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Evidence of Interaction Between FOS and MAPK3

The interaction score between FOS and MAPK3 is 31.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between FOS and MAPK3 = 0.15

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismFOS OrthologueMAPK3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00295556 0.231 IPI00003479 0.749
fly Q8MRE5 0.231 P40417 0.342

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in FOS and MAPK3:
Domains in FOSDomains in MAPK3
IPR004827 Basic-leucine zipper (bZIP) transcription factor
IPR008917 Eukaryotic transcription factor, DNA-binding
IPR000837 Fos transforming protein
IPR011700 bZIP_2.
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008351 JNK MAP kinase
IPR008349 ERK1/2 MAP kinase

The Chi square scores for co-occurrence of domains that are present in FOS and MAPK3 are listed below.

Domain 1Domain 2Chi Square
IPR008917 Eukaryotic transcription factor, DNA-binding IPR008351 JNK MAP kinase 10.8998
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR011009 Protein kinase-like 9.23719
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR000719 Protein kinase 8.28186
IPR008917 Eukaryotic transcription factor, DNA-binding IPR011009 Protein kinase-like 5.70607
IPR008917 Eukaryotic transcription factor, DNA-binding IPR003527 MAP kinase 5.24231
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR008351 JNK MAP kinase 4.74134
IPR008917 Eukaryotic transcription factor, DNA-binding IPR000719 Protein kinase 3.61835
IPR011700 bZIP_2. IPR000719 Protein kinase 2.59125
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR003527 MAP kinase 1.58426
IPR011700 bZIP_2. IPR011009 Protein kinase-like 1.1759
IPR000837 Fos transforming protein IPR000719 Protein kinase 0.999248
IPR008917 Eukaryotic transcription factor, DNA-binding IPR002290 Serine/threonine protein kinase 0.250234
IPR008917 Eukaryotic transcription factor, DNA-binding IPR008271 Serine/threonine protein kinase, active site 0.186644
IPR011700 bZIP_2. IPR002290 Serine/threonine protein kinase 0.0200923
IPR000837 Fos transforming protein IPR008271 Serine/threonine protein kinase, active site 0.0187022
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR008271 Serine/threonine protein kinase, active site 0.00153394
IPR011700 bZIP_2. IPR008271 Serine/threonine protein kinase, active site 0.00148976
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR002290 Serine/threonine protein kinase 0.000586009

The background colour of the table refers to:

  • Blue Domain is only present in FOS
  • Yellow Domain is only present in MAPK3
  • Green Domain is present in both FOS and MAPK3

 0.165
Post-translational Modifications

Protein: FOS

PTMResidueReference
Phosphorylation 232 PubMed, HPRD
Phosphorylation 325 PubMed, HPRD
Phosphorylation 331 PubMed, HPRD
Phosphorylation 362 PubMed, HPRD
Phosphorylation 374 PubMed, HPRD

Protein: MAPK3

PTMResidueReference
Phosphorylation 202 PubMed, HPRD
Phosphorylation 204 PubMed, HPRD
Phosphothreonine 202 PubMed, HPRD
Phosphotyrosine 204 PubMed, HPRD
Localisation

Protein: FOS

LocalisationReference
ER HPRD
Nucleus HPRD

Protein: MAPK3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between FOS and MAPK3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FOS andMAPK3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FOS has 855 interactors and MAPK3 has 1361 interactors of which there are 566 common interactors.

Common InteractorName of Common InteractorScore for FOS-Interactor (?)Score for MAPK3-Interactor (?)
JUNB JUNB: Transcription factor jun-B 6.19E3 82.20
JUN JUN: Transcription factor AP-1 2.90E3 65.60
JUND JUND: Transcription factor jun-D 3.64 0.171
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.827 38.50
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.822 0.069
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.461 0.136
BACH1 BACH1: Transcription regulator protein BACH1 0.416 0.152
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.385 0.110
ETS2 ETS2: Protein C-ets-2 0.307 0.191
H1FX H1FX: Histone H1x 0.307 0.077
ELF1 ELF1: ETS-related transcription factor Elf-1 0.307 0.123
KCTD12 KCTD12, C13orf2, KIAA1778, PFET1: BTB/POZ domain-containing protein KCTD12 0.276 0.029
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.275 0.029
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.275 0.110
MAFG MAFG: Transcription factor MafG 0.275 0.136
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.275 153.00
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.275 0.110
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.260 0.077
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.251 0.062
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.233 0.114
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.225 0.086
CREBBP CREBBP, CBP: CREB-binding protein 0.225 0.029
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.225 0.110
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.225 0.069
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.062
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.191 0.123
IRF3 IRF3: Interferon regulatory factor 3 0.191 0.077
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.191 0.109
RB1 RB1: Retinoblastoma-associated protein 0.191 0.062
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.188 0.056
NR4A2 NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2 0.188 23.60
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.171 0.110
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.171 0.136
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.171 0.056
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.171 0.069
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.165 0.083
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.165 0.165
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.165 0.083
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.083
MAPK15 N/A 0.165 0.083
AHR AHR: Aryl hydrocarbon receptor precursor 0.163 0.069
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.157 0.026
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.155 0.077
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.155 0.152
MEF2A N/A 0.155 0.052
MYB MYB: Myb proto-oncogene protein 0.152 0.055
GTF2F2 N/A 0.152 0.062
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.123
ERG ERG: Transcriptional regulator ERG 0.152 0.109
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.148 0.075
CREB1 CREB1: cAMP response element-binding protein 0.148 0.148
BRD4 N/A 0.148 0.025
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.148 0.075
RBL1 RBL1: Retinoblastoma-like protein 1 0.148 0.075
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.146 0.056
IRS2 IRS2: Insulin receptor substrate 2 0.144 0.191
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.140 0.0898
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.139 0.086
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.139 0.097
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.069
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.139 0.056
CXorf9 N/A 0.139 0.049
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.069
VDR VDR, NR1I1: Vitamin D3 receptor 0.139 0.056
STAT6 STAT6: Signal transducer and activator of transcription 6 0.137 65.60
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.136 65.60
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.136 0.056
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.136 8.99
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.136 41.40
STAT2 STAT2: Signal transducer and activator of transcription 2 0.127 0.109
ROCK1 ROCK1: Rho-associated protein kinase 1 0.127 0.109
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.126 0.057
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.123 0.049
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.123 0.097
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.118 0.086
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.118 0.049
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.118 0.069
RPS6KB1 N/A 0.114 0.056
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.114 0.056
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.114 0.056
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.114 33.10
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.112 0.069
ETS1 ETS1, EWSR2: Protein C-ets-1 0.110 0.136
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.110 0.069
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.110 0.136
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.110 0.049
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.110 0.044
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.110 0.056
ETV1 ETV1, ER81: ETS translocation variant 1 0.110 0.109
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.109 0.083
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.109 0.083
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.109 0.055
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.099 0.049
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.098 0.109
FOXL2 FOXL2: Forkhead box protein L2 0.098 0.044
RFX1 RFX1: MHC class II regulatory factor RFX1 0.097 0.049
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.097 0.044
ELK1 ELK1: ETS domain-containing protein Elk-1 0.097 0.136
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.097 0.044
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.097 0.029
ID2 ID2: DNA-binding protein inhibitor ID-2 0.0971 0.077
XRCC1 XRCC1: DNA-repair protein XRCC1 0.096 0.026
SP100 N/A 0.096 0.039
NFATC1 N/A 0.096 0.055
NBN NBN, NBS, NBS1, P95: Nibrin 0.096 0.039
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.088 0.044
STK10 STK10: Uncharacterized protein STK10 0.087 0.069
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.086 0.056
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.086 0.171
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.086 0.056
RELA RELA, NFKB3: Transcription factor p65 0.086 0.069
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.086 53.10
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.086 26.80
SOX4 SOX4: Transcription factor SOX-4 0.086 0.0308
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.086 0.056
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.086 0.0308
C20orf18 N/A 0.083 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.083 0.075
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.083 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.083 0.075
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.083 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.083 0.028
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.083 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.083 0.028
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.083 0.028
UHRF1 0.083 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.083
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.083 0.025
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.081 0.062
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.080 0.096
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.080 0.062
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.080 0.026
SH3BP3 0.080 0.032
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.080 0.026
DMXL2 DMXL2, KIAA0856: DmX-like protein 2 0.078 0.029
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.078 0.136
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.077 0.026
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.077 0.048
DIDO1 N/A 0.075 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.075 0.148
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.075 0.148
CCNT2 CCNT2: Cyclin-T2 0.075 0.148
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.075
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.075 0.025
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.075 0.025
SOX8 SOX8: Transcription factor SOX-8 0.075 0.047
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.075
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.075
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.075 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.075
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.148
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.075 71.20
DLX3 DLX3: Homeobox protein DLX-3 0.075 0.025
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.075 0.075
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.075 0.025
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.075 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 35.90
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.074 0.086
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.074 0.026
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.071 0.056
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.071 0.056
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.071 0.069
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.071 0.069
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.071 0.114
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.070 0.032
GAB2 N/A 0.070 0.251
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.070 0.029
VIM VIM: Vimentin 0.070 0.048
MARK2 N/A 0.070 0.026
PLEK PLEK, P47: Pleckstrin 0.070 0.123
NUP214 N/A 0.070 0.026
CCNH CCNH: Cyclin-H 0.069 0.136
MEF2C MEF2C: Myocyte-specific enhancer factor 2C 0.069 0.029
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.069 0.0308
TP53 TP53, P53: Cellular tumor antigen p53 0.069 0.049
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.067 0.029
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.067 112.00
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.066 0.056
HCK N/A 0.066 0.136
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.066 0.136
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.066 0.136
SYK SYK: Tyrosine-protein kinase SYK 0.066 0.110
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.064 0.049
KIAA1012 KIAA1012: Protein TRS85 homolog 0.063 0.069
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.063 0.086
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.063 0.029
DOK1 DOK1: Docking protein 1 0.063 0.136
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.063 0.069
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.063 0.038
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.062 0.026
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.062 0.055
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.062 0.0425
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.062 0.026
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.062 0.032
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.060 0.062
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.060 0.062
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.060 0.055
RERE RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei 0.056 0.139
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.056 0.049
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.056 0.069
NFIB N/A 0.056 0.096
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.056 0.026
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.055 0.096
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.049
STAT4 STAT4: Signal transducer and activator of transcription 4 0.055 0.097
ZHX3 ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3 0.055 0.0425
PPARG CREB3L2-PPARgamma 0.055 0.049
PGR PGR, NR3C3: Progesterone receptor 0.055 0.049
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.054 0.056
CDK6 CDK6: Cell division protein kinase 6 0.054 0.049
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.054 0.056
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.054 0.114
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.054 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.052 0.083
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.052 0.028
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.052 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.052 0.083
TFAP4 TFAP4: Transcription factor AP-4 0.052 0.075
HES6 HES6: Transcription cofactor HES-6 0.052 0.083
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.052 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.052 0.028
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.052 0.028
ZNF579 ZNF579: Zinc finger protein 579 0.052 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.052 0.075
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.052 0.174
CDC2 CDC2: Cell division control protein 2 homolog 0.052 0.075
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.052 0.152
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.052 0.062
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.052 0.026
WDR1 N/A 0.052 0.026
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.052 0.032
ATF2 N/A 0.051 0.051
ELK3 ELK3, NET, SAP2: ETS domain-containing protein Elk-3 0.051 0.051
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.050 0.050
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.049 0.056
STAT3 0.049 0.148
NR4A1 CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor 0.049 0.044
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.049 0.049
CCNB1 Cyclin B1 0.049 0.088
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.049 33.10
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.049 0.031
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.049 54.60
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.049 0.028
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.049 0.114
SOX11 SOX11: Transcription factor SOX-11 0.049 0.035
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.049 0.110
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.048 0.055
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.048 0.077
MATR3 MATR3, KIAA0723: Matrin-3 0.048 0.032
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.048 0.096
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.048 0.055
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.047 0.075
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.047 0.025
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.047 0.075
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.047 35.90
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.047 35.90
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.047 0.025
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.047 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.047 0.075
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.047 0.025
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.047 0.025
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.075
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.047 0.025
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.047 0.137
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.047 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.047 0.075
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.047 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.047 0.075
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.047 0.075
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.047 0.075
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.047 0.025
MAX MAX: Protein max 0.047 0.075
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.047 0.075
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.047 0.075
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.047 0.025
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.047 0.025
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.046 0.056
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.046 0.029
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.046 0.069
DIAPH1 Diaphanous 1 0.046 0.995
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.046 0.046
WDR44 WDR44: WD repeat-containing protein 44 0.046 0.029
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.046 0.056
COPA COPA: Coatomer subunit alpha 0.046 0.029
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.046 0.874
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.038
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.046 0.029
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.0446 0.123
LYN LYN: Tyrosine-protein kinase Lyn 0.0446 0.136
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0446 0.026
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.0446 0.077
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.0446 0.060
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.044 0.136
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.044 41.40
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.043 0.110
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.043 0.044
MYCN MYCN, NMYC: N-myc proto-oncogene protein 0.043 0.056
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.043 0.139
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.043 0.114
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.043 0.069
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.0425 0.062
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.0425 0.123
PTMA N/A 0.0425 0.039
ARFGAP1 N/A 0.0425 0.096
RBM14 RBM14, SIP: RNA-binding protein 14 0.0425 0.026
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.055
RGS14 N/A 0.0425 0.026
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.041 108.00
GMIP GMIP: GEM-interacting protein 0.040 0.069
PSCD4 PSCD4, CYT4: Cytohesin-4 0.040 0.110
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.040 0.136
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.040 0.069
FLII FLII, FLIL: Protein flightless-1 homolog 0.040 0.029
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.040 0.136
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.040 0.086
STK16 N/A 0.039 0.055
MECP2 MECP2: Methyl-CpG-binding protein 2 0.039 0.052
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.039 0.062
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.039 0.062
PRKAA1 N/A 0.039 0.055
CDKL5 N/A 0.039 0.055
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.038 0.029
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.038 0.114
HDAC4 HDAC4, KIAA0288: Histone deacetylase 4 0.038 0.038
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.038 0.029
COPE COPE: Coatomer subunit epsilon 0.038 0.114
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.038 0.038
FNBP1 N/A 0.038 0.069
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.038 0.056
CUL5 CUL5, VACM1: Cullin-5 0.038 0.029
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.038 0.038
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.038 0.225
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.038 1.59
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.037 0.191
MVP MVP, LRP: Major vault protein 0.036 0.032
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.036 0.062
LIMS1 N/A 0.036 0.026
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.036 0.075
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.035 0.049
MTA1 MTA1: Metastasis-associated protein MTA1 0.035 0.056
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.035 0.049
CDK2 CDK2: Cell division protein kinase 2 0.035 2.30
CDK5 CDK5: Cell division protein kinase 5 0.035 0.139
CDK4 CDK4: Cell division protein kinase 4 0.035 0.049
CDK7 CDK7, MO15: Cell division protein kinase 7 0.035 0.049
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.035 0.049
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.035 0.139
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.035 10.80
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.034 0.062
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.034 0.077
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.034 0.077
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.033 0.038
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.033 41.40
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.033 65.60
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.032 0.062
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.032 0.026
GTF3C1 N/A 0.032 0.0425
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.062
TOP2B N/A 0.032 0.026
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.032 0.032
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.032 0.032
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.032 0.136
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.032 0.043
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.032 0.110
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.032 82.20
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.032 0.046
ACTG1 ACTB: Actin, cytoplasmic 1 0.032 0.029
VAV1 VAV1, VAV: Proto-oncogene vav 0.032 0.110
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.031 0.109
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.031 0.114
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.031 0.109
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.031 0.049
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.031 0.114
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.0308 0.114
HES1 HES1, HL, HRY: Transcription factor HES-1 0.0308 0.049
DYRK3 N/A 0.0308 0.049
SALL1 SALL1, SAL1: Sal-like protein 1 0.0308 0.029
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.0308 0.049
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.0308 0.044
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.0308 0.069
MYF5 MYF5: Myogenic factor 5 0.0308 0.044
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.0308 0.050
PPP1R8 N/A 0.029 0.035
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.029 0.069
SOS1 SOS1: Son of sevenless homolog 1 0.029 0.110
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.029 30.70
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.029 0.225
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.029 0.056
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.029 0.028
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.049
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.029 0.038
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.029 0.029
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.029 0.029
ZFYVE16 ZFYVE16, KIAA0305: Zinc finger FYVE domain-containing protein 16 0.029 0.038
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.029 0.029
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.029 0.069
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.029 0.136
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.029 0.102
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.029 0.044
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
BID BID: BH3-interacting domain death agonist 0.028 0.165
NES N/A 0.028 0.025
FLJ23436 N/A 0.028 0.025
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
MAPKAPK5 N/A 0.028 0.083
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
C13orf8 N/A 0.028 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
PPEF1 N/A 0.028 0.028
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.083
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
CABLES1 N/A 0.028 0.028
ZNF265 N/A 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
IRF7 N/A 0.028 0.028
RAB4A N/A 0.028 0.052
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.083
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
HDAC8 N/A 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.083
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.028 0.075
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
SNRPB N/A 0.028 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.028 0.148
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
CORO6 N/A 0.028 0.028
PHLDB2 N/A 0.028 0.028
KIF1B N/A 0.028 0.028
DUSP15 N/A 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
WDR54 N/A 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.083
HDAC7A N/A 0.028 0.025
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.028 0.049
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.028 0.050
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.028 0.086
MYO3A MYO3A: Myosin IIIA 0.028 0.044
HAND1 HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1 0.028 0.049
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.028 0.086
RGS7 RGS7: Regulator of G-protein signaling 7 0.0273 0.036
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.027 0.098
SPIC SPIC: Transcription factor Spi-C 0.027 0.027
CREM hCREM-1: HCREM 1alpha protein 0.027 0.027
CREM CREM, RP11-324I22.1-005: cAMP responsive element modulator 0.027 0.027
HSFY1 HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked 0.027 0.027
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.027 0.152
ZYX ZYX: Zyxin 0.027 0.032
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.027 0.052
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.027 0.077
DNM2 N/A 0.027 0.032
FLNA FLNA, FLN, FLN1: Filamin-A 0.027 0.032
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.027 0.077
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.026 0.372
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.026 0.049
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.026 1.98
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.026 0.109
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.026 0.152
MDM4 MDM4, MDMX: Mdm4 protein 0.026 0.049
SMARCC2 N/A 0.026 0.0425
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.026 0.077
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.026 0.026
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.026 0.0425
TCF7L2 N/A 0.026 0.032
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.026 0.032
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.0253 0.033
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.047
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.075
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
KCTD1 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.075
GIT2 N/A 0.025 0.075
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
CAMKK1 N/A 0.025 0.025
GRK6 N/A 0.025 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 33.30
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.025
SEC13L1 N/A 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
TCEA1 N/A 0.025 0.025
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.047
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.025
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.137
CAMK2A N/A 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
MAP2K3 N/A 0.025 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.025
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.025
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
MAPK8IP3 N/A 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.025
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.148
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.025
RNF20 0.025 0.025
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
BCOR N/A 0.025 0.025
HTATIP N/A 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.075
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
PRKCB1 N/A 0.025 0.025
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 33.30
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.025
ELMO1 N/A 0.025 0.148
SON 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 33.30
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
NIPBL N/A 0.025 0.025
NUP98 N/A 0.025 0.025
ATXN2L N/A 0.025 0.025
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.025
C20orf77 N/A 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.025
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.025
0.572
Total Score 31.20