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Evidence of Interaction Between FOS and MAPKAPK5

The interaction score between FOS and MAPKAPK5 is 6.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in FOS and MAPKAPK5:
Domains in FOSDomains in MAPKAPK5
IPR004827 Basic-leucine zipper (bZIP) transcription factor
IPR008917 Eukaryotic transcription factor, DNA-binding
IPR000837 Fos transforming protein
IPR011700 bZIP_2.
IPR000719 Protein kinase
IPR008271 Serine/threonine protein kinase, active site

The Chi square scores for co-occurrence of domains that are present in FOS and MAPKAPK5 are listed below.

Domain 1Domain 2Chi Square
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR000719 Protein kinase 8.28186
IPR008917 Eukaryotic transcription factor, DNA-binding IPR000719 Protein kinase 3.61835
IPR011700 bZIP_2. IPR000719 Protein kinase 2.59125
IPR000837 Fos transforming protein IPR000719 Protein kinase 0.999248
IPR008917 Eukaryotic transcription factor, DNA-binding IPR008271 Serine/threonine protein kinase, active site 0.186644
IPR000837 Fos transforming protein IPR008271 Serine/threonine protein kinase, active site 0.0187022
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR008271 Serine/threonine protein kinase, active site 0.00153394
IPR011700 bZIP_2. IPR008271 Serine/threonine protein kinase, active site 0.00148976

The background colour of the table refers to:

  • Blue Domain is only present in FOS
  • Yellow Domain is only present in MAPKAPK5
  • Green Domain is present in both FOS and MAPKAPK5

 0.028
Post-translational Modifications

Protein: FOS

PTMResidueReference
Phosphorylation 232 PubMed, HPRD
Phosphorylation 325 PubMed, HPRD
Phosphorylation 331 PubMed, HPRD
Phosphorylation 362 PubMed, HPRD
Phosphorylation 374 PubMed, HPRD

Protein: MAPKAPK5

PTMResidueReference
Phosphorylation 182 PubMed, HPRD
Phosphothreonine 182 HPRD
Localisation

Protein: FOS

LocalisationReference
ER HPRD
Nucleus HPRD

Protein: MAPKAPK5

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between FOS and MAPKAPK5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FOS andMAPKAPK5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FOS has 855 interactors and MAPKAPK5 has 1770 interactors of which there are 741 common interactors.

Common InteractorName of Common InteractorScore for FOS-Interactor (?)Score for MAPKAPK5-Interactor (?)
JUNB JUNB: Transcription factor jun-B 6.19E3 0.052
JUN JUN: Transcription factor AP-1 2.90E3 0.052
JUND JUND: Transcription factor jun-D 3.64 0.052
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.827 0.165
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.822 0.028
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.461 0.028
BACH1 BACH1: Transcription regulator protein BACH1 0.416 0.052
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.385 0.083
ZFP36 ZFP36, G0S24, RNF162A, TIS11A, TTP: Tristetraproline 0.308 0.028
ETS2 ETS2: Protein C-ets-2 0.307 0.028
H1FX H1FX: Histone H1x 0.307 0.083
ELF1 ELF1: ETS-related transcription factor Elf-1 0.307 0.028
KCTD12 KCTD12, C13orf2, KIAA1778, PFET1: BTB/POZ domain-containing protein KCTD12 0.276 0.028
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.276 0.028
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.275 0.028
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.275 0.028
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.275 0.028
MAFG MAFG: Transcription factor MafG 0.275 0.028
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.275 0.083
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.275 0.028
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.260 0.028
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.251 0.028
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.233 0.083
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.225 0.028
BRPF1 BRPF1, BR140: Peregrin 0.225 0.028
CREBBP CREBBP, CBP: CREB-binding protein 0.225 0.028
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.225 0.165
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.225 0.083
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.028
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.191 0.052
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.191 0.028
IRF3 IRF3: Interferon regulatory factor 3 0.191 0.028
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.191 0.052
RB1 RB1: Retinoblastoma-associated protein 0.191 0.083
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.188 0.028
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.188 0.028
NR4A2 NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2 0.188 0.028
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.171 0.052
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.171 0.052
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.171 0.083
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.171 0.083
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.165 0.028
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.165 0.028
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.165 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.083
MAPK15 N/A 0.165 0.083
AHR AHR: Aryl hydrocarbon receptor precursor 0.163 0.028
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.157 0.028
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.155 0.028
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.155 0.165
MEF2A N/A 0.155 0.028
MYB MYB: Myb proto-oncogene protein 0.152 0.083
GTF2F2 N/A 0.152 0.028
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.083
ERG ERG: Transcriptional regulator ERG 0.152 0.028
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.148 0.083
CREB1 CREB1: cAMP response element-binding protein 0.148 0.165
BRD4 N/A 0.148 0.028
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.148 0.028
RBL1 RBL1: Retinoblastoma-like protein 1 0.148 0.083
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.146 0.083
MTF1 MTF1: Metal regulatory transcription factor 1 0.146 0.028
IRS2 IRS2: Insulin receptor substrate 2 0.144 0.165
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.140 0.152
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.139 0.083
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.139 0.165
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.139 0.028
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.028
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.139 0.028
CXorf9 N/A 0.139 0.028
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.028
VDR VDR, NR1I1: Vitamin D3 receptor 0.139 0.028
STAT6 STAT6: Signal transducer and activator of transcription 6 0.137 0.165
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.136 0.083
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.136 0.052
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.136 0.028
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.136 0.028
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.136 0.028
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.129 0.028
STAT2 STAT2: Signal transducer and activator of transcription 2 0.127 0.165
ROCK1 ROCK1: Rho-associated protein kinase 1 0.127 0.165
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.127 0.028
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.123 0.028
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.123 0.028
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.123 0.028
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.123 0.052
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.123 0.028
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.123 0.028
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.118 0.028
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.118 0.028
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.118 0.028
MEF2D MEF2D: Myocyte-specific enhancer factor 2D 0.114 0.028
RPS6KB1 N/A 0.114 0.028
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.114 0.028
PHF10 N/A 0.114 0.028
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.114 0.028
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.114 0.028
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.114 0.028
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.112 0.083
PCAF PCAF: Histone acetyltransferase PCAF 0.110 0.028
ETS1 ETS1, EWSR2: Protein C-ets-1 0.110 0.028
GMCL1L GMCL1L, GCL: Germ cell-less protein-like 1-like 0.110 0.028
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.110 0.028
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.110 0.028
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.110 0.083
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.110 0.083
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.110 0.083
ETV1 ETV1, ER81: ETS translocation variant 1 0.110 0.083
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.109 0.083
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.109 0.083
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.109 0.028
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.099 0.083
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.098 0.028
FOXL2 FOXL2: Forkhead box protein L2 0.098 0.028
TAF1 TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1 0.098 0.028
MLL MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX 0.097 0.028
RFX1 RFX1: MHC class II regulatory factor RFX1 0.097 0.028
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.097 0.028
ELK1 ELK1: ETS domain-containing protein Elk-1 0.097 0.028
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.097 0.028
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.097 0.028
ID2 ID2: DNA-binding protein inhibitor ID-2 0.0971 0.028
XRCC1 XRCC1: DNA-repair protein XRCC1 0.096 0.028
TGIF2 TGIF2: Homeobox protein TGIF2 0.096 0.028
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.096 0.028
SP100 N/A 0.096 0.028
NFATC1 N/A 0.096 0.083
NBN NBN, NBS, NBS1, P95: Nibrin 0.096 0.028
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.088 0.083
SAT SAT1, SAT: Diamine acetyltransferase 1 0.087 0.028
STK10 STK10: Uncharacterized protein STK10 0.087 0.028
YY1 YY1: Transcriptional repressor protein YY1 0.087 0.028
EGR1 EGR1, ZNF225: Early growth response protein 1 0.087 0.028
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.086 0.083
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.086 0.165
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.086 0.028
SRF SRF: Serum response factor 0.086 0.028
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.086 0.028
RELA RELA, NFKB3: Transcription factor p65 0.086 0.083
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.086 0.165
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.086 0.028
SOX4 SOX4: Transcription factor SOX-4 0.086 0.028
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.086 0.028
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.086 0.028
C20orf18 N/A 0.083 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.083 0.028
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.083 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.028
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.083 0.028
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.083 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.083 0.028
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.083 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.083 0.028
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.083 0.028
UHRF1 0.083 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.083
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.083 0.028
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.081 0.083
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.080 0.028
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.080 0.028
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.080 0.028
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.080 0.028
SH3BP3 0.080 0.028
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.080 0.028
DMXL2 DMXL2, KIAA0856: DmX-like protein 2 0.078 0.028
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.078 0.165
KIAA0690 N/A 0.078 0.028
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.078 0.028
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.077 0.028
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.077 0.028
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.077 0.028
DIDO1 N/A 0.075 0.028
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.075 0.083
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.075 0.083
CCNT2 CCNT2: Cyclin-T2 0.075 0.083
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.028
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.075 0.028
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.075 0.028
SOX8 SOX8: Transcription factor SOX-8 0.075 0.028
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.083
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.083
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.075 0.028
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.028
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.165
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.075 0.165
DLX3 DLX3: Homeobox protein DLX-3 0.075 0.028
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.075 0.028
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.075 0.028
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.075 0.028
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.028
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.074 0.083
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.074 0.028
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.072 0.028
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.071 0.028
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.071 0.028
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.071 0.028
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.071 0.028
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.071 0.028
SP3 SP3: Transcription factor Sp3 0.071 0.028
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.071 0.028
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.071 0.028
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.071 0.028
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.070 0.028
GAB2 N/A 0.070 0.165
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.070 0.028
VIM VIM: Vimentin 0.070 0.028
MARK2 N/A 0.070 0.028
PLEK PLEK, P47: Pleckstrin 0.070 0.165
NUP214 N/A 0.070 0.028
CCNH CCNH: Cyclin-H 0.069 0.083
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.069 0.028
MEF2C MEF2C: Myocyte-specific enhancer factor 2C 0.069 0.028
SATB1 SATB1: DNA-binding protein SATB1 0.069 0.028
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.069 0.028
TP53 TP53, P53: Cellular tumor antigen p53 0.069 0.028
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.067 0.028
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.067 0.165
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.066 0.028
HCK N/A 0.066 0.165
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.066 0.165
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.066 0.165
SYK SYK: Tyrosine-protein kinase SYK 0.066 0.165
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.064 0.083
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.063 0.028
KIAA1012 KIAA1012: Protein TRS85 homolog 0.063 0.028
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.063 0.028
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.063 0.028
DOK1 DOK1: Docking protein 1 0.063 0.165
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.063 0.028
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.063 0.083
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.063 0.028
EP300 N/A 0.063 0.028
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.063 0.028
CORO1C CORO1C, CRNN4: Coronin-1C 0.063 0.028
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.062 0.028
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.062 0.028
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.062 0.028
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.062 0.028
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.062 0.028
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.062 0.028
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.062 0.028
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.060 0.028
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.060 0.028
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.060 0.083
LIG4 LIG4: DNA ligase 4 0.056 0.028
RERE RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei 0.056 0.028
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.056 0.028
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.056 0.028
NFIB N/A 0.056 0.028
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.056 0.028
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.055 0.028
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.028
STAT4 STAT4: Signal transducer and activator of transcription 4 0.055 0.165
ZHX3 ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3 0.055 0.028
SATB2 SATB2, KIAA1034: DNA-binding protein SATB2 0.055 0.028
PPARG CREB3L2-PPARgamma 0.055 0.028
PGR PGR, NR3C3: Progesterone receptor 0.055 0.028
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.054 0.083
CDK6 CDK6: Cell division protein kinase 6 0.054 0.028
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.054 0.083
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.054 0.028
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.054 0.028
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.054 0.083
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.054 0.028
ZNF551 N/A 0.054 0.028
SP1 SP1, TSFP1: Transcription factor Sp1 0.054 0.028
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.054 0.028
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.054 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.052 0.052
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.052 0.028
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.052 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.052 0.028
TFAP4 TFAP4: Transcription factor AP-4 0.052 0.028
HES6 HES6: Transcription cofactor HES-6 0.052 0.028
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.052 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.052 0.028
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.052 0.028
ZNF579 ZNF579: Zinc finger protein 579 0.052 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.052 0.028
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.052 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.052 0.028
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.052 0.165
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.052 0.083
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.052 0.028
WDR1 N/A 0.052 0.028
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.052 0.028
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.052 0.028
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.052 0.028
EXOC2 N/A 0.051 0.028
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.050 0.083
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.049 0.028
YAP1 YAP1, YAP65: 65 kDa Yes-associated protein 0.049 0.028
STAT3 0.049 0.165
NR4A1 CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor 0.049 0.028
NKX2-5 NKX2-5, CSX, NKX2.5, NKX2E: Homeobox protein Nkx-2.5 0.049 0.028
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.049 0.028
CCNB1 Cyclin B1 0.049 0.083
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.049 0.083
ZBTB16 ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16 0.049 0.028
MYBL2 MYBL2, BMYB: Myb-related protein B 0.049 0.028
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.049 0.028
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.049 0.083
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.049 0.028
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.049 0.083
SOX11 SOX11: Transcription factor SOX-11 0.049 0.028
EN2 EN2: Homeobox protein engrailed-2 0.049 0.028
HOXB6 HOXB6, HOX2B: Homeobox protein Hox-B6 0.049 0.028
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.049 0.083
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.048 0.052
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.048 0.028
ZFX ZFX: Zinc finger X-chromosomal protein 0.048 0.028
MATR3 MATR3, KIAA0723: Matrin-3 0.048 0.028
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.048 0.028
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.048 0.028
SNAI1 SNAI1, SNAH: Zinc finger protein SNAI1 0.048 0.028
ZNF335 ZNF335: Zinc finger protein 335 0.048 0.028
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.048 0.028
ZNF267 ZNF267: Zinc finger protein 267 0.048 0.028
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.048 0.028
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.047 0.028
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.047 0.028
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.047 0.028
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.047 0.083
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.047 0.028
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.047 0.028
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.047 0.028
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.047 0.028
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.047 0.028
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.047 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.028
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.047 0.028
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.047 0.028
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.047 0.028
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.047 0.028
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.047 0.165
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.047 0.028
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.047 0.028
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.047 0.083
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.047 0.028
MAX MAX: Protein max 0.047 0.028
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.047 0.028
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.047 0.028
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.047 0.028
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.047 0.028
GSK3B N/A 0.046 0.028
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.046 0.083
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.046 0.028
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.046 0.028
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.046 0.083
DIAPH1 Diaphanous 1 0.046 0.028
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.046 0.028
WDR44 WDR44: WD repeat-containing protein 44 0.046 0.028
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.046 0.028
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.046 0.028
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.046 0.083
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.046 0.028
COPA COPA: Coatomer subunit alpha 0.046 0.028
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.046 0.028
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.046 0.165
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.028
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.046 0.028
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.046 0.028
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.046 0.028
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.0446 0.165
LYN LYN: Tyrosine-protein kinase Lyn 0.0446 0.165
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0446 0.028
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.0446 0.028
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.0446 0.052
CDX2 CDX2, CDX3: Homeobox protein CDX-2 0.044 0.028
SMCX JARID1C, DXS1272E, SMCX, XE169: Histone demethylase JARID1C 0.044 0.028
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.044 0.165
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.044 0.028
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.043 0.165
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.043 0.028
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.043 0.028
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.043 0.028
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.043 0.028
MYCN MYCN, NMYC: N-myc proto-oncogene protein 0.043 0.028
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.043 0.028
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.043 0.028
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.043 0.028
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.0425 0.028
DDX21 DDX21: Nucleolar RNA helicase 2 0.0425 0.028
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.0425 0.028
NCOA3 N/A 0.0425 0.028
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.0425 0.083
KIAA0853 N/A 0.0425 0.028
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.0425 0.165
PTMA N/A 0.0425 0.028
ARFGAP1 N/A 0.0425 0.052
RBM14 RBM14, SIP: RNA-binding protein 14 0.0425 0.028
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.028
RGS14 N/A 0.0425 0.028
IFI16 N/A 0.0425 0.028
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.0425 0.028
GNB2L1 Lung cancer oncogene 7 0.0425 0.028
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.041 0.083
GMIP GMIP: GEM-interacting protein 0.040 0.083
PSCD4 PSCD4, CYT4: Cytohesin-4 0.040 0.165
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.040 0.165
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.040 0.083
FLII FLII, FLIL: Protein flightless-1 homolog 0.040 0.028
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.040 0.165
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.040 0.083
STK16 N/A 0.039 0.028
MECP2 MECP2: Methyl-CpG-binding protein 2 0.039 0.028
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.039 0.028
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.039 0.028
PRKAA1 N/A 0.039 0.028
CDKL5 N/A 0.039 0.028
HIVEP1 N/A 0.039 0.028
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.038 0.028
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.038 0.028
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.038 0.028
HDAC3 HDAC3: Histone deacetylase 3 0.038 0.028
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.038 0.028
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.038 0.083
HDAC4 HDAC4, KIAA0288: Histone deacetylase 4 0.038 0.028
RUNX1 N/A 0.038 0.028
MYH9 MYH9: Myosin-9 0.038 0.028
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.038 0.028
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.038 0.028
SEC31L1 N/A 0.038 0.028
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.038 0.028
COPE COPE: Coatomer subunit epsilon 0.038 0.028
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.038 0.028
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.038 0.028
DDX51 DDX51: ATP-dependent RNA helicase DDX51 0.038 0.028
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.038 0.028
FNBP1 N/A 0.038 0.028
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.038 0.028
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.038 0.028
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.038 0.028
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.038 0.028
CUL5 CUL5, VACM1: Cullin-5 0.038 0.028
ARID3A ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein 0.038 0.028
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.038 0.028
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.038 0.028
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.038 0.028
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.038 0.028
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.038 0.028
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.038 0.028
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.038 0.165
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.038 0.028
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.038 0.028
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.038 0.028
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.038 0.028
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.037 0.165
MVP MVP, LRP: Major vault protein 0.036 0.028
RP2 RP2: Protein XRP2 0.036 0.028
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.036 0.083
IFI35 N/A 0.036 0.028
AHNAK AHNAK: AHNAK protein 0.036 0.028
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.036 0.028
LIMS1 N/A 0.036 0.028
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.036 0.028
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.035 0.028
MTA1 MTA1: Metastasis-associated protein MTA1 0.035 0.028
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.035 0.028
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.035 0.028
CDK2 CDK2: Cell division protein kinase 2 0.035 0.028
CDK5 CDK5: Cell division protein kinase 5 0.035 0.028
CDK4 CDK4: Cell division protein kinase 4 0.035 0.028
KLF5 KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5 0.035 0.028
CDK7 CDK7, MO15: Cell division protein kinase 7 0.035 0.028
ZNF224 ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224 0.035 0.028
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.035 0.028
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.035 0.028
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.034 0.028
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.034 0.028
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.034 0.028
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.033 0.028
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.033 0.028
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.033 0.165
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.032 0.028
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.032 0.028
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.032 0.028
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.032 0.028
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.032 0.028
GTF3C1 N/A 0.032 0.028
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.032 0.028
CHUK N/A 0.032 0.028
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.028
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.032 0.028
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.032 0.028
TOP2B N/A 0.032 0.028
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.032 0.028
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.032 0.028
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.032 0.165
LCP1 LCP1, PLS2: Plastin-2 0.032 0.028
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.032 0.028
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.032 0.052
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.032 0.165
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.032 0.083
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.032 0.028
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.032 0.028
ACTG1 ACTB: Actin, cytoplasmic 1 0.032 0.028
VAV1 VAV1, VAV: Proto-oncogene vav 0.032 0.165
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.031 0.165
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.031 0.028
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.031 0.083
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.031 0.028
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.031 0.028
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.0308 0.028
HES1 HES1, HL, HRY: Transcription factor HES-1 0.0308 0.028
DYRK3 N/A 0.0308 0.028
SALL1 SALL1, SAL1: Sal-like protein 1 0.0308 0.028
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.0308 0.083
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.0308 0.028
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.0308 0.028
MYF5 MYF5: Myogenic factor 5 0.0308 0.028
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.0308 0.028
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.029 0.028
PPP1R8 N/A 0.029 0.028
CBX3 CBX3: Chromobox protein homolog 3 0.029 0.028
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.029 0.028
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.029 0.028
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.029 0.028
POLB POLB: DNA polymerase beta 0.029 0.028
SOS1 SOS1: Son of sevenless homolog 1 0.029 0.165
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.029 0.028
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.029 0.028
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.029 0.028
SAPS3 N/A 0.029 0.028
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.029 0.028
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.029 0.028
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.029 0.165
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.029 0.165
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.029 0.028
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.029 0.083
COPB2 COPB2: Coatomer subunit beta' 0.029 0.028
CUL4B N/A 0.029 0.028
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.029 0.028
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.029 0.028
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.029 0.028
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.029 0.028
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.029 0.028
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.029 0.028
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.029 0.028
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.029 0.028
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.028
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.029 0.028
SSB SSB: Lupus La protein 0.029 0.028
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.029 0.028
TIAL1 TIAL1: Nucleolysin TIAR 0.029 0.028
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.029 0.028
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.029 0.028
ZFYVE16 ZFYVE16, KIAA0305: Zinc finger FYVE domain-containing protein 16 0.029 0.028
SYMPK SYMPK, SPK: Symplekin 0.029 0.028
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.029 0.028
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.029 0.028
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.029 0.028
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.029 0.028
KLHDC4 N/A 0.029 0.028
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.029 0.028
WBSCR20A N/A 0.029 0.028
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.029 0.165
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.029 0.028
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.029 0.028
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.029 0.028
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.029 0.028
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
BID BID: BH3-interacting domain death agonist 0.028 0.083
NES N/A 0.028 0.028
FLJ23436 N/A 0.028 0.028
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
C13orf8 N/A 0.028 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
PPEF1 N/A 0.028 0.028
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
CABLES1 N/A 0.028 0.028
ZNF265 N/A 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
IRF7 N/A 0.028 0.028
RAB4A N/A 0.028 0.052
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
HDAC8 N/A 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.028
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
SNRPB N/A 0.028 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.028 0.165
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
CORO6 N/A 0.028 0.028
PHLDB2 N/A 0.028 0.028
KIF1B N/A 0.028 0.028
DUSP15 N/A 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
WDR54 N/A 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.028
HDAC7A N/A 0.028 0.028
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.028 0.028
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.028 0.028
BAG3 BAG3, BIS: BAG family molecular chaperone regulator 3 0.028 0.028
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.028 0.028
MYO3A MYO3A: Myosin IIIA 0.028 0.028
SMARCA1 SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1 0.028 0.028
HAND1 HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1 0.028 0.028
BNC1 BNC1, BNC: Zinc finger protein basonuclin-1 0.028 0.028
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.028 0.028
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.027 0.165
CREM hCREM-1: HCREM 1alpha protein 0.027 0.027
CREM CREM, RP11-324I22.1-005: cAMP responsive element modulator 0.027 0.027
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.027 0.165
ZYX ZYX: Zyxin 0.027 0.028
DAPP1 N/A 0.027 0.028
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.027 0.028
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.027 0.083
DNM2 N/A 0.027 0.028
SRPR SRPR: Uncharacterized protein SRPR 0.027 0.028
FLNA FLNA, FLN, FLN1: Filamin-A 0.027 0.028
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.027 0.083
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.027 0.028
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.026 0.165
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.026 0.083
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.026 0.165
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.026 0.165
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.026 0.165
ABCF1 N/A 0.026 0.028
RBM6 RBM6, DEF3: RNA-binding protein 6 0.026 0.028
API5 N/A 0.026 0.028
STRN3 STRN3, GS2NA, SG2NA: Striatin-3 0.026 0.028
MDM4 MDM4, MDMX: Mdm4 protein 0.026 0.083
TCOF1 N/A 0.026 0.028
PHF8 PHF8, KIAA1111, ZNF422: PHD finger protein 8 0.026 0.028
COIL COIL, CLN80: Coilin 0.026 0.028
SMARCC2 N/A 0.026 0.028
SREBF2 N/A 0.026 0.028
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.026 0.083
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.026 0.028
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.026 0.028
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.026 0.028
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.026 0.028
TCF7L2 N/A 0.026 0.028
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.026 0.028
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.026 0.028
AFF1 N/A 0.026 0.028
SET SET: Protein SET 0.026 0.028
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.028
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.028
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.028
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.028
KCTD1 0.025 0.028
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.028
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.028
GIT2 N/A 0.025 0.052
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.028
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.028
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.028
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.028
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.028
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.028
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.028
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.028
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.028
CAMKK1 N/A 0.025 0.028
GRK6 N/A 0.025 0.028
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.165
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.028
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.028
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.028
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.028
SEC13L1 N/A 0.025 0.028
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.028
TCEA1 N/A 0.025 0.028
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.052
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.028
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.028
CAMK2A N/A 0.025 0.028
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.028
MAP2K3 N/A 0.025 0.028
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.028
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.028
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.028
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.028
MAPK8IP3 N/A 0.025 0.028
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.028
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.028
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.028
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.028
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.028
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.028
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.028
ADK ADK: Adenosine kinase 0.025 0.028
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.165
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.028
RNF20 0.025 0.028
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.028
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.028
BCOR N/A 0.025 0.028
HTATIP N/A 0.025 0.028
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.028
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.028
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.028
PRKCB1 N/A 0.025 0.028
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.028
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.165
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.165
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.028
ELMO1 N/A 0.025 0.165
SON 0.025 0.028
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.165
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.028
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.028
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.028
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.028
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.028
NIPBL N/A 0.025 0.028
NUP98 N/A 0.025 0.028
ATXN2L N/A 0.025 0.028
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.028
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.028
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.028
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.028
C20orf77 N/A 0.025 0.028
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.028
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.028
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.028
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.028
0.572
Total Score 6.40