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Evidence of Interaction Between STAT5A and CREBBP

The interaction score between STAT5A and CREBBP is 1.07E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between STAT5A and CREBBP = 0.32

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology
OrganismSTAT5A OrthologueCREBBP OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00103415 1 IPI00478752 0.421
  • InVitro
  • InVivo

Get References From PubMed
human IPI00000106 0.075 IPI00478752 0.421
human IPI00298887 0.082 IPI00478752 0.421
  • InVitro
  • InVivo
  • Immunoprecipitation

Get References From PubMed
worm Q9NAD6 1 P34545 0.421
fly Q24151 0.903 O01368 0.385

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.58
Domains Domains present in STAT5A and CREBBP:
Domains in STAT5ADomains in CREBBP
IPR008967 p53-like transcription factor, DNA-binding
IPR000980 SH2 motif
IPR001217 STAT protein
IPR011992 EF-Hand_type.
IPR012345 STAT_DNA_bd.
IPR001487 Bromodomain
IPR000197 TAZ finger
IPR000433 Zn-finger, ZZ type
IPR003101 Coactivator CBP, KIX
IPR009255 Protein of unknown function DUF906
IPR010303 Protein of unknown function DUF902

The Chi square scores for co-occurrence of domains that are present in STAT5A and CREBBP are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR001487 Bromodomain 5.72482
IPR012345 STAT_DNA_bd. IPR000197 TAZ finger 3.9426
IPR012345 STAT_DNA_bd. IPR003101 Coactivator CBP, KIX 3.9426
IPR012345 STAT_DNA_bd. IPR009255 Protein of unknown function DUF906 3.9426
IPR001217 STAT protein IPR000197 TAZ finger 3.9426
IPR012345 STAT_DNA_bd. IPR010303 Protein of unknown function DUF902 3.9426
IPR001217 STAT protein IPR003101 Coactivator CBP, KIX 3.9426
IPR001217 STAT protein IPR009255 Protein of unknown function DUF906 3.9426
IPR001217 STAT protein IPR010303 Protein of unknown function DUF902 3.9426
IPR012345 STAT_DNA_bd. IPR001487 Bromodomain 2.00418
IPR001217 STAT protein IPR001487 Bromodomain 2.00418
IPR000980 SH2 motif IPR000433 Zn-finger, ZZ type 1.96312
IPR012345 STAT_DNA_bd. IPR000433 Zn-finger, ZZ type 1.56898
IPR001217 STAT protein IPR000433 Zn-finger, ZZ type 1.56898
IPR011992 EF-Hand_type. IPR001487 Bromodomain 0.804602
IPR011992 EF-Hand_type. IPR000433 Zn-finger, ZZ type 0.765888
IPR000980 SH2 motif IPR000197 TAZ finger 0.612223
IPR000980 SH2 motif IPR003101 Coactivator CBP, KIX 0.612223
IPR000980 SH2 motif IPR009255 Protein of unknown function DUF906 0.612223
IPR000980 SH2 motif IPR010303 Protein of unknown function DUF902 0.612223
IPR011992 EF-Hand_type. IPR003101 Coactivator CBP, KIX 0.0563285
IPR011992 EF-Hand_type. IPR009255 Protein of unknown function DUF906 0.0563285
IPR011992 EF-Hand_type. IPR010303 Protein of unknown function DUF902 0.0563285
IPR011992 EF-Hand_type. IPR000197 TAZ finger 0.0563285

The background colour of the table refers to:

  • Blue Domain is only present in STAT5A
  • Yellow Domain is only present in CREBBP
  • Green Domain is present in both STAT5A and CREBBP

 0.049
Post-translational Modifications

Protein: STAT5A

PTMResidueReference
Dephosphorylation 694 PubMed, HPRD
Phosphorylation 694 PubMed, HPRD
Phosphorylation 726 PubMed, HPRD
Phosphorylation 780 PubMed, HPRD
Phosphotyrosine 694 PubMed, HPRD

Protein: CREBBP

PTMResidueReference
Methylation 702 PubMed, HPRD
Methylation 714 PubMed, HPRD
Methylation 742 PubMed, HPRD
Methylation 768 PubMed, HPRD
Phosphorylation 302 PubMed, HPRD
Phosphorylation 437 PubMed, HPRD
Localisation

Protein: STAT5A

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: CREBBP

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between STAT5A and CREBBP that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between STAT5A andCREBBP. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , STAT5A has 1739 interactors and CREBBP has 1102 interactors of which there are 682 common interactors.

Common InteractorName of Common InteractorScore for STAT5A-Interactor (?)Score for CREBBP-Interactor (?)
STAT5B STAT5B: Signal transducer and activator of transcription 5B 409.00 111.00
STAT6 STAT6: Signal transducer and activator of transcription 6 370.00 66.00
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 131.00 35.90
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 112.00 0.029
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 66.00 0.087
STAT3 12.60 0.044
MAP2K3 N/A 12.00 0.025
STAT4 STAT4: Signal transducer and activator of transcription 4 7.69 0.086
PIAS1 PIAS1, DDXBP1: E3 SUMO-protein ligase PIAS1 4.13 1.61
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 3.64 0.032
PIAS4 PIAS4, PIASG: E3 SUMO-protein ligase PIAS4 2.57 0.741
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 2.17 0.067
CSK CSK: Tyrosine-protein kinase CSK 2.17 0.032
LYN LYN: Tyrosine-protein kinase Lyn 1.78 0.032
RELB RELB: Transcription factor RelB 1.66 5.36
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.17 0.044
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.874 0.033
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.859 0.032
BMX N/A 0.775 0.032
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.586 0.041
GATA3 GATA3: Trans-acting T-cell-specific transcription factor GATA-3 0.542 0.741
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.471 0.344
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.461 0.040
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.461 0.063
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.461 0.275
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.461 0.046
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.461 0.111
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.416 0.0971
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.372 0.063
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.372 0.029
DOK1 DOK1: Docking protein 1 0.372 0.139
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.372 0.0818
FNBP1 N/A 0.372 0.063
RPS6KB1 N/A 0.372 0.046
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.372 0.112
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.372 0.032
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.372 0.071
LCP1 LCP1, PLS2: Plastin-2 0.372 0.246
VAV1 VAV1, VAV: Proto-oncogene vav 0.372 0.111
GATA5 GATA5: Transcription factor GATA-5 0.356 0.642
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.307 0.087
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.307 0.0425
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.0446
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.307 0.091
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.307 0.036
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.307 0.0425
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.304 0.046
STK10 STK10: Uncharacterized protein STK10 0.275 0.063
WASPIP N/A 0.275 0.040
MSN MSN: Moesin 0.275 0.090
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.275 0.063
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.275 0.046
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.275 11.40
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.275 0.188
PSCD4 PSCD4, CYT4: Cytohesin-4 0.275 0.0818
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.275 0.233
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.275 0.046
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.275 0.046
CXorf9 N/A 0.275 0.046
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.275 0.063
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.275 0.046
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.275 0.038
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.275 0.038
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.139
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.275 0.063
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.274 0.416
FUBP1 N/A 0.260 0.027
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.036
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.251 0.096
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.251 0.057
FLNA FLNA, FLN, FLN1: Filamin-A 0.251 0.202
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.251 0.052
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.251 0.210
ROCK1 ROCK1: Rho-associated protein kinase 1 0.251 0.155
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.251 0.060
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.251 0.0425
VASP VASP: Vasodilator-stimulated phosphoprotein 0.251 0.101
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.246 0.225
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.246 0.139
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.246 0.046
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.067
ATM ATM: Serine-protein kinase ATM 0.225 0.038
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.225 0.111
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.225 0.038
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.225 0.051
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.225 0.139
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.225 0.0818
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.225 0.038
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.225 0.038
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.225 0.188
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.225 0.038
LIMS1 N/A 0.210 0.027
PLEK PLEK, P47: Pleckstrin 0.202 0.155
IRF3 IRF3: Interferon regulatory factor 3 0.202 0.307
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.191 0.036
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.191 0.032
GAB2 N/A 0.191 0.127
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.127
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.191 0.032
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.191 0.026
IRS2 IRS2: Insulin receptor substrate 2 0.191 0.127
THOC1 THOC1, HPR1: THO complex subunit 1 0.188 0.041
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.188 0.027
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.188 0.046
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.188 0.032
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.188 0.032
MYH9 MYH9: Myosin-9 0.181 0.275
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.171 0.046
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.171 0.033
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.171 0.029
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.041
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.171 0.038
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.171 0.046
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.171 0.038
VIL2 N/A 0.171 0.054
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.171 0.038
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.171 0.038
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.171 0.063
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.032
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.171 0.063
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.165 0.028
MAPKAPK5 N/A 0.165 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.049
NF2 NF2, SCH: Merlin 0.165 0.052
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.165 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.028
PSCD2 N/A 0.165 0.049
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.049
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.028
MAPK15 N/A 0.165 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.049
CNN2 CNN2: Calponin-2 0.165 0.049
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.028
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.165 0.028
PPEF1 N/A 0.165 0.083
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.028
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.155 0.074
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.155 0.096
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.153 0.0425
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.152 0.0453
LIMK2 LIMK2: LIM domain kinase 2 0.152 0.075
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.152 0.0425
PRKAA1 N/A 0.152 0.032
STK16 N/A 0.152 0.032
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.152 0.032
SOS1 SOS1: Son of sevenless homolog 1 0.148 0.139
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.148 0.139
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.148 0.038
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.148 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.148 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.148 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.075
ACTN4 ACTN4: Alpha-actinin-4 0.148 0.098
ELMO1 N/A 0.148 0.075
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.148 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.148 0.025
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.044
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.044
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.148 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.148 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.148 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.025
MYO18A 0.148 0.044
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.148 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.148 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.148 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.148 0.025
ARHGEF7 N/A 0.148 0.044
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.148 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.075
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.025
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.044
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.148 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.148 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.148 0.025
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.036
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.148 0.025
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.146 0.111
ACTG1 ACTB: Actin, cytoplasmic 1 0.139 39.30
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.067
BRPF1 BRPF1, BR140: Peregrin 0.139 0.114
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.139 0.032
GMIP GMIP: GEM-interacting protein 0.139 0.032
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.139 0.078
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.139 0.111
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.139 0.032
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.137 0.038
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.137 0.046
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.136 0.046
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.136 0.029
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.136 0.0818
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.136 0.029
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.136 0.051
RASA3 RASA3: Ras GTPase-activating protein 3 0.136 0.041
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.136 0.038
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.127 0.027
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.127 0.091
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.127 0.075
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.127 0.052
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.126 0.026
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.126 0.026
STAT2 STAT2: Signal transducer and activator of transcription 2 0.126 0.096
ETS2 ETS2: Protein C-ets-2 0.126 0.191
ERG ERG: Transcriptional regulator ERG 0.124 0.123
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.124 0.127
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.124 0.251
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.124 0.0425
H1FX H1FX: Histone H1x 0.124 0.251
ELF1 ELF1: ETS-related transcription factor Elf-1 0.124 0.416
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.123 0.081
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.123 0.026
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.057
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.123 0.026
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.123 0.026
GAS2 GAS2: Growth arrest-specific protein 2 0.123 0.032
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.123 0.037
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.123 0.026
GAB1 GAB1: GRB2-associated-binding protein 1 0.123 0.077
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.118 0.158
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.114 0.038
EXOC2 N/A 0.114 0.067
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.114 0.090
AIP AIP, XAP2: AH receptor-interacting protein 0.114 0.046
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.114 0.372
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.111 0.046
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.111 0.038
HDAC3 HDAC3: Histone deacetylase 3 0.111 0.071
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.111 0.046
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.111 0.029
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.111 0.046
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.111 0.118
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.111 0.063
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.111 0.038
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.111 0.038
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.111 0.063
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.110 0.051
PLD2 PLD2: Phospholipase D2 0.110 0.051
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.110 0.051
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.110 0.073
APS SH2B2, APS: SH2B adapter protein 2 0.110 0.067
PLD1 PLD1: Phospholipase D1 0.110 0.029
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.110 0.054
DAB1 DAB1: Disabled homolog 1 0.110 0.028
ACTN1 ACTN1: Alpha-actinin-1 0.110 0.113
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.110 0.041
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.109 0.028
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.062
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.109 0.037
DAPK2 DAPK2: Death-associated protein kinase 2 0.109 0.026
ARFGAP1 N/A 0.101 0.0425
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.099 0.026
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.099 0.029
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.099 0.029
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.098 0.026
SPTAN1 N/A 0.098 0.081
CNN3 CNN3: Calponin-3 0.098 0.032
MCF2 MCF2, DBL: Proto-oncogene DBL 0.098 0.072
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.062
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.098 0.025
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.098 0.025
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.098 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.098 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.098 0.025
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.030
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.098 0.025
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.035
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.097 0.027
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.097 0.029
PSD TYL: TYL protein 0.097 0.033
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.096 0.075
ZYX ZYX: Zyxin 0.096 0.027
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.091 0.123
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.091 0.0425
XRCC1 XRCC1: DNA-repair protein XRCC1 0.091 0.0425
RB1 RB1: Retinoblastoma-associated protein 0.091 0.0425
NBN NBN, NBS, NBS1, P95: Nibrin 0.091 0.210
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.091 0.060
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.091 0.096
DDX21 DDX21: Nucleolar RNA helicase 2 0.091 0.0425
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.091 0.251
SP100 N/A 0.091 0.307
SP3 SP3: Transcription factor Sp3 0.090 0.233
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.090 0.063
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.090 0.188
YY1 YY1: Transcriptional repressor protein YY1 0.090 0.188
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.090 0.029
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.090 0.114
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.090 0.046
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.090 0.038
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.088 0.029
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.088 0.033
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.088 0.049
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.026
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.086 13.60
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.086 0.086
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.086 0.067
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.086 0.137
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.083 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.083 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.083 0.049
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.083 0.049
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.083 0.049
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.083 0.049
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.0818 0.038
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.0818 0.046
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.0818 0.275
HDAC4 HDAC4, KIAA0288: Histone deacetylase 4 0.0818 0.046
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.0818 0.038
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.0818 0.038
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.0818 0.188
HDAC2 HDAC2: Histone deacetylase 2 0.0818 0.054
JUNB JUNB: Transcription factor jun-B 0.0818 0.275
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.0818 0.087
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0818 0.097
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.0818 0.078
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.0818 0.029
JUND JUND: Transcription factor jun-D 0.0818 0.372
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.0818 0.275
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.0818 0.097
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.0818 0.046
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.0818 0.114
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.081 0.152
MVP MVP, LRP: Major vault protein 0.080 0.027
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.080 0.036
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.078 0.028
PARVA PARVA, MXRA2: Alpha-parvin 0.078 0.029
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.078 0.046
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.078 0.032
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.077 0.075
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.100
BACH1 BACH1: Transcription regulator protein BACH1 0.075 0.416
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.075 0.307
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.075 0.029
NFATC1 N/A 0.075 0.127
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.075 0.039
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.075 0.307
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.075 0.026
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.044
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.075 0.044
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.075 0.044
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.075 0.044
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.044
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.075 0.025
GIT2 N/A 0.075 0.025
MATR3 MATR3, KIAA0723: Matrin-3 0.074 0.127
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.074 0.210
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.074 0.052
MYB MYB: Myb proto-oncogene protein 0.074 0.123
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.073 0.035
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.0727 0.055
TP73 TP73, P73: Tumor protein p73 0.072 0.031
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.071 0.029
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.071 0.137
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.052
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.052
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.070 0.052
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.029
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.069 0.038
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.067 0.225
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.067 0.171
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.067 0.029
RELA RELA, NFKB3: Transcription factor p65 0.067 0.188
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.067 0.038
TP53 TP53, P53: Cellular tumor antigen p53 0.067 0.086
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.067 0.063
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.067 0.188
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.067 0.188
MTF1 MTF1: Metal regulatory transcription factor 1 0.067 0.139
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.067 0.114
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.067 0.029
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.065 0.055
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.064 0.069
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.064 0.056
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.064 0.049
UBE4A N/A 0.063 0.032
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.038
DIAPH1 Diaphanous 1 0.063 0.063
HNRPK N/A 0.063 0.032
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.063 0.032
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.046
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.063 0.063
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.063 0.045
TRIM16 TRIM16, EBBP: Tripartite motif-containing protein 16 0.062 0.055
KCNH2 KCNH2, ERG, ERG1, HERG, HERG1: Potassium voltage-gated channel subfamily H membe 0.062 0.030
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.061 0.127
HIVEP1 N/A 0.061 0.127
ZNF267 ZNF267: Zinc finger protein 267 0.061 0.307
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.060 0.057
EIF3S10 EIF3S10, KIAA0139: Eukaryotic translation initiation factor 3 subunit 10 0.060 0.029
RAB32 RAB32: Ras-related protein Rab-32 0.058 0.029
GTF2F2 N/A 0.057 0.152
VIM VIM: Vimentin 0.057 0.026
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.056 0.028
PARD3 N/A 0.056 0.026
GRLF1 N/A 0.055 0.026
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.054 0.114
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.054 0.086
ZNF551 N/A 0.054 0.136
CHP CHP: Calcium-binding protein p22 0.054 0.051
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.054 0.029
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.054 0.067
CASP8 N/A 0.052 0.036
TRRAP N/A 0.052 0.0425
DNM2 N/A 0.052 0.027
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.052 0.036
ABCF1 N/A 0.052 0.0425
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.052 0.0425
CHUK N/A 0.052 0.0425
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.052 0.052
HD HD, IT15: Huntingtin 0.052 0.075
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.052 0.036
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
PLEC1 PLEC1: Plectin-1 0.051 0.051
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.039
JUN JUN: Transcription factor AP-1 0.051 0.225
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.051 0.038
MAFG MAFG: Transcription factor MafG 0.051 0.171
MLL MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX 0.051 0.114
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.051 26.00
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.051 0.225
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.051 0.171
RANBP9 RANBP9, RANBPM: Ran-binding protein 9 0.051 0.029
ETS1 ETS1, EWSR2: Protein C-ets-1 0.051 0.225
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.051 0.225
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.051 0.275
NOS1 NOS1: Nitric-oxide synthase, brain 0.050 0.029
S100A7 S100A7, PSOR1: Protein S100-A7 0.049 0.032
S100A3 S100A3, S100E: Protein S100-A3 0.049 0.029
S100B S100B: Protein S100-B 0.049 0.032
KIAA0196 N/A 0.049 0.086
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.049 0.165
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.049 0.028
DSP DSP: Desmoplakin 0.049 0.165
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.049 0.165
HDAC8 N/A 0.049 0.052
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.049 0.083
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.049 0.165
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.049 0.083
HES6 HES6: Transcription cofactor HES-6 0.049 0.083
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.049 0.086
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.048 0.026
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.047 0.044
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.047 0.044
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.047 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.047 0.044
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.046 0.046
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.046 0.032
SEC24B SEC24B: Protein transport protein Sec24B 0.046 0.032
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.046 0.038
SAPS3 N/A 0.046 0.038
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.046 0.040
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.046 0.046
RP2 RP2: Protein XRP2 0.046 0.032
KIAA1012 KIAA1012: Protein TRS85 homolog 0.046 0.063
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.046 0.038
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.046 0.046
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.046 0.032
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.063
ZFX ZFX: Zinc finger X-chromosomal protein 0.046 0.096
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.046 0.251
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.046 0.055
ERF ERF: ETS domain-containing transcription factor ERF 0.0453 0.191
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.045 0.051
PTMA N/A 0.0446 0.052
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.0446 0.0425
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.0446 0.0425
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.044 0.029
RBL1 RBL1: Retinoblastoma-like protein 1 0.044 0.025
BRD4 N/A 0.044 0.047
CREB1 CREB1: cAMP response element-binding protein 0.044 0.148
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.044 0.025
CCNT2 CCNT2: Cyclin-T2 0.044 0.025
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.044 0.148
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.044 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.044 0.148
HDAC7A N/A 0.044 0.025
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.044 0.075
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.044 0.025
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.044 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.044 0.025
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.044 0.148
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.044 0.054
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.043 0.067
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.043 0.056
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.0425 0.0425
UBAP2 N/A 0.0425 0.0425
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.0425 0.032
MARK2 N/A 0.0425 0.052
API5 N/A 0.0425 0.032
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.0425 0.0425
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.041 0.171
ZNF335 ZNF335: Zinc finger protein 335 0.041 0.114
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.041 0.110
ZNF224 ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224 0.041 0.136
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.041 0.114
RYR2 RYR2: Ryanodine receptor 2 0.041 0.025
KIAA0157 KIAA0157: Uncharacterized protein KIAA0157 0.0407 0.0782
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.041 0.136
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.041 0.136
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.041 0.225
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.041 0.171
PCAF PCAF: Histone acetyltransferase PCAF 0.041 0.054
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.041 0.136
MYF5 MYF5: Myogenic factor 5 0.041 0.049
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.041 0.110
CCNH CCNH: Cyclin-H 0.041 0.029
ZNF579 ZNF579: Zinc finger protein 579 0.04 0.083
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.04 0.165
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.04 0.083
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.04 0.083
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.04 0.083
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.04 0.083
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.040 0.046
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.040 0.038
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.040 0.046
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.040 0.038
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.040 0.046
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.040 0.038
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.040 0.038
RUNX1 N/A 0.040 13.90
PHF10 N/A 0.040 0.114
TIAL1 TIAL1: Nucleolysin TIAR 0.040 0.046
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.040 0.046
PPP1R8 N/A 0.040 0.046
IRF5 IRF5: Interferon regulatory factor 5 0.039 0.041
IRF1 IRF1: Interferon regulatory factor 1 0.039 0.083
COPE COPE: Coatomer subunit epsilon 0.038 0.038
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.038 0.063
GSK3B N/A 0.038 0.046
COPA COPA: Coatomer subunit alpha 0.038 0.046
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.038 0.029
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.038 0.038
KLHDC4 N/A 0.038 0.046
MDN1 MDN1, KIAA0301: Midasin 0.038 0.029
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.038 0.038
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.038 0.032
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.038 0.046
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.038 0.063
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.037 0.062
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.037 0.123
SH3BP3 0.037 0.127
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.037 0.251
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.036 0.052
SET SET: Protein SET 0.036 0.032
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.036 0.070
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.036 0.026
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.036 0.210
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.036 0.052
GNB2L1 Lung cancer oncogene 7 0.036 0.052
RBM14 RBM14, SIP: RNA-binding protein 14 0.036 0.052
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.036 0.052
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.036 0.0425
TOP2B N/A 0.036 0.052
TGIF2 TGIF2: Homeobox protein TGIF2 0.036 0.251
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.036 0.075
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.036 0.075
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.036 0.075
CETN1 CETN1, CEN1, CETN: Centrin-1 0.036 0.075
SOX8 SOX8: Transcription factor SOX-8 0.036 0.025
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.036 0.075
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.036 0.075
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.036 0.075
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.036 0.030
MYL3 MYL3: Myosin light polypeptide 3 0.035 0.029
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.035 0.029
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.035 0.056
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.035 4.05
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.035 0.090
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.035 0.029
GABPA GABPA, E4TF1A: GA-binding protein alpha chain 0.035 0.028
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.0333 0.152
NR4A2 NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2 0.033 65.60
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.033 26.80
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.033 41.40
SP1 SP1, TSFP1: Transcription factor Sp1 0.033 33.10
VDR VDR, NR1I1: Vitamin D3 receptor 0.033 0.136
KCTD12 KCTD12, C13orf2, KIAA1778, PFET1: BTB/POZ domain-containing protein KCTD12 0.033 0.038
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.033 0.136
ETV1 ETV1, ER81: ETS translocation variant 1 0.033 0.109
TAF1 TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1 0.032 0.039
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.032 0.032
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.032 0.026
LIG1 LIG1: DNA ligase 1 0.032 0.029
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.032 0.046
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.032 0.188
EP300 N/A 0.032 0.063
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.032 0.188
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.032 0.063
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.032 0.038
POLA2 POLA2: DNA polymerase subunit alpha B 0.032 0.029
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.032 0.046
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.032 0.038
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.032 0.063
NOL1 N/A 0.032 0.038
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.032 0.038
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.032 0.046
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.032 0.029
CBX3 CBX3: Chromobox protein homolog 3 0.032 0.225
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.032 0.029
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.032 0.038
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.032 0.038
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.032 0.046
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.032 0.046
UNG N/A 0.032 0.029
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.032 0.046
NUP153 N/A 0.032 0.038
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.032 0.046
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.032 0.038
WBSCR20A N/A 0.032 0.046
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.032 0.038
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.032 0.029
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.032 0.063
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.032 0.038
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.032 0.038
IRF2 IRF2: Interferon regulatory factor 2 0.032 0.083
RNF31 ISGF3G, IRF9: Transcriptional regulator ISGF3 subunit gamma 0.032 0.083
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.031 0.029
SALL1 SALL1, SAL1: Sal-like protein 1 0.031 0.049
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.0308 0.033
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.0308 0.029
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.030 0.137
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.029 0.123
PPL PPL, KIAA0568: Periplakin 0.029 0.045
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.029 0.136
FOXL2 FOXL2: Forkhead box protein L2 0.029 0.097
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.029 0.097
ELK1 ELK1: ETS domain-containing protein Elk-1 0.029 0.110
RFX1 RFX1: MHC class II regulatory factor RFX1 0.029 0.097
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.029 0.029
KIAA0690 N/A 0.029 0.038
SYMPK SYMPK, SPK: Symplekin 0.029 0.029
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
PHLDB2 N/A 0.028 0.028
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.0333
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
SI SI: Sucrase-isomaltase, intestinal [Contains: Sucrase 0.028 0.057
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.028 0.029
PPARG CREB3L2-PPARgamma 0.027 0.110
EGR1 EGR1, ZNF225: Early growth response protein 1 0.027 0.056
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.027 0.110
SNAI1 SNAI1, SNAH: Zinc finger protein SNAI1 0.027 0.056
OSBPL9 N/A 0.027 0.027
IFI16 N/A 0.027 0.052
TCOF1 N/A 0.027 0.0425
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.027 0.052
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.027 0.052
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.027 0.0425
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.027 0.0425
NCOA3 N/A 0.027 0.052
WDR1 N/A 0.027 0.052
KIAA0853 N/A 0.027 0.052
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.027 0.032
DNMT1 DNMT1, AIM, DNMT: DNA 0.027 0.0425
ZHX3 ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3 0.0263 0.123
PGR PGR, NR3C3: Progesterone receptor 0.0263 0.109
HES1 HES1, HL, HRY: Transcription factor HES-1 0.026 0.044
SAT SAT1, SAT: Diamine acetyltransferase 1 0.026 0.0425
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.026
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.075
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
PRKCB1 N/A 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
NIPBL N/A 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
BCOR N/A 0.025 0.025
CAMKK1 N/A 0.025 0.025
GRK6 N/A 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
CAMK2A N/A 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.075
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
0.347
Total Score 1.07E4