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Evidence of Interaction Between UBE2I and STAM2

The interaction score between UBE2I and STAM2 is 4.27.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between UBE2I and STAM2 = 0.20

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction 0.027
Post-translational Modifications

Protein: UBE2I

PTMResidueReference

Protein: STAM2

PTMResidueReference
Phosphorylation 192 PubMed, HPRD
Phosphorylation 371 PubMed, HPRD
Phosphorylation 372 PubMed, HPRD
Phosphorylation 374 PubMed, HPRD
Phosphotyrosine 371 HPRD
Phosphotyrosine 374 HPRD
Localisation

Protein: UBE2I

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: STAM2

LocalisationReference
Endosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between UBE2I and STAM2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between UBE2I andSTAM2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , UBE2I has 238 interactors and STAM2 has 1227 interactors of which there are 30 common interactors.

Common InteractorName of Common InteractorScore for UBE2I-Interactor (?)Score for STAM2-Interactor (?)
SUMO2 SUMO2, SMT3B, SMT3H2: Small ubiquitin-related modifier 2 precursor 0.130 0.113
SF3A1 SF3A1, SAP114: Splicing factor 3 subunit 1 0.130 0.113
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.090 0.069
RAD23B RAD23B: UV excision repair protein RAD23 homolog B 0.083 0.028
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.067 0.152
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.065 36.10
UBE2D2 UBE2D2, UBC4, UBCH5B: Ubiquitin-conjugating enzyme E2 D2 0.059 0.028
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.057 0.113
ELF1 ELF1: ETS-related transcription factor Elf-1 0.057 0.037
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.050 0.049
QARS QARS: Glutaminyl-tRNA synthetase 0.049 0.029
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.0471 0.113
EDD1 EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1 0.039 0.029
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.039 0.073
GGA1 GGA1: GGA1 protein 0.039 0.060
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.0308 0.097
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.0308 0.191
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.0308 0.032
TCEB2 TCEB2: Transcription elongation factor B polypeptide 2 0.030 0.032
NEDD8 NEDD8: NEDD8 precursor 0.030 0.073
UBE2G1 UBE2G1, UBE2G: Ubiquitin-conjugating enzyme E2 G1 0.0278 0.046
UBE2D3 UBE2D3, UBCH5C: Ubiquitin-conjugating enzyme E2 D3 0.0278 0.0308
EIF3S5 N/A 0.027 0.053
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
MID2 N/A 0.027 0.027
UBL7 UBL7, BMSCUBP, SB132: Ubiquitin-like protein 7 0.027 0.027
C20orf86 C20orf86: Ankyrin repeat-containing protein C20orf86 precursor 0.027 0.027
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.027 0.028
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.027 0.113
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.0255 0.029
0.347
Total Score 4.27