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Evidence of Interaction Between ID3 and ASCL3

The interaction score between ID3 and ASCL3 is 24.10.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in ID3 and ASCL3:
Domains in ID3Domains in ASCL3
IPR001092 Basic helix-loop-helix dimerization domain bHLH
IPR011598 HLH_DNA_bd.
IPR001092 Basic helix-loop-helix dimerization domain bHLH

The Chi square scores for co-occurrence of domains that are present in ID3 and ASCL3 are listed below.

Domain 1Domain 2Chi Square
IPR001092 Basic helix-loop-helix dimerization domain bHLH IPR001092 Basic helix-loop-helix dimerization domain bHLH 587.923
IPR011598 HLH_DNA_bd. IPR001092 Basic helix-loop-helix dimerization domain bHLH 543.5

The background colour of the table refers to:

  • Blue Domain is only present in ID3
  • Yellow Domain is only present in ASCL3
  • Green Domain is present in both ID3 and ASCL3

 0.265
Post-translational Modifications

Protein: ID3

PTMResidueReference
Phosphorylation 5 PubMed, HPRD

Protein: ASCL3

PTMResidueReference
Localisation

Protein: ID3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: ASCL3

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between ID3 and ASCL3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between ID3 andASCL3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , ID3 has 796 interactors and ASCL3 has 120 interactors of which there are 109 common interactors.

Common InteractorName of Common InteractorScore for ID3-Interactor (?)Score for ASCL3-Interactor (?)
HES1 HES1, HL, HRY: Transcription factor HES-1 1.98 0.237
HAND1 HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1 1.50 0.237
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 1.30 0.237
MAX MAX: Protein max 1.30 0.237
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 1.30 0.237
TFAP4 TFAP4: Transcription factor AP-4 1.30 0.237
HES6 HES6: Transcription cofactor HES-6 1.30 0.265
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 1.30 0.265
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 1.30 0.237
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 1.20 0.237
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 1.20 0.237
AHR AHR: Aryl hydrocarbon receptor precursor 1.20 0.237
ID2 ID2: DNA-binding protein inhibitor ID-2 0.859 0.265
MYF5 MYF5: Myogenic factor 5 0.859 0.237
MYCN MYCN, NMYC: N-myc proto-oncogene protein 0.859 0.237
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.859 0.237
ID1 ID1, ID: DNA-binding protein inhibitor ID-1 0.824 0.265
ID4 ID4: DNA-binding protein inhibitor ID-4 0.666 0.265
MITF N/A 0.617 0.0258
MYC myc proto-oncogene protein 0.617 0.0258
TCF12 TCF12, HEB, HTF4: Transcription factor 12 0.305 0.265
TCF21 TCF21, POD1: Transcription factor 21 0.305 0.265
EPAS1 EPAS1, HIF2A, MOP2: Endothelial PAS domain-containing protein 1 0.305 0.237
OLIG3 OLIG3, BHLHB7: Oligodendrocyte transcription factor 3 0.265 0.265
SIRT7 SIRT7, SIR2L7: NAD-dependent deacetylase sirtuin-7 0.265 0.237
OLIG1 OLIG1: Oligodendrocyte transcription factor 1 0.265 0.265
TWIST2 TWIST2, DERMO1: Twist-related protein 2 0.265 0.265
HES4 HES4: Transcription factor HES-4 0.265 0.237
MLX MLX, TCFL4: Max-like protein X 0.265 0.237
SIM2 SIM2: Single-minded homolog 2 0.265 0.237
USF1 USF1, USF: Upstream stimulatory factor 1 0.265 0.237
NEUROD2 NEUROD2, NDRF: Neurogenic differentiation factor 2 0.265 0.237
USF2 USF2: Upstream stimulatory factor 2 0.265 0.237
BHLHB8 BHLHB8, MIST1: Class B basic helix-loop-helix protein 8 0.265 0.265
TFEB TFEB: Transcription factor EB 0.244 0.237
BHLHB3 BHLHB3, DEC2, SHARP1: Class B basic helix-loop-helix protein 3 0.244 0.265
MXD4 MXD4, MAD4: Max-interacting transcriptional repressor MAD4 0.244 0.265
MLXIP MLXIP, KIAA0867, MIR: MLX-interacting protein 0.244 0.237
ATOH1 ATOH1, ATH1: Protein atonal homolog 1 0.244 0.237
HEY1 CDNA FLJ35118 fis, clone PLACE6007436, highly similar to Homo sapiens hairy and 0.244 0.237
TCF15 TCF15, BHLHEC2: Transcription factor 15 0.197 0.237
ASCL1 ASCL1, ASH1: Achaete-scute homolog 1 0.197 0.237
TWIST1 TWIST1, TWIST: Twist-related protein 1 0.197 0.237
NEUROG2 NEUROG2, ATOH4, NGN2: Neurogenin-2 0.197 0.237
CLOCK CLOCK, KIAA0334: Circadian locomoter output cycles protein kaput 0.197 0.237
MNT MNT, ROX: Max-binding protein MNT 0.197 0.265
NPAS1 NPAS1, MOP5: Neuronal PAS domain-containing protein 1 0.197 0.237
NEUROG1 NEUROG1, NEUROD3, NGN, NGN1: Neurogenin-1 0.197 0.237
NEUROD4 NEUROD4, ATOH3: Neurogenic differentiation factor 4 0.197 0.237
TCF4 TCF4, ITF2, SEF2: Transcription factor 4 0.197 0.265
ARNT2 ARNT2, KIAA0307: Aryl hydrocarbon receptor nuclear translocator 2 0.176 0.265
MYF6 MYF6: Myogenic factor 6 0.174 0.237
ASCL2 ASCL2: Achaete-scute homolog 2 0.174 0.237
NHLH1 NHLH1, HEN1: Helix-loop-helix protein 1 0.174 0.237
BHLHB2 BHLHB2, DEC1, SHARP2, STRA13: Class B basic helix-loop-helix protein 2 0.174 0.265
TFEC TFEC, Tfec, tcag7.74: TFEC isoform 0.174 0.237
NHLH2 NHLH2, HEN2: Helix-loop-helix protein 2 0.174 0.237
LYL1 LYL1: Protein lyl-1 0.174 0.237
SIM2 N/A 0.174 0.265
NCOA2 NCOA2, TIF2: Nuclear receptor coactivator 2 0.174 0.237
HAND2 HAND2, DHAND: Heart- and neural crest derivatives-expressed protein 2 0.174 0.237
NEUROD1 NEUROD1, NEUROD: Neurogenic differentiation factor 1 0.157 0.237
NEUROD6 NEUROD6, ATOH2, My051: Neurogenic differentiation factor 6 0.157 0.237
OLIG2 OLIG2, BHLHB1, PRKCBP2, RACK17: Oligodendrocyte transcription factor 2 0.157 0.237
MXD1 MXD1, MAD: MAD protein 0.157 0.237
MYOG MYOG, MYF4: Myogenin 0.157 0.237
PER3 PER3, GIG13: Period circadian protein homolog 3 0.152 0.027
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.152 0.027
MEF2A N/A 0.123 0.027
SP100 N/A 0.123 0.027
PER2 PER2, KIAA0347: Period circadian protein homolog 2 0.123 0.027
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.109 0.027
GM632 SOX18: Transcription factor SOX-18 0.041 0.027
MEF2B MEF2B, XMEF2: Myocyte-specific enhancer factor 2B 0.041 0.027
PER1 PER1, KIAA0482, PER, RIGUI: Period circadian protein homolog 1 0.0308 0.027
HMG20B HMG20B, BRAF35, HMGX2, SMARCE1R: SWI/SNF-related matrix-associated actin-depende 0.0308 0.027
SIM1 SIM1: Single-minded homolog 1 0.0288 0.0288
TCF3 N/A 0.0288 0.0288
MYOD1 MYOD1, MYF3, MYOD: Myoblast determination protein 1 0.0288 0.0258
ARNTL ARNTL, BMAL1, MOP3: Aryl hydrocarbon receptor nuclear translocator-like protein 0.0288 0.0288
SREBF2 SREBF2, SREBP2: Sterol regulatory element-binding protein 2 0.0288 0.0258
TCF3 TCF3: TCF3 protein 0.0288 0.0288
NPAS3 NPAS3, MOP6: Neuronal PAS domain-containing protein 3 0.0288 0.0258
TFE3 TFE3: Transcription factor E3 0.0288 0.0258
MSC MSC, ABF1: Musculin 0.0288 0.0288
MAX max: Max protein 0.0288 0.0288
MYOD1 N/A 0.0288 0.0288
NCOA1 N/A 0.0288 0.0288
MYCL1 MYCL1, LMYC, MYCL: L-myc-1 proto-oncogene protein 0.0288 0.0258
EBF3 EBF3, COE3: Transcription factor COE3 0.0288 0.0258
MXI1 MXI1: MAX-interacting protein 1 0.0288 0.0288
HIF3A HIF3A, MOP7: Hypoxia-inducible factor 3 alpha 0.0288 0.0288
MYCL2 WUGSC:H_DJ0320J15.1: WUGSC:H_DJ0320J15.1 protein 0.0288 0.0288
NPAS2 NPAS2, MOP4: Neuronal PAS domain-containing protein 2 0.0288 0.0288
NCOA1 N/A 0.0288 0.0288
TCFL5 TCFL5, CHA, E2BP1: Transcription factor-like 5 protein 0.0288 0.0288
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.0288 0.0288
PHTF1 PHTF1, PHTF: Putative homeodomain transcription factor 1 0.0288 0.0258
NEUROG3 NEUROG3, ATOH5, NGN3: Neurogenin-3 0.0288 0.0288
FIGLA FIGLA: Factor in the germline alpha 0.0288 0.0288
MYCL2 MYCL2: L-myc-2 protein 0.0288 0.0288
SREBF1 SREBF1, SREBP1: Sterol regulatory element-binding protein 1 0.0288 0.0288
EBF2 EBF2, COE2: Transcription factor COE2 0.0288 0.0288
SOX7 SOX7: Transcription factor SOX-7 0.027 0.027
PAX3 PAX3, HUP2: Paired box protein Pax-3 0.027 0.027
WHSC1 WHSC1, KIAA1090, MMSET, NSD2, TRX5: Probable histone-lysine N-methyltransferase 0.027 0.027
SOX15 SOX15, SOX12, SOX20, SOX26, SOX27: SOX-15 protein 0.027 0.027
WHSC1 N/A 0.027 0.027
SOX17 SOX17: Transcription factor SOX-17 0.027 0.027
0.228
Total Score 24.10