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Evidence of Interaction Between APS and ITGB4

The interaction score between APS and ITGB4 is 6.52.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between APS and ITGB4 = -0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in APS and ITGB4:
Domains in APSDomains in ITGB4
IPR001849 Pleckstrin-like
IPR000980 SH2 motif
IPR011993 PH_type.
IPR006209 EGF-like domain
IPR003961 Fibronectin, type III
IPR003962 Fibronectin, type III subdomain
IPR003644 Na-Ca exchanger/integrin-beta4
IPR001169 Integrin beta, C-terminal
IPR002369 Integrin, beta chain
IPR012896 Integrin_B_tail.
IPR012013 Integrin_B4.

The Chi square scores for co-occurrence of domains that are present in APS and ITGB4 are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR003961 Fibronectin, type III 184.508
IPR000980 SH2 motif IPR006209 EGF-like domain 19.373
IPR001849 Pleckstrin-like IPR006209 EGF-like domain 16.9121
IPR001849 Pleckstrin-like IPR003961 Fibronectin, type III 7.30258
IPR011993 PH_type. IPR006209 EGF-like domain 5.24203
IPR011993 PH_type. IPR003961 Fibronectin, type III 3.27464
IPR011993 PH_type. IPR003962 Fibronectin, type III subdomain 0.197385
IPR000980 SH2 motif IPR003962 Fibronectin, type III subdomain 0.00533797
IPR001849 Pleckstrin-like IPR003962 Fibronectin, type III subdomain 0.000483792

The background colour of the table refers to:

  • Blue Domain is only present in APS
  • Yellow Domain is only present in ITGB4
  • Green Domain is present in both APS and ITGB4

 0.109
Post-translational Modifications

Protein: APS

PTMResidueReference
Phosphorylation 598 PubMed, HPRD
Phosphotyrosine 629 HPRD

Protein: ITGB4

PTMResidueReference
N-linked 695 PubMed, HPRD
Proteolytic Cleavage 134 PubMed, HPRD
Proteolytic Cleavage 444 PubMed, HPRD
Localisation

Protein: APS

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD

Protein: ITGB4

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between APS and ITGB4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between APS andITGB4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , APS has 1316 interactors and ITGB4 has 1218 interactors of which there are 657 common interactors.

Common InteractorName of Common InteractorScore for APS-Interactor (?)Score for ITGB4-Interactor (?)
CSK CSK: Tyrosine-protein kinase CSK 2.94 0.065
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 2.17 0.065
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 1.78 0.065
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 1.78 0.072
LYN LYN: Tyrosine-protein kinase Lyn 1.50 0.072
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 1.50 0.081
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.50 0.072
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 1.35 0.072
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.30 0.044
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.30 0.044
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.20 0.072
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.17 0.109
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.17 0.109
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 1.17 0.109
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 1.13 0.251
SYK SYK: Tyrosine-protein kinase SYK 1.07 0.072
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.980 0.165
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.980 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.980 0.165
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.975 0.072
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.975 0.065
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.975 0.340
BMX N/A 0.975 0.065
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.902 0.109
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.878 0.165
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.878 0.165
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.878 0.165
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.878 0.165
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.874 0.081
HCK N/A 0.874 0.072
JAK1 0.874 0.072
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.874 0.065
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.872 0.166
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.808 0.109
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.808 0.123
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.808 0.152
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.808 0.109
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.770 0.072
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.770 0.072
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.770 0.0407
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.770 0.072
MET MET: Hepatocyte growth factor receptor precursor 0.731 0.416
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.655 0.033
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.655 0.109
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.655 0.251
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.655 0.123
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.655 0.109
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.655 0.191
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.655 0.085
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.655 0.123
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.617 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.617 0.051
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.586 0.109
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.581 0.109
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.581 0.109
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.577 0.064
INSR INSR: Insulin receptor precursor 0.577 0.123
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.577 0.109
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.577 0.515
KIT KIT: Mast/stem cell growth factor receptor precursor 0.577 0.109
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.561 0.109
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.561 0.109
FLT4 VEGFR3 long form 0.553 0.051
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.520 0.109
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.515 0.065
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.484 0.044
ALK ALK: ALK tyrosine kinase receptor precursor 0.445 0.072
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.416 0.029
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.307 0.072
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.275 0.037
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.275 0.037
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.274 0.109
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.274 0.109
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.274 0.109
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.027
ROCK1 ROCK1: Rho-associated protein kinase 1 0.251 0.072
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.251 0.072
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.251 0.072
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.251 0.072
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.225 0.065
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.225 0.0453
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.225 0.032
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.225 0.072
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.225 0.065
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.225 0.072
CXorf9 N/A 0.225 0.065
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.225 0.062
FNBP1 N/A 0.225 0.065
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.225 0.126
FGFR2 N/A 0.217 0.027
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.202 0.098
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.202 0.098
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.195 0.027
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.191 0.0453
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.191 0.037
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.191 0.065
GAB1 GAB1: GRB2-associated-binding protein 1 0.191 0.065
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.191 0.026
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.191 0.029
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.191 0.0453
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.191 0.032
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.191 0.037
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.171 0.081
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.081
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.171 0.100
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.171 0.029
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.171 0.033
CD2AP CD2AP: CD2-associated protein 0.171 0.029
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.171 0.029
PLD1 PLD1: Phospholipase D1 0.171 0.072
VIL2 N/A 0.171 0.126
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.081
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.171 0.100
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.171 0.081
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.171 0.065
VAV1 VAV1, VAV: Proto-oncogene vav 0.171 0.065
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.171 0.100
TLN1 TLN1: Uncharacterized protein TLN1 0.171 0.029
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.171 0.065
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.171 0.065
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.171 0.081
STAT6 STAT6: Signal transducer and activator of transcription 6 0.171 0.072
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.171 0.072
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.171 0.049
WEE1 WEE1: Wee1-like protein kinase 0.171 0.037
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.171 0.037
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.166 0.098
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.166 0.109
PLEK PLEK, P47: Pleckstrin 0.166 0.041
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.166 0.098
PSCD2 N/A 0.165 0.109
AMPH AMPH, AMPH1: Amphiphysin 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.049
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.044
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.049
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.165 0.049
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.165 0.049
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.049
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
NF2 NF2, SCH: Merlin 0.165 0.109
MAPK15 N/A 0.165 0.109
STAT3 0.165 0.044
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.165 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.049
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.044
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.049
EEF2K EEF2K: Elongation factor 2 kinase 0.165 0.049
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.165 0.049
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.165 0.044
CDC2 CDC2: Cell division control protein 2 homolog 0.165 0.049
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
MAPKAPK5 N/A 0.165 0.049
MCF2 MCF2, DBL: Proto-oncogene DBL 0.152 0.029
STK16 N/A 0.152 0.0407
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.152 0.072
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.152 0.072
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.152 0.032
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.152 0.037
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.152 0.072
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.152 0.072
VASP VASP: Vasodilator-stimulated phosphoprotein 0.152 0.081
DAPK2 DAPK2: Death-associated protein kinase 2 0.152 0.037
GRLF1 N/A 0.152 0.032
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.152 0.029
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.148 0.123
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.148 0.109
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.148 0.049
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.148 0.044
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.109
ELMO1 N/A 0.148 0.109
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.148 0.109
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.148 0.109
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.148 0.049
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.109
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.109
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.109
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.109
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.148 0.109
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.109
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.148 0.083
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.109
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.148 0.049
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.049
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.148 0.109
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.148 0.109
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.049
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.148 0.049
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.148 0.049
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.148 0.049
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.148 0.049
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.148 0.049
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.148 0.044
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.109
ARHGEF7 N/A 0.148 0.109
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.136 0.100
PLD2 PLD2: Phospholipase D2 0.136 0.081
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.136 0.032
CDK7 CDK7, MO15: Cell division protein kinase 7 0.136 0.057
STK10 STK10: Uncharacterized protein STK10 0.136 0.032
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.136 0.026
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.136 0.032
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.136 0.037
CDK4 CDK4: Cell division protein kinase 4 0.136 0.037
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.136 0.032
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.136 0.037
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.136 0.032
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.136 0.032
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.136 0.057
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.136 0.037
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.136 0.032
DOK1 DOK1: Docking protein 1 0.136 0.072
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.136 0.0453
PSCD4 PSCD4, CYT4: Cytohesin-4 0.136 0.065
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.136 0.029
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.136 0.081
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.136 0.123
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.136 0.029
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.136 0.037
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.136 0.029
RPS6KB1 N/A 0.136 0.072
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.136 0.062
CDK2 CDK2: Cell division protein kinase 2 0.136 0.037
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.136 0.032
CRKL CRKL: Crk-like protein 0.136 0.081
CDK5 CDK5: Cell division protein kinase 5 0.136 0.032
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.136 0.072
CRLF3 N/A 0.126 0.033
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.126 0.098
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.126 0.109
IL9R IL9R: Interleukin-9 receptor precursor 0.126 0.109
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.126 0.098
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.126 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.126 0.045
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.126 0.123
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.126 0.098
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.126 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.123 0.029
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.123 0.065
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.123 0.081
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.123 0.029
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.123 0.032
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.123 0.026
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.123 0.037
IRS1 IRS1: Insulin receptor substrate 1 0.123 0.166
SPTAN1 N/A 0.123 0.081
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.123 0.065
GAB2 N/A 0.123 0.029
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.114 0.029
MDN1 MDN1, KIAA0301: Midasin 0.114 0.029
ITGB7 ITGB7: Integrin beta-7 precursor 0.113 0.098
TTN N/A 0.110 0.081
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.110 0.091
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.110 0.081
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.110 0.065
PSD TYL: TYL protein 0.110 0.065
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.110 0.032
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.110 0.072
RIN1 RIN1: Ras and Rab interactor 1 0.110 0.0407
DAB1 DAB1: Disabled homolog 1 0.110 0.072
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.110 0.033
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.110 0.0453
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.110 0.037
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.110 0.072
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.110 0.032
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.110 0.037
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.110 0.0453
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.110 0.032
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.110 0.032
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.110 0.029
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.110 0.081
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.110 0.029
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.110 0.072
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.110 0.100
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.110 0.081
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.110 0.072
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.110 0.081
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.110 0.029
SORBS3 SORBS3, SCAM1: Vinexin 0.110 0.100
STAM2 STAM2: Signal transducing adapter molecule 2 0.110 0.072
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.110 0.081
TLN2 TLN2: Uncharacterized protein TLN2 0.110 0.072
RASA3 RASA3: Ras GTPase-activating protein 3 0.110 0.029
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.110 0.032
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.110 0.166
ATM ATM: Serine-protein kinase ATM 0.110 0.029
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.110 0.072
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.110 0.055
MSN MSN: Moesin 0.110 0.081
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.110 0.065
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.110 0.032
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.110 0.032
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.110 0.037
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.110 0.057
MYO3A MYO3A: Myosin IIIA 0.110 0.032
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.110 0.072
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.110 0.081
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.110 0.029
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.109 0.028
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.109 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.109 0.028
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.109 0.165
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.109 0.165
NULL A1BG: Alpha-1B-glycoprotein precursor 0.109 0.165
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.165
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.109 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.109 0.028
KIR3DL1 N/A 0.109 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.109 0.028
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.109 0.083
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.109 0.165
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.109 0.165
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.109 0.165
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.109 0.056
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.056
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.109 0.165
FN1 N/A 0.109 0.165
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.165
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.109 0.032
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.109 0.057
PRKAA1 N/A 0.109 0.032
IRS2 IRS2: Insulin receptor substrate 2 0.109 0.081
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.109 0.032
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.109 0.032
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.109 0.029
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.109 0.081
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.100 0.123
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.100 0.051
GHR GHR: Growth hormone receptor precursor 0.100 0.109
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.100 0.123
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.100 0.098
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.100 0.033
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.100 0.109
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.100 0.123
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.100 0.109
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.100 0.025
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.100 0.109
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.100 0.109
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.100 0.098
SORL1 SORL1: Sortilin-related receptor precursor 0.100 0.109
PVR PVR, PVS: Poliovirus receptor precursor 0.100 0.152
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.100 0.109
LILRB1 N/A 0.100 0.037
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.098 0.072
CNN3 CNN3: Calponin-3 0.098 0.057
CTTN CTTN, EMS1: Src substrate cortactin 0.098 0.126
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.098 0.165
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.098 0.034
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.098 0.034
CNTN4 CNTN4: Contactin-4 precursor 0.098 0.165
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.165
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.098 0.028
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.098 0.0688
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.165
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.165
ATRN N/A 0.098 0.165
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.098 0.0688
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.098 0.0688
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.098 0.0688
CNTN1 CNTN1: Contactin-1 precursor 0.098 0.165
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.098 0.083
APP APP, A4, AD1: Amyloid beta A4 protein precursor 0.098 0.165
BSG N/A 0.098 0.165
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.097 0.032
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.100
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.072
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.097 0.037
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.097 0.065
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.097 0.072
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.097 0.126
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.097 0.072
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.097 0.032
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.097 0.081
PMP2 PMP2: Myelin P2 protein 0.097 0.0453
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.097 0.100
FUBP1 N/A 0.096 0.029
ITGAE ITGAE: Integrin alpha-E precursor 0.091 0.109
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.090 0.055
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.090 0.109
SOS1 SOS1: Son of sevenless homolog 1 0.090 0.045
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.090 0.0416
NEO1 NEO1, NGN: Neogenin precursor 0.090 0.152
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.090 0.045
DCC DCC: Netrin receptor DCC precursor 0.090 0.109
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.090 0.062
RDX RDX: Radixin 0.088 0.100
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.088 0.072
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.088 0.032
LCP1 LCP1, PLS2: Plastin-2 0.086 0.029
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.081 0.098
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.081 0.109
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.081 0.109
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.081 0.109
TP73 TP73, P73: Tumor protein p73 0.081 0.045
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.081 0.109
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.081 0.098
ETS2 ETS2: Protein C-ets-2 0.081 0.0794
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.081 0.123
GPA33 GPA33: Cell surface A33 antigen precursor 0.081 0.109
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.081 0.064
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.081 0.109
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.081 0.049
PRLR PRLR: Prolactin receptor precursor 0.081 0.123
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.081 0.109
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.080 0.032
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.077 0.029
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.075 0.109
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.049
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.073 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.073 0.045
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.073 0.109
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.073 0.123
PTPRZ1 N/A 0.073 0.109
STAT4 STAT4: Signal transducer and activator of transcription 4 0.072 0.045
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.072 0.041
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.072 0.123
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.072 0.123
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.072 0.123
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.072 0.214
CD7 CD7: T-cell antigen CD7 precursor 0.072 0.109
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.072 0.191
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.072 0.109
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.072 0.152
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.072 0.098
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.072 0.109
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.072 0.077
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.072 0.123
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.072 0.109
EGF EGF: Pro-epidermal growth factor precursor 0.072 0.123
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.072 0.109
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.072 0.416
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.072 0.109
CIITA CIITA, MHC2TA: MHC class II transactivator 0.070 0.032
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.069 0.037
GMIP GMIP: GEM-interacting protein 0.069 0.032
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.0688 0.109
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.0688 0.109
F3 F3: Tissue factor precursor 0.065 0.852
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.065 0.055
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.065 0.051
EPOR EPOR: Erythropoietin receptor precursor 0.065 0.109
SCML2 SCML2: Sex comb on midleg-like protein 2 0.065 0.045
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.065 0.063
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.065 0.055
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.064 0.152
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.064 0.109
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.064 0.152
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.064 0.045
APLP2 APLP2, APPL2: Amyloid-like protein 2 precursor 0.064 0.152
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.064 0.109
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.064 0.055
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.064 0.109
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.123
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.063 0.072
CENTA1 CENTA1: Centaurin-alpha 1 0.063 0.051
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.062 0.109
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.060 0.037
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.109
TNC TNC, HXB: Tenascin precursor 0.058 0.191
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.057 0.072
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.057 0.032
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.057 0.072
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.057 0.055
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.056 0.049
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.056 0.032
WWC1 WWC1, KIAA0869: WW domain-containing protein 1 0.056 0.057
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.056 0.0407
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.056 0.037
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.053 0.030
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.052 0.049
S100A16 S100A16, AAG13: Protein S100-A16 0.052 0.049
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
NULL Ig lambda chain V-II region NEI 0.051 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-68 alpha chain precursor 0.051 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-27 alpha chain precursor 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
IGHM N/A 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
HLA-DRA HLA-DRA, HLA-DRA1: HLA class II histocompatibility antigen, DR alpha chain precu 0.051 0.051
HLA-DQB1 HLA-DQB1: HLA class II histocompatibility antigen, DQB1*0602 beta chain precurso 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
TRB@ TCRB: T-cell receptor beta chain V region CTL-L17 precursor 0.051 0.051
IGHA2 IGHA2: Ig alpha-2 chain C region 0.051 0.051
NULL Ig heavy chain V-III region WEA 0.051 0.051
NULL TCRA: T-cell receptor alpha chain V region CTL-L17 precursor 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
HLA-DRB2 HLA class II histocompatibility antigen, DW2.2/DR2.2 beta chain (Fragment) 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
IGHG1 N/A 0.051 0.051
IGHE IGHE: Ig epsilon chain C region 0.051 0.051
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
IGHG3 N/A 0.051 0.051
ITGB1 ITGB1, FNRB, MDF2, MSK12: Integrin beta-1 precursor 0.051 0.051
FCGR2A FCGR2A, CD32, FCG2, FCGR2A1, IGFR2: Low affinity immunoglobulin gamma Fc region 0.051 0.051
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
IGHD N/A 0.051 0.051
IGHA1 N/A 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
GRB10 N/A 0.051 0.051
HLA-A N/A 0.051 0.051
NULL Ig kappa chain V-I region CAR 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.051 0.340
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.051 0.100
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.051 0.123
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.051 0.191
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.044
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.050 0.057
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.049 0.083
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.049 0.165
MUCDHL MUPCDH, MUCDHL, UNQ2781/PRO7168: Mucin and cadherin-like protein precursor 0.049 0.028
DLK1 DLK1, DLK: Delta-like protein precursor 0.049 0.165
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.165
CDH6 CDH6: Cadherin-6 precursor 0.049 0.083
DRD2 DRD2: D(2) dopamine receptor 0.049 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.083
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
TMPRSS9 N/A 0.049 0.165
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.049 0.072
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.048 0.100
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.0338
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.047 0.049
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.046 0.032
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.051
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.051
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.046 0.051
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.046 0.081
DLG2 DLG2: Disks large homolog 2 0.046 0.029
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.046 0.072
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.046 0.100
NOTCH4 N/A 0.0453 0.109
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.0453 0.098
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.0453 0.049
CSPG2 N/A 0.045 0.072
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.045 0.072
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.045 0.100
ACTN1 ACTN1: Alpha-actinin-1 0.044 0.0286
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.044 0.0446
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.083
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.028
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.044 0.028
JAG2 JAG2: Jagged-2 precursor 0.044 0.165
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.028
TNN TNN: Tenascin-N precursor 0.042 0.030
EGFL4 MEGF8, C19orf49, EGFL4, KIAA0817: Multiple epidermal growth factor-like domains 0.042 0.038
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.0416 0.033
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.041 0.166
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.041 0.100
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.041 0.072
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.041 0.100
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.041 0.032
MEP1B MEP1B: Meprin A subunit beta precursor 0.041 0.109
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.041 0.123
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.041 0.077
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.041 0.109
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.081
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.041 0.072
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.041 0.029
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.039 0.032
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.039 0.032
S100A7 S100A7, PSOR1: Protein S100-A7 0.039 0.037
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.038 0.0338
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.037 0.051
FADD FADD, MORT1: Protein FADD 0.037 0.026
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.037 0.416
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.037 0.055
LYPD3 LYPD3, C4.4A, UNQ491/PRO1007: Ly6/PLAUR domain-containing protein 3 precursor 0.037 0.096
DSG3 DSG3: Desmoglein-3 precursor 0.037 0.0425
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.037 0.109
DSC2 DSC2, DSC3: Desmocollin-2 precursor 0.037 0.032
CDH17 CDH17: Cadherin-17 precursor 0.037 0.026
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.037 0.109
DSG2 DSG2: Desmoglein-2 precursor 0.037 0.087
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.037 0.072
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.037 0.081
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.037 0.081
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.036 0.028
CETN1 CETN1, CEN1, CETN: Centrin-1 0.036 0.034
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.035 0.032
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.035 0.036
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.035 0.0446
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.034 0.091
S100B S100B: Protein S100-B 0.034 0.0453
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.0338 0.038
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.0338
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.0688
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.034 0.109
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.049
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.062
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.033 0.032
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.033 0.152
TSHR N/A 0.033 0.055
MEP1A MEP1A: Meprin A subunit alpha precursor 0.033 0.152
LDLR LDLR: Low-density lipoprotein receptor precursor 0.033 0.251
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.033 0.127
SELE SELE, ELAM1: E-selectin precursor 0.032 0.109
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.032 0.109
CD44 N/A 0.032 0.152
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.109
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.032 0.191
UMOD UMOD: Uromodulin precursor 0.032 0.109
AREG AREG, SDGF: Amphiregulin precursor 0.032 1.81
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.032 0.026
SPINT2 SPINT2, HAI2, KOP: Kunitz-type protease inhibitor 2 precursor 0.032 0.416
CDH5 CDH5: Cadherin-5 precursor 0.032 0.077
CDH13 CDH13, CDHH: Cadherin-13 precursor 0.032 0.026
CD82 CD82, KAI1, SAR2, ST6, TSPAN27: CD82 antigen 0.032 0.062
MUC2 MUC2, SMUC: Mucin-2 precursor 0.031 0.072
MYL3 MYL3: Myosin light polypeptide 3 0.0308 0.032
BMP1 N/A 0.030 0.109
F7 F7: Coagulation factor VII precursor 0.030 0.096
PLAT PLAT: Tissue-type plasminogen activator precursor 0.030 0.109
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.030 0.055
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.030 0.049
CDH2 CDH2, CDHN, NCAD: Cadherin-2 precursor 0.029 0.049
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.029 0.251
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 0.029 0.109
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.029 0.062
F10 F10: Coagulation factor X precursor 0.029 0.115
HPN HPN, TMPRSS1: Serine protease hepsin 0.029 0.109
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.029 0.029
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.029 0.037
THOP1 THOP1: Thimet oligopeptidase 0.029 0.072
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.028 0.109
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.028 0.032
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
YAP1 YAP1, YAP65: 65 kDa Yes-associated protein 0.0263 0.063
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.0263 0.032
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.0263 0.026
ANXA3 ANXA3, ANX3: Annexin A3 0.0263 0.025
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.026 0.049
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.026 0.109
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.026 0.055
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.026 0.032
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.026 0.081
PKP3 PKP3: Plakophilin-3 0.026 0.0446
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.026 0.032
RYR1 0.025 0.025
RYR2 RYR2: Ryanodine receptor 2 0.025 0.025
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.049
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.049
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.109
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.049
0.228
Total Score 6.52