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Evidence of Interaction Between STAT5A and ADAM33

The interaction score between STAT5A and ADAM33 is 22.30.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismSTAT5A OrthologueADAM33 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00103415 1 IPI00643672 0.176
human IPI00000106 0.075 IPI00643672 0.176
human IPI00298887 0.082 IPI00643672 0.176
worm Q9NAD6 1 O17569 0.176
fly Q24151 0.903 Q86P79 0.138

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in STAT5A and ADAM33:
Domains in STAT5ADomains in ADAM33
IPR008967 p53-like transcription factor, DNA-binding
IPR000980 SH2 motif
IPR001217 STAT protein
IPR011992 EF-Hand_type.
IPR012345 STAT_DNA_bd.
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR006209 EGF-like domain
IPR006210 Type I EGF
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
IPR001818 Peptidase M10A and M12B, matrixin and adamalysin
IPR000742 EGF_2.

The Chi square scores for co-occurrence of domains that are present in STAT5A and ADAM33 are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR000742 EGF_2. 22.1588
IPR000980 SH2 motif IPR006586 ADAM, cysteine-rich 20.1367
IPR000980 SH2 motif IPR006209 EGF-like domain 19.373
IPR000980 SH2 motif IPR002870 Peptidase M12B, propeptide 13.7924
IPR000980 SH2 motif IPR006210 Type I EGF 13.0655
IPR011992 EF-Hand_type. IPR006209 EGF-like domain 12.2238
IPR011992 EF-Hand_type. IPR000742 EGF_2. 10.281
IPR000980 SH2 motif IPR001590 Peptidase M12B, ADAM/reprolysin 7.8978
IPR011992 EF-Hand_type. IPR006210 Type I EGF 7.44226
IPR000980 SH2 motif IPR001762 Disintegrin 5.76494
IPR000980 SH2 motif IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site 0.796114
IPR011992 EF-Hand_type. IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site 0.450995
IPR000980 SH2 motif IPR001818 Peptidase M10A and M12B, matrixin and adamalysin 0.109583
IPR011992 EF-Hand_type. IPR001818 Peptidase M10A and M12B, matrixin and adamalysin 0.00145049

The background colour of the table refers to:

  • Blue Domain is only present in STAT5A
  • Yellow Domain is only present in ADAM33
  • Green Domain is present in both STAT5A and ADAM33

 0.109
Post-translational Modifications

Protein: STAT5A

PTMResidueReference
Dephosphorylation 694 PubMed, HPRD
Phosphorylation 694 PubMed, HPRD
Phosphorylation 726 PubMed, HPRD
Phosphorylation 780 PubMed, HPRD
Phosphotyrosine 694 PubMed, HPRD

Protein: ADAM33

PTMResidueReference
N-linked 231 PubMed, HPRD
N-linked 276 PubMed, HPRD
Localisation

Protein: STAT5A

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: ADAM33

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between STAT5A and ADAM33 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between STAT5A andADAM33. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , STAT5A has 1739 interactors and ADAM33 has 1256 interactors of which there are 629 common interactors.

Common InteractorName of Common InteractorScore for STAT5A-Interactor (?)Score for ADAM33-Interactor (?)
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 1.16E3 0.148
JAK2 JAK2: Tyrosine-protein kinase JAK2 1.04E3 0.098
ZAP70 ZAP70: Uncharacterized protein ZAP70 856.00 0.098
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 600.00 0.148
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 563.00 46.90
KIT KIT: Mast/stem cell growth factor receptor precursor 487.00 0.148
CRKL CRKL: Crk-like protein 430.00 0.098
STAT5B STAT5B: Signal transducer and activator of transcription 5B 409.00 0.062
STAT6 STAT6: Signal transducer and activator of transcription 6 370.00 0.098
INSR INSR: Insulin receptor precursor 277.00 0.148
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 250.00 0.075
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 131.00 0.062
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 112.00 0.025
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 112.00 0.098
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 47.50 0.044
GRAP GRAP: GRB2-related adapter protein 31.80 9.04
STAT3 12.60 0.040
STAT4 STAT4: Signal transducer and activator of transcription 4 7.69 0.062
FGFR2 N/A 6.17 0.025
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 3.64 0.098
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 2.42 0.109
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 2.17 0.098
SYK SYK: Tyrosine-protein kinase SYK 2.17 0.098
CSK CSK: Tyrosine-protein kinase CSK 2.17 0.098
HCK N/A 1.78 0.098
LYN LYN: Tyrosine-protein kinase Lyn 1.78 0.098
JAK1 1.78 0.098
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 1.78 0.098
P4HB P4HB, ERBA2L, PDI, PDIA1, PO4DB: Protein disulfide-isomerase precursor 1.51 0.062
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 1.50 0.109
TXK TXK, PTK4: Tyrosine-protein kinase TXK 1.35 0.098
FLT3 FLT3, STK1: FL cytokine receptor precursor 1.33 0.148
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.30 0.044
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.30 0.044
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 1.20 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.17 0.098
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 1.17 0.044
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.980 0.083
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.980 0.083
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.980 0.165
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.878 0.075
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.878 0.148
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.878 0.148
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.878 0.148
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.874 0.098
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.874 0.098
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.859 0.049
BMX N/A 0.775 0.109
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.775 0.109
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.775 0.109
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.770 0.098
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.694 0.098
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.655 0.148
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.655 0.148
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.654 0.165
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.617 0.051
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.586 0.075
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.586 0.148
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.586 0.148
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.586 0.050
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.586 0.148
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.581 0.165
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.577 0.050
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.577 0.050
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.577 0.148
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.577 0.148
FLT4 VEGFR3 long form 0.553 0.046
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.520 0.148
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.520 0.148
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.520 0.075
MET MET: Hepatocyte growth factor receptor precursor 0.519 0.083
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.484 0.040
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.465 0.148
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.461 0.044
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.461 0.044
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.461 0.044
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.461 0.098
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.416 0.049
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.372 0.044
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.372 0.044
DOK1 DOK1: Docking protein 1 0.372 0.044
FNBP1 N/A 0.372 0.098
RPS6KB1 N/A 0.372 0.044
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.372 0.044
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.372 0.098
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.372 0.098
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.372 0.044
CD2AP CD2AP: CD2-associated protein 0.372 0.040
VAV1 VAV1, VAV: Proto-oncogene vav 0.372 0.098
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.340 0.083
ALK ALK: ALK tyrosine kinase receptor precursor 0.318 0.098
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.307 0.049
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.044
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.307 0.109
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.307 0.109
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.275 0.044
STK10 STK10: Uncharacterized protein STK10 0.275 0.044
MSN MSN: Moesin 0.275 0.044
CDK4 CDK4: Cell division protein kinase 4 0.275 0.044
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.275 0.044
CDK2 CDK2: Cell division protein kinase 2 0.275 0.044
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.275 0.075
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.275 0.098
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.275 0.044
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.275 0.044
PSCD4 PSCD4, CYT4: Cytohesin-4 0.275 0.044
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.275 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.275 0.044
CXorf9 N/A 0.275 0.098
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.275 0.044
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.275 0.044
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.275 0.044
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.275 0.044
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.044
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.274 0.0688
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.274 0.028
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.027
FUBP1 N/A 0.260 0.044
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.044
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.251 0.049
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.251 0.044
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.251 0.044
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.251 0.049
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.251 0.049
ROCK1 ROCK1: Rho-associated protein kinase 1 0.251 0.049
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.251 0.049
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.251 0.049
VASP VASP: Vasodilator-stimulated phosphoprotein 0.251 0.049
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.246 0.030
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.044
ATM ATM: Serine-protein kinase ATM 0.225 0.036
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.098
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.225 0.044
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.225 0.044
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.225 0.036
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.225 0.044
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.225 0.044
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.225 0.075
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.225 0.044
TLN1 TLN1: Uncharacterized protein TLN1 0.225 0.040
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.202 0.083
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.202 0.165
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.202 0.165
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.202 0.083
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.202 0.083
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.202 0.165
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.202 0.165
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.202 0.165
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.202 0.083
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.202 0.165
PLEK PLEK, P47: Pleckstrin 0.202 0.034
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.202 0.028
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.200 0.027
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.109
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.191 0.109
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.191 0.049
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.109
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.191 0.049
IRS2 IRS2: Insulin receptor substrate 2 0.191 0.049
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.181 0.148
WEE1 WEE1: Wee1-like protein kinase 0.171 0.044
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.171 0.044
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.171 0.044
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.171 0.044
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.171 0.098
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.044
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.171 0.044
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.171 0.044
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.171 0.044
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.171 0.044
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.171 0.044
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.171 0.098
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.171 0.075
VIL2 N/A 0.171 0.044
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.171 0.044
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.171 0.044
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.171 0.044
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.171 0.044
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.098
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.171 0.098
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.171 0.044
SORL1 SORL1: Sortilin-related receptor precursor 0.166 0.165
CCR5 CCR5: CCR5 receptor (Fragment) 0.166 0.028
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.166 0.165
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.166 0.165
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.166 0.165
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.166 0.083
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.166 0.165
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.166 0.165
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.166 0.165
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.166 0.083
LILRB1 N/A 0.166 0.056
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.049
MAPKAPK5 N/A 0.165 0.049
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
NF2 NF2, SCH: Merlin 0.165 0.049
AMPH AMPH, AMPH1: Amphiphysin 0.165 0.109
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.049
PSCD2 N/A 0.165 0.049
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.049
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.049
MAPK15 N/A 0.165 0.049
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.049
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.044
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.044
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.165 0.109
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.165 0.109
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.109
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.165 0.049
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.049
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.152 0.056
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.152 0.044
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.152 0.049
PRKAA1 N/A 0.152 0.049
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.152 0.044
SOS1 SOS1: Son of sevenless homolog 1 0.148 0.030
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.148 0.075
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.148 0.040
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.148 0.098
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.148 0.044
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.098
CDC2 CDC2: Cell division control protein 2 homolog 0.148 0.044
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.044
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.044
ACTN4 ACTN4: Alpha-actinin-4 0.148 1.44
ELMO1 N/A 0.148 0.044
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.148 0.044
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.148 0.040
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.044
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.148 0.044
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.148 0.044
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.148 0.098
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.148 0.044
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.036
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.148 0.098
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.148 0.044
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.148 0.044
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.148 0.044
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.148 0.044
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.044
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.044
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.044
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.148 0.044
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.148 0.044
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.044
TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 0.145 0.027
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.139 0.044
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.044
CDK5 CDK5: Cell division protein kinase 5 0.136 0.044
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.136 0.036
CDK7 CDK7, MO15: Cell division protein kinase 7 0.136 0.044
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.136 0.044
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.136 0.044
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.136 0.044
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.136 0.044
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.126 0.034
CD7 CD7: T-cell antigen CD7 precursor 0.126 0.165
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.126 0.083
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.126 0.083
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.126 0.083
STAT2 STAT2: Signal transducer and activator of transcription 2 0.126 0.0688
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.123 0.044
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.123 0.109
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.123 0.049
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.123 0.049
GAB1 GAB1: GRB2-associated-binding protein 1 0.123 0.049
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.113 0.075
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.113 0.075
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.110 0.044
RDX RDX: Radixin 0.110 0.044
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.110 0.098
PLD2 PLD2: Phospholipase D2 0.110 0.044
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.110 0.098
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.110 0.044
STAM2 STAM2: Signal transducing adapter molecule 2 0.110 0.098
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.110 0.044
APS SH2B2, APS: SH2B adapter protein 2 0.110 0.098
PLD1 PLD1: Phospholipase D1 0.110 0.044
RIN1 RIN1: Ras and Rab interactor 1 0.110 0.040
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.110 0.098
DAB1 DAB1: Disabled homolog 1 0.110 0.098
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.028
NULL A1BG: Alpha-1B-glycoprotein precursor 0.109 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.109 0.083
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.109 0.056
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.083
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.056
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.109 0.028
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.109 0.083
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.109 0.083
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.109 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.083
KIR3DL1 N/A 0.109 0.165
FN1 N/A 0.109 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.109 0.028
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.109 0.083
LAT LAT: Linker for activation of T-cells family member 1 0.109 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.083
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.109 0.028
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.109 0.165
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.109 0.028
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.109 0.083
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.109 0.083
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.049
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.109 0.049
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.109 0.049
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.109 0.049
DAPK2 DAPK2: Death-associated protein kinase 2 0.109 0.049
GPA33 GPA33: Cell surface A33 antigen precursor 0.100 0.083
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.100 0.028
GHR GHR: Growth hormone receptor precursor 0.100 0.083
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.100 0.028
EPOR EPOR: Erythropoietin receptor precursor 0.100 0.083
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.100 0.083
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.100 0.028
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.100 0.083
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.099 0.075
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.099 0.044
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.099 0.044
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.099 0.044
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.099 0.040
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.099 0.044
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.099 0.044
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.099 0.044
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.098 0.049
SPTAN1 N/A 0.098 0.109
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.049
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.025
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.098 0.030
CNTN4 CNTN4: Contactin-4 precursor 0.098 0.075
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.098 0.030
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.098 0.030
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.075
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
CNTN1 CNTN1: Contactin-1 precursor 0.098 0.075
BSG N/A 0.098 0.148
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.098 0.075
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.098 0.025
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.098 0.025
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.097 0.044
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.097 0.075
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.098
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.097 0.044
TTN N/A 0.097 0.098
PSD TYL: TYL protein 0.097 0.044
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.097 0.098
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.097 0.044
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.044
SORBS3 SORBS3, SCAM1: Vinexin 0.097 0.098
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.097 0.044
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.094 0.098
XRCC1 XRCC1: DNA-repair protein XRCC1 0.091 0.0688
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.090 0.148
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.088 0.044
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.088 0.044
MYO3A MYO3A: Myosin IIIA 0.088 0.044
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.088 0.044
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.088 0.098
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.088 0.044
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.088 0.044
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.088 0.040
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.088 0.044
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.088 0.044
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.088 0.098
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.044
CTTN CTTN, EMS1: Src substrate cortactin 0.088 0.109
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.083 0.049
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.148
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.081 0.165
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.081 0.165
IL9R IL9R: Interleukin-9 receptor precursor 0.081 0.083
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.081 0.083
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.081 0.083
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.081 0.083
ANXA2 ANXA2, ANX2, ANX2L4, CAL1H, LPC2D: Annexin A2 0.081 0.028
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.080 0.049
CSPG2 N/A 0.0794 0.109
TLN2 TLN2: Uncharacterized protein TLN2 0.078 0.098
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.078 0.098
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.0782 0.051
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.075 0.028
FADD FADD, MORT1: Protein FADD 0.075 0.028
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.075 0.165
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.075 0.028
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.075 0.036
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.074 0.165
ADCY3 ADCY3, KIAA0511: Adenylate cyclase type 3 0.073 0.025
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.073 0.050
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.073 0.075
PVR PVR, PVS: Poliovirus receptor precursor 0.0727 0.165
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.0727 0.165
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.0727 0.165
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.0727 0.165
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.0727 0.034
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.0727 0.165
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.0727 0.165
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.072 0.028
EGF EGF: Pro-epidermal growth factor precursor 0.072 0.165
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.072 0.083
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.072 0.083
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.072 0.083
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.072 0.083
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.072 0.165
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.072 0.165
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.072 0.165
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.072 0.165
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.049
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.0688 0.109
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.0688 0.109
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.067 0.148
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.065 0.148
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.065 0.148
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.065 0.075
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.065 0.083
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.065 0.165
PRLR PRLR: Prolactin receptor precursor 0.065 0.083
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.065 0.165
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.065 0.083
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.065 0.083
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.065 0.165
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.065 0.165
F3 F3: Tissue factor precursor 0.065 0.083
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.065 0.0688
ITGB4 N/A 0.065 0.165
DCC DCC: Netrin receptor DCC precursor 0.064 0.148
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.064 0.075
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.064 0.075
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.064 0.062
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.064 0.075
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.075
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.064 0.062
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.063 0.049
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.062 0.098
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.062 0.098
CD44 N/A 0.061 0.165
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.061 0.165
TNC TNC, HXB: Tenascin precursor 0.058 0.148
PTPRZ1 N/A 0.058 0.075
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.058 0.148
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.058 0.165
C5AR1 C5AR1, C5AR, C5R1: C5a anaphylatoxin chemotactic receptor 0.057 0.028
FPR1 FPR1: fMet-Leu-Phe receptor 0.057 0.028
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.056 0.044
SEMA4D SEMA4D, CD100, SEMAJ: Semaphorin-4D precursor 0.053 0.027
NEO1 NEO1, NGN: Neogenin precursor 0.052 0.148
NULL Ig heavy chain V-III region WEA 0.051 0.051
HLA-DRB2 HLA class II histocompatibility antigen, DW2.2/DR2.2 beta chain (Fragment) 0.051 0.051
FCGR2A FCGR2A, CD32, FCG2, FCGR2A1, IGFR2: Low affinity immunoglobulin gamma Fc region 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
HLA-A N/A 0.051 0.051
GRB10 N/A 0.051 0.051
TRB@ TCRB: T-cell receptor beta chain V region CTL-L17 precursor 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
IGHG3 N/A 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
NULL TCRA: T-cell receptor alpha chain V region CTL-L17 precursor 0.051 0.051
IGHA2 IGHA2: Ig alpha-2 chain C region 0.051 0.051
IGHA1 N/A 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
IGHM N/A 0.051 0.051
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
NULL Ig kappa chain V-I region CAR 0.051 0.051
IGHD N/A 0.051 0.051
IGHG1 N/A 0.051 0.051
NULL Ig lambda chain V-II region NEI 0.051 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-68 alpha chain precursor 0.051 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-27 alpha chain precursor 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
IGHE IGHE: Ig epsilon chain C region 0.051 0.051
HLA-DRA HLA-DRA, HLA-DRA1: HLA class II histocompatibility antigen, DR alpha chain precu 0.051 0.051
HLA-DQB1 HLA-DQB1: HLA class II histocompatibility antigen, DQB1*0602 beta chain precurso 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.034
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.051 0.025
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.075
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.051 0.025
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.049 0.165
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.165
C3AR1 C3AR1, AZ3B, C3R1, HNFAG09: C3a anaphylatoxin chemotactic receptor 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.165
TBXA2R TBXA2R: Thromboxane A2 receptor 0.049 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.165
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.049 0.028
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.049 0.028
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.049 0.165
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.049 0.028
DRD2 DRD2: D(2) dopamine receptor 0.049 0.028
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.036
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.046 0.165
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.046 0.046
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.046
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.046 0.109
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.046 0.109
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.046 0.109
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.165
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.0453 0.165
EDG1 EDG1: Sphingosine 1-phosphate receptor Edg-1 0.0453 0.028
IL8RB IL8RB, CXCR2: High affinity interleukin-8 receptor B 0.0453 0.028
FPRL1 FPRL1, FPR2, FPRH1, LXA4R: FMLP-related receptor I 0.0453 0.028
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.045 0.109
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.045 0.109
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.045 0.109
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.045 0.109
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.0446 0.028
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.044 0.044
PMP2 PMP2: Myelin P2 protein 0.044 0.044
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.025
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.025
PSEN1 PSEN1, AD3, PS1, PSNL1: Presenilin-1 0.044 0.062
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.044 0.025
ATRN N/A 0.044 0.148
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.025
JAG2 JAG2: Jagged-2 precursor 0.044 0.148
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.0425 0.049
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.0425 0.04
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0425 0.04
IPO7 IPO7: Uncharacterized protein IPO7 0.0425 0.044
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.041 0.044
DLG2 DLG2: Disks large homolog 2 0.041 0.040
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.041 0.109
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.041 0.109
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.041 0.109
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.098
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.041 0.098
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.041 0.098
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.041 0.098
TAPBPL TAPBPL: Tapasin-related protein precursor 0.039 0.027
HLA-F HLA-F, HLA-5.4, HLAF: HLA class I histocompatibility antigen, alpha chain F prec 0.039 0.027
HLA-E HLA-E, XXbac-BPG34K20.2-001: MHC class Ib antigen 0.039 0.027
VPREB1 VPREB1, VPREB: Immunoglobulin iota chain precursor 0.039 0.027
FCER1A FCER1A, FCE1A: High affinity immunoglobulin epsilon receptor subunit alpha precu 0.039 0.027
APEH APEH, D3F15S2, D3S48E, DNF15S2: Acylamino-acid-releasing enzyme 0.038 0.040
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.038 0.098
MDN1 MDN1, KIAA0301: Midasin 0.038 0.044
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.038 0.040
B2M B2M, CDABP0092, HDCMA22P: Beta-2-microglobulin precursor [Contains: Beta-2-micro 0.037 0.044
F2R F2R, CF2R, PAR1, TR: Proteinase-activated receptor 1 precursor 0.037 0.028
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.037 0.028
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.037 0.028
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.165
MC4R MC4R: Melanocortin receptor 4 0.037 0.028
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.037 0.165
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.037 0.044
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.037 0.098
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.037 0.098
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.036 0.025
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.035 0.098
SSTR3 SSTR3: Somatostatin receptor type 3 0.033 0.025
TRHR TRHR: Thyrotropin-releasing hormone receptor 0.033 0.025
SCTR SCTR: Secretin receptor precursor 0.033 0.025
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.033 0.028
P2RY4 P2RY4, NRU: P2Y purinoceptor 4 0.033 0.028
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.032 0.028
KCNJ3 KCNJ3, GIRK1: G protein-activated inward rectifier potassium channel 1 0.032 0.028
HTR6 HTR6: 5-hydroxytryptamine receptor 6 0.032 0.028
ATP2B1 N/A 0.032 0.028
F2RL2 F2RL2, PAR3: Proteinase-activated receptor 3 precursor 0.032 0.028
KCNJ1 KCNJ1, ROMK1: ATP-sensitive inward rectifier potassium channel 1 0.032 0.028
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.032 0.028
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.032 0.109
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.032 0.030
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.032 0.036
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.032 0.044
IGSF6 IGSF6, DORA: Immunoglobulin superfamily member 6 precursor. 0.032 0.027
LILRB2 N/A 0.032 0.027
CD86 CD86, CD28LG2: T-lymphocyte activation antigen CD86 precursor 0.032 0.027
HLA-DQB1 HLA-DQB, HLA-DRB1: HLA class II histocompatibility antigen, DQ(1) beta chain pre 0.032 0.027
LRFN4 LRFN4: Leucine-rich repeat and fibronectin type-III domain-containing protein 4 0.032 0.027
FCGRT FCGRT, FCRN: IgG receptor FcRn large subunit p51 precursor 0.032 0.027
BTN3A2 BTN3A2, BT3.2, BTF3, BTF4: Butyrophilin subfamily 3 member A2 precursor 0.032 0.027
HLA-DRB5 HLA-Dw12: Cell surface glycoprotein 0.032 0.027
CD300A CD300A, CMRF35H: CMRF35-H antigen precursor 0.032 0.027
LILRA1 LIR6, LILRA1: Leukocyte immunoglobulin-like receptor subfamily A member 1 precur 0.032 0.027
HLA-DPA1 HLA-DPA1, HLA-DP1A, HLASB: HLA class II histocompatibility antigen, DP alpha cha 0.032 0.027
HLA-DRB5 HLA-DRB3: HLA class II histocompatibility antigen, DRB3-1 beta chain precursor 0.032 0.027
BTN3A3 BTN3A3, BTF3: Butyrophilin subfamily 3 member A3 precursor 0.032 0.027
MFAP3 MFAP3: Microfibril-associated glycoprotein 3 precursor 0.032 0.027
MARCO MARCO, SCARA2: Macrophage receptor MARCO 0.031 0.0688
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.030 0.051
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.030 0.051
TNN TNN: Tenascin-N precursor 0.030 0.046
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.029 0.025
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.029 0.148
CHRM2 CHRM2: Muscarinic acetylcholine receptor M2 0.029 0.025
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.165
F2RL3 F2RL3, PAR4: Proteinase-activated receptor 4 precursor 0.029 0.028
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.029 0.165
LYPD3 LYPD3, C4.4A, UNQ491/PRO1007: Ly6/PLAUR domain-containing protein 3 precursor 0.029 0.165
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.165
RHO RHO, OPN2: Rhodopsin 0.029 0.028
NOTCH4 N/A 0.029 0.148
DRD1 DRD1: D(1A) dopamine receptor 0.029 0.025
HPN HPN, TMPRSS1: Serine protease hepsin 0.029 0.148
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.029 0.148
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.029 0.148
TSHR N/A 0.029 0.047
PSEN2 PSEN2, AD4, PS2, PSNL2, STM2: Presenilin-2 0.029 0.062
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.029 0.025
PREP PREP, PEP: Prolyl endopeptidase 0.029 0.098
THOP1 THOP1: Thimet oligopeptidase 0.029 0.098
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.029 0.040
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
CD69 CD69: Early activation antigen CD69 0.027 0.165
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.027 0.165
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.165
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.0263 0.028
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.026 0.025
KCNJ12 KCNJ12, IRK2, KCNJN1: ATP-sensitive inward rectifier potassium channel 12 0.026 0.025
TACR2 TACR2, NK2R, NKNAR, TAC2R: Substance-K receptor 0.026 0.025
CALCRL CALCRL, CGRPR: Calcitonin gene-related peptide type 1 receptor precursor 0.026 0.025
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.026 0.148
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.026 0.025
HTR2C HTR2C, HTR1C: 5-hydroxytryptamine receptor 2C 0.026 0.025
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.026 0.075
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.098
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.098
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.098
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.036
0.572
Total Score 22.30