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Evidence of Interaction Between POLR2A and PRPF40A

The interaction score between POLR2A and PRPF40A is 10.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismPOLR2A OrthologuePRPF40A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL140C 1 YKL012W 1
  • ReconstitutedComplex

Get References From PubMed
worm P16356 1 P34600 0.391
fly P04052 1 Q9VQK5 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in POLR2A and PRPF40A:
Domains in POLR2ADomains in PRPF40A
IPR000684 Eukaryotic RNA polymerase II heptapeptide repeat
IPR000722 RNA polymerase, alpha subunit
IPR006592 RNA polymerase I subunit A, N-terminal
IPR007066 RNA polymerase Rpb1, domain 3
IPR007073 RNA polymerase Rpb1, domain 7
IPR007075 RNA polymerase Rpb1, domain 6
IPR007080 RNA polymerase Rpb1, domain 1
IPR007081 RNA polymerase Rpb1, domain 5
IPR007083 RNA polymerase Rpb1, domain 4
IPR001202 WW/Rsp5/WWP domain
IPR002713 FF domain

The Chi square scores for co-occurrence of domains that are present in POLR2A and PRPF40A are listed below.

Domain 1Domain 2Chi Square
IPR000684 Eukaryotic RNA polymerase II heptapeptide repeat IPR001202 WW/Rsp5/WWP domain 23.8784
IPR007073 RNA polymerase Rpb1, domain 7 IPR001202 WW/Rsp5/WWP domain 23.8784
IPR007075 RNA polymerase Rpb1, domain 6 IPR001202 WW/Rsp5/WWP domain 23.8784
IPR000722 RNA polymerase, alpha subunit IPR001202 WW/Rsp5/WWP domain 21.51
IPR006592 RNA polymerase I subunit A, N-terminal IPR001202 WW/Rsp5/WWP domain 21.51
IPR007066 RNA polymerase Rpb1, domain 3 IPR001202 WW/Rsp5/WWP domain 21.51
IPR007080 RNA polymerase Rpb1, domain 1 IPR001202 WW/Rsp5/WWP domain 21.51
IPR007081 RNA polymerase Rpb1, domain 5 IPR001202 WW/Rsp5/WWP domain 21.51
IPR007083 RNA polymerase Rpb1, domain 4 IPR001202 WW/Rsp5/WWP domain 21.51

The background colour of the table refers to:

  • Blue Domain is only present in POLR2A
  • Yellow Domain is only present in PRPF40A
  • Green Domain is present in both POLR2A and PRPF40A

 0.051
Post-translational Modifications

Protein: POLR2A

PTMResidueReference
Phosphorylation 1836 PubMed, HPRD
Phosphorylation 1878 PubMed, HPRD
Phosphorylation 1882 PubMed, HPRD
Phosphorylation 1896 PubMed, HPRD
Phosphorylation 1927 PubMed, HPRD
Phosphorylation 1929 PubMed, HPRD
Phosphorylation 1930 PubMed, HPRD
Phosphorylation 1934 PubMed, HPRD
Phosphoserine 1896 HPRD
Phosphoserine 1934 HPRD
Phosphotyrosine 145 HPRD

Protein: PRPF40A

PTMResidueReference
Phosphoserine 888 HPRD
Phosphoserine 938 HPRD
Localisation

Protein: POLR2A

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: PRPF40A

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between POLR2A and PRPF40A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between POLR2A andPRPF40A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , POLR2A has 803 interactors and PRPF40A has 78 interactors of which there are 55 common interactors.

Common InteractorName of Common InteractorScore for POLR2A-Interactor (?)Score for PRPF40A-Interactor (?)
PRPF40B DKFZp434O1520, PRPF40B, hCG_20201: Putative uncharacterized protein DKFZp434O152 1.27 0.119
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.284 0.026
RBM14 RBM14, SIP: RNA-binding protein 14 0.210 0.051
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.210 0.051
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.210 0.051
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.188 0.046
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.187 0.046
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.187 0.046
RBM6 RBM6, DEF3: RNA-binding protein 6 0.155 0.051
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.139 0.046
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.139 0.046
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.139 0.170
TIAL1 TIAL1: Nucleolysin TIAR 0.139 0.170
SSB SSB: Lupus La protein 0.139 0.046
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.139 0.046
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.139 0.046
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.139 0.046
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.139 12.20
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.127 0.051
MATR3 MATR3, KIAA0723: Matrin-3 0.127 0.051
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.127 0.051
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.114 0.046
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.114 0.046
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.114 0.046
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.114 0.046
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.114 12.20
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.114 0.046
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.114 0.046
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.114 0.046
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.114 0.046
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.096 0.051
HTATSF1 HTATSF1: HIV Tat-specific factor 1 0.086 0.046
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.083 0.051
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.083 0.051
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.075 0.046
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.075 0.046
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.075 0.046
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.075 12.20
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.075 0.046
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.075 0.046
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.075 0.046
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.075 0.046
RBM7 0.069 0.046
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.067 0.046
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.063 0.218
ARS2 ARS2, ASR2: Arsenite-resistance protein 2 0.061 0.046
PPARGC1A PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1: Peroxisome proliferator-activated receptor 0.055 0.051
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.046 1.15
G3BP2 G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2 0.044 0.046
MGC9315 CPSF7: Cleavage and polyadenylation specificity factor subunit 7 0.0407 0.051
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.038 1.15
RBM16 N/A 0.036 0.046
SAFB2 SAFB2, KIAA0138: Scaffold attachment factor B2 0.036 0.046
RBM25 RBM25, RNPC7: Probable RNA-binding protein 25 0.036 0.046
C20orf6 ESF1, ABTAP, HDCMC28P, C20orf6: ESF1 homolog 0.030 0.046
2.15E-3
Total Score 10.50