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Evidence of Interaction Between WDR53 and H2AFZ

The interaction score between WDR53 and H2AFZ is 0.978.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in WDR53 and H2AFZ:
Domains in WDR53Domains in H2AFZ
IPR001680 G-protein beta WD-40 repeat
IPR007125 Histone core
IPR002119 Histone H2A
IPR007124 Histone-fold/TFIID-TAF/NF-Y

The Chi square scores for co-occurrence of domains that are present in WDR53 and H2AFZ are listed below.

Domain 1Domain 2Chi Square
IPR001680 G-protein beta WD-40 repeat IPR007124 Histone-fold/TFIID-TAF/NF-Y 5.81512
IPR001680 G-protein beta WD-40 repeat IPR007125 Histone core 4.13382

The background colour of the table refers to:

  • Blue Domain is only present in WDR53
  • Yellow Domain is only present in H2AFZ
  • Green Domain is present in both WDR53 and H2AFZ

 8.18E-3
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction

Protein: H2AFZ

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between WDR53 and H2AFZ that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between WDR53 andH2AFZ. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , WDR53 has 58 interactors and H2AFZ has 246 interactors of which there are 30 common interactors.

Common InteractorName of Common InteractorScore for WDR53-Interactor (?)Score for H2AFZ-Interactor (?)
HIST1H2AB N/A 0.027 1.46
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.027 1.46
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.027 1.27
HIST1H2BB HIST1H2BB, H2BFF: Histone H2B type 1-B 0.027 1.27
HIST2H2BE HIST2H2BE, H2BFQ: Histone H2B type 2-E 0.027 3.75
HIST1H2BJ HIST1H2BJ, H2BFR: Histone H2B type 1-J 0.027 1.17
CENPA CENPA: Histone H3-like centromeric protein A 0.027 0.137
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.027 11.70
SF3B3 N/A 0.027 0.263
TAF4 TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135: Transcription initiation factor 0.027 0.060
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 0.027 0.060
DR1 DR1: TATA-binding protein-associated phosphoprotein 0.027 0.044
H2AFX H2AFX, H2AX: Histone H2A.x 0.027 32.60
H2BFS H2BFS: Histone H2B type F-S 0.027 1.46
SOS1 SOS1: Son of sevenless homolog 1 0.027 0.028
TAF11 TAF11, TAF2I, PRO2134: Transcription initiation factor TFIID subunit 11 0.027 0.060
HIST1H2AD HIST1H2AD, H2AFG: Histone H2A type 1-D 0.027 0.027
HIST1H2BD HIST1H2BD, H2BFB, HIRIP2: Histone H2B type 1-D 0.027 1.17
SOS2 SOS2: Son of sevenless homolog 2 0.027 0.028
TAF12 TAF12, TAF15, TAF2J, TAFII20: Transcription initiation factor TFIID subunit 12 0.027 0.044
HIST1H2BO HIST1H2BO, H2BFH, H2BFN: Histone H2B type 1-O 0.027 4.16
HIST1H2BG HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2B 0.027 7.31
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.027 0.074
TAF9 TAF9, TAF2G, TAFII31: Transcription initiation factor TFIID subunit 9 0.027 0.074
DDB1 DDB1, XAP1: DNA damage-binding protein 1 0.027 0.036
HIST1H2BK HIST1H2BK, H2BFT, HIRIP1: Histone H2B type 1-K 0.027 1.93
NFYB NFYB, HAP3: Nuclear transcription factor Y subunit beta 0.027 0.044
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 0.027 0.044
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.027 0.060
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.027 0.950
0.299
Total Score 0.978