040	0.139
RARS	RARS: Arginyl-tRNA synthetase, cytoplasmic	0.040	0.046
LCP1	LCP1, PLS2: Plastin-2	0.040	0.461
RAP1A	RAP1A, KREV1: Ras-related protein Rap-1A precursor	0.040	0.078
YWHAZ	YWHAZ: 14-3-3 protein zeta/delta	0.040	0.046
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.040	6.03
PSMA2	PSMA2, PSC3: Proteasome subunit alpha type-2	0.040	0.139
PCBP2	PCBP2: Poly(rC)-binding protein 2	0.040	0.188
LPXN	LPXN, LDLP: Leupaxin	0.040	0.087
ACTG1	ACTB: Actin, cytoplasmic 1	0.040	0.078
RAN	RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran	0.040	0.029
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	0.040	0.038
EEF1A1	EEF1A1: Elongation factor 1-alpha	0.040	0.063
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.040	0.461
USP7	USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7	0.040	0.046
THOC1	THOC1, HPR1: THO complex subunit 1	0.040	0.071
PPP1CB	PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit	0.040	0.063
HCLS1	HCLS1, HS1: Hematopoietic lineage cell-specific protein	0.040	1.62
VAV1	VAV1, VAV: Proto-oncogene vav	0.040	6.03
EIF3S8	EIF3S8: Eukaryotic translation initiation factor 3 subunit 8	0.040	0.078
NCK1	NCK1, NCK: Cytoplasmic protein NCK1	0.040	2.17
MSN	MSN: Moesin	0.040	0.372
CAD	CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0.040	0.114
WASPIP	N/A	0.040	0.416
HSP90AA1	Hsp89-alpha-delta-N	0.040	0.114
IMPDH2	IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2	0.040	0.114
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.040	0.038
WAS	WAS, IMD2: Wiskott-Aldrich syndrome protein	0.040	0.763
CD2AP	CD2AP: CD2-associated protein	0.040	0.515
IQGAP1	IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1	0.040	0.852
MAPK4	MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4	0.039	0.109
MDM4	MDM4, MDMX: Mdm4 protein	0.039	0.037
NEK3	NEK3: Serine/threonine-protein kinase Nek3	0.039	0.191
CBLC	CBLC, CBL3, RNF57: Signal transduction protein CBL-C	0.039	0.644
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.039	0.123
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.038	0.171
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.038	0.110
FKBP1A	FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A	0.038	0.029
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.038	0.036
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.038	0.032
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.038	0.225
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.038	0.129
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.038	0.040
ARID3A	ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein	0.038	0.027
WEE1	WEE1: Wee1-like protein kinase	0.038	0.110
BIRC4	BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4	0.037	0.048
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.037	0.123
PHB2	PHB2, BAP, REA: Prohibitin-2	0.036	0.080
DNM2	N/A	0.036	0.052
PSTPIP1	PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1	0.036	0.416
LIMS1	N/A	0.036	0.087
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.036	0.132
MPG	N/A	0.036	0.052
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.036	0.060
IFI35	N/A	0.036	0.144
VAV2	VAV2, RP11-153P4.1-003: Vav 2 oncogene	0.036	0.070
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.036	0.032
PCTK1	PCTK1: Serine/threonine-protein kinase PCTAIRE-1	0.035	0.098
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.035	0.110
PRKCA	PRKCA, PKCA, PRKACA: Protein kinase C alpha type	0.035	0.088
CDKL5	N/A	0.035	0.098
GRK1	GRK1, RHOK: Rhodopsin kinase precursor	0.034	0.109
STK39	STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase	0.033	0.097
PRKCQ	PRKCQ, PRKCT: Protein kinase C theta type	0.033	0.088
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.032	0.307
GAB2	N/A	0.032	0.307
NUP214	N/A	0.032	0.027
RXRA	RXRA, NR2B1: Retinoic acid receptor RXR-alpha	0.032	0.027
LYN	LYN: Tyrosine-protein kinase Lyn	0.032	14.30
HSPH1	HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa	0.032	0.029
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.032	0.046
MTHFD1	MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic	0.032	0.029
OSBP	OSBP, OSBP1: Oxysterol-binding protein 1	0.032	0.275
SNX17	SNX17, KIAA0064: Sorting nexin-17	0.032	0.763
PREP	PREP, PEP: Prolyl endopeptidase	0.032	0.038
FLII	FLII, FLIL: Protein flightless-1 homolog	0.032	0.146
CTPS	CTPS: CTP synthase 1	0.032	0.114
NME2	NME2, NM23B: Nucleoside diphosphate kinase B	0.032	0.038
RRM2	RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2	0.032	0.029
TBCE	TBCE: Tubulin-specific chaperone E	0.032	0.038
NRAS	NRAS, HRAS1: GTPase NRas precursor	0.032	0.063
TBK1	TBK1, NAK: Serine/threonine-protein kinase TBK1	0.032	0.225
CASP3	CASP3, CPP32: Caspase-3 precursor	0.032	0.029
MAD1L1	MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1	0.032	0.063
EHD1	EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1	0.032	0.372
HSPD1		0.032	0.029
PSCD4	PSCD4, CYT4: Cytohesin-4	0.032	1.62
YWHAB	YWHAB: 14-3-3 protein beta/alpha	0.032	0.078
TAGLN2	TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein	0.032	0.461
PAK6	PAK6, PAK5: Serine/threonine-protein kinase PAK 6	0.031	0.110
ROCK2	ROCK2, KIAA0619: Rho-associated protein kinase 2	0.031	0.099
MYO3A	MYO3A: Myosin IIIA	0.031	0.088
DYRK3	N/A	0.0308	0.097
PRKCG	PRKCG, PKCG: Protein kinase C gamma type	0.0308	0.097
HIPK3	HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3	0.0308	0.110
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	0.0308	0.808
PRKG1	PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme	0.0308	0.171
PAK4	PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4	0.0308	0.088
SEL1L	SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor	0.030	0.086
ZFP36	ZFP36, G0S24, RNF162A, TIS11A, TTP: Tristetraproline	0.029	0.0446
STAT4	STAT4: Signal transducer and activator of transcription 4	0.029	0.644
SSH1	SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1	0.029	0.113
AHR	AHR: Aryl hydrocarbon receptor precursor	0.029	0.027
FOS	FOS, G0S7: Proto-oncogene protein c-fos	0.029	0.066
KCTD12	KCTD12, C13orf2, KIAA1778, PFET1: BTB/POZ domain-containing protein KCTD12	0.029	0.032
JUN	JUN: Transcription factor AP-1	0.029	0.040
BID	BID: BH3-interacting domain death agonist	0.028	0.04
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.165
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.028	0.04
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.165
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
SYTL4	Endocrine transmitter regulatory protein	0.028	0.04
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.109
PPEF1	N/A	0.028	0.165
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.165
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.083
PHLDB2	N/A	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.165
MAPKAPK5	N/A	0.028	0.165
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.028	0.04
NF2	NF2, SCH: Merlin	0.028	0.165
HES6	HES6: Transcription cofactor HES-6	0.028	0.049
GSK3A	GSK3A: Glycogen synthase kinase-3 alpha	0.028	0.088
PAK7	PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7	0.028	0.099
HIPK2	HIPK2: Homeodomain-interacting protein kinase 2	0.028	0.088
CAMK1	CAMK1: Calcium/calmodulin-dependent protein kinase type 1	0.028	0.110
INSL3	JAK3: Tyrosine-protein kinase JAK3	0.027	0.872
MVP	MVP, LRP: Major vault protein	0.027	0.070
SLC9A3R1	SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50	0.027	0.0425
CASP8	N/A	0.027	0.052
CIITA	CIITA, MHC2TA: MHC class II transactivator	0.027	0.087
DAPP1	N/A	0.027	0.087
BLNK	BLNK, BASH, SLP65: B-cell linker protein	0.027	6.73
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	0.027	4.07
CFLAR	CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec	0.027	0.155
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.027	0.026
RPS6KA3	RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3	0.026	0.114
FAM65A	FAM65A, KIAA1930: Protein FAM65A	0.026	0.026
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.026	1.20
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.026	0.123
IRS2	IRS2: Insulin receptor substrate 2	0.026	0.307
CDKN1A	CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi	0.026	0.0453
SAMD9	SAMD9, C7orf5, DRIF1, KIAA2004, OEF1: Sterile alpha motif domain-containing prot	0.0255	0.050
GRK6	N/A	0.025	0.025
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.165
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.148
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.025	0.165
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.148
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.025	0.098
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.025	0.098
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.025
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.025	0.165
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.109
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.098
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.148
CCNT2	CCNT2: Cyclin-T2	0.025	0.036
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
GIT2	N/A	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
CREB1	CREB1: cAMP response element-binding protein	0.025	0.049
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.025	0.036
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.025	0.025
MAP2K3	N/A	0.025	0.025
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.025	0.036
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.025	0.148
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
PRKCB1	N/A	0.025	0.025
CAMK2A	N/A	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.025	0.980
BCOR	N/A	0.025	0.028
CAMKK1	N/A	0.025	0.028
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.148
DCLRE1C	N/A	0.025	0.025
SFRS2IP	SFRS2IP, CASP11, SIP1: SFRS2-interacting protein	0.025	0.025

0.228

Total Score

2.93